Isabelle Boileau

Summary

Affiliation: Centre for Addiction and Mental Health
Country: Canada

Publications

  1. ncbi Amphetamine-induced increases in extracellular dopamine, drug wanting, and novelty seeking: a PET/[11C]raclopride study in healthy men
    Marco Leyton
    Department of Psychiatry, McGill University, Montreal, Quebec, Canada
    Neuropsychopharmacology 27:1027-35. 2002
  2. ncbi Modeling sensitization to stimulants in humans: an [11C]raclopride/positron emission tomography study in healthy men
    Isabelle Boileau
    McConnell Brain Imaging Center, Montreal Neurological Institute, Montreal, Quebec, Canada
    Arch Gen Psychiatry 63:1386-95. 2006
  3. doi Elevated serotonin transporter binding in depressed patients with Parkinson's disease: a preliminary PET study with [11C]DASB
    Isabelle Boileau
    Human Neurochemical Pathology Laboratory, Centre for Addiction and Mental Health, University of Toronto, Toronto, Ontario, Canada
    Mov Disord 23:1776-80. 2008
  4. doi Dopamine modulating drugs influence striatal (+)-[11C]DTBZ binding in rats: VMAT2 binding is sensitive to changes in vesicular dopamine concentration
    Junchao Tong
    Human Neurochemical Pathology Laboratory, Centre for Addiction and Mental Health, Toronto, Ontario, Canada
    Synapse 62:873-6. 2008
  5. doi The D2/3 dopamine receptor in pathological gambling: a positron emission tomography study with [11C]-(+)-propyl-hexahydro-naphtho-oxazin and [11C]raclopride
    Isabelle Boileau
    Addiction Imaging Research Group, Centre for Addiction and Mental Health, Toronto, ON, Canada
    Addiction 108:953-63. 2013
  6. pmc Higher binding of the dopamine D3 receptor-preferring ligand [11C]-(+)-propyl-hexahydro-naphtho-oxazin in methamphetamine polydrug users: a positron emission tomography study
    Isabelle Boileau
    Addiction Imaging Research Group, Vivian M Rakoff PET Imaging Centre, Human Brain Laboratory, Centre for Addiction and Mental Health, Toronto, Ontario, Canada M5T 1R8
    J Neurosci 32:1353-9. 2012
  7. doi Decreased binding of the D3 dopamine receptor-preferring ligand [11C]-(+)-PHNO in drug-naive Parkinson's disease
    Isabelle Boileau
    Human Neurochemical Pathology Laboratory, University of Toronto, Toronto, Ontario, Canada
    Brain 132:1366-75. 2009
  8. doi Increased vesicular monoamine transporter binding during early abstinence in human methamphetamine users: Is VMAT2 a stable dopamine neuron biomarker?
    Isabelle Boileau
    Human Neurochemical Pathology Laboratory, University of Toronto, Toronto, Ontario, Canada
    J Neurosci 28:9850-6. 2008
  9. ncbi Conditioned dopamine release in humans: a positron emission tomography [11C]raclopride study with amphetamine
    Isabelle Boileau
    McConnell Brain Imaging Center, Montreal Neurological Institute, Montreal, Quebec, Canada H3A 2B4
    J Neurosci 27:3998-4003. 2007
  10. doi Influence of a low dose of amphetamine on vesicular monoamine transporter binding: a PET (+)[11C]DTBZ study in humans
    Isabelle Boileau
    Human Neurochemical Pathology Laboratory, Centre for Addiction and Mental Health, University of Toronto, Toronto, Ontario, Canada
    Synapse 64:417-20. 2010

Collaborators

Detail Information

Publications32

  1. ncbi Amphetamine-induced increases in extracellular dopamine, drug wanting, and novelty seeking: a PET/[11C]raclopride study in healthy men
    Marco Leyton
    Department of Psychiatry, McGill University, Montreal, Quebec, Canada
    Neuropsychopharmacology 27:1027-35. 2002
    ..Mesolimbic DA might mediate interest in obtaining reward rather than reward, per se. Individual differences in amphetamine-induced DA release might be related to predispositions to drug and novelty seeking...
