Paul D Arnold

Summary

Affiliation: Centre for Addiction and Mental Health
Country: Canada

Publications

  1. ncbi request reprint Childhood anxiety disorders and developmental issues in anxiety
    Paul Arnold
    Department of Psychiatry, Centre for Addiction and Mental Health and the University of Toronto, Toronto, ON, Canada
    Curr Psychiatry Rep 5:252-65. 2003
  2. ncbi request reprint Association of a glutamate (NMDA) subunit receptor gene (GRIN2B) with obsessive-compulsive disorder: a preliminary study
    Paul D Arnold
    Child Psychiatry Program, Neurogenetics Section, 1st Floor, Centre for Addiction and Mental Health, University of Toronto, 250 College Street, Toronto, Ontario, Canada M5T 1R8
    Psychopharmacology (Berl) 174:530-8. 2004
  3. doi request reprint Glutamate system genes and brain volume alterations in pediatric obsessive-compulsive disorder: a preliminary study
    Ke Wu
    Program in Genetics and Genome Biology, Hospital for Sick Children, Toronto, ON, Canada M5G 1X8
    Psychiatry Res 211:214-20. 2013
  4. ncbi request reprint Tumor necrosis factor-alpha gene is not associated with obsessive-compulsive disorder
    Gwyneth Zai
    Institute of Medical Science, Department of Psychiatry, University of Toronto, Toronto, Ontario, Canada
    Psychiatr Genet 16:43-5. 2006
  5. ncbi request reprint Genetics of anxiety disorders
    Paul D Arnold
    Anxiety Disorders Clinic, Centre for Addiction and Mental Health, University of Toronto, 250 College Street, Toronto, ON M5T 1R8, Canada
    Curr Psychiatry Rep 6:243-54. 2004
  6. ncbi request reprint No association between the Pro197Leu polymorphism in the glutathione peroxidase (GPX1) gene and schizophrenia
    Takahiro Shinkai
    Neurogenetics Section, Centre for Addiction and Mental Health, Clarke Division, Department of Psychiatry, University of Toronto, Toronto, Ontario, Canada
    Psychiatr Genet 14:177-80. 2004
  7. pmc The role of glutamate signaling in the pathogenesis and treatment of obsessive-compulsive disorder
    Ke Wu
    Program in Genetics and Genomic Biology, Hospital for Sick Children, Toronto, ON, Canada M5G 1X8
    Pharmacol Biochem Behav 100:726-35. 2012
  8. pmc Serotonin transporter promoter gain-of-function genotypes are linked to obsessive-compulsive disorder
    Xian Zhang Hu
    Laboratory of Neurogenetics, National Institute on Alcohol Abuse and Alcoholism, Rockville, MD 20852, USA
    Am J Hum Genet 78:815-26. 2006

Detail Information

Publications8

  1. ncbi request reprint Childhood anxiety disorders and developmental issues in anxiety
    Paul Arnold
    Department of Psychiatry, Centre for Addiction and Mental Health and the University of Toronto, Toronto, ON, Canada
    Curr Psychiatry Rep 5:252-65. 2003
    ..This article will review significant diagnostic and developmental issues, and highlight recent studies in psychosocial and pharmacologic therapies of pediatric anxiety disorders...
  2. ncbi request reprint Association of a glutamate (NMDA) subunit receptor gene (GRIN2B) with obsessive-compulsive disorder: a preliminary study
    Paul D Arnold
    Child Psychiatry Program, Neurogenetics Section, 1st Floor, Centre for Addiction and Mental Health, University of Toronto, 250 College Street, Toronto, Ontario, Canada M5T 1R8
    Psychopharmacology (Berl) 174:530-8. 2004
    ....
  3. doi request reprint Glutamate system genes and brain volume alterations in pediatric obsessive-compulsive disorder: a preliminary study
    Ke Wu
    Program in Genetics and Genome Biology, Hospital for Sick Children, Toronto, ON, Canada M5G 1X8
    Psychiatry Res 211:214-20. 2013
    ..Our other top ranked association findings were with ACC, OFC and thalamus. These preliminary results suggest that sequence variants in glutamate candidate genes may be associated with structural neuroimaging phenotypes of OCD...
  4. ncbi request reprint Tumor necrosis factor-alpha gene is not associated with obsessive-compulsive disorder
    Gwyneth Zai
    Institute of Medical Science, Department of Psychiatry, University of Toronto, Toronto, Ontario, Canada
    Psychiatr Genet 16:43-5. 2006
    ..3, a region that has been found to be weakly associated with obsessive-compulsive disorder in linkage studies. One functional polymorphism, G-308A, has been found within the gene...
  5. ncbi request reprint Genetics of anxiety disorders
    Paul D Arnold
    Anxiety Disorders Clinic, Centre for Addiction and Mental Health, University of Toronto, 250 College Street, Toronto, ON M5T 1R8, Canada
    Curr Psychiatry Rep 6:243-54. 2004
    ..Given the rapid acceleration in knowledge of the human genome, a more definitive understanding of the genetic roots of these complex conditions may be anticipated in the relatively near future...
  6. ncbi request reprint No association between the Pro197Leu polymorphism in the glutathione peroxidase (GPX1) gene and schizophrenia
    Takahiro Shinkai
    Neurogenetics Section, Centre for Addiction and Mental Health, Clarke Division, Department of Psychiatry, University of Toronto, Toronto, Ontario, Canada
    Psychiatr Genet 14:177-80. 2004
    ..The aim of this study is to examine whether a potentially functional polymorphism, a proline (Pro) to leucine (Leu) substitution at codon 197 (Pro197Leu) of the human GPX1 gene, is associated with susceptibility to schizophrenia...
  7. pmc The role of glutamate signaling in the pathogenesis and treatment of obsessive-compulsive disorder
    Ke Wu
    Program in Genetics and Genomic Biology, Hospital for Sick Children, Toronto, ON, Canada M5G 1X8
    Pharmacol Biochem Behav 100:726-35. 2012
    ..We conclude the review by outlining a glutamate hypothesis for OCD, which we hope will inform further research into etiology and treatment for this severe neuropsychiatric condition...
  8. pmc Serotonin transporter promoter gain-of-function genotypes are linked to obsessive-compulsive disorder
    Xian Zhang Hu
    Laboratory of Neurogenetics, National Institute on Alcohol Abuse and Alcoholism, Rockville, MD 20852, USA
    Am J Hum Genet 78:815-26. 2006
    ..The L(A) allele was twofold overtransmitted to the patients with OCD. The HTTLPR L(A)L(A) genotype exerts a moderate (1.8-fold) effect on risk of OCD, which crystallizes the evidence that the HTT gene has a role in OCD...