Research Topics
Species | Andre C CarpentierSummaryCountry: Canada Publications
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Publications
Effect of alipogene tiparvovec (AAV1-LPL(S447X)) on postprandial chylomicron metabolism in lipoprotein lipase-deficient patientsAndre C Carpentier
Department of Medicine, Division of Endocrinology, Universite de Sherbrooke, Sherbrooke, Quebec, Canada J1H 5N4
J Clin Endocrinol Metab 97:1635-44. 2012....
Optimal strategy to identify incidence of diagnostic of diabetes using administrative dataShabnam Asghari
PRIMUS Group, Centre de Recherche Clinique Etienne Le Bel, CHUS, Sherbrooke QC, Canada
BMC Med Res Methodol 9:62. 2009..The present study aimed to compare criteria for the selection of diabetes incident cases in a medical administrative database...- Integrated obesity care management system -implementation and research protocolJean Patrice Baillargeon
Division of Endocrinology, Department of Medicine, Universite de Sherbrooke, Sherbrooke, Quebec, Canada
BMC Health Serv Res 7:163. 2007..The current research proposal is aimed at the development and implementation of an innovative, integrated, interdisciplinary obesity care management system involving both primary and secondary care professionals... - Postprandial fatty acid metabolism in the development of lipotoxicity and type 2 diabetesAndre C Carpentier
Department of Medicine, Division of Endocrinology, University of Sherbrooke, Quebec, J1H 5N4, Canada
Diabetes Metab 34:97-107. 2008..This review focuses on those mechanisms and on the potential implication of their dysregulation for tissue lipotoxicity in the development of T2D... - Plasma nonesterified Fatty Acid intolerance and hyperglycemia are associated with intravenous lipid-induced impairment of insulin sensitivity and disposition indexAndre C Carpentier
Division of Endocrinology, Centre Hospitalier Universitaire de Sherbrooke, Sherbrooke, Quebec, Canada J1H 5N4
J Clin Endocrinol Metab 95:1256-64. 2010..007 and P = 0.01, respectively) and DI (P = 0.001 and P = 0.007, respectively). Conclusion: Mild hyperglycemia and NEFA intolerance to iv lipid are associated with susceptibility to lipid-induced reduction in S(I) and DI... 
Mechanism of insulin-stimulated clearance of plasma nonesterified fatty acids in humansAndre C Carpentier
Division of Endocrinology, Department of Medicine, Centre Hospitalier Universitaire de Sherbrooke, Sherbrooke, Quebec, Canada J1H 5N4
Am J Physiol Endocrinol Metab 292:E693-701. 2007..We conclude that insulin stimulates plasma NEFA clearance by reducing the endogenous appearance rate of NEFA. The relationship between plasma NEFA level and appearance rate is nonlinear...- On the suppression of plasma nonesterified fatty acids by insulin during enhanced intravascular lipolysis in humansAndre C Carpentier
Division of Endocrinology, Centre Hospitalier Universitaire de Sherbrooke, Sherbrooke, Quebec, Canada J1H 5N4
Am J Physiol Endocrinol Metab 289:E849-56. 2005..Our results also suggest that insulin may affect plasma NEFA clearance independently of the suppression of intracellular lipolysis... - Mechanism of reduced myocardial glucose utilization during acute hypertriglyceridemia in ratsSébastien L Ménard
Department of Medicine, Centre Hospitalier Universitaire de Sherbrooke, Universite de Sherbrooke, QC, Canada
Mol Imaging Biol 11:6-14. 2009..The purpose of the research is to study the effect of acute inhibition of intravascular lipolysis on myocardial substrate selection during hypertriglyceridemia using in vivo radiotracer analysis and positron emission tomography... - Organ-specific dietary fatty acid uptake in humans using positron emission tomography coupled to computed tomographySébastien M Labbé
Division of Endocrinology, Centre Hospitalier Universitaire de Sherbrooke, Sherbrooke, QC, Canada
