Andre C Carpentier

Summary

Country: Canada

Publications

  1. pmc Normal postprandial nonesterified fatty acid uptake in muscles despite increased circulating fatty acids in type 2 diabetes
    Sébastien M Labbé
    Centre de Recherche Clinique Etienne Le Bel, Quebec, Canada
    Diabetes 60:408-15. 2011
  2. pmc Increased myocardial uptake of dietary fatty acids linked to cardiac dysfunction in glucose-intolerant humans
    Sébastien M Labbé
    Department of Medicine, Division of Endocrinology, Centre de Recherche Clinique Etienne Lebel, Universite de Sherbrooke, Sherbrooke, Quebec, Canada
    Diabetes 61:2701-10. 2012
  3. ncbi request reprint The 2012 CDA-CIHR INMD young investigator award lecture: dysfunction of adipose tissues and the mechanisms of ectopic fat deposition in type 2 diabetes
    Andre C Carpentier
    CIHR GSK Chair in Diabetes Department of Medicine, Division of Endocrinology, Universite de Sherbrooke, Centre de Recherche Clinique Etienne Le Bel, Centre Hospitalier Universitaire de Sherbrooke, Sherbrooke, Quebec, Canada Electronic address
    Can J Diabetes 37:109-14. 2013
  4. doi request reprint Effect of alipogene tiparvovec (AAV1-LPL(S447X)) on postprandial chylomicron metabolism in lipoprotein lipase-deficient patients
    Andre C Carpentier
    Department of Medicine, Division of Endocrinology, Universite de Sherbrooke, Sherbrooke, Quebec, Canada J1H 5N4
    J Clin Endocrinol Metab 97:1635-44. 2012
  5. pmc Integrated obesity care management system -implementation and research protocol
    Jean Patrice Baillargeon
    Division of Endocrinology, Department of Medicine, Universite de Sherbrooke, Sherbrooke, Quebec, Canada
    BMC Health Serv Res 7:163. 2007
  6. ncbi request reprint On the suppression of plasma nonesterified fatty acids by insulin during enhanced intravascular lipolysis in humans
    Andre C Carpentier
    Division of Endocrinology, Centre Hospitalier Universitaire de Sherbrooke, Sherbrooke, Quebec, Canada J1H 5N4
    Am J Physiol Endocrinol Metab 289:E849-56. 2005
  7. ncbi request reprint Plasma nonesterified Fatty Acid intolerance and hyperglycemia are associated with intravenous lipid-induced impairment of insulin sensitivity and disposition index
    Andre C Carpentier
    Division of Endocrinology, Centre Hospitalier Universitaire de Sherbrooke, Sherbrooke, Quebec, Canada J1H 5N4
    J Clin Endocrinol Metab 95:1256-64. 2010
  8. ncbi request reprint Mechanism of insulin-stimulated clearance of plasma nonesterified fatty acids in humans
    Andre C Carpentier
    Division of Endocrinology, Department of Medicine, Centre Hospitalier Universitaire de Sherbrooke, Sherbrooke, Quebec, Canada J1H 5N4
    Am J Physiol Endocrinol Metab 292:E693-701. 2007
  9. ncbi request reprint Postprandial fatty acid metabolism in the development of lipotoxicity and type 2 diabetes
    Andre C Carpentier
    Department of Medicine, Division of Endocrinology, University of Sherbrooke, Quebec, J1H 5N4, Canada
    Diabetes Metab 34:97-107. 2008
  10. doi request reprint Mechanism of reduced myocardial glucose utilization during acute hypertriglyceridemia in rats
    Sébastien L Ménard
    Department of Medicine, Centre Hospitalier Universitaire de Sherbrooke, Universite de Sherbrooke, QC, Canada
    Mol Imaging Biol 11:6-14. 2009

Collaborators

Detail Information

Publications39

  1. pmc Normal postprandial nonesterified fatty acid uptake in muscles despite increased circulating fatty acids in type 2 diabetes
    Sébastien M Labbé
    Centre de Recherche Clinique Etienne Le Bel, Quebec, Canada
    Diabetes 60:408-15. 2011
    ..Postprandial plasma nonesterified fatty acid (NEFA) appearance is increased in type 2 diabetes. Our objective was to determine whether skeletal muscle uptake of plasma NEFA is abnormal during the postprandial state in type 2 diabetes...
