Vincenzo De Luca

Summary

Affiliation: Centre for Addiction and Mental Health
Country: Canada

Publications

  1. ncbi request reprint Suggestive association between the C825T polymorphism of the G-protein beta3 subunit gene (GNB3) and clinical improvement with antipsychotics in schizophrenia
    Daniel J Muller
    Neurogenetics Section, Centre for Addiction and Mental Health, Department of Psychiatry, University of Toronto, Toronto, ON, Canada
    Eur Neuropsychopharmacol 15:525-31. 2005
  2. doi request reprint Schizophrenia severity and clozapine treatment outcome association with oxytocinergic genes
    Renan P Souza
    Neurogenetics Section, Centre for Addiction and Mental Health, Toronto, ON, Canada
    Int J Neuropsychopharmacol 13:793-8. 2010
  3. doi request reprint Ethnicity and suicide attempt: analysis in bipolar disorder and schizophrenia
    Ali Bani-Fatemi
    Group for Suicide Studies, CAMH, Department of Psychiatry, University of Toronto, 250 College St, M5T 1R8 Toronto, ON, Canada
    BMC Psychiatry 13:252. 2013
  4. doi request reprint Comparing self-reported ethnicity and structure-determined ethnicity: analysis of antipsychotic-induced weight gain
    Vincenzo De Luca
    Department of Psychiatry, University of Toronto, Schizophrenia Program, CAMH, 250 College Street, Toronto, ON M5T1R8, Canada
    Pharmacogenomics 14:1943. 2013
  5. doi request reprint Genetic interactions in the adrenergic system genes: analysis of antipsychotic-induced weight gain
    Vincenzo De Luca
    Neurogenetics Section, Centre for Addictions and Mental Health, Toronto, ON, Canada
    Hum Psychopharmacol 26:386-91. 2011
  6. ncbi request reprint Association study between the novel functional polymorphism of the serotonin transporter gene and suicidal behaviour in schizophrenia
    Vincenzo De Luca
    Neurogenetics Section, Clarke Site, Centre for Addiction and Mental Health, Department of Psychiatry, University of Toronto, 250 College Street R 30, Toronto, Ontario, Canada M5T 1R8
    Eur Neuropsychopharmacol 16:268-71. 2006
  7. ncbi request reprint Promoter polymorphism of second tryptophan hydroxylase isoform (TPH2) in schizophrenia and suicidality
    Vincenzo De Luca
    Neurogenetics Section, Clarke Site, Centre for Addiction and Mental Health, Department of Psychiatry, University of Toronto, 250 College Street, R 30, Toronto, Ontario, Canada M5T 1R8
    Psychiatry Res 134:195-8. 2005
  8. ncbi request reprint Association of the HTR2C gene and antipsychotic induced weight gain: a meta-analysis
    Vincenzo De Luca
    University of Toronto, Centre for Addiction and Mental Health, Neurogenetics Section, Toronto, ON, Canada
    Int J Neuropsychopharmacol 10:697-704. 2007
  9. doi request reprint Association of HPA axis genes with suicidal behaviour in schizophrenia
    V De Luca
    Neurogenetics Section, Centre for Addiction and Mental Health, University of Toronto, Toronto, Ontario, Canada
    J Psychopharmacol 24:677-82. 2010
  10. ncbi request reprint Gene-gene interaction between MAOA and COMT in suicidal behavior
    Vincenzo De Luca
    Neurogenetics Section, Clarke Site, Centre for Addiction and Mental Health, Department of Psychiatry, University of Toronto, Ont, Canada
    Neurosci Lett 383:151-4. 2005

Collaborators

Detail Information

Publications81

  1. ncbi request reprint Suggestive association between the C825T polymorphism of the G-protein beta3 subunit gene (GNB3) and clinical improvement with antipsychotics in schizophrenia
    Daniel J Muller
    Neurogenetics Section, Centre for Addiction and Mental Health, Department of Psychiatry, University of Toronto, Toronto, ON, Canada
    Eur Neuropsychopharmacol 15:525-31. 2005
    ..8 to 7%. Our results further suggest that this effect is only attributable to Caucasians when compared to African-Americans. Moreover, our findings point to the role of intracellular mechanisms in antipsychotic response...
  2. doi request reprint Schizophrenia severity and clozapine treatment outcome association with oxytocinergic genes
    Renan P Souza
    Neurogenetics Section, Centre for Addiction and Mental Health, Toronto, ON, Canada
    Int J Neuropsychopharmacol 13:793-8. 2010
    ..Additional association studies in independent samples will be able evaluate whether OXT and OXTR genes are truly playing a role in the clozapine treatment outcome...
  3. doi request reprint Ethnicity and suicide attempt: analysis in bipolar disorder and schizophrenia
    Ali Bani-Fatemi
    Group for Suicide Studies, CAMH, Department of Psychiatry, University of Toronto, 250 College St, M5T 1R8 Toronto, ON, Canada
    BMC Psychiatry 13:252. 2013
    ..The present analysis assessed whether risk for suicide attempt was associated with White European ethnicity in 907 subjects with schizophrenia or bipolar disorder...