Am J Physiol Endocrinol Metab 300:E445-53. 2011..This novel noninvasive method to determine tissue dietary fatty acid distribution in humans should prove useful in the study of the mechanisms leading to lipotoxicity... - Increased myocardial uptake of dietary fatty acids linked to cardiac dysfunction in glucose-intolerant humansSébastien M Labbé
Department of Medicine, Division of Endocrinology, Centre de Recherche Clinique Etienne Lebel, Universite de Sherbrooke, Sherbrooke, Quebec, Canada
Diabetes 61:2701-10. 2012.... - Brown adipose tissue oxidative metabolism contributes to energy expenditure during acute cold exposure in humansVeronique Ouellet
Centre de Recherche de l Institut Universitaire de Cardiologie et de Pneumologie de Quebec, Universite Laval, Quebec City, Quebec, Canada
J Clin Invest 122:545-52. 2012..We also observed an increase in BAT radio density upon cold exposure, indicating reduced BAT triglyceride content. In sum, our study provides evidence that BAT acts as a nonshivering thermogenesis effector in humans... - Abnormal in vivo myocardial energy substrate uptake in diet-induced type 2 diabetic cardiomyopathy in ratsSébastien L Ménard
Division of Endocrinology, Department of Medicine, University de Sherbrooke, Sherbrooke, QC, Canada
Am J Physiol Endocrinol Metab 298:E1049-57. 2010..In this model, increased myocardial fatty acid exposure likely occurs from circulating triglyceride, but not from circulating plasma NEFA... - Update on adipose tissue blood flow regulationRichard Sotorník
Diabetes and Metabolism Research Group, Division of Endocrinology, Department of Medicine, Centre Hospitalier, Universitaire de Sherbrooke, Universite de Sherbrooke, Sherbrooke, Quebec, Canada
Am J Physiol Endocrinol Metab 302:E1157-70. 2012.... - Increased postprandial nonesterified fatty acid appearance and oxidation in type 2 diabetes is not fully established in offspring of diabetic subjectsFrançois Normand-Lauzière
Division of Endocrinology, Department of Medicine, Universite de Sherbrooke, Sherbrooke, Quebec, Canada
PLoS ONE 5:e10956. 2010..However, it is currently unknown whether plasma NEFA appearance and oxidation are abnormal during the postprandial state in these subjects at high-risk of developing T2D... - Normal postprandial nonesterified fatty acid uptake in muscles despite increased circulating fatty acids in type 2 diabetesSébastien M Labbé
Centre de Recherche Clinique Etienne Le Bel, Quebec, Canada
Diabetes 60:408-15. 2011..Postprandial plasma nonesterified fatty acid (NEFA) appearance is increased in type 2 diabetes. Our objective was to determine whether skeletal muscle uptake of plasma NEFA is abnormal during the postprandial state in type 2 diabetes... - Comparison of foot-to-foot and hand-to-foot bioelectrical impedance methods in a population with a wide range of body mass indicesClaudia Gagnon
Department of Medicine, Division of Endocrinology, Centre de Recherche Clinique Etienne Le Bel, Faculte de Medecine et des Sciences de la Sante, Universite de Sherbrooke, Sherbrooke, Canada
Metab Syndr Relat Disord 8:437-41. 2010..We aimed to compare multifrequency hand-to-foot (HF-BIA) and foot-to-foot (FF-BIA) bioelectrical impedance analysis techniques to assess fat-free mass (FFM) in a population with a wide range of body mass indices (BMI)... - Angiotensin II type 2 receptor promotes adipocyte differentiation and restores adipocyte size in high-fat/high-fructose diet-induced insulin resistance in ratsMichaël Shum
Division of Endocrinology, Department of Medicine, Faculte de Medecine et des Sciences de la Sante, Universite de Sherbrooke, Sherbrooke, Quebec, Canada