  2. ncbi Modeling sensitization to stimulants in humans: an [11C]raclopride/positron emission tomography study in healthy men
    Isabelle Boileau
    McConnell Brain Imaging Center, Montreal Neurological Institute, Montreal, Quebec, Canada
    Arch Gen Psychiatry 63:1386-95. 2006
    ..A similar phenomenon, referred to as endogenous sensitization, is also believed to play a role in the emergence of positive symptoms in patients with schizophrenia...
  3. doi Elevated serotonin transporter binding in depressed patients with Parkinson's disease: a preliminary PET study with [11C]DASB
    Isabelle Boileau
    Human Neurochemical Pathology Laboratory, Centre for Addiction and Mental Health, University of Toronto, Toronto, Ontario, Canada
    Mov Disord 23:1776-80. 2008
    ....
  4. doi Dopamine modulating drugs influence striatal (+)-[11C]DTBZ binding in rats: VMAT2 binding is sensitive to changes in vesicular dopamine concentration
    Junchao Tong
    Human Neurochemical Pathology Laboratory, Centre for Addiction and Mental Health, Toronto, Ontario, Canada
    Synapse 62:873-6. 2008
    ..We suggest that in vivo (+)-[11C]DTBZ binding in imaging studies is subject to competition by vesicular dopamine and, in this respect, is not a "stable" dopamine biomarker as is generally assumed...
  5. doi The D2/3 dopamine receptor in pathological gambling: a positron emission tomography study with [11C]-(+)-propyl-hexahydro-naphtho-oxazin and [11C]raclopride
    Isabelle Boileau
    Addiction Imaging Research Group, Centre for Addiction and Mental Health, Toronto, ON, Canada
    Addiction 108:953-63. 2013
    ....
  6. pmc Higher binding of the dopamine D3 receptor-preferring ligand [11C]-(+)-propyl-hexahydro-naphtho-oxazin in methamphetamine polydrug users: a positron emission tomography study
    Isabelle Boileau
    Addiction Imaging Research Group, Vivian M Rakoff PET Imaging Centre, Human Brain Laboratory, Centre for Addiction and Mental Health, Toronto, Ontario, Canada M5T 1R8
    J Neurosci 32:1353-9. 2012
    ..Pharmacological studies are needed to establish whether normalization of D3 receptor function could reduce vulnerability to relapse in stimulant abuse...
  7. doi Decreased binding of the D3 dopamine receptor-preferring ligand [11C]-(+)-PHNO in drug-naive Parkinson's disease
    Isabelle Boileau
    Human Neurochemical Pathology Laboratory, University of Toronto, Toronto, Ontario, Canada
    Brain 132:1366-75. 2009
    ....
  8. doi Increased vesicular monoamine transporter binding during early abstinence in human methamphetamine users: Is VMAT2 a stable dopamine neuron biomarker?
    Isabelle Boileau
    Human Neurochemical Pathology Laboratory, University of Toronto, Toronto, Ontario, Canada
    J Neurosci 28:9850-6. 2008
    ..If correct, (+)[(11)C]DTBZ might be a useful imaging probe to correlate changes in brain dopamine stores and behavior in users of methamphetamine...
  9. ncbi Conditioned dopamine release in humans: a positron emission tomography [11C]raclopride study with amphetamine
    Isabelle Boileau
    McConnell Brain Imaging Center, Montreal Neurological Institute, Montreal, Quebec, Canada H3A 2B4
    J Neurosci 27:3998-4003. 2007
    ..These results suggest that cues associated with amphetamine increase dopamine transmission, providing evidence that this system is involved in reward prediction in humans...