  4. doi request reprint Comparing self-reported ethnicity and structure-determined ethnicity: analysis of antipsychotic-induced weight gain
    Vincenzo De Luca
    Department of Psychiatry, University of Toronto, Schizophrenia Program, CAMH, 250 College Street, Toronto, ON M5T1R8, Canada
    Pharmacogenomics 14:1943. 2013
    ..Response to: Kaufman JS, Hamra G. In Chan et al. the difference between p < 0.05 and p < 0.05 is p > 0.05. Pharmacogenomics14(16), 1941-1942 (2013). ..
  5. doi request reprint Genetic interactions in the adrenergic system genes: analysis of antipsychotic-induced weight gain
    Vincenzo De Luca
    Neurogenetics Section, Centre for Addictions and Mental Health, Toronto, ON, Canada
    Hum Psychopharmacol 26:386-91. 2011
    ....
  6. ncbi request reprint Association study between the novel functional polymorphism of the serotonin transporter gene and suicidal behaviour in schizophrenia
    Vincenzo De Luca
    Neurogenetics Section, Clarke Site, Centre for Addiction and Mental Health, Department of Psychiatry, University of Toronto, 250 College Street R 30, Toronto, Ontario, Canada M5T 1R8
    Eur Neuropsychopharmacol 16:268-71. 2006
    ..031). These findings suggest that the intron 2 VNTR polymorphism in serotonin transporter gene may influence suicidal behaviour in schizophrenia...
  7. ncbi request reprint Promoter polymorphism of second tryptophan hydroxylase isoform (TPH2) in schizophrenia and suicidality
    Vincenzo De Luca
    Neurogenetics Section, Clarke Site, Centre for Addiction and Mental Health, Department of Psychiatry, University of Toronto, 250 College Street, R 30, Toronto, Ontario, Canada M5T 1R8
    Psychiatry Res 134:195-8. 2005
    ..These findings suggest that these 5' marker haplotypes in the TPH2 gene do not influence suicidal behavior in schizophrenia...
  8. ncbi request reprint Association of the HTR2C gene and antipsychotic induced weight gain: a meta-analysis
    Vincenzo De Luca
    University of Toronto, Centre for Addiction and Mental Health, Neurogenetics Section, Toronto, ON, Canada
    Int J Neuropsychopharmacol 10:697-704. 2007
    ..Our meta-analysis provides support for the association of HTR2C in weight gain but indicates that firmly establishing the role of pharmacogenetics in clinical psychiatry requires much larger sample sizes that have been hitherto reported...
  9. doi request reprint Association of HPA axis genes with suicidal behaviour in schizophrenia
    V De Luca
    Neurogenetics Section, Centre for Addiction and Mental Health, University of Toronto, Toronto, Ontario, Canada
    J Psychopharmacol 24:677-82. 2010
    ..This is to our knowledge the first study on suicidal behaviour investigating the interaction among the HPA axis genes...
  10. ncbi request reprint Gene-gene interaction between MAOA and COMT in suicidal behavior
    Vincenzo De Luca
    Neurogenetics Section, Clarke Site, Centre for Addiction and Mental Health, Department of Psychiatry, University of Toronto, Ont, Canada
    Neurosci Lett 383:151-4. 2005
    ..These findings suggest that MAOA and COMT genes may not influence suicidal behavior in patients with bipolar disorder...
  11. ncbi request reprint Untranslated region haplotype in dysbindin gene: analysis in schizophrenia
    V De Luca
    Department of Psychiatry, Neurogenetics Section, Clarke Site, Centre for Addiction and Mental Health, University of Toronto, Toronto, Ont, Canada
    J Neural Transm 112:1263-7. 2005
    ..The sample size of our study is 117 families. No biased transmission towards the disorder was detected by haplotype analysis using TRANSMIT...
  12. ncbi request reprint Genetic interaction between alpha4 and beta2 subunits of high affinity nicotinic receptor: analysis in schizophrenia
    Vincenzo De Luca
    Neurogenetics Section, Clarke Site, Centre for Addiction and Mental Health, Department of Psychiatry, University of Toronto, 250 College Street R 30, Toronto, ON, Canada, M5T 1R8
    Exp Brain Res 174:292-6. 2006
    ..010), while neither was sufficient alone to confer susceptibility. Our present study provided the first line of direct evidence suggesting that the CHRNA4 gene combined with CHRNB2 receptor gene may be linked to schizophrenia...
  13. ncbi request reprint Identification of a naturally occurring 21 bp deletion in alpha 2c noradrenergic receptor gene and cognitive correlates to antipsychotic treatment
    Vincenzo De Luca
    Neurogenetics Section, Centre for Addiction and Mental Health, Department of Psychiatry, University of Toronto, 250 College Street R 30, Toronto, Ont, Canada M5T 1R8
    Pharmacol Res 51:381-4. 2005
    ..Our results suggest that the novel polymorphism may not play a major role in antipsychotic response...
  14. ncbi request reprint Gene-gene interaction between MAOA and COMT in suicidal behavior: analysis in schizophrenia
    Vincenzo De Luca
    Neurogenetics Section, Clarke Site, Centre for Addiction and Mental Health, Department of Psychiatry, University of Toronto, 250 College Street R 30, Toronto, Ontario, Canada M5T 1R8
    Brain Res 1097:26-30. 2006
    ..545). These results suggest that epistasis between MAOA and COMT genes may not influence suicidal behavior in patients with schizophrenia...
