Research Topics
| Z Jeff DaskalakisSummaryAffiliation: Centre for Addiction and Mental Health Country: Canada Publications
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Detail Information
Publications
Combined transcranial magnetic stimulation and electroencephalography: its past, present and futureZafiris J Daskalakis
Centre for Addiction and Mental Health, University of Toronto, Toronto, Ontario, Canada
Brain Res 1463:93-107. 2012..We will conclude by highlighting the limitations of this work and discuss their potential future applications as a biomarker of disease states...- Dysfunctional neural plasticity in patients with schizophreniaZafiris J Daskalakis
Centre for Addiction and Mental Health, Department of Psychiatry, University of Toronto, Toronto, Ontario, Canada
Arch Gen Psychiatry 65:378-85. 2008..In schizophrenia, dysfunctional neural plasticity has been proposed as a key pathophysiological mechanism... - Increased cortical inhibition in persons with schizophrenia treated with clozapineZafiris J Daskalakis
Centre for Addiction and Mental Health, University of Toronto, Toronto, Ontario, Canada
J Psychopharmacol 22:203-9. 2008..Our results also confirm previous findings suggesting that deficits in CI are related to the severity of psychotic symptoms in persons with schizophrenia... 
Repetitive transcranial magnetic stimulation for major depressive disorder: a reviewZ Jeff Daskalakis
Schizophrenia Program, Centre for Addiction and Mental Health, University of Toronto, Toronto, Ontario
Can J Psychiatry 53:555-66. 2008..For several reasons that will be reviewed, cortical excitability may represent an important mechanism, linked to the therapeutic efficacy of this disorder...- Evaluating the relationship between long interval cortical inhibition, working memory and gamma band activity in the dorsolateral prefrontal cortexZafiris J Daskalakis
Centre for Addiction and Mental Health, Faculty of Medicine, University of Toronto, Toronto, Ontario, Canada
Clin EEG Neurosci 39:150-5. 2008..However, our data does suggest that LICI was related to 3-back performance providing evidence implicating DLPFC GABAergic inhibitory neurotransmission in WM performance... - Reduced cerebellar inhibition in schizophrenia: a preliminary studyZafiris J Daskalakis
Schizophrenia Program, Centre for Addiction and Mental Health, University of Toronto, Ont M5T 1R8, Canada
Am J Psychiatry 162:1203-5. 2005..The authors' goal was to use transcranial magnetic stimulation to measure cerebellar inhibition, a proxy of cerebellar activity, as the principal output of the cerebellum is inhibitory... - Effect of antipsychotics on cortical inhibition using transcranial magnetic stimulationZafiris J Daskalakis
Schizophrenia Program, Centre for Addiction and Mental Health, Department of Psychiatry, University of Toronto, Toronto, Ontario, Canada
Psychopharmacology (Berl) 170:255-62. 2003..Therefore, single administration of an antipsychotic has no effect on CI or resting motor threshold. Whether chronic, repeated administration of antipsychotics has effects on CI requires further investigation... - Transcranial magnetic stimulation: a new investigational and treatment tool in psychiatryZafiris J Daskalakis
Schizophrenia and Continuing Care Program, Centre for Addiction and Mental Health, 7th Floor Clarke Division, University of Toronto, 250 College Street, Toronto, Ontario, Canada
J Neuropsychiatry Clin Neurosci 14:406-15. 2002..The most serious side effect of high-frequency rTMS is seizures. TMS represents an exciting new frontier in neuroscience research, providing insights into the pathophysiology and treatment of various neuropsychiatric disorders... - Evidence for impaired cortical inhibition in schizophrenia using transcranial magnetic stimulationZafiris J Daskalakis
Schizophrenia and Continuing Care Program, Centre for Addiction and Mental Health, Department of Psychiatry, Toronto Western General Hospital, University of Toronto, Ontario, Canada
Arch Gen Psychiatry 59:347-54. 2002.... - The relationship between cortical inhibition, antipsychotic treatment, and the symptoms of schizophreniaShi Kai Liu
