Research Topics
| Jean AddingtonSummaryAffiliation: Centre for Addiction and Mental Health Country: Canada Publications
Research Grants
| Collaborators
|
Detail Information
Publications
Early intervention for psychosis: who refers?Jean Addington
Schizophr Res 84:176-7. 2006
Early detection of psychosis: finding those at clinical high riskJean Addington
Department of Psychiatry, University of Toronto, Toronto, Ontario, Canada
Early Interv Psychiatry 2:147-53. 2008..The aim of this paper was to describe the development of a research clinic for individuals who appear to be at risk of developing a psychosis and the process for educating the community and obtaining referrals...- The course of cognitive functioning in first episode psychosis: changes over time and impact on outcomeJean Addington
Department of Psychiatry, University of Toronto, Toronto, Canada
Schizophr Res 78:35-43. 2005..Finally there are implications for improved methodology in the assessment of both cognitive and social functioning... - Implementing cognitive-behavioural therapy for first-episode psychosisJean Addington
Centre for Addiction and Mental Health, 250 College Street, Toronto, Ontario M5S 2S1, Canada
Br J Psychiatry Suppl 48:s72-6. 2005..Guidelines for integrating CBT into an early psychosis service are presented... - The role of family work in early psychosisJean Addington
Department of Psychiatry, University of Toronto, Canada
Schizophr Res 79:77-83. 2005..Thus, thirdly we will describe a recovery model that has its origins in the Calgary First Episode Program and has since been expanded for use in the First Episode Psychosis Program in Toronto, Canada... - Facial affect recognition: a mediator between cognitive and social functioning in psychosis?Jean Addington
Department of Psychiatry, University of Toronto, Canada
Schizophr Res 85:142-50. 2006..This 1-year longitudinal study tested the hypothesis that facial affect recognition mediates the relationship between cognitive and social functioning... - Diagnostic stability over one year in first-episode psychosisJean Addington
Department of Psychiatry, University of Toronto, Toronto, Canada
Schizophr Res 86:71-5. 2006..Schizophrenia can be reliably diagnosed at the initial assessment. There are clinical implications for dealing with the risk of shifting diagnosis for those who present with schizophrenia spectrum and other psychotic disorders... - Influence of social perception and social knowledge on cognitive and social functioning in early psychosisJean Addington
Centre for Addiction and Mental Health, 250 College Street, Toronto, Ontario M5T 1R8, Canada
Br J Psychiatry 189:373-8. 2006..Social cognition has been implicated in the relationship between cognition and social functioning... 
North American Prodrome Longitudinal Study: a collaborative multisite approach to prodromal schizophrenia researchJean Addington
Centre for Addiction and Mental Health, 250 College Street, Toronto, Ontario, M5T 1R8, Canada
Schizophr Bull 33:665-72. 2007....- Patterns, predictors and impact of substance use in early psychosis: a longitudinal studyJ Addington
Department of Psychiatry, University of Toronto, Toronto, ON, Canada
Acta Psychiatr Scand 115:304-9. 2007..The purpose was to determine the prevalence of substance use and its impact on outcome 3 years after presentation for a first-episode of psychosis... - Social and cognitive functioning in psychosisJean Addington
Department of Psychiatry, University of Toronto, Toronto, Canada
Schizophr Res 99:176-81. 2008..This study supports the association between cognition and social functioning but indicates that this is a function of how social functioning is conceptualized and assessed... - Social functioning in individuals at clinical high risk for psychosisJean Addington
Department of Psychiatry, University of Toronto, Toronto, Canada
Schizophr Res 99:119-24. 2008.... - Facial affect recognition in individuals at clinical high risk for psychosisJean Addington
Centre for Addiction and Mental Health, 250 College Street, Toronto, Ontario M5T 1R8, Canada
Br J Psychiatry 192:67-8. 2008..Deficits in facial affect recognition appear to be present before the onset of psychosis and may be a vulnerability marker... - Social cognition mediates illness-related and cognitive influences on social function in patients with schizophrenia-spectrum disordersJean Addington
Department of Psychiatry, University of Toronto, Toronto, Canada
J Psychiatry Neurosci 35:49-54. 2010..The objective of the current study was to use structural equation modelling to test the hypothesis that the relation between cognitive performance and social function is mediated by patients' social cognitive abilities... - The promise of early interventionJean Addington
Department of Psychiatry, University of Toronto, Toronto, Ontario, Canada
Early Interv Psychiatry 1:294-307. 2007..However, there are still many unanswered issues which are in developing stages or which require further investigation... - The diagnosis and assessment of individuals prodromal for schizophrenic psychosisJean Addington
