Z Jeff Daskalakis

Summary

Affiliation: Centre for Addiction and Mental Health
Country: Canada

Publications

  1. pmc Personality goes a long a way: an interhemispheric connectivity study
    Sylco S Hoppenbrouwers
    Department of Experimental Psychology, Utrecht University Utrecht, Netherlands
    Front Psychiatry 1:140. 2010
  2. pmc The effect of repetitive transcranial magnetic stimulation on gamma oscillatory activity in schizophrenia
    Mera S Barr
    Schizophrenia Program, Department of Psychiatry, Centre for Addiction and Mental Health, University of Toronto, Toronto, Ontario, Canada
    PLoS ONE 6:e22627. 2011
  3. pmc A randomized double-blind sham-controlled study of transcranial direct current stimulation for treatment-resistant major depression
    Daniel M Blumberger
    Department of Psychiatry, Centre for Addiction and Mental Health, University of Toronto Toronto, ON, Canada
    Front Psychiatry 3:74. 2012
  4. doi request reprint Combined transcranial magnetic stimulation and electroencephalography: its past, present and future
    Zafiris J Daskalakis
    Centre for Addiction and Mental Health, University of Toronto, Toronto, Ontario, Canada
    Brain Res 1463:93-107. 2012
  5. doi request reprint Increased cortical inhibition in persons with schizophrenia treated with clozapine
    Zafiris J Daskalakis
    Centre for Addiction and Mental Health, University of Toronto, Toronto, Ontario, Canada
    J Psychopharmacol 22:203-9. 2008
  6. ncbi request reprint Reduced cerebellar inhibition in schizophrenia: a preliminary study
    Zafiris J Daskalakis
    Schizophrenia Program, Centre for Addiction and Mental Health, University of Toronto, Ont M5T 1R8, Canada
    Am J Psychiatry 162:1203-5. 2005
  7. doi request reprint Dysfunctional neural plasticity in patients with schizophrenia
    Zafiris J Daskalakis
    Centre for Addiction and Mental Health, Department of Psychiatry, University of Toronto, Toronto, Ontario, Canada
    Arch Gen Psychiatry 65:378-85. 2008
  8. ncbi request reprint Effect of antipsychotics on cortical inhibition using transcranial magnetic stimulation
    Zafiris J Daskalakis
    Schizophrenia Program, Centre for Addiction and Mental Health, Department of Psychiatry, University of Toronto, Toronto, Ontario, Canada
    Psychopharmacology (Berl) 170:255-62. 2003
  9. ncbi request reprint Evidence for impaired cortical inhibition in schizophrenia using transcranial magnetic stimulation
    Zafiris J Daskalakis
    Schizophrenia and Continuing Care Program, Centre for Addiction and Mental Health, Department of Psychiatry, Toronto Western General Hospital, University of Toronto, Ontario, Canada
    Arch Gen Psychiatry 59:347-54. 2002
  10. ncbi request reprint Evaluating the relationship between long interval cortical inhibition, working memory and gamma band activity in the dorsolateral prefrontal cortex
    Zafiris J Daskalakis
    Centre for Addiction and Mental Health, Faculty of Medicine, University of Toronto, Toronto, Ontario, Canada
    Clin EEG Neurosci 39:150-5. 2008

Collaborators

Detail Information

Publications44

  1. pmc Personality goes a long a way: an interhemispheric connectivity study
    Sylco S Hoppenbrouwers
    Department of Experimental Psychology, Utrecht University Utrecht, Netherlands
    Front Psychiatry 1:140. 2010
    ..This is the first study to relate personality features to interhemispheric connectivity through TMS-EEG and suggests that Agreeableness relates to the effectiveness of prefrontal communication between hemispheres...
  2. pmc The effect of repetitive transcranial magnetic stimulation on gamma oscillatory activity in schizophrenia
    Mera S Barr
    Schizophrenia Program, Department of Psychiatry, Centre for Addiction and Mental Health, University of Toronto, Toronto, Ontario, Canada
    PLoS ONE 6:e22627. 2011
    ..Repetitive transcranial magnetic stimulation (rTMS) represents a non-invasive method to stimulate the cortex that has been shown to enhance cognition and γ oscillatory activity during WM...
  3. pmc A randomized double-blind sham-controlled study of transcranial direct current stimulation for treatment-resistant major depression
    Daniel M Blumberger
    Department of Psychiatry, Centre for Addiction and Mental Health, University of Toronto Toronto, ON, Canada
    Front Psychiatry 3:74. 2012
    ..Ongoing, controlled studies should provide further clarification on the efficacy of this stimulation configuration in TRD. ClinicalTrials.gov Identifier: NCT01078948...
