Genomes and Genes
Paul D Arnold
Affiliation: Centre for Addiction and Mental Health
- Childhood anxiety disorders and developmental issues in anxietyPaul Arnold
Department of Psychiatry, Centre for Addiction and Mental Health and the University of Toronto, Toronto, ON, Canada
Curr Psychiatry Rep 5:252-65. 2003..This article will review significant diagnostic and developmental issues, and highlight recent studies in psychosocial and pharmacologic therapies of pediatric anxiety disorders...
- Association of a glutamate (NMDA) subunit receptor gene (GRIN2B) with obsessive-compulsive disorder: a preliminary studyPaul D Arnold
Child Psychiatry Program, Neurogenetics Section, 1st Floor, Centre for Addiction and Mental Health, University of Toronto, 250 College Street, Toronto, Ontario, Canada M5T 1R8
Psychopharmacology (Berl) 174:530-8. 2004....
- Glutamate system genes and brain volume alterations in pediatric obsessive-compulsive disorder: a preliminary studyKe Wu
Program in Genetics and Genome Biology, Hospital for Sick Children, Toronto, ON, Canada M5G 1X8
Psychiatry Res 211:214-20. 2013..Our other top ranked association findings were with ACC, OFC and thalamus. These preliminary results suggest that sequence variants in glutamate candidate genes may be associated with structural neuroimaging phenotypes of OCD...
- Tumor necrosis factor-alpha gene is not associated with obsessive-compulsive disorderGwyneth Zai
Institute of Medical Science, Department of Psychiatry, University of Toronto, Toronto, Ontario, Canada
Psychiatr Genet 16:43-5. 2006..3, a region that has been found to be weakly associated with obsessive-compulsive disorder in linkage studies. One functional polymorphism, G-308A, has been found within the gene...
- Meta-analysis and association of brain-derived neurotrophic factor (BDNF) gene with obsessive-compulsive disorderGwyneth Zai
aNeurogenetics Section, Centre for Addiction and Mental Health bDepartment of Psychiatry and Institute of Medical Science, University of Toronto cDepartment of Psychiatry and Program in Genetics and Genome Biology, Hospital for Sick Children dFrederick W Thompson Anxiety Disorders Centre and Department of Psychiatry, Sunnybrook Health Sciences Centre, Toronto, Ontario, Canada
Psychiatr Genet 25:95-6. 2015....
- Genetics of anxiety disordersPaul D Arnold
Anxiety Disorders Clinic, Centre for Addiction and Mental Health, University of Toronto, 250 College Street, Toronto, ON M5T 1R8, Canada
Curr Psychiatry Rep 6:243-54. 2004..Given the rapid acceleration in knowledge of the human genome, a more definitive understanding of the genetic roots of these complex conditions may be anticipated in the relatively near future...
- No association between the Pro197Leu polymorphism in the glutathione peroxidase (GPX1) gene and schizophreniaTakahiro Shinkai
Neurogenetics Section, Centre for Addiction and Mental Health, Clarke Division, Department of Psychiatry, University of Toronto, Toronto, Ontario, Canada
Psychiatr Genet 14:177-80. 2004..The aim of this study is to examine whether a potentially functional polymorphism, a proline (Pro) to leucine (Leu) substitution at codon 197 (Pro197Leu) of the human GPX1 gene, is associated with susceptibility to schizophrenia...
- The role of glutamate signaling in the pathogenesis and treatment of obsessive-compulsive disorderKe Wu
Program in Genetics and Genomic Biology, Hospital for Sick Children, Toronto, ON, Canada M5G 1X8
Pharmacol Biochem Behav 100:726-35. 2012..We conclude the review by outlining a glutamate hypothesis for OCD, which we hope will inform further research into etiology and treatment for this severe neuropsychiatric condition...
- Serotonin transporter promoter gain-of-function genotypes are linked to obsessive-compulsive disorderXian Zhang Hu
Laboratory of Neurogenetics, National Institute on Alcohol Abuse and Alcoholism, Rockville, MD 20852, USA
Am J Hum Genet 78:815-26. 2006..The L(A) allele was twofold overtransmitted to the patients with OCD. The HTTLPR L(A)L(A) genotype exerts a moderate (1.8-fold) effect on risk of OCD, which crystallizes the evidence that the HTT gene has a role in OCD...