  10. doi Influence of a low dose of amphetamine on vesicular monoamine transporter binding: a PET (+)[11C]DTBZ study in humans
    Isabelle Boileau
    Human Neurochemical Pathology Laboratory, Centre for Addiction and Mental Health, University of Toronto, Toronto, Ontario, Canada
    Synapse 64:417-20. 2010
    ..Our data suggest that a low amphetamine dose is unlikely to cause sufficient DA depletion to detect increased (+)[11C]DTBZ binding and that a higher dose might be required...
  11. pmc Decreased cerebral cortical serotonin transporter binding in ecstasy users: a positron emission tomography/[(11)C]DASB and structural brain imaging study
    Stephen J Kish
    Human Neurochemical Pathology Laboratory, Centre for Addiction and Mental Health, 250 College Street, Toronto, Ontario M5T 1R8, Canada
    Brain 133:1779-97. 2010
    ....
  12. doi Dopamine response to psychosocial stress in humans and its relationship to individual differences in personality traits
    Ivonne Suridjan
    Research Imaging Centre, Centre for Addiction and Mental Health, Toronto, Canada
    J Psychiatr Res 46:890-7. 2012
    ..Previous studies have reported inter-individual variability in the dopamine (DA) response to stress. This variability might be related to individual differences in the vulnerability to experience the negative effect of stress...
  13. ncbi Decreasing amphetamine-induced dopamine release by acute phenylalanine/tyrosine depletion: A PET/[11C]raclopride study in healthy men
    Marco Leyton
    Department of Psychiatry, McGill University, Montreal, Quebec, Canada
    Neuropsychopharmacology 29:427-32. 2004
    ..82, p<0.05). Together, the results provide the first direct evidence that APTD decreases stimulated DA release in human brain. APTD may be a suitable new tool for human neuropsychopharmacology research...
  14. ncbi Is brain gliosis a characteristic of chronic methamphetamine use in the human?
    Junchao Tong
    Human Brain Laboratory, Research Imaging Centre, Centre for Addiction and Mental Health, Toronto, Ontario, Canada Addiction Imaging Research Group, Research Imaging Centre, Centre for Addiction and Mental Health, Toronto, Ontario, Canada Electronic address
    Neurobiol Dis 67:107-18. 2014
    ..However, a logistically more difficult quantitative histopathological study is needed to confirm whether glial changes occur or do not occur in brain of human methamphetamine (and amphetamine) users...
  15. pmc Heightened D(3) dopamine receptor levels in cocaine dependence and contributions to the addiction behavioral phenotype: a positron emission tomography study with [(11)C]-(+)-PHNO
    Doris E Payer
    1 Addiction Imaging Research Group, Centre for Addiction and Mental Health, Toronto, ON, Canada 2 Research Imaging Centre and Vivian M Rakoff PET Imaging Centre, Centre for Addiction and Mental Health, Toronto, ON, Canada
    Neuropsychopharmacology 39:311-8. 2014
    ..D3 upregulation is emerging as a biomarker in preclinical models of addiction, and human PET studies of this receptor system can help guide novel pharmacological strategies for treatment. ..
  16. pmc Mapping human brain fatty acid amide hydrolase activity with PET
    Pablo M Rusjan
    Research Imaging Centre, Campbell Family Mental Health Research Institute, Centre for Addiction and Mental Health, Toronto, Ontario, Canada
    J Cereb Blood Flow Metab 33:407-14. 2013
    ..Simulations showed that [(11)C]CURB binding in healthy subjects is far from a flow-limited uptake...
  17. ncbi Alcohol promotes dopamine release in the human nucleus accumbens
    Isabelle Boileau
    McConnell Brain Imaging Centre, Montreal Neurological Institute, McGill University, 3801 University Street, Montreal, Quebec, Canada H3A 2B4
    Synapse 49:226-31. 2003
    ..These findings support the hypothesis that mesolimbic dopamine activation is a common property of abused substances, possibly mediating their reinforcing effects...