  4. doi request reprint Combined transcranial magnetic stimulation and electroencephalography: its past, present and future
    Zafiris J Daskalakis
    Centre for Addiction and Mental Health, University of Toronto, Toronto, Ontario, Canada
    Brain Res 1463:93-107. 2012
    ..We will conclude by highlighting the limitations of this work and discuss their potential future applications as a biomarker of disease states...
  5. doi request reprint Increased cortical inhibition in persons with schizophrenia treated with clozapine
    Zafiris J Daskalakis
    Centre for Addiction and Mental Health, University of Toronto, Toronto, Ontario, Canada
    J Psychopharmacol 22:203-9. 2008
    ..Our results also confirm previous findings suggesting that deficits in CI are related to the severity of psychotic symptoms in persons with schizophrenia...
  6. ncbi request reprint Reduced cerebellar inhibition in schizophrenia: a preliminary study
    Zafiris J Daskalakis
    Schizophrenia Program, Centre for Addiction and Mental Health, University of Toronto, Ont M5T 1R8, Canada
    Am J Psychiatry 162:1203-5. 2005
    ..The authors' goal was to use transcranial magnetic stimulation to measure cerebellar inhibition, a proxy of cerebellar activity, as the principal output of the cerebellum is inhibitory...
  7. doi request reprint Dysfunctional neural plasticity in patients with schizophrenia
    Zafiris J Daskalakis
    Centre for Addiction and Mental Health, Department of Psychiatry, University of Toronto, Toronto, Ontario, Canada
    Arch Gen Psychiatry 65:378-85. 2008
    ..In schizophrenia, dysfunctional neural plasticity has been proposed as a key pathophysiological mechanism...
  8. ncbi request reprint Effect of antipsychotics on cortical inhibition using transcranial magnetic stimulation
    Zafiris J Daskalakis
    Schizophrenia Program, Centre for Addiction and Mental Health, Department of Psychiatry, University of Toronto, Toronto, Ontario, Canada
    Psychopharmacology (Berl) 170:255-62. 2003
    ..Therefore, single administration of an antipsychotic has no effect on CI or resting motor threshold. Whether chronic, repeated administration of antipsychotics has effects on CI requires further investigation...
  9. ncbi request reprint Evidence for impaired cortical inhibition in schizophrenia using transcranial magnetic stimulation
    Zafiris J Daskalakis
    Schizophrenia and Continuing Care Program, Centre for Addiction and Mental Health, Department of Psychiatry, Toronto Western General Hospital, University of Toronto, Ontario, Canada
    Arch Gen Psychiatry 59:347-54. 2002
    ....
  10. ncbi request reprint Evaluating the relationship between long interval cortical inhibition, working memory and gamma band activity in the dorsolateral prefrontal cortex
    Zafiris J Daskalakis
    Centre for Addiction and Mental Health, Faculty of Medicine, University of Toronto, Toronto, Ontario, Canada
    Clin EEG Neurosci 39:150-5. 2008
    ..However, our data does suggest that LICI was related to 3-back performance providing evidence implicating DLPFC GABAergic inhibitory neurotransmission in WM performance...
  11. ncbi request reprint Repetitive transcranial magnetic stimulation for major depressive disorder: a review
    Z Jeff Daskalakis
    Schizophrenia Program, Centre for Addiction and Mental Health, University of Toronto, Toronto, Ontario
    Can J Psychiatry 53:555-66. 2008
    ..For several reasons that will be reviewed, cortical excitability may represent an important mechanism, linked to the therapeutic efficacy of this disorder...
  12. ncbi request reprint Transcranial magnetic stimulation: a new investigational and treatment tool in psychiatry
    Zafiris J Daskalakis
    Schizophrenia and Continuing Care Program, Centre for Addiction and Mental Health, 7th Floor Clarke Division, University of Toronto, 250 College Street, Toronto, Ontario, Canada
    J Neuropsychiatry Clin Neurosci 14:406-15. 2002
    ..The most serious side effect of high-frequency rTMS is seizures. TMS represents an exciting new frontier in neuroscience research, providing insights into the pathophysiology and treatment of various neuropsychiatric disorders...
  13. ncbi request reprint Cortical inhibitory dysfunction in bipolar disorder: a study using transcranial magnetic stimulation
    Andrea J Levinson
    Mood and Anxiety Division, Centre for Addiction and Mental Health, University of Toronto, Ontario, Canada
    J Clin Psychopharmacol 27:493-7. 2007
    ..Using 3 transcranial magnetic stimulation paradigms, known as short-interval CI (SICI), cortical silent period (SP), and interhemispheric inhibition (IHI), the authors measured inhibition in the motor cortex...
