H Anisman

Summary

Affiliation: Carleton University
Country: Canada

Publications

  1. ncbi Stress, depression, and anhedonia: caveats concerning animal models
    Hymie Anisman
    Institute of Neuroscience, Carleton University, LSRB, Ottawa, Ont, Canada K1S 5B6
    Neurosci Biobehav Rev 29:525-46. 2005
  2. ncbi The effects of cortisol administration on social status and brain monoaminergic activity in rainbow trout Oncorhynchus mykiss
    Joseph D DiBattista
    Ottawa Carleton Institute of Biology, Ottawa, ON, K1N 6N5 Canada
    J Exp Biol 208:2707-18. 2005
  3. ncbi Corticotropin-releasing hormone, arginine vasopressin, gastrin-releasing peptide, and neuromedin B alterations in stress-relevant brain regions of suicides and control subjects
    Zul Merali
    Institute of Mental Health Research, University of Ottawa, Ontario, Canada
    Biol Psychiatry 59:594-602. 2006
  4. ncbi Maternal programming of defensive responses through sustained effects on gene expression
    Tie Yuan Zhang
    McGill Program for the Study of Behavior, Genes and Environment, McGill University, Canada
    Biol Psychol 73:72-89. 2006
  5. ncbi Ruminative coping among patients with dysthymia before and after pharmacotherapy
    Owen Kelly
    University of Ottawa Institute of Mental Health Research, Ottawa, Ontario, Canada
    Depress Anxiety 24:233-43. 2007
  6. ncbi Posttraumatic stress symptoms and salivary cortisol levels
    H Anisman
    Institute of Neuroscience, Carleton University, Ottawa, Ontario, Canada
    Am J Psychiatry 158:1509-11. 2001
  7. doi Neurotransmitter, peptide and cytokine processes in relation to depressive disorder: comorbidity between depression and neurodegenerative disorders
    Hymie Anisman
    Institute of Neuroscience, Carleton University, Ottawa, Ontario K1S 5B6, Canada
    Prog Neurobiol 85:1-74. 2008
  8. ncbi Interferon-alpha effects are exaggerated when administered on a psychosocial stressor backdrop: cytokine, corticosterone and brain monoamine variations
    Hymie Anisman
    Institute of Neuroscience, Carleton University, Ontario, Canada K1S 5B6
    J Neuroimmunol 186:45-53. 2007
  9. ncbi Conceptual, spatial, and cue learning in the Morris water maze in fast or slow kindling rats: attention deficit comorbidity
    Hymie Anisman
    Institute of Neuroscience, Carleton University, Ottawa, Ontario, Canada, K1S 5B6
    J Neurosci 22:7809-17. 2002
  10. ncbi Cytokines, stress, and depressive illness
    H Anisman
    Institute of Neuroscience, Carleton University, Ottowa, Ont, Canada K1S 5B6
    Brain Behav Immun 16:513-24. 2002

Detail Information

Publications108 found, 100 shown here

  1. ncbi Stress, depression, and anhedonia: caveats concerning animal models
    Hymie Anisman
    Institute of Neuroscience, Carleton University, LSRB, Ottawa, Ont, Canada K1S 5B6
    Neurosci Biobehav Rev 29:525-46. 2005
    ..The paradigm is sensitive to several factors known to acts as moderators of stress responses, but analyses remain to be conducted with regard to several such variables...
  2. ncbi The effects of cortisol administration on social status and brain monoaminergic activity in rainbow trout Oncorhynchus mykiss
    Joseph D DiBattista
    Ottawa Carleton Institute of Biology, Ottawa, ON, K1N 6N5 Canada
    J Exp Biol 208:2707-18. 2005
    ....
  3. ncbi Corticotropin-releasing hormone, arginine vasopressin, gastrin-releasing peptide, and neuromedin B alterations in stress-relevant brain regions of suicides and control subjects
    Zul Merali
    Institute of Mental Health Research, University of Ottawa, Ontario, Canada
    Biol Psychiatry 59:594-602. 2006
    ..Postmortem levels of several stress- and depression-relevant neuropeptides were assessed in brain regions of depressed suicides relative to control subjects that had died of other causes...