Am J Physiol Endocrinol Metab 304:E197-210. 2013..These results indicate that AT2R is involved in early adipocyte differentiation, while in mature adipocytes and in a model of insulin resistance AT2R activation restores normal adipocyte morphology and improves insulin sensitivity... - Short- and long-term effects of continuous versus intermittent restrictive diet approaches on body composition and the metabolic profile in overweight and obese postmenopausal women: a pilot studyHélène Arguin
Department of Social and Preventive Medicine, Division of Kinesiology, Laval University, Quebec, Quebec, Canada
Menopause 19:870-6. 2012..The objective of this study was to compare changes in body composition and the metabolic profile between women taking an intermittent diet (ID) and women taking a continuous diet (CD)... - Effects of rapid or slow weight loss on body composition and metabolic risk factors in obese postmenopausal women. A pilot studyMartin Senechal
Faculty of Physical Education and Sports, University of Sherbrooke, Canada J1K 2R1
Appetite 58:831-4. 2012..A slower WL seems to be more beneficial to improve body composition as well as metabolic risk factors in postmenopausal women... - Ghrelin levels are associated with hunger as measured by the Three-Factor Eating Questionnaire in healthy young adultsFabienne Langlois
Department of Medicine, Division of Endocrinology, Faculte de Medecine et des Sciences de la Sante, Université de Sherbrooke and Centre de recherche Clinique Étienne Le Bel, Centre Hospitalier Universitaire de Sherbrooke, Quebec, Canada
Physiol Behav 104:373-7. 2011..In conclusion, we demonstrated that ghrelin, a biological marker, is associated with self-reported perception of hunger, independently of anthropometric measures and lifestyle... - Adipose tissue insulin resistance in peripubertal girls with first-degree family history of polycystic ovary syndromeAndréanne Trottier
Division of Endocrinology, Department of Medicine, Universite de Sherbrooke, Sherbrooke, Quebec, Canada
Fertil Steril 98:1627-34. 2012..To assess metabolic and endocrine defects in girls genetically predisposed to polycystic ovary syndrome (PCOS)... - Effectiveness of a multidisciplinary program for management of obesity: the Unité d'Enseignement, de Traitement et de Recherche sur l'Obésité (UETRO) database studyCarole N Kamga-Ngandé
Department of Medicine, Division of Endocrinology, Centre de Recherche Clinique Etienne Le Bel, Centre Hospitalier Universitaire de Sherbrooke, Faculte de Medecine et des Sciences de la Sante, Universite de Sherbrooke, Quebec, Canada
Metab Syndr Relat Disord 7:297-304. 2009..We report here the effectiveness of this program for weight reduction over the first year of follow up... - Stroke and cardiovascular morbidity and mortality associated with rosiglitazone use in elderly diabetic patientsAlain Vanasse
Department of Family Medicine, Faculty of Medicine, Universite de Sherbrooke, 3001 12th Avenue North, Sherbrooke, QC, Canada
Diab Vasc Dis Res 6:87-93. 2009..87, 95% CI 0.76-0.99).The risk of hospital admission for stroke was not significantly affected by rosiglitazone use. Further studies are needed to better understand the mechanisms explaining these associations... - Interindividual variations in resting metabolic rate during weight loss in obese postmenopausal women A pilot studyMartin Senechal
Research Centre on Aging, Social Services and Health Centre University Institute of Geriatrics of Sherbrooke, Canada J1H 4C4
Metabolism 59:478-85. 2010..Baseline RMR, changes in RHR, and FM accumulations (total and trunk) seem to be important factors to consider when studying the effects of weight loss on RMR... - Acute in vivo elevation of intravascular triacylglycerol lipolysis impairs peripheral T cell activation in humansAnis Larbi
Division of Geriatrics, University of Sherbrooke, Sherbrooke, , Canada
