Alex Wong

Summary

Affiliation: Carleton University
Country: Canada

Publications

  1. pmc Genomics of adaptation during experimental evolution of the opportunistic pathogen Pseudomonas aeruginosa
    Alex Wong
    Department of Biology, Carleton University, Ottawa, Canada
    PLoS Genet 8:e1002928. 2012
  2. pmc Temporally variable selection on proteolysis-related reproductive tract proteins in Drosophila
    Alex Wong
    Department of Molecular Biology and Genetics, Cornell University, USA
    Mol Biol Evol 29:229-38. 2012
  3. ncbi request reprint Evolution of genes and genomes on the Drosophila phylogeny
    Andrew G Clark
    Department of Molecular Biology and Genetics, Cornell University, Ithaca, New York 14853, USA
    Nature 450:203-18. 2007
  4. pmc Immortal coils: conserved dimerization motifs of the Drosophila ovulation prohormone ovulin
    Alex Wong
    Department of Molecular Biology and Genetics, Cornell University, Ithaca, NY 14853, USA
    Insect Biochem Mol Biol 40:303-10. 2010
  5. ncbi request reprint Evidence for positive selection on Drosophila melanogaster seminal fluid protease homologs
    Alex Wong
    Department of Molecular Biology and Genetics, Cornell University, NY, USA
    Mol Biol Evol 25:497-506. 2008
  6. pmc A role for Acp29AB, a predicted seminal fluid lectin, in female sperm storage in Drosophila melanogaster
    Alex Wong
    Department of Molecular Biology and Genetics, Cornell University, Ithaca, New York 13902, USA
    Genetics 180:921-31. 2008
  7. pmc Evolution in the fast lane: rapidly evolving sex-related genes in Drosophila
    Wilfried Haerty
    Department of Biology, McMaster University, Hamilton, Ontario L8S 4K1, Canada
    Genetics 177:1321-35. 2007
  8. pmc Evidence for structural constraint on ovulin, a rapidly evolving Drosophila melanogaster seminal protein
    Alex Wong
    Department of Molecular Biology and Genetics, Biotechnology Building Room 423, Cornell University, Ithaca, NY 14853, USA
    Proc Natl Acad Sci U S A 103:18644-9. 2006
  9. doi request reprint Parallel evolution and local differentiation in quinolone resistance in Pseudomonas aeruginosa
    Alex Wong
    Center for Advanced Research in Environmental Genomics, Department of Biology, University of Ottawa, Ottawa, ON, Canada
    Microbiology 157:937-44. 2011
  10. ncbi request reprint Mitch a rapidly evolving component of the Ndc80 kinetochore complex required for correct chromosome segregation in Drosophila
    Byron Williams
    Department of Molecular Biology and Genetics, Cornell University, Ithaca, NY 14853 2703, USA
    J Cell Sci 120:3522-33. 2007