  4. ncbi Maternal programming of defensive responses through sustained effects on gene expression
    Tie Yuan Zhang
    McGill Program for the Study of Behavior, Genes and Environment, McGill University, Canada
    Biol Psychol 73:72-89. 2006
    ....
  5. ncbi Ruminative coping among patients with dysthymia before and after pharmacotherapy
    Owen Kelly
    University of Ottawa Institute of Mental Health Research, Ottawa, Ontario, Canada
    Depress Anxiety 24:233-43. 2007
    ..Inflexibility in the ability to combine various coping efforts effectively may be characteristic of individuals with dysthymia, potentially increasing risk for recurrence...
  6. ncbi Posttraumatic stress symptoms and salivary cortisol levels
    H Anisman
    Institute of Neuroscience, Carleton University, Ottawa, Ontario, Canada
    Am J Psychiatry 158:1509-11. 2001
    ..This study assessed the relationship between posttraumatic stress symptoms and salivary cortisol levels after a severe ice storm...
  7. doi Neurotransmitter, peptide and cytokine processes in relation to depressive disorder: comorbidity between depression and neurodegenerative disorders
    Hymie Anisman
    Institute of Neuroscience, Carleton University, Ottawa, Ontario K1S 5B6, Canada
    Prog Neurobiol 85:1-74. 2008
    ..As well, stressful events may result in the sensitization of neurochemical and cytokine processes, so that later re-exposure to these stimuli may promote rapid and exaggerated responses that favor illness recurrence...
  8. ncbi Interferon-alpha effects are exaggerated when administered on a psychosocial stressor backdrop: cytokine, corticosterone and brain monoamine variations
    Hymie Anisman
    Institute of Neuroscience, Carleton University, Ontario, Canada K1S 5B6
    J Neuroimmunol 186:45-53. 2007
    ..It is suggested that the depressive effects of immunotherapy in humans likewise reflects the synergistic actions of the cytokine and the ongoing distress experienced by patients...
  9. ncbi Conceptual, spatial, and cue learning in the Morris water maze in fast or slow kindling rats: attention deficit comorbidity
    Hymie Anisman
    Institute of Neuroscience, Carleton University, Ottawa, Ontario, Canada, K1S 5B6
    J Neurosci 22:7809-17. 2002
    ..These various attributes of the fast rats may serve as a potentially useful animal model of disorders characterized by an attention deficit...
  10. ncbi Cytokines, stress, and depressive illness
    H Anisman
    Institute of Neuroscience, Carleton University, Ottowa, Ont, Canada K1S 5B6
    Brain Behav Immun 16:513-24. 2002
    ....
  11. ncbi Further evidence for the depressive effects of cytokines: anhedonia and neurochemical changes
    Hymie Anisman
    Institute of Neuroscience, Life Science Research Building, Carleton University, Ottawa, ON, Canada
    Brain Behav Immun 16:544-56. 2002
    ....
  12. ncbi Considering cytokine panels
    Hymie Anisman
    Institute of Neuroscience, Carleton University, Ottawa, Ont, Canada K1S 5B6
    Brain Behav Immun 18:221-2. 2004
  13. pmc Cascading effects of stressors and inflammatory immune system activation: implications for major depressive disorder
    Hymie Anisman
    Institute of Neuroscience, Carleton University, Ottawa, Ontario, Canada
    J Psychiatry Neurosci 34:4-20. 2009
    ....
  14. ncbi Cytokines as a stressor: implications for depressive illness
    Hymie Anisman
    Institute of Neuroscience, Carleton University, Ottawa, Ontario, Canada
    Int J Neuropsychopharmacol 5:357-73. 2002
    ..Given that the effects of cytokines are evident within hypothalamic, as well as extrahypothalamic sites, including various limbic regions, it is suggested that cytokines may impact on emotional changes, including depression...