  2. pmc Increased myocardial uptake of dietary fatty acids linked to cardiac dysfunction in glucose-intolerant humans
    Sébastien M Labbé
    Department of Medicine, Division of Endocrinology, Centre de Recherche Clinique Etienne Lebel, Universite de Sherbrooke, Sherbrooke, Quebec, Canada
    Diabetes 61:2701-10. 2012
    ....
  3. ncbi request reprint The 2012 CDA-CIHR INMD young investigator award lecture: dysfunction of adipose tissues and the mechanisms of ectopic fat deposition in type 2 diabetes
    Andre C Carpentier
    CIHR GSK Chair in Diabetes Department of Medicine, Division of Endocrinology, Universite de Sherbrooke, Centre de Recherche Clinique Etienne Le Bel, Centre Hospitalier Universitaire de Sherbrooke, Sherbrooke, Quebec, Canada Electronic address
    Can J Diabetes 37:109-14. 2013
    ....
  4. doi request reprint Effect of alipogene tiparvovec (AAV1-LPL(S447X)) on postprandial chylomicron metabolism in lipoprotein lipase-deficient patients
    Andre C Carpentier
    Department of Medicine, Division of Endocrinology, Universite de Sherbrooke, Sherbrooke, Quebec, Canada J1H 5N4
    J Clin Endocrinol Metab 97:1635-44. 2012
    ....
  5. pmc Integrated obesity care management system -implementation and research protocol
    Jean Patrice Baillargeon
    Division of Endocrinology, Department of Medicine, Universite de Sherbrooke, Sherbrooke, Quebec, Canada
    BMC Health Serv Res 7:163. 2007
    ..The current research proposal is aimed at the development and implementation of an innovative, integrated, interdisciplinary obesity care management system involving both primary and secondary care professionals...
  6. ncbi request reprint On the suppression of plasma nonesterified fatty acids by insulin during enhanced intravascular lipolysis in humans
    Andre C Carpentier
    Division of Endocrinology, Centre Hospitalier Universitaire de Sherbrooke, Sherbrooke, Quebec, Canada J1H 5N4
    Am J Physiol Endocrinol Metab 289:E849-56. 2005
    ..Our results also suggest that insulin may affect plasma NEFA clearance independently of the suppression of intracellular lipolysis...
  7. ncbi request reprint Plasma nonesterified Fatty Acid intolerance and hyperglycemia are associated with intravenous lipid-induced impairment of insulin sensitivity and disposition index
    Andre C Carpentier
    Division of Endocrinology, Centre Hospitalier Universitaire de Sherbrooke, Sherbrooke, Quebec, Canada J1H 5N4
    J Clin Endocrinol Metab 95:1256-64. 2010
    ..It is currently unclear why susceptibility to lipid-induced impairment of beta-cell function varies in different populations...
  8. ncbi request reprint Mechanism of insulin-stimulated clearance of plasma nonesterified fatty acids in humans
    Andre C Carpentier
    Division of Endocrinology, Department of Medicine, Centre Hospitalier Universitaire de Sherbrooke, Sherbrooke, Quebec, Canada J1H 5N4
    Am J Physiol Endocrinol Metab 292:E693-701. 2007
    ..We conclude that insulin stimulates plasma NEFA clearance by reducing the endogenous appearance rate of NEFA. The relationship between plasma NEFA level and appearance rate is nonlinear...
  9. ncbi request reprint Postprandial fatty acid metabolism in the development of lipotoxicity and type 2 diabetes
    Andre C Carpentier
    Department of Medicine, Division of Endocrinology, University of Sherbrooke, Quebec, J1H 5N4, Canada
    Diabetes Metab 34:97-107. 2008
    ..This review focuses on those mechanisms and on the potential implication of their dysregulation for tissue lipotoxicity in the development of T2D...