  18. ncbi The hedonic response to cigarette smoking is proportional to dopamine release in the human striatum as measured by positron emission tomography and [11C]raclopride
    Sean P Barrett
    McConnell Brain Imaging Centre, Montreal Neurological Institute, Montreal, Canada
    Synapse 54:65-71. 2004
    ..These results suggest that pleasurable drug experiences are associated with increased dopamine transmission in the dorsal striatum while unpleasant experiences may be related to decreased dopamine release in this region...
  19. ncbi Stress-induced dopamine release in humans at risk of psychosis: a [11C]raclopride PET study
    Alexandra Soliman
    McConnell Brain Imaging Centre, Montreal Neurological Institute, Montreal, Canada
    Neuropsychopharmacology 33:2033-41. 2008
    ..Our findings suggest the presence of abnormalities in the dopamine response to stress in negative symptom schizotypy, and provide indirect evidence of a link to frontal function...
  20. pmc Elevation of dopamine induced by cigarette smoking: novel insights from a [(11)C]-(+)-PHNO PET study in humans
    Bernard Le Foll
    1 Translational Addiction Research Laboratory, Centre for Addiction and Mental Health, Toronto, ON, Canada 2 Alcohol Research and Treatment Clinic, Addiction Medicine Services, Ambulatory Care and Structured Treatments, Centre for Addiction and Mental Health, Toronto, ON, Canada 3 Campbell Family Mental Health Research Institute, Centre for Addiction and Mental Health, Toronto, ON, Canada 4 Department of Family and Community Medicine, University of Toronto, Toronto, ON, Canada 5 Department of Pharmacology, University of Toronto, Toronto, ON, Canada 6 Department of Psychiatry, Division of Brain and Therapeutics, University of Toronto, Toronto, ON, Canada 7 Institute of Medical Sciences, University of Toronto, Toronto, ON, Canada
    Neuropsychopharmacology 39:415-24. 2014
    ..We propose that due to the robust effect of smoking on [(11)C]-(+)-PHNO binding, this radiotracer represents an ideal translational tool to investigate novel therapeutic strategies targeting DA transmission. ..
  21. pmc Distribution of monoamine oxidase proteins in human brain: implications for brain imaging studies
    Junchao Tong
    Human Brain Laboratory, Centre for Addiction and Mental Health, Toronto, Ontario, Canada M5T 1R8
    J Cereb Blood Flow Metab 33:863-71. 2013
    ..However, compared with in vitro data, the latter PET measures underestimated regional contrast by ∼2-fold. Further studies are needed to address cause of the in vivo vs. in vitro nonproportionality...
  22. pmc Distribution of vesicular monoamine transporter 2 protein in human brain: implications for brain imaging studies
    Junchao Tong
    Human Brain Laboratory, Centre for Addiction and Mental Health, Toronto, Ontario, Canada
    J Cereb Blood Flow Metab 31:2065-75. 2011
    ....
  23. doi Brain serotonin transporter in human methamphetamine users
    Stephen J Kish
    Human Neurochemical Pathology Laboratory, Centre for Addiction and Mental Health, 250 College Street, Toronto, Ontario, Canada
    Psychopharmacology (Berl) 202:649-61. 2009
    ....
  24. pmc Stress-Induced Dopamine Response in Subjects at Clinical High Risk for Schizophrenia with and without Concurrent Cannabis Use
    Romina Mizrahi
    1 PET Centre, Centre for Addiction and Mental Health, Toronto, ON, Canada 2 Faculty of Medicine, Division of Brain and Therapeutics, Department of Psychiatry, University of Toronto, Toronto, ON, Canada
    Neuropsychopharmacology 39:1479-89. 2014
    ..Our finding does not support the cross-sensitization hypothesis, which posits greater dopaminergic reactivity to stress in CHR cannabis users, but adds to the growing body of literature showing reduced DA (stress) response in addiction. ..
  25. pmc Presentation of smoking-associated cues does not elicit dopamine release after one-hour smoking abstinence: A [11C]-(+)-PHNO PET study
    Lina Chiuccariello
    Translational Addiction Research Laboratory, Centre for Addiction and Mental Health, Toronto, Canada
    PLoS ONE 8:e60382. 2013
    ....