  15. pmc Serotonin receptor subtype and p11 mRNA expression in stress-relevant brain regions of suicide and control subjects
    Hymie Anisman
    Institute of Neuroscience, Carleton University, Ottawa, ON, Canada
    J Psychiatry Neurosci 33:131-41. 2008
    ..Our objective was to investigate which 5-HT receptor subtypes might be associated with depression and suicide, whether receptor differences vary across brain regions and whether they are moderated by sex...
  16. ncbi Sensitization associated with stressors and cytokine treatments
    Hymie Anisman
    Institute of Neurosciences, Carleton University, Ont, K1S 5B6, Ottawa, Canada
    Brain Behav Immun 17:86-93. 2003
    ..Cytokines may independently prime multiple regulatory systems, and by virtue of the neurochemical changes imparted, have both immediate and proactive influences on the evolution of psychopathology...
  17. ncbi Cytokines, stress and depressive illness: brain-immune interactions
    Hymie Anisman
    Institute of Neurosciences, Carleton University and Institute of Mental Health Research, Royal Ottawa Hospital, University of Ottawa, Canada
    Ann Med 35:2-11. 2003
    ..Furthermore, such effects are subject to a sensitization effect so that a history of stressful experiences or cytokine activation augment the response to later challenges and hence the evolution of depression..
  18. ncbi Neurochemical sensitization associated with systemic administration of tumor necrosis factor-alpha: adjuvant action in combination with bovine serum albumin
    Hymie Anisman
    Institute of Neuroscience, Carleton University, Ottawa, Ontario, Canada K1S 5B6
    J Neuroimmunol 145:91-102. 2003
    ..It is suggested that mTNF-alpha acts as an adjuvant to the anaphylactic actions elicited by BSA, but may provoke a sensitization of monoamine activity which is time-dependent and varies across brain regions...
  19. ncbi Cytokines as a precipitant of depressive illness: animal and human studies
    Hymie Anisman
    Institute of Neuroscience, Carleton University, Ottawa, Ontario K1S 5B6, Canada
    Curr Pharm Des 11:963-72. 2005
    ..Further, the effects of the cytokine treatments may act synergistically with stressors, and cytokines may provoke a sensitization effect so that the effects of later stressor experiences are exacerbated...
  20. ncbi Acoustic startle and fear-potentiated startle in rats selectively bred for fast and slow kindling rates: relation to monoamine activity
    H Anisman
    Institute of Neuroscience, Carleton University, Ottawa, Ontario K1S 5B6, Canada
    Eur J Neurosci 12:4405-16. 2000
    ..This suggested that relative to Slow rats, dopamine neurons in prefrontal cortex of Fast rats do not react normally to environmental stimuli, and this phenomenon could lead to disturbances of attention or impulsivity...
  21. ncbi Do early-life events permanently alter behavioral and hormonal responses to stressors?
    H Anisman
    Institute of Neuroscience, Carleton University, Ottawa, Ontario, Canada
    Int J Dev Neurosci 16:149-64. 1998
    ..In contrast, in relatively hardy animals the early-life manipulations may have less obvious effects...
  22. ncbi Stressor-induced corticotropin-releasing hormone, bombesin, ACTH and corticosterone variations in strains of mice differentially responsive to stressors
    H Anisman
    Institute of Neurosciences, Carleton University, Ottawa, Ontario
    Stress 2:209-20. 1998
    ....
  23. ncbi Endocrine and cytokine correlates of major depression and dysthymia with typical or atypical features
    H Anisman
    Institute of Neurosciences, Carleton University, Ottawa, Ontario, Canada
    Mol Psychiatry 4:182-8. 1999
    ..Given that circulating cytokines influence neuroendocrine functioning, and may affect neurovegetative features, a role for interleukins may exist with respect to the pathophysiology of certain subtypes of depression...