  10. doi request reprint Mechanism of reduced myocardial glucose utilization during acute hypertriglyceridemia in rats
    Sébastien L Ménard
    Department of Medicine, Centre Hospitalier Universitaire de Sherbrooke, Universite de Sherbrooke, QC, Canada
    Mol Imaging Biol 11:6-14. 2009
    ..The purpose of the research is to study the effect of acute inhibition of intravascular lipolysis on myocardial substrate selection during hypertriglyceridemia using in vivo radiotracer analysis and positron emission tomography...
  11. doi request reprint Organ-specific dietary fatty acid uptake in humans using positron emission tomography coupled to computed tomography
    Sébastien M Labbé
    Division of Endocrinology, Centre Hospitalier Universitaire de Sherbrooke, Sherbrooke, QC, Canada
    Am J Physiol Endocrinol Metab 300:E445-53. 2011
    ..This novel noninvasive method to determine tissue dietary fatty acid distribution in humans should prove useful in the study of the mechanisms leading to lipotoxicity...
  12. ncbi request reprint The effect of insulin on the intracellular distribution of 14(R,S)-[18F]Fluoro-6-thia-heptadecanoic acid in rats
    Xiuli Ci
    Department of Medicine, Division of Endocrinology, Centre Hospitalier Universitaire de Sherbrooke, Universite de Sherbrooke, Sherbrooke, Quebec, Canada
    Mol Imaging Biol 8:237-44. 2006
    ..The aim of this study was to determine the effect of hyperinsulinemia on myocardial and hepatic distribution and metabolism of 14(R,S)-[18F]fluoro-6-thia-heptadecanoic acid ([18F]FTHA)...
  13. ncbi request reprint Acute in vivo elevation of intravascular triacylglycerol lipolysis impairs peripheral T cell activation in humans
    Anis Larbi
    Division of Geriatrics, University of Sherbrooke, Sherbrooke, Quebec, Canada
    Am J Clin Nutr 82:949-56. 2005
    ..Previous studies have shown suppressive effects of polyunsaturated fatty acids (PUFAs) on T cell proliferation, but the precise mechanism for this effect has not been fully investigated in vivo in humans...
  14. ncbi request reprint Increased brown adipose tissue oxidative capacity in cold-acclimated humans
    Denis P Blondin
    Faculty of Health Sciences D P B, H C T, F H, University of Ottawa, Ottawa, Ontario, Canada K1N 6N5 Centre de Recherche de l Institut Universitaire de Cardiologie et de Pneumologie de Québec S M L, D R, Universite Laval, Quebec City, Quebec, Canada G1V 4G5 Department of Medicine C N, M K, S P, A C C, Centre de Recherche Clinique Etienne Le Bel, Universite de Sherbrooke, Sherbrooke, Quebec, Canada and Department of Nuclear Medicine and Radiobiology S P, B G, E E T, Universite de Sherbrooke, Sherbrooke, Quebec, Canada J1H 5N4
    J Clin Endocrinol Metab 99:E438-46. 2014
    ..Although many mammalian models have demonstrated the phenotypic flexibility of this tissue through chronic cold exposure, little is known about the metabolic plasticity of BAT in humans...
  15. doi request reprint Abnormal in vivo myocardial energy substrate uptake in diet-induced type 2 diabetic cardiomyopathy in rats
    Sébastien L Ménard
    Division of Endocrinology, Department of Medicine, University de Sherbrooke, Sherbrooke, QC, Canada
    Am J Physiol Endocrinol Metab 298:E1049-57. 2010
    ..In this model, increased myocardial fatty acid exposure likely occurs from circulating triglyceride, but not from circulating plasma NEFA...
  16. pmc Brown adipose tissue oxidative metabolism contributes to energy expenditure during acute cold exposure in humans
    Veronique Ouellet
    Centre de Recherche de l Institut Universitaire de Cardiologie et de Pneumologie de Quebec, Universite Laval, Quebec City, Quebec, Canada
    J Clin Invest 122:545-52. 2012
    ..We also observed an increase in BAT radio density upon cold exposure, indicating reduced BAT triglyceride content. In sum, our study provides evidence that BAT acts as a nonshivering thermogenesis effector in humans...