  15. doi request reprint 5-HT2C receptor and MAO-A interaction analysis: no association with suicidal behaviour in bipolar patients
    Vincenzo De Luca
    Dept of Psychiatry, University of Toronto, 250 College Street, R 30, Toronto ON, Canada M5T 1R8
    Eur Arch Psychiatry Clin Neurosci 258:428-33. 2008
    ..Furthermore, we performed a particular gene-gene interaction for the X-linked serotonergic genes (HTR2C and MAOA), and found no association among this intergenic haplotype combination and suicidal behaviour in bipolar disorder...
  16. ncbi request reprint Power based association analysis (PBAT) of serotonergic and noradrenergic polymorphisms in bipolar patients with suicidal behaviour
    Vincenzo De Luca
    Centre for Addiction and Mental Health, Department of Psychiatry, University of Toronto, ON, Canada
    Prog Neuropsychopharmacol Biol Psychiatry 32:197-203. 2008
    ....
  17. ncbi request reprint HTR2C haplotypes and antipsychotics-induced weight gain: X-linked multimarker analysis
    Vincenzo De Luca
    Department of Psychiatry, Centre for Addiction and Mental Health, Neurogenetics Section, University of Toronto, Toronto, ON, Canada
    Hum Psychopharmacol 22:463-7. 2007
    ....
  18. ncbi request reprint Association study between the corticotropin-releasing hormone receptor 2 gene and suicidality in bipolar disorder
    Vincenzo De Luca
    Neurogenetics Section, Centre for Addiction and Mental Health, Department of Psychiatry, University of Toronto, 250 College Street, R 30, Toronto, Ontario, Canada
    Eur Psychiatry 22:282-7. 2007
    ..This is to our knowledge the first investigation on suicidal behavior and genetic variation at the CRHR2 locus, an important regulator of the HPA axis...
  19. ncbi request reprint Association study of a novel functional polymorphism of the serotonin transporter gene in bipolar disorder and suicidal behaviour
    Vincenzo De Luca
    Neurogenetics Section, Clarke Site, Centre for Addiction and Mental Health, Department of Psychiatry, University of Toronto, 250 College Street R 30, Toronto, Ontario, Canada, M5T 1R8, Canada
    Psychopharmacology (Berl) 182:128-31. 2005
    ..84 df=4 P=0.76). These findings suggest that this new polymorphism in the 5-HTT gene may not influence suicidal behaviour in patients with bipolar disorder...
  20. ncbi request reprint Association study of tardive dyskinesia and twelve DRD2 polymorphisms in schizophrenia patients
    Clement C Zai
    Centre for Addiction and Mental Health, Toronto, Ontario, Canada
    Int J Neuropsychopharmacol 10:639-51. 2007
    ..047). Taken together, the present study suggests that DRD2 may be involved in TD in the Caucasian population, although further studies are warranted...
  21. doi request reprint Genetic study of BDNF, DRD3, and their interaction in tardive dyskinesia
    Clement C Zai
    Centre for Addiction and Mental Health, Toronto, Ontario, Canada
    Eur Neuropsychopharmacol 19:317-28. 2009
    ..007). We also found evidence of interaction between BDNF and DRD3 polymorphisms. Further studies are needed to confirm these findings...
  22. doi request reprint Association study of the gamma-aminobutyric acid type a receptor gamma2 subunit gene with schizophrenia
    Clement C Zai
    Neurogenetics Section, Centre for Addiction and Mental Health, Toronto, Ontario, Canada
    Schizophr Res 114:33-8. 2009
    ..18; p<1 x 10(-3)). Taken together, the results of the present study suggest that GABRG2 may be involved in SCZ susceptibility, but further studies are required...
  23. ncbi request reprint Genetic association analysis of the glutathione peroxidase (GPX1) gene polymorphism (Pro197Leu) with tardive dyskinesia
    Takahiro Shinkai
    Neurogenetics Section, Centre for Addiction and Mental Health, Clarke Division, Department of Psychiatry, University of Toronto, Toronto, Ontario, Canada, M5T 1R8
    Psychiatry Res 141:123-8. 2006
    ..Our results suggest that the GPX1 gene polymorphism does not confer increased susceptibility to TD, although further studies are warranted before a conclusion can be drawn...
  24. doi request reprint Finite mixture regression model analysis on antipsychotics induced weight gain: investigation of the role of the serotonergic genes
    Behdin Nowrouzi
    Laurentian University, Sudbury, Ontario, Canada
    Eur Neuropsychopharmacol 23:224-8. 2013
    ..The mixture regression model appears to be a useful strategy to highlight different weight gain subgroups that are affected differently by clinical and genetic predictors...
  25. ncbi request reprint Association study of four dopamine D1 receptor gene polymorphisms and clozapine treatment response
    Rudi Hwang
    Neurogenetics Section, Centre for Addiction and Mental Health, University of Toronto, Toronto, Canada
    J Psychopharmacol 21:718-27. 2007
    ..2003), a trend in the same direction was observed as well. Our findings suggest that the rs4532 SNP may have a small effect if any. Further studies in larger, independent samples are required to validate these findings...