  24. ncbi Psychogenic, neurogenic, and systemic stressor effects on plasma corticosterone and behavior: mouse strain-dependent outcomes
    H Anisman
    Institute of Neuroscience, Carleton University, Ottawa, Ontario, Canada
    Behav Neurosci 115:443-54. 2001
    ..It appears that whereas stressor reactivity and adrenal glucocorticoid release may be exaggerated in BALB/cByJ mice, such effects may be dependent on the specific characteristic of the stressor situation...
  25. ncbi Corticotropin releasing hormone receptor alterations elicited by acute and chronic unpredictable stressor challenges in stressor-susceptible and resilient strains of mice
    Hymie Anisman
    Institute of Neuroscience, Carleton University, Ottawa, Ontario, Canada
    Behav Brain Res 181:180-90. 2007
    ....
  26. doi Experiential and genetic contributions to depressive- and anxiety-like disorders: clinical and experimental studies
    Hymie Anisman
    Institute of Neuroscience, Carleton University, Ottawa, Ontario K1S 5B6, Canada
    Neurosci Biobehav Rev 32:1185-206. 2008
    ..It is suggested that depression is a life-long disorder, which even after effective treatment, has a high rate of re-occurrence owing to sensitized processes or epigenetic factors that promote persistent alterations of gene expression...
  27. doi Influence of continuous infusion of interleukin-1beta on depression-related processes in mice: corticosterone, circulating cytokines, brain monoamines, and cytokine mRNA expression
    Hymie Anisman
    Institute of Neuroscience, Carleton University, Ottawa, Ontario, Canada
    Psychopharmacology (Berl) 199:231-44. 2008
    ....
  28. doi Impact of repeated stressor exposure on the release of corticotropin-releasing hormone, arginine-vasopressin and bombesin-like peptides at the anterior pituitary
    Z Merali
    University of Ottawa, Department of Psychology, Ottawa, Ontario, K1N 6N5, Canada
    Behav Brain Res 198:105-12. 2009
    ....
  29. doi Plasticity of the GABA(A) receptor subunit cassette in response to stressors in reactive versus resilient mice
    M O Poulter
    Molecular Brain Research Group, Robarts Research Institute, Department of Physiology and Pharmacology, University of Western Ontario, London, ON, Canada
    Neuroscience 165:1039-51. 2010
    ..These findings support the view that analyses involving subunit organization, rather than just differences in absolute levels, may be expedient in assessing GABA(A) functioning in stressor-related psychological disturbances...
  30. ncbi Differential impact of predator or immobilization stressors on central corticotropin-releasing hormone and bombesin-like peptides in Fast and Slow seizing rat
    Z Merali
    School of Psychology, University of Ottawa, 11 Marie Curie, Ottawa, ON, Canada K1N 6N5
    Brain Res 906:60-73. 2001
    ..Taken together, the results demonstrate that these two lines of rats show differential endocrinological and neurochemical response patterns to these stressors...
  31. ncbi Maternal factors and monoamine changes in stress-resilient and susceptible mice: cross-fostering effects
    Priya Prakash
    Institute of Neuroscience, Carleton University, Life Science Research Bldg, Ottawa, Ontario, Canada
    Brain Res 1111:122-33. 2006
    ..Although monoamine variations were largely determined by genetic factors, maternal influences contributed to stressor-elicited neurochemical changes in some regions, particularly dopamine activation within the prefrontal cortex...
  32. ncbi Aversive and appetitive events evoke the release of corticotropin-releasing hormone and bombesin-like peptides at the central nucleus of the amygdala
    Z Merali
    School of Psychology, University of Ottawa, Ottawa, Ontario, Canada K1N 6N5
    J Neurosci 18:4758-66. 1998
    ..Rather than evoking feelings of fear and anxiety, these systems may serve to draw attention to events or cues of biological significance, such as those associated with food availability as well as those posing a threat to survival...