Centre for Addiction and Mental Health, University of Toronto, Ontario, Canada
Biol Psychiatry 65:503-9. 2009..Such differential association patterns between clinical symptoms and CI deficits and their relationship to antipsychotic treatment thus might provide insights to the pathophysiology of schizophrenia... - Cortical inhibitory dysfunction in bipolar disorder: a study using transcranial magnetic stimulationAndrea J Levinson
Mood and Anxiety Division, Centre for Addiction and Mental Health, University of Toronto, Ontario, Canada
J Clin Psychopharmacol 27:493-7. 2007..Using 3 transcranial magnetic stimulation paradigms, known as short-interval CI (SICI), cortical silent period (SP), and interhemispheric inhibition (IHI), the authors measured inhibition in the motor cortex... - Long-interval cortical inhibition from the dorsolateral prefrontal cortex: a TMS-EEG studyZafiris J Daskalakis
Schizophrenia Program, Department of Psychiatry, Centre for Addiction and Mental Health, Faculty of Medicine, University of Toronto, Toronto, ON, Canada
Neuropsychopharmacology 33:2860-9. 2008..These data suggest that CI can be recorded by combining TMS with EEG and may facilitate future research attempting to ascertain the role of CI in the pathophysiology of several neurological and psychiatric disorders... 
Exploring the connectivity between the cerebellum and motor cortex in humansZafiris J Daskalakis
Schizophrenia Program, Centre for Addiction and Mental Health, Toronto, Ontario, Canada
J Physiol 557:689-700. 2004..The third experiment showed that the interaction between CBI and LICI reduced CBI. Collectively, these findings suggest that cerebellar stimulation results in changes to both inhibitory and excitatory neurones in the human motor cortex...- Actigraphic measurement of the effects of single-dose haloperidol and olanzapine on spontaneous motor activity in normal subjectsMichael Kiang
Schizophrenia Division, Centre for Addiction and Mental Health, Department of Psychiatry, University of Toronto, Toronto, Ont
J Psychiatry Neurosci 28:293-9. 2003..Our results suggest that actigraphy is useful as a sensitive, noninvasive tool for measuring the effect of antipsychotics on spontaneous motor activity... - Evidence for gamma inhibition deficits in the dorsolateral prefrontal cortex of patients with schizophreniaFaranak Farzan
Centre for Addiction and Mental Health, University of Toronto, Toronto, Ontario, M5T 1R8, Canada
Brain 133:1505-14. 2010.... - Suppression of gamma-oscillations in the dorsolateral prefrontal cortex following long interval cortical inhibition: a TMS-EEG studyFaranak Farzan
Department of Psychiatry, Center for Addiction and Mental Health, University of Toronto, Toronto, ON M5T1R8, Canada
Neuropsychopharmacology 34:1543-51. 2009..Such specificity suggests that the modulation of gamma-oscillations may represent an important neurophysiological process that may, in part, be responsible for optimal DLPFC functioning in healthy human subjects... - Evidence for impaired long-term potentiation in schizophrenia and its relationship to motor skill learningMarina V Frantseva
Schizophrenia Program, Centre for Addiction and Mental Health, Department of Psychiatry, University of Toronto, Toronto, Ontario, Canada
Cereb Cortex 18:990-6. 2008..These data provide evidence for disrupted LTP in SCZ, whereas the association between LTP with motor skill learning suggests that the deficits in learning and memory in SCZ may be mediated through disordered LTP... - The effects of repetitive transcranial magnetic stimulation on cortical inhibition in healthy human subjectsZafiris J Daskalakis
Centre for Addiction and Mental Health, University of Toronto, Toronto, ON, Canada
Exp Brain Res 174:403-12. 2006..Baseline physiological characteristics may be further explored as a method to select patients who may benefit from rTMS treatment... - The role of cortical inhibition in the pathophysiology and treatment of schizophreniaZafiris J Daskalakis
Schizophrenia Program, Centre for Addiction and Mental Health, Department of Psychiatry, University of Toronto, Toronto, Ontario, Canada