  26. ncbi request reprint Association analyses of the DAOA/G30 and D-amino-acid oxidase genes in schizophrenia: further evidence for a role in schizophrenia
    Takahiro Shinkai
    Center for Addiction and Mental Health, Department of Psychiatry, University of Toronto, Toronto, Ontario, M5T 1R8, Canada, and Wakato Hospital, Kitakyushu, Japan
    Neuromolecular Med 9:169-77. 2007
    ..Further research is warranted to determine the functional variation underlying these findings and to relate this to the pathophysiology of schizophrenia...
  27. ncbi request reprint Association study of 12 polymorphisms spanning the dopamine D(2) receptor gene and clozapine treatment response in two treatment refractory/intolerant populations
    Rudi Hwang
    Neurogenetics Section, Center for Addiction and Mental Health, University of Toronto, 250 College Street, Toronto, Ontario M5T 1R8, Canada
    Psychopharmacology (Berl) 181:179-87. 2005
    ..Genetic factors affecting the density and/or function of D(2) receptors may therefore affect AP response...
  28. doi request reprint Parent of origin effect and differential allelic expression of BDNF Val66Met in suicidal behaviour
    Vincenzo De Luca
    Department of Psychiatry, University of Toronto, Toronto, Canada
    World J Biol Psychiatry 12:42-7. 2011
    ....
  29. doi request reprint The catechol-O-methyl-transferase gene in tardive dyskinesia
    Clement C Zai
    Neurogenetics Section, Centre for Addiction and Mental Health, Toronto, Ontario, Canada
    World J Biol Psychiatry 11:803-12. 2010
    ..Changes in dopamine neurotransmission have been implicated in the etiology of TD, and catechol-O-methyl-transferase (COMT) is an enzyme that metabolizes dopamine...
  30. doi request reprint Methylation and QTDT analysis of the 5-HT2A receptor 102C allele: analysis of suicidality in major psychosis
    Vincenzo De Luca
    Centre for Addiction and Mental Health, Department of Psychiatry, University of Toronto, 250 College Road, Toronto, Ontario, Canada
    J Psychiatr Res 43:532-7. 2009
    ..This result suggests that methylation of the 102C allele does not influence completed suicide...
  31. ncbi request reprint N-methyl-D-aspartate receptor NR2B subunit gene GRIN2B in schizophrenia and bipolar disorder: Polymorphisms and mRNA levels
    Livia Martucci
    Neurogenetics Section, CAMH, Clarke Division, University of Toronto, R 31, 250 College Street, Toronto ON, Canada M5T 1R8
    Schizophr Res 84:214-21. 2006
    ..005). GRIN2B expression levels in schizophrenia, bipolar disorder and controls were not significantly different. The genetic findings suggest a role for GRIN2B in schizophrenia and bipolar disorder...
  32. doi request reprint Correlation of a set of gene variants, life events and personality features on adult ADHD severity
    Daniel J Muller
    Neurogenetics Section, Centre for Addiction and Mental Health CAMH, University of Toronto, Toronto, ON, Canada M5T 1R8
    J Psychiatr Res 44:598-604. 2010
    ..However, several limitations such as the small sample size and the exclusion of patients with other severe comorbid psychiatric disorders could have influenced the significance of present findings...
  33. doi request reprint Role of ethnicity in antipsychotic-induced weight gain and tardive dyskinesia: genes or environment?
    Lai Fong Chan
    Centre for Addiction and Mental Health, Department of Psychiatry, University of Toronto, Toronto, Ontario, Canada
    Pharmacogenomics 14:1273-81. 2013
    ..This study explored the role of self-reported ethnicity and genetic ancestry on antipsychotic (AP)-induced weight gain and tardive dyskinesia (TD) in schizophrenia...
  34. doi request reprint Analysis of treatment-resistant schizophrenia and 384 markers from candidate genes
    Celine Teo
    Centre for Addiction and Mental Health, Department of Psychiatry, University of Toronto, Ontario, Toronto, Canada
    Pharmacogenet Genomics 22:807-11. 2012
    ..However, this phenotype can be assessed retrospectively in cross-sectional studies and these preliminary results point out the importance of choosing alternative phenotypes in psychiatric pharmacogenetics...
  35. doi request reprint The brain-derived neurotrophic factor gene in suicidal behaviour: a meta-analysis
    Clement C Zai
    Neurogenetics Section, Centre for Addiction and Mental Health, Toronto, ON, Canada
    Int J Neuropsychopharmacol 15:1037-42. 2012
    ..017; fixed-effects model: p=0.008). Taken together, the results from our study suggest that BDNF Val⁶⁶Met is involved in suicidality. Further studies are required to elucidate its role in suicidal behaviour...
  36. doi request reprint Analysis of BDNF Val66Met allele-specific mRNA levels in bipolar disorder
    Vincenzo De Luca
    Neurogenetics, Centre for Addiction and Mental Health, Toronto, ON, Canada
    Neurosci Lett 441:229-32. 2008
    ..The Val/Met ratio was much lower in the brain vs. B lymphoblasts. These data do not support a role for genomic imprinting as a modifier of the contribution of BDNF gene to risk of susceptibility to BD...