  33. ncbi Does amygdaloid corticotropin-releasing hormone (CRH) mediate anxiety-like behaviors? Dissociation of anxiogenic effects and CRH release
    Z Merali
    Institute of Mental Health Research, University of Ottawa, Ottawa, Ontario, Canada K1N 6 N5
    Eur J Neurosci 20:229-39. 2004
    ..Rather than provoking anxiety, these systems might serve to draw attention to events or cues of biological significance, including those posing a threat to survival...
  34. ncbi Effects of interleukin-1beta and mild stress on alterations of norepinephrine, dopamine and serotonin neurotransmission: a regional microdialysis study
    Z Merali
    School of Psychology, University of Ottawa, Ont, Canada
    Brain Res 761:225-35. 1997
    ..These data also lend support to the contention that neurogenic stressors may have a much greater impact on central neurotransmission under conditions of immune activation...
  35. ncbi Influence of psychogenic and neurogenic stressors on neuroendocrine and central monoamine activity in fast and slow kindling rats
    D C McIntyre
    Institute of Neuroscience, Carleton University, Ottawa, Ontario, Canada
    Brain Res 840:65-74. 1999
    ..Similarly, DA alterations also were greater in the left medial amygdala in response to stressors. Despite very different behavioral styles, however, the two lines often exhibited similar amine alterations in response to both stressors...
  36. ncbi Sensitization to the neuroendocrine, central monoamine and behavioural effects of murine tumor necrosis factor-alpha: peripheral and central mechanisms
    S Hayley
    Institute of Neuroscience, Life Science Research Building, Carleton University, Ottawa, Ontario K1S 5B6, Canada
    Eur J Neurosci 15:1061-76. 2002
    ..Moreover, it appears that mTNF-alpha promotes central neurochemical plasticity through independent central and peripheral mechanisms...
  37. ncbi Central monoamine and plasma corticosterone changes induced by a bacterial endotoxin: sensitization and cross-sensitization effects
    S Hayley
    Institute of Neuroscience, Carleton University, Ottawa, Ontario K1S 5B6, Canada
    Eur J Neurosci 13:1155-65. 2001
    ....
  38. ncbi Impact of chronic intermittent challenges in stressor-susceptible and resilient strains of mice
    Beth Tannenbaum
    Institute of Neuroscience, Carleton University, Ottawa, Ontario, Canada
    Biol Psychiatry 53:292-303. 2003
    ....
  39. doi Synergistic and additive actions of a psychosocial stressor and endotoxin challenge: Circulating and brain cytokines, plasma corticosterone and behavioral changes in mice
    Julie Gibb
    Institute of Neuroscience, Carleton University, LSRB 1125 Colonial By Drive, Ottawa, Ont, Canada K1S 5B6
    Brain Behav Immun 22:573-89. 2008
    ....
  40. ncbi Central bombesin activates the hypothalamic-pituitary-adrenal axis. Effects on regional levels and release of corticotropin-releasing hormone and arginine-vasopressin
    P Kent
    School of Psychology, University of Ottawa, Ottawa, Ontario, K1N 6N5, Canada
    Neuroendocrinology 73:203-14. 2001
    ....
  41. ncbi Neurochemical and behavioral alterations elicited by a chronic intermittent stressor regimen: implications for allostatic load
    B Tannenbaum
    Institute of Neuroscience, Life Sciences Research Centre, Carleton University, 1125 Colonel By Drive, Ottawa, Ontario K1S 5B6, Canada
    Brain Res 953:82-92. 2002
    ..It is suggested that chronic stressor exposure may instigate relatively protracted neurochemical effects, thereby influencing the behavioral responses to later psychological and systemic challenges...
  42. doi Interferon-gamma deficiency modifies the effects of a chronic stressor in mice: Implications for psychological pathology
    Darcy Litteljohn
    Institute of Neuroscience, Carleton University, 1125 Colonel By Drive, Ottawa, Ontario, Canada K1S5B6
    Brain Behav Immun 24:462-73. 2010
    ..At the same time, however, IFN-gamma deficiency appears to blunt some of the neurochemical, corticoid and cytokine alterations ordinarily associated with chronic stressor exposure...