Am J Clin Nutr 82:949-56. 2005..Our results have important implications for nutritional therapy in patients at high risk of septic complications and may also be of relevance to postprandial lipid metabolism disorders such as insulin resistance and type 2 diabetes... - Lower leptin levels are associated with higher risk of weight gain over 2 years in healthy young adultsCatherine Allard
a Centre de recherche clinique Etienne Le Bel, Department of Medicine, Universite de Sherbrooke, QC J1H 5N4, Canada
Appl Physiol Nutr Metab 38:280-5. 2013..02). In the subsample measured at 4 years (n = 63), baseline leptin levels were not associated with 4-year weight changes. Lower leptin levels are associated with a higher risk of weight gain over 2 years in healthy young adults... - Modulation of T-cell signalling by non-esterified fatty acidsPascal Brassard
Department of Medicine and Centre de recherche Clinique Etienne Le Bel, Faculty of Medicine, Universite de Sherbrooke, QC, Canada
Prostaglandins Leukot Essent Fatty Acids 77:337-43. 2007..Further mechanistic studies and randomized controlled clinical trials are needed to assess more accurately their effects in healthy and pathological states... - Outdoor temperature, age, sex, body mass index, and diabetic status determine the prevalence, mass, and glucose-uptake activity of 18F-FDG-detected BAT in humansVeronique Ouellet
Centre de Recherche de l Institut Universitaire de Cardiologie et de Pneumologie de Quebec, Faculty of Medicine, Universite Laval, Quebec, Quebec, Canada
J Clin Endocrinol Metab 96:192-9. 2011.... - Adrenocortical dysregulation as a major player in insulin resistance and onset of obesityClaude Roberge
Department of Medicine, Faculty of Medicine, Universite de Sherbrooke, 3001, 12th Ave North, Sherbrooke, QC, Canada J1H 5N4
Am J Physiol Endocrinol Metab 293:E1465-78. 2007.... - Image-derived input function in dynamic human PET/CT: methodology and validation with 11C-acetate and 18F-fluorothioheptadecanoic acid in muscle and 18F-fluorodeoxyglucose in brainEtienne Croteau
Department of Nuclear Medicine and Radiobiology, Faculty of Medicine and Health Sciences, Universite de Sherbrooke, Sherbrooke, QC, Canada
Eur J Nucl Med Mol Imaging 37:1539-50. 2010..The data were obtained from two different research studies, one using (18)F-FDG for brain imaging and the other using (11)C-acetate and (18)F-fluoro-6-thioheptadecanoic acid ((18)F-FTHA) in femoral muscles... - Subcutaneous adipose tissue metabolism and pharmacology: a new investigative techniqueElizabeth Martin
Diabetes and Metabolism Research Group, Division of Endocrinology, Department of Medicine, Sherbrooke University Hospital Centre, Sherbrooke, QC J1H 5N4, Canada
Can J Physiol Pharmacol 89:383-91. 2011..The ATM method improves the accuracy and feasibility of physiological and pharmacological studies on the regulation of ATBF in vivo in humans... - The effect of insulin on the intracellular distribution of 14(R,S)-[18F]Fluoro-6-thia-heptadecanoic acid in ratsXiuli Ci
Department of Medicine, Division of Endocrinology, Centre Hospitalier Universitaire de Sherbrooke, , Sherbrooke, , Canada
Mol Imaging Biol 8:237-44. 2006..CONCLUSIONS: [18F]FTHA is sensitive to insulin-induced modifications of free fatty acid oxidative metabolism in rats but is insensitive to changes in nonoxidative fatty acid metabolism... - L-T3 preparation for whole-body scintigraphy: a randomized-controlled trialRebecca Leboeuf
Department of Medicine, Division of Endocrinology, Faculté de médecine et des sciences de santé, Universite de Sherbrooke, Sherbrooke, Quebec, Canada
Clin Endocrinol (Oxf) 67:839-44. 2007..Objectives To compare the hypothyroid state in patients receiving either placebo or L-T(3) following L-T(4) withdrawal and to evaluate the time needed for adequate TSH elevation in preparation for WBS...