  37. ncbi request reprint Molecular analysis of a chromosome 4 inversion segregating in a large schizophrenia kindred from Hong Kong
    Albert K Mensah
    Molecular Neuropsychiatry and Development Laboratory, Toronto, Canada
    Schizophr Res 95:228-35. 2007
    ..016). This study suggests that the 4q breakpoint regions may harbour a gene that contributes to the illness in the large Hong Kong pedigree, and this 4q25 region should be examined further in other schizophrenia samples...
  38. doi request reprint Association study of BDNF and DRD3 genes in schizophrenia diagnosis using matched case-control and family based study designs
    Clement C Zai
    Neurogenetics Section, Centre for Addiction and Mental Health, Toronto, Ontario, Canada M5T 1R8
    Prog Neuropsychopharmacol Biol Psychiatry 34:1412-8. 2010
    ..We did not find a statistically significant association with the other DRD3 and BDNF polymorphisms. Taken together, the results from the present study suggest that BDNF and DRD3 may not be involved in SCZ susceptibility...
  39. ncbi request reprint The SNAP-25 gene may be associated with clinical response and weight gain in antipsychotic treatment of schizophrenia
    Daniel J Muller
    Neurogenetics Section, Centre for Addiction and Mental Health, Department of Psychiatry, University of Toronto, 250 College Street R30, Toronto, Ont M5T 1R8, Canada
    Neurosci Lett 379:81-9. 2005
    ..Weight changes do not seem to be associated with polymorphism of the SNAP-25 gene, however, replication in independent samples is warranted...
  40. ncbi request reprint Adrenergic alpha 2C receptor genomic organization: association study in adult ADHD
    Vincenzo De Luca
    Psychiatric Neurogenetics, Department of Psychiatry, Clarke Site, Centre for Addiction and Mental Health, University of Toronto, Toronto, Ontario, Canada
    Am J Med Genet B Neuropsychiatr Genet 127:65-7. 2004
    ..There was no preferential transmission of any allele. These findings exclude a strong effect of this ADRA2C marker on risk for ADHD in our sample of adult proband families...
  41. ncbi request reprint Parent-of-origin effect and genomic imprinting of the HTR2A receptor gene T102C polymorphism in psychosis
    Vincenzo De Luca
    Centre for Addiction and Mental Health, Department of Psychiatry, University of Toronto, Toronto, Ontario, Canada
    Psychiatry Res 151:243-8. 2007
    ....
  42. doi request reprint Glial cell line-derived neurotrophic factor receptor alpha 2 (GFRA2) gene is associated with tardive dyskinesia
    Renan P Souza
    Neurogenetics Section, Neuroscience Department, Centre for Addiction and Mental Health, Toronto, Ontario, Canada
    Psychopharmacology (Berl) 210:347-54. 2010
    ..Clinical trials have also investigated whether GDNF may ameliorate Parkinson's disease symptoms...
  43. doi request reprint Are serotonin 3A and 3B receptor genes associated with suicidal behavior in schizophrenia subjects?
    Renan P Souza
    Neurogenetics Section, Neuroscience Department, Centre for Addiction and Mental Health, Toronto, ON, Canada
    Neurosci Lett 489:137-41. 2011
    ..Moreover, gene-gene interaction and haplotype association may have consistent results for genes located in the same chromosome...
  44. doi request reprint Oxidative stress in tardive dyskinesia: genetic association study and meta-analysis of NADPH quinine oxidoreductase 1 (NQO1) and Superoxide dismutase 2 (SOD2, MnSOD) genes
    Clement C Zai
    Neurogenetics Section, Centre for Addiction and Mental Health, 250 College Street, Toronto, Ontario, Canada M5T 1R8
    Prog Neuropsychopharmacol Biol Psychiatry 34:50-6. 2010
    ..2000) reported an association between TD and the Manganese superoxide dismutase SOD2 (MnSOD) gene Ala9Val (rs4880) polymorphism in a Japanese sample, but most research groups failed to replicate their positive findings...
  45. ncbi request reprint Brain-derived neurotrophic factor (BDNF) gene and rapid-cycling bipolar disorder: family-based association study
    Daniel J Muller
    Neurogenetics Section, Centre for Addiction and Mental Health Department of Psychiatry, University of Toronto, 250 College Street R30, Toronto, Ontario M5T1R8, Canada
    Br J Psychiatry 189:317-23. 2006
    ..We have previously reported the Val66Met and GT(n) repeat polymorphisms of the brain-derived neurotrophic factor (BDNF) gene to be associated with bipolar disorder. However, these findings have not been replicated consistently...
  46. pmc Association of alpha4beta2 nicotinic receptor and heavy smoking in schizophrenia
    Sophocles Voineskos
    Neurogenetics Section, Clarke Site, Centre for Addiction and Mental Health, Department of Psychiatry, University of Toronto, Toronto, Ont
    J Psychiatry Neurosci 32:412-6. 2007
    ..Schizophrenia patients are usually heavy smokers. In this study we hypothesized that high-affinity nicotinic receptors are associated with smoking in such patients...
  47. doi request reprint Influence of serotonin 3A and 3B receptor genes on clozapine treatment response in schizophrenia
    Renan P Souza
    Neurogenetics Section, Department of Neuroscience, Centre for Addiction and Mental Health, University of Toronto, 250 College Street, Toronto, Ontario, Canada
    Pharmacogenet Genomics 20:274-6. 2010
    ..Further studies are necessary to confirm the reported associations...