  17. pmc Increased postprandial nonesterified fatty acid appearance and oxidation in type 2 diabetes is not fully established in offspring of diabetic subjects
    François Normand-Lauzière
    Division of Endocrinology, Department of Medicine, Universite de Sherbrooke, Sherbrooke, Quebec, Canada
    PLoS ONE 5:e10956. 2010
    ..However, it is currently unknown whether plasma NEFA appearance and oxidation are abnormal during the postprandial state in these subjects at high-risk of developing T2D...
  18. ncbi request reprint Improved cardiac function and dietary fatty acid metabolism after modest weight loss in subjects with impaired glucose tolerance
    Sébastien M Labbé
    Division of Endocrinology, Department of Medicine, Universite de Sherbrooke, Quebec, Canada and
    Am J Physiol Endocrinol Metab 306:E1388-96. 2014
    ..Modest weight loss corrects the exaggerated myocardial channeling of dietary fatty acids and improves myocardial energy substrate metabolism and function in IGT subjects. ..
  19. doi request reprint Update on adipose tissue blood flow regulation
    Richard Sotorník
    Diabetes and Metabolism Research Group, Division of Endocrinology, Department of Medicine, Centre Hospitalier, Universitaire de Sherbrooke, Universite de Sherbrooke, Sherbrooke, Quebec, Canada
    Am J Physiol Endocrinol Metab 302:E1157-70. 2012
    ....
  20. pmc Angiotensin II type 2 receptor promotes adipocyte differentiation and restores adipocyte size in high-fat/high-fructose diet-induced insulin resistance in rats
    Michaël Shum
    Division of Endocrinology, Department of Medicine, Faculte de Medecine et des Sciences de la Sante, Universite de Sherbrooke, Sherbrooke, Quebec, Canada
    Am J Physiol Endocrinol Metab 304:E197-210. 2013
    ..These results indicate that AT2R is involved in early adipocyte differentiation, while in mature adipocytes and in a model of insulin resistance AT2R activation restores normal adipocyte morphology and improves insulin sensitivity...
  21. doi request reprint Ghrelin levels are associated with hunger as measured by the Three-Factor Eating Questionnaire in healthy young adults
    Fabienne Langlois
    Department of Medicine, Division of Endocrinology, Faculte de Medecine et des Sciences de la Sante, Université de Sherbrooke and Centre de recherche Clinique Étienne Le Bel, Centre Hospitalier Universitaire de Sherbrooke, Quebec, Canada
    Physiol Behav 104:373-7. 2011
    ..In conclusion, we demonstrated that ghrelin, a biological marker, is associated with self-reported perception of hunger, independently of anthropometric measures and lifestyle...
  22. doi request reprint Comparison of foot-to-foot and hand-to-foot bioelectrical impedance methods in a population with a wide range of body mass indices
    Claudia Gagnon
    Department of Medicine, Division of Endocrinology, Centre de Recherche Clinique Etienne Le Bel, Faculte de Medecine et des Sciences de la Sante, Universite de Sherbrooke, Sherbrooke, Canada
    Metab Syndr Relat Disord 8:437-41. 2010
    ..We aimed to compare multifrequency hand-to-foot (HF-BIA) and foot-to-foot (FF-BIA) bioelectrical impedance analysis techniques to assess fat-free mass (FFM) in a population with a wide range of body mass indices (BMI)...
  23. doi request reprint Intestinal lipid handling: evidence and implication of insulin signaling abnormalities in human obese subjects
    Alain Veilleux
    From the Department of Nutrition, Universite de Montreal, Research Center, CHU Sainte Justine, Montreal, Quebec, Canada A V, E G, E L Department of Surgery, Universite Laval, Quebec, Canada P M Department of Medicine, Universite de Sherbrooke, Centre Hospitalier Universitaire de Sherbrooke, Sherbrooke, Canada A C C Centre de Recherche de l Institut Universitaire de Cardiologie et de Pneumologie de Québec, Quebec, Canada D R and Laboratoire de Lipidologie, Métabolisme et Nutrition, Hopital Sainte Justine, Montreal, Quebec, Canada E L
    Arterioscler Thromb Vasc Biol 34:644-53. 2014
    ..This work aimed to establish whether intestinal insulin resistance modifies lipid and lipoprotein homeostasis in the intestine of obese subjects...