  14. ncbi request reprint The relationship between cortical inhibition, antipsychotic treatment, and the symptoms of schizophrenia
    Shi Kai Liu
    Centre for Addiction and Mental Health, University of Toronto, Ontario, Canada
    Biol Psychiatry 65:503-9. 2009
    ..Such differential association patterns between clinical symptoms and CI deficits and their relationship to antipsychotic treatment thus might provide insights to the pathophysiology of schizophrenia...
  15. doi request reprint Long-interval cortical inhibition from the dorsolateral prefrontal cortex: a TMS-EEG study
    Zafiris J Daskalakis
    Schizophrenia Program, Department of Psychiatry, Centre for Addiction and Mental Health, Faculty of Medicine, University of Toronto, Toronto, ON, Canada
    Neuropsychopharmacology 33:2860-9. 2008
    ..These data suggest that CI can be recorded by combining TMS with EEG and may facilitate future research attempting to ascertain the role of CI in the pathophysiology of several neurological and psychiatric disorders...
  16. pmc Exploring the connectivity between the cerebellum and motor cortex in humans
    Zafiris J Daskalakis
    Schizophrenia Program, Centre for Addiction and Mental Health, Toronto, Ontario, Canada
    J Physiol 557:689-700. 2004
    ..The third experiment showed that the interaction between CBI and LICI reduced CBI. Collectively, these findings suggest that cerebellar stimulation results in changes to both inhibitory and excitatory neurones in the human motor cortex...
  17. pmc Actigraphic measurement of the effects of single-dose haloperidol and olanzapine on spontaneous motor activity in normal subjects
    Michael Kiang
    Schizophrenia Division, Centre for Addiction and Mental Health, Department of Psychiatry, University of Toronto, Toronto, Ont
    J Psychiatry Neurosci 28:293-9. 2003
    ..To quantitatively examine the effects of haloperidol and olanzapine on spontaneous motor activity in normal subjects...
  18. doi request reprint Suppression of gamma-oscillations in the dorsolateral prefrontal cortex following long interval cortical inhibition: a TMS-EEG study
    Faranak Farzan
    Department of Psychiatry, Center for Addiction and Mental Health, University of Toronto, Toronto, ON M5T1R8, Canada
    Neuropsychopharmacology 34:1543-51. 2009
    ..Such specificity suggests that the modulation of gamma-oscillations may represent an important neurophysiological process that may, in part, be responsible for optimal DLPFC functioning in healthy human subjects...
  19. doi request reprint Evidence for gamma inhibition deficits in the dorsolateral prefrontal cortex of patients with schizophrenia
    Faranak Farzan
    Centre for Addiction and Mental Health, University of Toronto, Toronto, Ontario, M5T 1R8, Canada
    Brain 133:1505-14. 2010
    ....
  20. ncbi request reprint Evidence for impaired long-term potentiation in schizophrenia and its relationship to motor skill learning
    Marina V Frantseva
    Schizophrenia Program, Centre for Addiction and Mental Health, Department of Psychiatry, University of Toronto, Toronto, Ontario, Canada
    Cereb Cortex 18:990-6. 2008
    ..These data provide evidence for disrupted LTP in SCZ, whereas the association between LTP with motor skill learning suggests that the deficits in learning and memory in SCZ may be mediated through disordered LTP...
  21. ncbi request reprint The role of cortical inhibition in the pathophysiology and treatment of schizophrenia
    Zafiris J Daskalakis
    Schizophrenia Program, Centre for Addiction and Mental Health, Department of Psychiatry, University of Toronto, Toronto, Ontario, Canada
    Brain Res Rev 56:427-42. 2007
    ..We will conclude by reviewing the role of CI as a mechanism mediating the therapeutic action of antipsychotic medications...
  22. ncbi request reprint Quetiapine: an effective antipsychotic in first-episode schizophrenia despite only transiently high dopamine-2 receptor blockade
    Sitra Tauscher-Wisniewski
    Schizophrenia and Continuing Care Program, Centre for Addiction and Mental Health, Department of Psychiatry, University of Toronto, Toronto, Canada
    J Clin Psychiatry 63:992-7. 2002
    ..We treated patients experiencing their first episode of schizophrenia with a single daily dose of quetiapine to achieve a transient daily peak of D(2) receptor blockade, to determine if this would lead to an antipsychotic response...
  23. ncbi request reprint Relationship between P50 suppression and the cortical silent period
    Bertram Moller
    Schizophrenia Program, Centre for Addiction and Mental Health, Universty of Toronto, 250 College Street, M5T IR8, Toronto, Ontario, Canada
    Neuroreport 18:1503-6. 2007
    ....