  26. doi Increased stress-induced dopamine release in psychosis
    Romina Mizrahi
    Positron Emission Tomography Centre, Centre for Addiction and Mental Health, University of Toronto, Toronto, Canada
    Biol Psychiatry 71:561-7. 2012
    ..However, there is no direct evidence that brain dopaminergic response to stress is exaggerated in psychosis...
  27. ncbi Greater monoamine oxidase a binding in alcohol dependence
    Brittany A Matthews
    Research Imaging Centre and Campbell Family Mental Health Research Institute, Centre for Addiction and Mental Health and Department of Psychiatry and Department of Pharmacology, University of Toronto, Toronto, Ontario, Canada
    Biol Psychiatry 75:756-64. 2014
    ....
  28. doi Combined insular and striatal dopamine dysfunction are associated with executive deficits in Parkinson's disease with mild cognitive impairment
    Leigh Christopher
    1 Morton and Gloria Shulman Movement Disorder Unit and E J Safra Parkinson Disease Program, Toronto Western Hospital, UHN, University of Toronto, Ontario, M5T 2S8, Canada
    Brain 137:565-75. 2014
    ..Furthermore, these findings suggest a crucial and direct role for dopaminergic modulation in the insula in facilitating cognitive function. ..
  29. doi Methamphetamine use and schizophrenia: a population-based cohort study in California
    Russell C Callaghan
    Centre for Addiction and Mental Health, Toronto
    Am J Psychiatry 169:389-96. 2012
    ..This possibility is discounted in the Western literature. To investigate the relationship between drug use and later schizophrenia, the authors conducted a large-scale cohort study of drug users initially free of persistent psychosis...
  30. ncbi What is the role of the D3 receptor in addiction? A mini review of PET studies with [(11)C]-(+)-PHNO
    Doris Payer
    Addiction Imaging Research Group, Centre for Addiction and Mental Health, Toronto, Ontario, Canada Campbell Family Mental Health Institute, Centre for Addiction and Mental Health, Toronto, Ontario, Canada Research Imaging Centre, Centre for Addiction and Mental Health, Toronto, Ontario, Canada Addictions, Centre for Addiction and Mental Health, Toronto, Ontario, Canada Schizophrenia Programs, Centre for Addiction and Mental Health, Toronto, Ontario, Canada Department of Psychiatry, University of Toronto, Toronto, Ontario, Canada
    Prog Neuropsychopharmacol Biol Psychiatry 52:4-8. 2014
    ..In this mini review we present recent human data suggesting that the D3 receptor may contribute to core features of addiction, and discuss the usefulness of the PET imaging probe [(11)C]-(+)-PHNO in investigating this question. ..
  31. ncbi Dopamine D3 receptor ligands for drug addiction treatment: update on recent findings
    Bernard Le Foll
    Translational Addiction Research Laboratory, Campbell Family Mental Health Research Institute, Centre for Addiction and Mental Health, Toronto, ON, Canada Alcohol Research and Treatment Clinic, Addiction Medicine Services, Ambulatory Care and Structured Treatments, Centre for Addiction and Mental Health, Toronto, ON, Canada Department of Family and Community Medicine, Pharmacology and Toxicology, Psychiatry, Institute of Medical Sciences, University of Toronto, Toronto, ON, Canada Electronic address
    Prog Brain Res 211:255-75. 2014
    ..The first results of clinical investigations are now being provided. Overall, those recent findings support further exploration of D3 ligands to treat drug addiction. ..
  32. ncbi Dopamine transmission in the human striatum during monetary reward tasks
    David H Zald
    Department of Psychology, Vanderbilt University, Nashville, Tennessee 37212, USA
    J Neurosci 24:4105-12. 2004
    ..The implications of these results are discussed in relation to conflicting models of dopaminergic functioning arising from studies using electrophysiological and microdialysis techniques in animals...