Department of Psychiatry, University of Toronto, Toronto, Canada
CNS Spectr 9:588-94. 2004..This article reviews and describes measures that are currently being used and further developed in order to determine both the diagnostic criteria for the prodromal state and the severity of these putatively prodromal symptoms... - The first episode of psychosis: the experience of relativesJ Addington
Department of Psychiatry, University of Calgary, Alberta, Canada
Acta Psychiatr Scand 108:285-9. 2003..The aim was to determine the extent of and the correlates of the distress and impact of care families of patients with first episode psychosis were experiencing when they first came for treatment... - Symptom outcome 1 year after admission to an early psychosis programJean Addington
Department of Psychiatry, University of Toronto, Toronto, Ontario
Can J Psychiatry 48:204-7. 2003..To determine the change in positive, negative, and depressive symptoms after 1 year in an early psychosis program... - Patterns of premorbid functioning in first-episode psychosis: initial presentationJean Addington
Department of Psychiatry, University of Calgary, Calgary, AB, Canada
Schizophr Res 62:23-30. 2003.... - Cognitive functioning in first episode psychosis: initial presentationJean Addington
Department of Psychiatry, University of Calgary, Foothills Hospital, Calgary, Canada
Schizophr Res 62:59-64. 2003..There was no evidence to support differences in cognition among the different schizophrenia spectrum diagnostic groups... - Weight gain in first-episode psychosisJean Addington
Department of Psychiatry, University of Toronto, Toronto, Onatrio
Can J Psychiatry 48:272-6. 2003..To examine the extent of weight gain in the first year of treatment in an early psychosis program... - The prodromal stage of psychotic illness: observation, detection or intervention?Jean Addington
Department of Psychiatry, University of Toronto, Toronto, Ont
J Psychiatry Neurosci 28:93-7. 2003..This article briefly reviews some of the newer developments and concerns in this area of psychosis research... - Three-year outcome of family work in an early psychosis programJean Addington
Department of Psychiatry, University of Toronto, Canada M5T 1R8
Schizophr Res 79:107-16. 2005..This family intervention embedded within a treatment program proved to be highly acceptable and effective... - Pathways to care: help seeking behaviour in first episode psychosisJ Addington
Department of Psychiatry, University of Calgary, Calgary, Alberta, Canada
Acta Psychiatr Scand 106:358-64. 2002..To determine the number of attempts it took before patients with a first episode of psychosis received adequate help, the signs or symptoms that led them to seek help and the people from whom they attempted to seek help... - Suicidal behaviour in early psychosisJ Addington
Department of Psychiatry, University of Calgary, Calgary, Alberta, Canada
Acta Psychiatr Scand 109:116-20. 2004..This was to determine the prevalence of suicidal behaviours prior to and during the first year of treatment in a comprehensive early psychosis program (EPP) and to identify predictors of suicidal behaviour... - At clinical high risk for psychosis: outcome for nonconvertersJean Addington
Centre for Mental Health Research and Education, University of Calgary, 3280 Hospital Dr, NW, Calgary, Alberta T2N 4Z6
Am J Psychiatry 168:800-5. 2011..Less is known about the outcome among this group, referred to as false positive individuals... - Negative symptoms in individuals at clinical high risk of psychosisDanijela Piskulic
Department of Psychiatry, University of Calgary, Calgary, Alberta, Canada
Psychiatry Res 196:220-4. 2012..Thus, early and persistent negative symptoms may represent a vulnerability for risk of developing psychosis... - Predictors of disengagement from treatment in an early psychosis programJacqueline Stowkowy
Hotchkiss Brain Institute, Department of Psychiatry, University of Calgary, Alberta, Canada
Schizophr Res 136:7-12. 2012..The purpose of this study is to determine the rate of disengagement from a three year FE treatment program and the predictors of disengagement... - The association of insight with psychotic symptoms, depression, and cognition in early psychosis: a 3-year follow-upHuma Saeedi
Centre for Addiction and Mental Health, Toronto, Canada
Schizophr Res 89:123-8. 2007..For this group depression may be a significant concern at least upon initial presentation. Those with poor insight have increased symptoms throughout the first three years and possibly poorer cognitive functioning... - Outcome of a first episode of psychosis in adolescence: a 2-year follow-upAlissa Pencer
Department of Psychology, University of Calgary, Calgary, Alberta, Canada