  24. ncbi request reprint Short- and long-term effects of continuous versus intermittent restrictive diet approaches on body composition and the metabolic profile in overweight and obese postmenopausal women: a pilot study
    Hélène Arguin
    Department of Social and Preventive Medicine, Division of Kinesiology, Laval University, Quebec, Quebec, Canada
    Menopause 19:870-6. 2012
    ..The objective of this study was to compare changes in body composition and the metabolic profile between women taking an intermittent diet (ID) and women taking a continuous diet (CD)...
  25. doi request reprint Effects of rapid or slow weight loss on body composition and metabolic risk factors in obese postmenopausal women. A pilot study
    Martin Senechal
    Faculty of Physical Education and Sports, University of Sherbrooke, Canada J1K 2R1
    Appetite 58:831-4. 2012
    ..A slower WL seems to be more beneficial to improve body composition as well as metabolic risk factors in postmenopausal women...
  26. pmc Image-derived input function in dynamic human PET/CT: methodology and validation with 11C-acetate and 18F-fluorothioheptadecanoic acid in muscle and 18F-fluorodeoxyglucose in brain
    Etienne Croteau
    Department of Nuclear Medicine and Radiobiology, Faculty of Medicine and Health Sciences, Universite de Sherbrooke, Sherbrooke, QC, Canada
    Eur J Nucl Med Mol Imaging 37:1539-50. 2010
    ..The data were obtained from two different research studies, one using (18)F-FDG for brain imaging and the other using (11)C-acetate and (18)F-fluoro-6-thioheptadecanoic acid ((18)F-FTHA) in femoral muscles...
  27. doi request reprint Stroke and cardiovascular morbidity and mortality associated with rosiglitazone use in elderly diabetic patients
    Alain Vanasse
    Department of Family Medicine, Faculty of Medicine, Universite de Sherbrooke, 3001 12th Avenue North, Sherbrooke, QC, Canada
    Diab Vasc Dis Res 6:87-93. 2009
    ..87, 95% CI 0.76-0.99).The risk of hospital admission for stroke was not significantly affected by rosiglitazone use. Further studies are needed to better understand the mechanisms explaining these associations...
  28. doi request reprint Outdoor temperature, age, sex, body mass index, and diabetic status determine the prevalence, mass, and glucose-uptake activity of 18F-FDG-detected BAT in humans
    Veronique Ouellet
    Centre de Recherche de l Institut Universitaire de Cardiologie et de Pneumologie de Quebec, Faculty of Medicine, Universite Laval, Quebec, Quebec, Canada
    J Clin Endocrinol Metab 96:192-9. 2011
    ....
  29. pmc Adipose tissue insulin resistance in peripubertal girls with first-degree family history of polycystic ovary syndrome
    Andréanne Trottier
    Division of Endocrinology, Department of Medicine, Universite de Sherbrooke, Sherbrooke, Quebec, Canada
    Fertil Steril 98:1627-34. 2012
    ..To assess metabolic and endocrine defects in girls genetically predisposed to polycystic ovary syndrome (PCOS)...
  30. ncbi request reprint Effectiveness of a multidisciplinary program for management of obesity: the Unité d'Enseignement, de Traitement et de Recherche sur l'Obésité (UETRO) database study
    Carole N Kamga-Ngandé
    Department of Medicine, Division of Endocrinology, Centre de Recherche Clinique Etienne Le Bel, Centre Hospitalier Universitaire de Sherbrooke, Faculte de Medecine et des Sciences de la Sante, Universite de Sherbrooke, Quebec, Canada
    Metab Syndr Relat Disord 7:297-304. 2009
    ..We report here the effectiveness of this program for weight reduction over the first year of follow up...
  31. doi request reprint Interindividual variations in resting metabolic rate during weight loss in obese postmenopausal women A pilot study
    Martin Senechal
    Research Centre on Aging, Social Services and Health Centre University Institute of Geriatrics of Sherbrooke, Canada J1H 4C4
    Metabolism 59:478-85. 2010
    ..Baseline RMR, changes in RHR, and FM accumulations (total and trunk) seem to be important factors to consider when studying the effects of weight loss on RMR...