  43. ncbi Anticipatory cues differentially provoke in vivo peptidergic and monoaminergic release at the medial prefrontal cortex
    Zul Merali
    School of Psychology, University of Ottawa, Ottawa, Ontario, Canada
    Neuropsychopharmacology 29:1409-18. 2004
    ..The activity of DA and 5-HT neurons, in contrast, is more closely aligned with the cognitive appraisal of predictor stimuli...
  44. doi Nesfatin-1 increases anxiety- and fear-related behaviors in the rat
    Z Merali
    Department of Psychology, University of Ottawa, Ottawa, ON, Canada
    Psychopharmacology (Berl) 201:115-23. 2008
    ..However, the relation between nesfatin-1 and stressor-related behaviors like anxiety and/or fear has not yet been investigated...
  45. ncbi Time-dependent sensitization of corticotropin-releasing hormone, arginine vasopressin and c-fos immunoreactivity within the mouse brain in response to tumor necrosis factor-alpha
    S Hayley
    Institute of Neuroscience, Life Science Research Building, Carleton University, 1125 Colonel By Drive, Ottawa, Ontario, Canada K1S 5B6
    Neuroscience 106:137-48. 2001
    ..It is suggested that such a sensitization may influence the response to immunological and traumatic insults and may thus be relevant to behavioral pathology...
  46. ncbi Influence of psychosocial, psychogenic and neurogenic stressors on several aspects of immune functioning in mice
    Z W Lu
    Institute of Neuroscience, Carleton University, Ottawa, Ontario, Canada
    Stress 3:55-70. 1999
    ..It is suggested that analysis of stressor effects need to consider in greater detail the characteristics of the organism being stressed, as well as the characteristics of the stressor itself...
  47. ncbi Influence of poly I:C on sickness behaviors, plasma cytokines, corticosterone and central monoamine activity: moderation by social stressors
    Reno Gandhi
    Institute of Neuroscience, Carleton University, Ottawa, Ont, Canada K1S 5B6
    Brain Behav Immun 21:477-89. 2007
    ..Mechanisms that might be responsible for the interactive effects of social disruption and immune activation are presented, and the data were related to depressive symptoms associated with stressor and cytokine treatments...
  48. pmc CRF receptor 1 regulates anxiety behavior via sensitization of 5-HT2 receptor signaling
    Ana C Magalhaes
    J Allyn Taylor Centre for Cell Biology, Molecular Brain Research Group, Robarts Research and the Department of Physiology and Pharmacology, The University of Western Ontario, London, Ontario, Canada
    Nat Neurosci 13:622-9. 2010
    ..These data suggest a mechanism by which CRF, a peptide known to be released by stress, enhances anxiety-related behavior via sensitization of 5-HT(2)R signaling...
  49. ncbi Influence of chronic interleukin-2 infusion and stressors on sickness behaviors and neurochemical change in mice
    Kerry Sudom
    Institute of Neuroscience, Carleton University, Ottawa, Ont K 1S 5B6, Canada
    Neuroimmunomodulation 11:341-50. 2004
    ..The present investigation assessed several behavioral and neurochemical effects of chronic IL-2 infusion...
  50. ncbi Rodent models of depression: learned helplessness induced in mice
    H Anisman
    Carleton University, Ottawa, Ontario, Canada
    Curr Protoc Neurosci . 2001
    ..This unit describes the procedure used to assess the effects of controllable and uncontrollable shock on subsequent shock escape performance in mice using an escape-delay procedure...
  51. ncbi Bombesin-induced HPA and sympathetic activation requires CRH receptors
    P Kent
    School of Psychology, University of Ottawa, 11 Marie Curie, Ottawa, Ontario, Canada
    Peptides 22:57-65. 2001
    ..These findings support the notion that BN-induced HPA axis and sympathetic activation are mediated, at least in part, via activation of CRH neurons...