  48. doi request reprint Neuregulin 1 and age of onset in the major psychoses
    Daphne Voineskos
    Centre for Addiction and Mental Health, 250 College Street, R 30, Toronto, ON, M5T 1R8, Canada
    J Neural Transm 116:479-86. 2009
    ..Ours was the first study to investigate the NRG1 core haplotype with age of onset of major psychoses, and despite our preliminary negative findings, this area deserves further investigation...
  49. doi request reprint Association and CpG SNP analysis of HTR4 polymorphisms with suicidal behavior in subjects with schizophrenia
    Gina Polsinelli
    Neurogenetics Section, Centre for Addiction and Mental Health CAMH, Toronto, Canada
    J Neural Transm 120:253-8. 2013
    ..Moreover, although not significant, the CpG SNP potential methylation analysis would be informative for future methylation analysis on this gene...
  50. doi request reprint Association of antipsychotic induced weight gain and body mass index with GNB3 gene: a meta-analysis
    Renan P Souza
    Neurogenetics Section, Centre for Addiction and Mental Health, University of Toronto, Canada
    Prog Neuropsychopharmacol Biol Psychiatry 32:1848-53. 2008
    ..Our meta-analysis indicates that firmly establishing the role of pharmacogenetics in clinical psychiatry requires much larger sample sizes that have been reported...
  51. doi request reprint DRD4 VNTR polymorphism and age at onset of severe mental illnesses
    Vanessa Faria Gonçalves
    Neurogenetics Section, Neuroscience Department, Centre for Addiction and Mental Health, Toronto, ON, Canada vanessa
    Neurosci Lett 519:9-13. 2012
    ..028). In summary, our results suggest that the 7R is associated with AAO in both schizophrenia and bipolar disorders. The effect was observed across both sexes in bipolar disorder, but specifically in females for schizophrenia...
  52. doi request reprint Dopaminergic system genes in childhood aggression: possible role for DRD2
    Clement C Zai
    Neurogenetics Section, Centre for Addiction and Mental Health, Toronto, Canada
    World J Biol Psychiatry 13:65-74. 2012
    ..OBJECTIVE. We examined selected members of the dopaminergic system genes for association with child aggression...
  53. ncbi request reprint No association between the Pro197Leu polymorphism in the glutathione peroxidase (GPX1) gene and schizophrenia
    Takahiro Shinkai
    Neurogenetics Section, Centre for Addiction and Mental Health, Clarke Division, Department of Psychiatry, University of Toronto, Toronto, Ontario, Canada
    Psychiatr Genet 14:177-80. 2004
    ..The aim of this study is to examine whether a potentially functional polymorphism, a proline (Pro) to leucine (Leu) substitution at codon 197 (Pro197Leu) of the human GPX1 gene, is associated with susceptibility to schizophrenia...
  54. ncbi request reprint Evidence of association between smoking and alpha7 nicotinic receptor subunit gene in schizophrenia patients
    Vincenzo De Luca
    Neurogenetics Section, Clarke Site, Centre for Addiction and Mental Health, Department of Psychiatry, Toronto, Ontario, Canada
    Neuropsychopharmacology 29:1522-6. 2004
    ..37, 3 df, p=0.015). Although this novel finding requires replication, it suggests that further study into the relationship between schizophrenia and nicotine system genes is warranted...
  55. ncbi request reprint Polymorphisms in glutamate decarboxylase genes: analysis in schizophrenia
    Vincenzo De Luca
    Neurogenetics Section, Clarke Site, Centre for Addiction and Mental Health, Department of Psychiatry, University of Toronto, Ontario, Canada
    Psychiatr Genet 14:39-42. 2004
    ..Although our results are negative, this was the first study to investigate GAD genes in schizophrenia, and further studies of these genes, particularly with schizophrenia subtypes, may prove valuable...
  56. ncbi request reprint Linkage of M5 muscarinic and alpha7-nicotinic receptor genes on 15q13 to schizophrenia
    Vincenzo De Luca
    Department of Psychiatry, Neurogenetics Section, Clarke Site, Centre for Addiction and Mental Health, University of Toronto, Toronto, Ont, Canada
    Neuropsychobiology 50:124-7. 2004
    ..Our present study provided the first line of direct evidence suggesting that the CHRM5 gene combined with the CHRNA7 gene may be linked to schizophrenia...
  57. ncbi request reprint Lack of association between the corticotrophin-releasing hormone receptor 2 gene and panic disorder
    Subi Tharmalingam
    Neurogenetics Section, Centre for Addiction and Mental Health, University of Toronto, Canada
    Psychiatr Genet 16:93-7. 2006
    ..Further studies investigating additional polymorphisms in this gene and other components of the CRH signalling system may prove useful...
  58. doi request reprint Investigation of the dopamine D5 receptor gene (DRD5) in adult attention deficit hyperactivity disorder
    Alessio Squassina
    Neurogenetics Section, Centre for Addiction and Mental Health, Department of Psychiatry, University of Toronto, 250 College Street, Toronto, ON M5T 1R8, Canada
    Neurosci Lett 432:50-3. 2008
    ..Our findings add to the literature suggesting DRD5 (CA)(n) repeat has a modest effect in modulating susceptibility to adult ADHD but further studies are required...