Detail Information

Publications17

  1. pmc Genomics of adaptation during experimental evolution of the opportunistic pathogen Pseudomonas aeruginosa
    Alex Wong
    Department of Biology, Carleton University, Ottawa, Canada
    PLoS Genet 8:e1002928. 2012
    ..Experimental evolutionary approaches to understanding pathogen adaptation should provide an important complement to studies of the evolution of clinical isolates...
  2. pmc Temporally variable selection on proteolysis-related reproductive tract proteins in Drosophila
    Alex Wong
    Department of Molecular Biology and Genetics, Cornell University, USA
    Mol Biol Evol 29:229-38. 2012
    ..Moreover, available functional information concerning the genes that show evidence of selection suggests that both sexual selection and immune processes have been important in the evolutionary history of this group of molecules...
  3. ncbi request reprint Evolution of genes and genomes on the Drosophila phylogeny
    Andrew G Clark
    Department of Molecular Biology and Genetics, Cornell University, Ithaca, New York 14853, USA
    Nature 450:203-18. 2007
    ..These may prove to underlie differences in the ecology and behaviour of these diverse species...
  4. pmc Immortal coils: conserved dimerization motifs of the Drosophila ovulation prohormone ovulin
    Alex Wong
    Department of Molecular Biology and Genetics, Cornell University, Ithaca, NY 14853, USA
    Insect Biochem Mol Biol 40:303-10. 2010
    ..Consistent with this view, in comparisons of 8510 proteins across 6 species of Drosophila we find that rates of amino acid divergence are higher for proteins with coiled-coil protein-interaction domains than for non-coiled-coil proteins...
  5. ncbi request reprint Evidence for positive selection on Drosophila melanogaster seminal fluid protease homologs
    Alex Wong
    Department of Molecular Biology and Genetics, Cornell University, NY, USA
    Mol Biol Evol 25:497-506. 2008
    ..The second gene, CG9997, was previously shown to be essential for normal sperm usage, suggesting that sexual selection may underlie its history of adaptation...
  6. pmc A role for Acp29AB, a predicted seminal fluid lectin, in female sperm storage in Drosophila melanogaster
    Alex Wong
    Department of Molecular Biology and Genetics, Cornell University, Ithaca, New York 13902, USA
    Genetics 180:921-31. 2008
    ..Moreover, Acp29AB's effects on sperm storage and sperm competition may explain previously documented evidence for positive selection on the Acp29AB locus...
  7. pmc Evolution in the fast lane: rapidly evolving sex-related genes in Drosophila
    Wilfried Haerty
    Department of Biology, McMaster University, Hamilton, Ontario L8S 4K1, Canada
    Genetics 177:1321-35. 2007
    ..SFP genes also show evidence of lineage-specific gene loss and/or gain. These results bring us closer to understanding the details of the evolutionary dynamics of SRR genes with respect to species divergence...
  8. pmc Evidence for structural constraint on ovulin, a rapidly evolving Drosophila melanogaster seminal protein
    Alex Wong
    Department of Molecular Biology and Genetics, Biotechnology Building Room 423, Cornell University, Ithaca, NY 14853, USA
    Proc Natl Acad Sci U S A 103:18644-9. 2006
    ..We therefore suggest that domains involved in ovulin's self-interaction form a conserved structural backbone for the protein, resulting in greater evolutionary flexibility at other sites...
  9. doi request reprint Parallel evolution and local differentiation in quinolone resistance in Pseudomonas aeruginosa
    Alex Wong
    Center for Advanced Research in Environmental Genomics, Department of Biology, University of Ottawa, Ottawa, ON, Canada
    Microbiology 157:937-44. 2011
    ..We further discuss the therapeutic implications of local differentiation in resistance mechanisms to a common antibiotic...
  10. ncbi request reprint Mitch a rapidly evolving component of the Ndc80 kinetochore complex required for correct chromosome segregation in Drosophila
    Byron Williams
    Department of Molecular Biology and Genetics, Cornell University, Ithaca, NY 14853 2703, USA
    J Cell Sci 120:3522-33. 2007
    ..Despite the crucial role of Mitch in cell division, the mitch gene has evolved very rapidly among species in the genus Drosophila...
  11. doi request reprint Evolutionary insight from whole-genome sequencing of experimentally evolved microbes
    Jeremy R Dettman
    Department of Biology and Centre for Advanced Research in Environmental Genomics, University of Ottawa, Ottawa, ON K1N 6N5, Canada
    Mol Ecol 21:2058-77. 2012
    ..We also outline an example of a computational pipeline for use in EE-WGS studies, based on freely available bioinformatics tools...
  12. ncbi request reprint Approaches for identifying targets of positive selection
    Jeffrey D Jensen
    Department of Molecular Biology and Genetics, Biotechnology Building, Cornell University, Ithaca, NY 14853, USA
    Trends Genet 23:568-77. 2007
    ....
  13. doi request reprint Evolution of protein-coding genes in Drosophila
    Amanda M Larracuente
    Department of Molecular Biology and Genetics, Cornell University, Ithaca, NY 14853, USA
    Trends Genet 24:114-23. 2008
    ....
  14. pmc Phylogenetic incongruence in the Drosophila melanogaster species group
    Alex Wong
    Department of Molecular Biology and Genetics, Biotechnology Building, Cornell University, Ithaca, NY 14853, USA
    Mol Phylogenet Evol 43:1138-50. 2007
    ..Such lineage sorting may lead to biased estimation of tree topology and evolutionary rates, and may confound inferences of positive selection...
  15. doi request reprint Testing the effects of mating system variation on rates of molecular evolution in primates
    Alex Wong
    Department of Biology, University of Ottawa, 30 Marie Curie, Ottawa, Ontario, Canada
    Evolution 64:2779-85. 2010
    ..Ultimately, comparative studies encompassing a range of mating systems and other life history traits will be required to make broad generalizations concerning the genomic effects of sperm competition...
  16. pmc Incompatibilities involving yeast mismatch repair genes: a role for genetic modifiers and implications for disease penetrance and variation in genomic mutation rates
    Ann Demogines
    Department of Molecular Biology and Genetics, Cornell University, Ithaca, New York, United States of America
    PLoS Genet 4:e1000103. 2008
    ....
  17. ncbi request reprint Sexual behavior: a seminal peptide stimulates appetites
    Alex Wong
    Department of Molecular Biology and Genetics, Cornell University, Ithaca, New York 14853, USA
    Curr Biol 16:R256-7. 2006
    ..These findings contribute significantly to our understanding of mating behaviors and resource allocation, and may provide insights useful for controlling the reproduction of insect pests...