Psychiatry Res 133:35-43. 2005..These adolescents are doing relatively well following their first episode and reinforce the need to address cannabis use as an integral part of a comprehensive treatment program... - Three-year outcome of treatment in an early psychosis programJean Addington
Department of Psychiatry, Alberta Centennial Mental Health Research Chair, Calgary, Alberta
Can J Psychiatry 54:626-30. 2009..Little is known about the follow-up arrangements offered to patients when their time in a FEP comes to an end... - Affect recognition in people at clinical high risk of psychosisJean Addington
Department of Psychiatry, Faculty of Medicine, University of Calgary, Calgary AB, Canada
Schizophr Res 140:87-92. 2012..While poorer affect recognition may be associated with vulnerability for psychosis, the current results suggest that it may not be a marker of developing a psychotic illness... - Serum monitoring of antipsychotic drug levels during concomitant administration of sertraline and antipsychotic medicationKathleen Pierson
Department of Psychiatry, University of Calgary, Foothills Hospital, Alberta
Can J Psychiatry 51:715-8. 2006..To assess whether pharmacokinetic drug interactions occur when sertraline is added to antipsychotic medications... - Symptom remission in first episode patientsJean Addington
Department of Psychiatry, University of Calgary, Calgary, Canada
Schizophr Res 106:281-5. 2008.... - North American Prodrome Longitudinal Study (NAPLS 2): overview and recruitmentJean Addington
Department of Psychiatry, University of Calgary, Calgary, Alberta, Canada
Schizophr Res 142:77-82. 2012..This paper describes the overall methodology of the NAPLS-2 project and reports on the ascertainment and demographics at the midway point of the study with (360 CHR) and 180 controls... - Treating young individuals at clinical high risk for psychosisCatherine Marshall
Hotchkiss Brain Institute, Department of Psychiatry, University of Calgary, Calgary, Alberta, Canada
Early Interv Psychiatry 6:60-8. 2012..Few studies have followed those who do not go on to develop a psychotic illness... - Outcome after discharge from an early psychosis programJean Addington
Department of Psychiatry, University of Calgary, Calgary, Canada
Schizophr Res 106:363-6. 2008..Results were that, although there was no further improvement in positive symptoms, there was continued improvement in social functioning and signs of improvement in negative symptoms... - Assessment of premorbid function in first-episode schizophrenia: modifications to the Premorbid Adjustment ScaleSarah Van Mastrigt
Departments of Psychiatry and Psychology, University of Calgary, Calgary, Alta
J Psychiatry Neurosci 27:92-101. 2002..Finally, we make recommendations to enhance the use of the PAS when evaluating patients who have experienced their first episode of schizophrenia... - Substance misuse at presentation to an early psychosis programSarah Van Mastrigt
Dept. of Psychiatry, University of Calgary, Calgary, Alberta, Canada
Soc Psychiatry Psychiatr Epidemiol 39:69-72. 2004..CONCLUSIONS: This study confirms the high rates of substance misuse, in particular cannabis, in first-episode psychosis. Implications for treatment are addressed... - Substance use and cognition in early psychosisAlissa Pencer
Department of Psychology, University of Calgary, Calgary, Alta
J Psychiatry Neurosci 28:48-54. 2003..However, substance use may have other detrimental effects on the process of the psychotic illness... - Insight in early psychosis: a 1-year follow-upAlisa R Mintz
Department of Psychology, University of Calgary, Calgary, Alberta, Canada
Schizophr Res 67:213-7. 2004..Insight improved significantly over 12 months, and was negatively correlated with both positive and negative symptoms, and positively correlated with depressive symptoms at admission. There were no associations with cognition... - Family assessment in early psychosisAmanda McCleery
Centre for Addiction and Mental Health, Toronto, Canada
Psychiatry Res 152:95-102. 2007..Overall, the CBI appeared to be a reliable and valid measure for use with FEP families. This short and easy to score measure may be useful for families of young people presenting with FEP... - One-year stability of diagnosis in first-episode nonaffective psychosis: influence of sexAna Cristina Chaves
Department of Psychiatry, University of Toronto, Ontario
Can J Psychiatry 51:711-4. 2006..CONCLUSIONS: At initial presentation, nonaffective first-episode psychosis studies may underestimate the number of men and overestimate the number of women who will eventually receive a schizophrenia diagnosis... - Substance misuse and cognitive functioning in early psychosis: a 2 year follow-upAmanda McCleery
Centre for Addiction and Mental Health, Toronto, Ontario, Canada M5T 1R8
Schizophr Res 88:187-91. 2006..These same patients demonstrated better performance at follow-up. These results do not provide evidence for a negative impact of substance use on cognition... - Exploring the neural correlates of delusions of referenceMahesh Menon