  24. doi request reprint Potentiation of gamma oscillatory activity through repetitive transcranial magnetic stimulation of the dorsolateral prefrontal cortex
    Mera S Barr
    Schizophrenia Program, Centre for Addiction and Mental Health, Department of Psychiatry, University of Toronto, Toronto, Ontario, Canada
    Neuropsychopharmacology 34:2359-67. 2009
    ....
  25. ncbi request reprint The effects of repetitive transcranial magnetic stimulation on cortical inhibition in healthy human subjects
    Zafiris J Daskalakis
    Centre for Addiction and Mental Health, University of Toronto, Toronto, ON, Canada
    Exp Brain Res 174:403-12. 2006
    ..Baseline physiological characteristics may be further explored as a method to select patients who may benefit from rTMS treatment...
  26. pmc The mechanisms of interhemispheric inhibition in the human motor cortex
    Zafiris J Daskalakis
    Centre for Addiction and Mental Health, Toronto, Ontario, Canada
    J Physiol 543:317-26. 2002
    ..In contrast, the mechanisms mediating short interval intracortical inhibition are probably different from those mediating long interval intracortical inhibition and interhemispheric inhibition although these systems appear to interact...
  27. doi request reprint Evidence of cortical inhibitory deficits in major depressive disorder
    Andrea J Levinson
    Centre for Addiction and Mental Health, University of Toronto, Toronto, ON ONM5T 1R8, Canada
    Biol Psychiatry 67:458-64. 2010
    ....
  28. doi request reprint New targets for rTMS in depression: a review of convergent evidence
    Jonathan Downar
    Department of Psychiatry, University of Toronto, Canada
    Brain Stimul 6:231-40. 2013
    ..The use of new targets may help to propel rTMS across the threshold of efficacy required of a first-line treatment, to assume a more widespread role in the treatment of depressed mood...
  29. ncbi request reprint Transcranial magnetic stimulation to understand the pathophysiology and treatment of substance use disorders
    Mera S Barr
    Schizophrenia Program, Centre for Addiction and Mental Health, Department of Psychiatry, University of Toronto, Ontario, Canada
    Curr Drug Abuse Rev 1:328-39. 2008
    ..Further work is needed to enhance our understanding of the altered neurophysiology in SUDs as well as the ways in which rTMS treatment can be directed to optimize treatment...
  30. ncbi request reprint An automated method to determine the transcranial magnetic stimulation-induced contralateral silent period
    Zafiris J Daskalakis
    Centre for Addiction and Mental Health, Schizophrenia and Continuing Care Program, University of Toronto, Ontario, Canada
    Clin Neurophysiol 114:938-44. 2003
    ..The determination of the return of voluntary motor activity is typically accomplished via visual inspection of the electromyography (EMG) waveform and may be subject to inaccuracy on the part of the rater...
  31. doi request reprint Dose-response curve of associative plasticity in human motor cortex and interactions with motor practice
    Behzad Elahi
    Division of Neurology, Toronto Western Hospital, University of Toronto, and Toronto Western Research Institute, University Health Network, Toronto, Ontario, Canada
    J Neurophysiol 111:594-601. 2014
    ..In conclusion, we found a dose-dependent effect of the number of stimulus pairs used in the PAS protocol on cortical plasticity. Homeostatic interaction between PAS and DMP was observed only after PAS270. ..
  32. ncbi request reprint Brain serotonin 5-HT(1A) receptor binding in schizophrenia measured by positron emission tomography and [11C]WAY-100635
    Johannes Tauscher
    PET Centre, Toronto, Ontario
    Arch Gen Psychiatry 59:514-20. 2002
    ....
  33. doi request reprint Repetitive transcranial magnetic stimulation for refractory symptoms in schizophrenia
    Daniel M Blumberger
    Department of Psychiatry, Centre for Addiction and Mental Health, University of Toronto, Toronto, Ontario, Canada
    Curr Opin Psychiatry 23:85-90. 2010
    ..Several published studies have assessed the use of repetitive transcranial magnetic stimulation (rTMS) in patients with schizophrenia...
  34. ncbi request reprint A transcranial magnetic stimulation study of inhibitory deficits in the motor cortex in patients with schizophrenia
    Paul B Fitzgerald
    Dandenong Psychiatric Research Centre, Monash University, Department of Psychological Medicine and Dandenong Area Mental Health Service, P O Box 956, Victoria, 3175, Dandenong, Australia
    Psychiatry Res 114:11-22. 2002
    ..These deficits appear to be of cortical origin. Their relationship to dysfunction in other cortical networks requires further elucidation...