  32. ncbi request reprint Adherence to vascular protection drugs in diabetic patients in Quebec: a population-based analysis
    Shabnam Asghari
    PRIMUS Group, Centre de Recherche Clinique Etienne Le Bel, CHUS, Sherbrooke QC, Canada
    Diab Vasc Dis Res 7:167-71. 2010
    ..In conclusion, despite the high cardiovascular risks associated with diabetes, less than one-third of diabetic adults took vascular-protection drugs regularly. This important issue needs proper attention...
  33. doi request reprint Lower leptin levels are associated with higher risk of weight gain over 2 years in healthy young adults
    Catherine Allard
    a Centre de recherche clinique Etienne Le Bel, Department of Medicine, Universite de Sherbrooke, QC J1H 5N4, Canada
    Appl Physiol Nutr Metab 38:280-5. 2013
    ..02). In the subsample measured at 4 years (n = 63), baseline leptin levels were not associated with 4-year weight changes. Lower leptin levels are associated with a higher risk of weight gain over 2 years in healthy young adults...
  34. ncbi request reprint Modulation of T-cell signalling by non-esterified fatty acids
    Pascal Brassard
    Department of Medicine and Centre de recherche Clinique Etienne Le Bel, Faculty of Medicine, Universite de Sherbrooke, QC, Canada
    Prostaglandins Leukot Essent Fatty Acids 77:337-43. 2007
    ..Further mechanistic studies and randomized controlled clinical trials are needed to assess more accurately their effects in healthy and pathological states...
  35. ncbi request reprint Biliopancreatic diversion with duodenal switch improves insulin sensitivity and secretion through caloric restriction
    Charles Étienne Plourde
    Department of Medicine, Division of Endocrinology, Centre de Recherche Clinique Etienne Le Bel, Universite de Sherbrooke, Quebec, Canada Centre de recherche de l Institut universitaire de cardiologie et de pneumologie de Québec, Universite Laval, Quebec, Canada
    Obesity (Silver Spring) 22:1838-46. 2014
    ..To assess the rapid improvement of insulin sensitivity and β-cell function following biliopancreatic diversion with duodenal switch (BPD-DS) and determine the role played by caloric restriction in these changes...
  36. ncbi request reprint Adrenocortical dysregulation as a major player in insulin resistance and onset of obesity
    Claude Roberge
    Department of Medicine, Faculty of Medicine, Universite de Sherbrooke, 3001, 12th Ave North, Sherbrooke, QC, Canada J1H 5N4
    Am J Physiol Endocrinol Metab 293:E1465-78. 2007
    ....
  37. doi request reprint Subcutaneous adipose tissue metabolism and pharmacology: a new investigative technique
    Elizabeth Martin
    Diabetes and Metabolism Research Group, Division of Endocrinology, Department of Medicine, Sherbrooke University Hospital Centre, Sherbrooke, QC J1H 5N4, Canada
    Can J Physiol Pharmacol 89:383-91. 2011
    ..The ATM method improves the accuracy and feasibility of physiological and pharmacological studies on the regulation of ATBF in vivo in humans...
  38. pmc Optimal strategy to identify incidence of diagnostic of diabetes using administrative data
    Shabnam Asghari
    PRIMUS Group, Centre de Recherche Clinique Etienne Le Bel, CHUS, Sherbrooke QC, Canada
    BMC Med Res Methodol 9:62. 2009
    ..The present study aimed to compare criteria for the selection of diabetes incident cases in a medical administrative database...
  39. ncbi request reprint L-T3 preparation for whole-body scintigraphy: a randomized-controlled trial
    Rebecca Leboeuf
    Department of Medicine, Division of Endocrinology, Faculté de médecine et des sciences de santé, Universite de Sherbrooke, Sherbrooke, Quebec, Canada
    Clin Endocrinol (Oxf) 67:839-44. 2007
    ..Objectives To compare the hypothyroid state in patients receiving either placebo or L-T(3) following L-T(4) withdrawal and to evaluate the time needed for adequate TSH elevation in preparation for WBS...