Department of Psychiatry, University of Toronto, Toronto, Canada
Biol Psychiatry 70:1127-33. 2011..The cortical midline structures (CMS) and subcortical regions, including the amygdala and striatum, are linked with self-reference in healthy adults. Less is known about the neural substrates of altered self-reference in schizophrenia... - Attribution style as a factor in psychosis and symptom resolutionRomina Mizrahi
CAMH, PET Centre, Toronto, Ontario, Canada
Schizophr Res 104:220-7. 2008.... - The association between social anxiety and social functioning in first episode psychosisMarcia Voges
Department of Psychology, University of Calgary, Canada
Schizophr Res 76:287-92. 2005..D.=27.42). Results were that negative symptoms and negative self-statements, but not social anxiety, were significant predictors of social functioning. This has implications for addressing these negative cognitions in early psychosis... - Cognitive behavioral therapy in prodromal psychosisJean Addington
Hotchkiss Brain Institute, Department of Psychiatry, University of Calgary, Alberta, Canada
Curr Pharm Des 18:558-65. 2012..Relatively few trials have been completed and this paper reviews the existing trials. Implications of these trials for the treatment of this early phase as well as for designing future studies are discussed... - Cognitive functioning in first-episode schizophreniaJean Addington
Department of Psychiatry, University of Calgary, Calgary, Alta
J Psychiatry Neurosci 27:188-92. 2002..To compare the cognitive functioning of a sample of patients experiencing their first episode of schizophrenia with that of patients with an established schizophrenia illness... - Using the global functioning social and role scales in a first-episode sampleDanijela Piskulic
Department of Psychiatry, University of Calgary, Calgary, AB, Canada
Early Interv Psychiatry 5:219-23. 2011..The purpose of this study was to determine if these measures would be useful in a first episode population... - Social cognition and negative symptoms in psychosisDanijela Piskulic
Department of Psychiatry, Hotchkiss Brain Institute, University of Calgary, Calgary AB, Canada
Psychiatry Res 188:283-5. 2011.... - Prediction and prevention of psychosis in youth at clinical high riskJean Addington
Hotchkiss Brain Institute, Department of Psychiatry, University of Calgary, Alberta, T2N 4N1, Canada
Annu Rev Clin Psychol 8:269-89. 2012..Next, treatment studies are reviewed. The review concludes with a framework for future early identification and treatment studies... - Increased stress-induced dopamine release in psychosisRomina Mizrahi
Positron Emission Tomography Centre, Centre for Addiction and Mental Health, University of Toronto, Toronto, Canada
Biol Psychiatry 71:561-7. 2012..However, there is no direct evidence that brain dopaminergic response to stress is exaggerated in psychosis... - A randomized controlled trial of cognitive behavioral therapy for individuals at clinical high risk of psychosisJean Addington
Department of Psychiatry, University of Calgary, Alberta, Canada
Schizophr Res 125:54-61. 2011.... - The course of cognitive functioning over six months in individuals at clinical high risk for psychosisMariapaola Barbato
Hotchkiss Brain Institute, Department of Psychiatry, University of Calgary, Alberta, Canada
Psychiatry Res 206:195-9. 2013..Future longitudinal research should address if further decline takes place during the prodrome or after conversion to psychosis... - Dopamine D2 and D3 binding in people at clinical high risk for schizophrenia, antipsychotic-naive patients and healthy controls while performing a cognitive taskIvonne Suridjan
PET Centre, Centre for Addiction and Mental Health, Toronto, Ont
J Psychiatry Neurosci 38:98-106. 2013..Preclinical studies in animal models of psychosis have shown a selective increase of D2 high as the common factor in psychosis, and the D3 receptor has been suggested to be involved in the pathophysiology of schizophrenia... - Cognitive-behavioral therapy for individuals at high risk of developing psychosisJean Addington
Department of Psychiatry, University of Calgary, 3330 Hospital Drive NW, Calgary, Alberta T2N4N1, Canada
J Clin Psychol 65:879-90. 2009..Cognitive behavioral therapy (CBT) has been tested as a potentially effective intervention in this group. Here, we describe two cases that were treated with CBT... - Double-blind, placebo-controlled comparison of the efficacy of sertraline as treatment for a major depressive episode in patients with remitted schizophreniaDonald Addington
Departments of Psychiatry, University of Calgary, Calgary, Alberta, Canada
J Clin Psychopharmacol 22:20-5. 2002..Testing the efficacy of widely accepted but poorly evaluated treatments should be a research priority. Future studies require a larger sample size and longer duration of treatment... - Maladaptive schemas as a mediator between social defeat and positive symptoms in young people at clinical high risk for psychosisJacqueline Stowkowy