  59. ncbi request reprint Association study between a functional glutathione S-transferase (GSTP1) gene polymorphism (Ile105Val) and tardive dyskinesia
    Takahiro Shinkai
    Neurogenetics Section, Centre for Addiction and Mental Health, Department of Psychiatry, University of Toronto, Ont, Canada M5T 1R8
    Neurosci Lett 388:116-20. 2005
    ..1, p=1.00) were observed between subjects with and without TD. Our results suggest that the GSTP1 gene polymorphism does not confer increased susceptibility to TD, although further studies are warranted before a conclusion can be drawn...
  60. doi request reprint Smoking in adult attention-deficit/hyperactivity disorder: interaction between 15q13 nicotinic genes and Temperament Character Inventory scores
    Mirko Manchia
    Centre for Addiction and Mental Health, Toronto, Ontario, Canada
    World J Biol Psychiatry 11:506-10. 2010
    ..However, Persistence score of the TCI was significantly associated with smoking status. Further investigation on the hypothesis of the molecular interaction between CHRNA7 and CHRFAM7A genes is warranted...
  61. ncbi request reprint Differential expression and parent-of-origin effect of the 5-HT2A receptor gene C102T polymorphism: analysis of suicidality in schizophrenia and bipolar disorder
    Vincenzo De Luca
    Centre for Addiction and Mental Health, Department of Psychiatry, University of Toronto, Toronto, Ontario, Canada
    Am J Med Genet B Neuropsychiatr Genet 144:370-4. 2007
    ..No association between the 5-HT2A C102T polymorphism and suicidal behavior in major psychoses was detected with the transmission/disequilibrium test (TDT)...
  62. ncbi request reprint Tryptophan hydroxylase 2 gene expression and promoter polymorphisms in bipolar disorder and schizophrenia
    Vincenzo De Luca
    Centre for Addiction and Mental Health, Department of Psychiatry, University of Toronto, Room 711, 250 College Street, Toronto, ON M5T 1R8, Canada
    Psychopharmacology (Berl) 183:378-82. 2005
    ..024). Further investigations of Tph2 are needed to clarify the potential role of this gene in the pathophysiology of bipolar disorder...
  63. doi request reprint Analysis of CpG SNPs in 34 genes: association test with suicide attempt in schizophrenia
    Ali Bani-Fatemi
    CAMH, Department of Psychiatry, University of Toronto, Canada
    Schizophr Res 147:262-8. 2013
    ..To date, there are no robust genetic or epigenetic predictors of suicide or suicide attempt in this specific population...
  64. ncbi request reprint No evidence of linkage or association between the norepinephrine transporter (NET) gene MnlI polymorphism and adult ADHD
    Vincenzo De Luca
    Psychiatric Neurogenetics, Clarke Site, Centre for Addiction and Mental Health, Department of Psychiatry, University of Toronto, Toronto, Ontario, Canada
    Am J Med Genet B Neuropsychiatr Genet 124:38-40. 2004
    ..The MnlI polymorphism was typed in 128 trios and analyzed using the transmission disequilibrium test (TDT). There was no preferential transmission of either allele (chi(2) = 0.209, df = 1, P = 0.647)...
  65. doi request reprint A family-based association study of the myelin-associated glycoprotein and 2',3'-cyclic nucleotide 3'-phosphodiesterase genes with schizophrenia
    Aristotle N Voineskos
    Centre for Addiction and Mental Health, University of Toronto, Toronto, Canada
    Psychiatr Genet 18:143-6. 2008
    ..003). No CNP-MAG gene-gene interaction conferred increased risk for schizophrenia. Our finding provides support for potential association of the CNP gene but not the MAG gene in schizophrenia in a Caucasian population...
  66. ncbi request reprint A drosophila model for attention deficit hyperactivity disorder (ADHD): No evidence of association with PRKG1 gene
    Vincenzo De Luca
    Neurogenetics Section, Clarke Site, Centre for Addiction and Mental Health, Department of Psychiatry, University of Toronto, Toronto, Ontario, Canada
    Neuromolecular Med 2:281-7. 2002
    ..778, df = 1, p = 0.316). These findings exclude a direct involvement of this genetic marker of the Protein kinase G gene in the pathogenesis of ADHD...
  67. doi request reprint The role of ethnicity in treatment refractory schizophrenia
    Celine Teo
    CAMH, Department of Psychiatry, University of Toronto, Toronto, Ontario, Canada M5T 1R8
    Compr Psychiatry 54:167-72. 2013
    ..A secondary goal was to analyze the number of antipsychotics failed due to side effects and number of antipsychotics failed due to non-response...
  68. ncbi request reprint Serotonin transporter polymorphisms and persistent, pervasive childhood aggression
    Joseph H Beitchman
    Division of Child and Adolescent Psychiatry, University of Toronto, and the Centre for Addiction and Mental Health, 250 College St, Toronto, ONT Canada, M5T 1R8
    Am J Psychiatry 163:1103-5. 2006
    ....