Brain Res Rev 56:427-42. 2007..We will conclude by reviewing the role of CI as a mechanism mediating the therapeutic action of antipsychotic medications... - Relationship between P50 suppression and the cortical silent periodBertram Moller
Schizophrenia Program, Centre for Addiction and Mental Health, Universty of Toronto, 250 College Street, M5T IR8, Toronto, Ontario, Canada
Neuroreport 18:1503-6. 2007.... - Potentiation of gamma oscillatory activity through repetitive transcranial magnetic stimulation of the dorsolateral prefrontal cortexMera S Barr
Schizophrenia Program, Centre for Addiction and Mental Health, Department of Psychiatry, University of Toronto, Toronto, Ontario, Canada
Neuropsychopharmacology 34:2359-67. 2009.... - Quetiapine: an effective antipsychotic in first-episode schizophrenia despite only transiently high dopamine-2 receptor blockadeSitra Tauscher-Wisniewski
Schizophrenia and Continuing Care Program, Centre for Addiction and Mental Health, Department of Psychiatry, University of Toronto, Toronto, Canada
J Clin Psychiatry 63:992-7. 2002..Future studies aimed at evaluating the relative merits of "transiently high" versus "continuously high" D(2) occupancy are warranted... - The mechanisms of interhemispheric inhibition in the human motor cortexZafiris J Daskalakis
Centre for Addiction and Mental Health, Toronto, Ontario, Canada
J Physiol 543:317-26. 2002..In contrast, the mechanisms mediating short interval intracortical inhibition are probably different from those mediating long interval intracortical inhibition and interhemispheric inhibition although these systems appear to interact... - Evidence of cortical inhibitory deficits in major depressive disorderAndrea J Levinson
Centre for Addiction and Mental Health, University of Toronto, Toronto, ON ONM5T 1R8, Canada
Biol Psychiatry 67:458-64. 2010.... - Transcranial magnetic stimulation to understand the pathophysiology and treatment of substance use disordersMera S Barr
Schizophrenia Program, Centre for Addiction and Mental Health, Department of Psychiatry, University of Toronto, Ontario, Canada
Curr Drug Abuse Rev 1:328-39. 2008..Further work is needed to enhance our understanding of the altered neurophysiology in SUDs as well as the ways in which rTMS treatment can be directed to optimize treatment... - An automated method to determine the transcranial magnetic stimulation-induced contralateral silent periodZafiris J Daskalakis
Centre for Addiction and Mental Health, Schizophrenia and Continuing Care Program, University of Toronto, Ontario, Canada
Clin Neurophysiol 114:938-44. 2003..SIGNIFICANCE: The CSP is an important neurophysiological measure of cortical inhibition and its determination by our AM provides a more objective and automated approach compared to visually guided methods... - Brain serotonin 5-HT(1A) receptor binding in schizophrenia measured by positron emission tomography and [11C]WAY-100635Johannes Tauscher
PET Centre, Toronto, Ontario
Arch Gen Psychiatry 59:514-20. 2002.... - Repetitive transcranial magnetic stimulation for refractory symptoms in schizophreniaDaniel M Blumberger
Department of Psychiatry, Centre for Addiction and Mental Health, University of Toronto, Toronto, Ontario, Canada
Curr Opin Psychiatry 23:85-90. 2010..Several published studies have assessed the use of repetitive transcranial magnetic stimulation (rTMS) in patients with schizophrenia... - Cortical inhibition in motor and non-motor regions: a combined TMS-EEG studyPaul B Fitzgerald
Alfred Psychiatry Research Centre, The Alfred and Monash University School of Psychology, Psychiatry and Psychological Medicine, Victoria, Australia
Clin EEG Neurosci 39:112-7. 2008..These data suggest that CI can be recorded by combining TMS with EEG and may facilitate future research attempting to ascertain the role of CI in the pathophysiology of several neurologic and psychiatric disorders... - Reduced motor facilitation during action observation in schizophrenia: a mirror neuron deficit?Peter G Enticott
Alfred Psychiatry Research Centre, School of Psychology, Psychiatry and Psychological Medicine, Monash University and the Alfred, Australia