Hotchkiss Brain Institute, Department of Psychiatry, University of Calgary, Alberta, Canada
Early Interv Psychiatry 6:87-90. 2012..The aim of this study was to examine whether negative beliefs about the self and others link social defeat to early signs of psychosis... - Performance measures for early psychosis treatment servicesDonald Addington
Department of Psychiatry, the University of Calgary in Alberta, Canada
Psychiatr Serv 56:1570-82. 2005..The requirements of the study were that the processes used to identify measures and gain consensus should be comprehensive, be reproducible, and reflect the perspective of multiple stakeholders in Canada... - Youth at ultra high risk for psychosis: using the Revised Network Episode Model to examine pathways to mental health careKatherine M Boydell
Child Health Evaluative Sciences, The Hospital for Sick Children Departments of Psychiatry and Dalla Lana School of Public Health Lawrence S Bloomberg Faculty of Nursing, University of Toronto, Toronto, Ontario Department of Psychiatry, University of Calgary, Calgary, Alberta, Canada
Early Interv Psychiatry 7:170-86. 2013..Understanding this process and the strategies that support positive early intervention on the part of youth and significant others is critical... - Pathways to care for those at clinical high risk of developing psychosisJacqueline Stowkowy
Hotchkiss Brain Institute, Department of Psychiatry, University of Calgary, Calgary, Alberta, Canada
Early Interv Psychiatry 7:80-3. 2013..Understanding the pathways to care is a prerequisite for early detection in first-episode patients with psychosis. Less in known about the pathways to care for individuals at clinical high risk for psychosis... - Recruitment and treatment practices for help-seeking "prodromal" patientsThomas H McGlashan
Department of Psychiatry, Yale University School of Medicine, New Haven, CT, USA
Schizophr Bull 33:715-26. 2007..References for details are noted... - Extracting spurious messages from noise and risk of schizophrenia-spectrum disorders in a prodromal populationRalph E Hoffman
Yale New Haven Psychiatric Hospital, 184 Liberty Street LV108, New Haven, CT 06519, USA
Br J Psychiatry 191:355-6. 2007..no drug) and length of speech illusion, with the latter strongly predicting subsequent conversion during medication-free intervals but not during olanzapine treatment... - Prediction of psychosis in youth at high clinical risk: a multisite longitudinal study in North AmericaTyrone D Cannon
Department of Psychology, University of California, Los Angeles, 1285 Franz Hall, Los Angeles, CA 90095
Arch Gen Psychiatry 65:28-37. 2008.... - Assessment of social judgments and complex mental states in the early phases of psychosisShannon M Couture
University of North Carolina at Chapel Hill, Department of Psychology, CB 3270, Davie Hall, Chapel Hill, NC 27599 3270, USA
Schizophr Res 100:237-41. 2008..Social cognition plays an important role in the functioning of individuals with psychosis. In this study, we explored two areas of social cognition not previously investigated early in the course of psychosis... - Weight gain in first-episode psychosis over three yearsJean Addington
Schizophr Res 86:335-6. 2006 - Clinical trials during the prodromal stage of schizophreniaJean Addington
Am J Psychiatry 162:1387. 2005 - Randomized, double-blind trial of olanzapine versus placebo in patients prodromally symptomatic for psychosisThomas H McGlashan
Department of Psychiatry, Yale University School of Medicine, 301 Cedar St, New Haven, CT 06519, USA
Am J Psychiatry 163:790-9. 2006..This study assessed the efficacy of olanzapine in delaying or preventing conversion to psychosis and reducing symptoms in people with prodromal symptoms of schizophrenia... - Biological, life course, and cross-cultural studies all point toward the value of dimensional and developmental ratings in the classification of psychosisRina Dutta
Division of Psychological Medicine and Psychiatry, Institute of Psychiatry, King s College London, UK
Schizophr Bull 33:868-76. 2007..However, we will begin by briefly reviewing the recent history of the classification of the psychoses... - Insight, knowledge, and beliefs about illness in first-episode psychosisLaura Quillams
Can J Psychiatry 48:350. 2003 - Randomized trial of olanzapine versus placebo in the symptomatic acute treatment of the schizophrenic prodromeScott W Woods
Department of Psychiatry, Yale University School of Medicine, New Haven, Connecticut 06519, USA
Biol Psychiatry 54:453-64. 2003..Extrapyramidal symptoms with olanzapine were minimal and similar to those with placebo. Future research over the longer term with more patients will be needed before recommendations can be made regarding routine treatment...
Research Grants
- Enhancing the Prospective Prediction of PsychosisJean Addington; Fiscal Year: 2007..Each site has proven its ability to recruit prodromal patients in a previous collaboration. ..