  35. ncbi request reprint Cortical inhibition in motor and non-motor regions: a combined TMS-EEG study
    Paul B Fitzgerald
    Alfred Psychiatry Research Centre, The Alfred and Monash University School of Psychology, Psychiatry and Psychological Medicine, Victoria, Australia
    Clin EEG Neurosci 39:112-7. 2008
    ..These data suggest that CI can be recorded by combining TMS with EEG and may facilitate future research attempting to ascertain the role of CI in the pathophysiology of several neurologic and psychiatric disorders...
  36. ncbi request reprint Reduced motor facilitation during action observation in schizophrenia: a mirror neuron deficit?
    Peter G Enticott
    Alfred Psychiatry Research Centre, School of Psychology, Psychiatry and Psychological Medicine, Monash University and the Alfred, Australia
    Schizophr Res 102:116-21. 2008
    ..Dysfunction within the mirror neuron system may contribute to the pathophysiology of schizophrenia...
  37. ncbi request reprint A functional magnetic resonance imaging study of the effects of low frequency right prefrontal transcranial magnetic stimulation in depression
    Paul B Fitzgerald
    Alfred Psychiatry Research Centre, The Alfred and Monash University Department of Psychological Medicine, Melbourne, Victoria, Australia
    J Clin Psychopharmacol 27:488-92. 2007
    ..Response to LFR-TMS is associated with a bilateral reduction in frontal activation that does not seem to be a nonspecific effect of treatment and differs from the response to HFL-TMS...
  38. ncbi request reprint A comprehensive review of the effects of rTMS on motor cortical excitability and inhibition
    Paul B Fitzgerald
    Alfred Psychiatry Research Centre, The Alfred and Monash University School of Psychiatry, Psychology and Psychological Medicine, Commercial Rd Melbourne, VIC 3004, Australia
    Clin Neurophysiol 117:2584-96. 2006
    ..Further research is required, however, before these paradigms can be more widely adopted...
  39. ncbi request reprint An analysis of functional neuroimaging studies of dorsolateral prefrontal cortical activity in depression
    Paul B Fitzgerald
    Alfred Psychiatry Research Centre, The Alfred and Monash University, Department of Psychological Medicine, Melbourne, Victoria 3004, Australia
    Psychiatry Res 148:33-45. 2006
    ..At this stage, the results of imaging studies published to date have limited capacity to inform the choice of optimal prefrontal cortical region for the use in rTMS treatment studies...
  40. pmc A meta-analytic study of changes in brain activation in depression
    Paul B Fitzgerald
    Alfred Psychiatry Research Centre, The Alfred and Monash University Department of Psychological Medicine, Commercial Rd Melbourne, Victoria, Australia
    Hum Brain Mapp 29:683-95. 2008
    ..The aim of this study was to use a quantitative meta-analytic technique to synthesise the results of much of this research...
  41. ncbi request reprint A comparative study of the effects of repetitive paired transcranial magnetic stimulation on motor cortical excitability
    Paul B Fitzgerald
    Alfred Psychiatry Research Centre, The Alfred and Monash University School of Psychiatry, Psychology and Psychological Medicine, Commercial Road, Melbourne, Victoria 3004, Australia
    J Neurosci Methods 165:265-9. 2007
    ..We aimed to compare the post-train effects of 15 min trains of rppTMS to investigate the potential therapeutic application of this technique as well as to compare it to a standard high frequency repetitive TMS paradigm...
  42. doi request reprint The use of repetitive transcranial magnetic stimulation and vagal nerve stimulation in the treatment of depression
    Paul B Fitzgerald
    The Alfred and Monash University School of Psychology, Psychiatry and Psychological Medicine, Victoria, Australia
    Curr Opin Psychiatry 21:25-9. 2008
    ..The aim of this paper is to review recent therapeutic trials of these techniques...
  43. doi request reprint Priming stimulation enhances the effectiveness of low-frequency right prefrontal cortex transcranial magnetic stimulation in major depression
    Paul B Fitzgerald
    Alfred Psychiatry Research Centre, The Alfred and Monash University Department of Psychological Medicine, Melbourne, Victoria, Australia
    J Clin Psychopharmacol 28:52-8. 2008
    ..The aim of this study was to investigate whether priming stimulation would enhance therapeutic response to low-frequency rTMS in patients with depression...
  44. pmc Repetitive transcranial magnetic stimulation for the treatment of depression: to stimulate or not to stimulate?
    Zafiris J Daskalakis
    J Psychiatry Neurosci 30:81-2. 2005