Schizophr Res 102:116-21. 2008..Dysfunction within the mirror neuron system may contribute to the pathophysiology of schizophrenia... - A transcranial magnetic stimulation study of inhibitory deficits in the motor cortex in patients with schizophreniaPaul B Fitzgerald
Dandenong Psychiatric Research Centre, Monash University, Department of Psychological Medicine and Dandenong Area Mental Health Service, P O Box 956, Victoria, 3175, Dandenong, Australia
Psychiatry Res 114:11-22. 2002..These deficits appear to be of cortical origin. Their relationship to dysfunction in other cortical networks requires further elucidation... - A functional magnetic resonance imaging study of the effects of low frequency right prefrontal transcranial magnetic stimulation in depressionPaul B Fitzgerald
Alfred Psychiatry Research Centre, The Alfred and Monash University Department of Psychological Medicine, Melbourne, Victoria, Australia
J Clin Psychopharmacol 27:488-92. 2007..Response to LFR-TMS is associated with a bilateral reduction in frontal activation that does not seem to be a nonspecific effect of treatment and differs from the response to HFL-TMS... - Priming stimulation enhances the effectiveness of low-frequency right prefrontal cortex transcranial magnetic stimulation in major depressionPaul B Fitzgerald
Alfred Psychiatry Research Centre, The Alfred and Monash University Department of Psychological Medicine, Melbourne, Victoria, Australia
J Clin Psychopharmacol 28:52-8. 2008..The aim of this study was to investigate whether priming stimulation would enhance therapeutic response to low-frequency rTMS in patients with depression... - A comparative study of the effects of repetitive paired transcranial magnetic stimulation on motor cortical excitabilityPaul B Fitzgerald
Alfred Psychiatry Research Centre, The Alfred and Monash University School of Psychiatry, Psychology and Psychological Medicine, Commercial Road, Melbourne, Victoria 3004, Australia
J Neurosci Methods 165:265-9. 2007..We aimed to compare the post-train effects of 15 min trains of rppTMS to investigate the potential therapeutic application of this technique as well as to compare it to a standard high frequency repetitive TMS paradigm... - The use of repetitive transcranial magnetic stimulation and vagal nerve stimulation in the treatment of depressionPaul B Fitzgerald
The Alfred and Monash University School of Psychology, Psychiatry and Psychological Medicine, Victoria, Australia
Curr Opin Psychiatry 21:25-9. 2008..The aim of this paper is to review recent therapeutic trials of these techniques... - An analysis of functional neuroimaging studies of dorsolateral prefrontal cortical activity in depressionPaul B Fitzgerald
Alfred Psychiatry Research Centre, The Alfred and Monash University, Department of Psychological Medicine, Melbourne, Victoria 3004, Australia
Psychiatry Res 148:33-45. 2006..At this stage, the results of imaging studies published to date have limited capacity to inform the choice of optimal prefrontal cortical region for the use in rTMS treatment studies... - A comprehensive review of the effects of rTMS on motor cortical excitability and inhibitionPaul B Fitzgerald
Alfred Psychiatry Research Centre, The Alfred and Monash University School of Psychiatry, Psychology and Psychological Medicine, Commercial Rd Melbourne, VIC 3004, Australia
Clin Neurophysiol 117:2584-96. 2006..Further research is required, however, before these paradigms can be more widely adopted... - Repetitive transcranial magnetic stimulation for the treatment of depression: to stimulate or not to stimulate?Zafiris J Daskalakis
J Psychiatry Neurosci 30:81-2. 2005 - A meta-analytic study of changes in brain activation in depressionPaul B Fitzgerald
Alfred Psychiatry Research Centre, The Alfred and Monash University Department of Psychological Medicine, Commercial Rd Melbourne, Victoria, Australia
Hum Brain Mapp 29:683-95. 2008..The aim of this study was to use a quantitative meta-analytic technique to synthesise the results of much of this research...