  69. doi request reprint Parent of origin effect and allelic expression imbalance of the serotonin transporter in bipolar disorder and suicidal behaviour
    Crystal Pinto
    Neurobiology of Schizophrenia Section, Neuroscience Department, Centre for Addiction and Mental Health Toronto, Toronto, ON, Canada
    Eur Arch Psychiatry Clin Neurosci 261:533-8. 2011
    ..Small sample size and the fact that RNA was obtained from lymphoblastoid cell lines were some of the limitations of this study...
  70. ncbi request reprint Gene expression of tryptophan hydroxylase 2 in post-mortem brain of suicide subjects
    Vincenzo De Luca
    Centre for Addiction and Mental Health, Department of Psychiatry, University of Toronto, Toronto, Ontario, Canada
    Int J Neuropsychopharmacol 9:21-5. 2006
    ..Further investigation of TPH2 gene expression is needed to clarify the potential role of this gene in the pathophysiology of suicide...
  71. doi request reprint Age at onset in Canadian OCD patients: mixture analysis and systematic comparison with other studies
    Vincenzo De Luca
    Centre for Addiction and Mental Health, Toronto, Canada
    J Affect Disord 133:300-4. 2011
    ..This study aimed to determine the distributions of the age at onset (AAO) using mixture analysis and better develop the understanding of AAO as a clinical feature of obsessive-compulsive disorder...
  72. pmc Weight gain, schizophrenia and antipsychotics: new findings from animal model and pharmacogenomic studies
    Fabio Panariello
    Department of Psychiatry, Centre for Addiction and Mental Health, University of Toronto, 250 College Street, Room 30, Toronto, ON, Canada M5T 1R8
    Schizophr Res Treatment 2011:459284. 2011
    ..We also outline major areas for future research...
  73. pmc Peripheral amino Acid levels in schizophrenia and antipsychotic treatment
    Vincenzo De Luca
    Department of Psychiatry, University of Toronto, Centre for Addiction and Mental Health, Toronto, Ontario, Canada
    Psychiatry Investig 5:203-8. 2008
    ..This review has also highlighted a considerable dearth of studies, specifically of studies evaluating antipsychotic side-effects...
  74. ncbi request reprint Association between three functional polymorphisms of the dopamine D2 receptor gene and polydipsia in schizophrenia
    Chima Matsumoto
    Department of Psychiatry, School of Medicine, University of Occupational and Environmental Health, Yahatanishi ku, Kitakyushu, Japan
    Int J Neuropsychopharmacol 8:245-53. 2005
    ..To confirm our findings, further studies are warranted on larger samples using more extensive biological measures for diagnosing the polydipsia phenotype...
  75. doi request reprint Genetic association between the dopamine D3 gene polymorphism (Ser9Gly) and schizophrenia in Japanese populations: evidence from a case-control study and meta-analysis
    Kensuke Utsunomiya
    Department of Psychiatry, School of Medicine, University of Occupational and Environmental Health, Kitakyushu, Japan
    Neurosci Lett 444:161-5. 2008
    ..Given that the Ser9Gly variant may play a putative role in DRD3 function, further studies on the DRD3 with linked variants are warranted...
  76. ncbi request reprint Haplotype association study between DRD1 gene and bipolar type I affective disorder in two samples from Canada and Sardinia
    Maria Del Zompo
    Department of Neurosciences B B Brodie, Section of Clinical Pharmacology, Center of Clinical Psychopharmacology, University of Cagliari, Cagliari, Italy
    Am J Med Genet B Neuropsychiatr Genet 144:237-41. 2007
    ..01. The fact that the same haplotype shows a similar trend for association in samples originating from different ethnic backgrounds seems to imply that the -800C/-48G/1403T haplotype may be considered as a risk factor for BP I disorder...
  77. ncbi request reprint Association study between functional polymorphisms in the cytochrome P450 1A2 and 2D6 genes and polydipsia in schizophrenia
    Chima Matsumoto
    Department of Psychiatry, School of Medicine, University of Occupational and Environmental Health, Kitakyushu, Japan
    Neuromolecular Med 8:381-8. 2006
    ....
  78. ncbi request reprint 759C/T genetic variation of 5HT(2C) receptor and clozapine-induced weight gain
    Vincenzo S Basile
    Lancet 360:1790-1. 2002
  79. ncbi request reprint Serotonin system genes and childhood-onset aggression
    Helene M Mik
    Psychiatr Genet 17:11. 2007
  80. pmc Wound-inducible biosynthesis of phytoalexin hydroxycinnamic acid amides of tyramine in tryptophan and tyrosine decarboxylase transgenic tobacco lines
    Gabriel Guillet
    Department of Biological Sciences, University of Montreal, Montreal, Quebec, Canada H3C 3J7
    Plant Physiol 137:692-9. 2005
    ..These results provide experimental evidence that, under some circumstances, TYDC activity can exert a rate-limiting control over the carbon flux allocated to the biosynthesis of hydroxycinnamic acid amides of tyramine...
  81. ncbi request reprint Utilization of the genetic resources of wild species to create a nontransgenic high flavonoid tomato
    Michael G Willits
    Syngenta Biotechnology, Inc, 3054 East Cornwallis Road, Research Triangle Park, North Carolina 27709 2257, USA
    J Agric Food Chem 53:1231-6. 2005
    ..puberulum) and demonstrate the opportunities for restoring functional pathways using the genetic resources of wild species, resulting in production of healthier foods...