  52. ncbi The limits of 'adaptive' coping: well-being and mood reactions to stressors among women in abusive dating relationships
    Kimberly Matheson
    Department of Psychology, Carleton University, Ottawa, Ont, Canada K1S 5B6
    Stress 10:75-91. 2007
    ..It seems that in some contexts, reduced distress might limit active efforts to alter a dysfunctional situation...
  53. ncbi Corticosterone changes in response to stressors, acute and protracted actions of tumor necrosis factor-alpha, and lipopolysaccharide treatments in mice lacking the tumor necrosis factor-alpha p55 receptor gene
    Shawn Hayley
    Institute of Neuroscience, Carleton University, Ottawa, Ont, Canada
    Neuroimmunomodulation 11:241-6. 2004
    ..Systemic administration of the proinflammatory cytokine, tumor necrosis factor-alpha (TNF-alpha), has acute as well as sensitizing effects on behavioral and neurochemical functioning...
  54. doi Altered metabolic and neurochemical responses to chronic unpredictable stressors in ghrelin receptor-deficient mice
    Z R Patterson
    Institute of Neuroscience, Carleton University, 1125 Colonel By Drive, Ottawa, K1S 5B6 ON, Canada
    Eur J Neurosci 32:632-9. 2010
    ....
  55. doi Effects of fluoxetine on the reproductive axis of female goldfish (Carassius auratus)
    Jan A Mennigen
    Department of Biology, Centre for Advanced Research in Environmental Genomics, University of Ottawa, Ottawa, Ontario, Canada
    Physiol Genomics 35:273-82. 2008
    ..We discuss these findings in the context of endocrine disruption because fluoxetine has been detected in the environment...
  56. doi The desire to gamble: the influence of outcomes on the priming effects of a gambling episode
    Matthew M Young
    Department of Psychology, Carleton University, 1125 Colonel By Drive, B550 Loeb Building, K1S 5B6 Ottawa, Ontario, Canada
    J Gambl Stud 24:275-93. 2008
    ..The data were related to motivational factors associated with gambling, gambling persistence, and chasing losses...
  57. pmc c-Jun mediates axotomy-induced dopamine neuron death in vivo
    S J Crocker
    Neuroscience Research Institute, University of Ottawa, Ottawa, ON K1H 8M5, Canada
    Proc Natl Acad Sci U S A 98:13385-90. 2001
    ..Ad.c-JunDN also delayed the degeneration of dopaminergic nigral axons in the striatum after MFB axotomy. Taken together, these findings suggest that activation of c-Jun mediates the loss of dopamine neurons after axotomy injury...
  58. ncbi Role of bombesin-related peptides in the mediation or integration of the stress response
    Z Merali
    School of Psychology, University of Ottawa, Ontario, Canada
    Cell Mol Life Sci 59:272-87. 2002
    ..Several hypothetical mechanisms for such peptidergic interactions are discussed as to the implications of considering BN-LPs as 'stress peptides'...
  59. ncbi Murine tumor necrosis factor-alpha sensitizes plasma corticosterone activity and the manifestation of shock: modulation by histamine
    Shawn Hayley
    Institute of Neuroscience, Life Science Research Building, Carleton University, 1125 Colonel By Drive, Ottawa, Ontario, Canada
    J Neuroimmunol 131:60-9. 2002
    ..It is suggested that mTNF-alpha-induced illness and the neuroendocrine sensitization are mediated by endogenous histamine...
  60. ncbi The pathogenesis of clinical depression: stressor- and cytokine-induced alterations of neuroplasticity
    S Hayley
    Institute of Neuroscience, Carleton University, 1125 Colonel By Drive, Ottawa, Ontario, Canada K1S 5B6
    Neuroscience 135:659-78. 2005
    ..Thus, depressive illness may be considered a disorder of neuroplasticity as well as one of neurochemical imbalances, and cytokines may act as mediators of both aspects of this illness...
  61. doi Impact of stressors in a natural context on release of cortisol in healthy adult humans: a meta-analysis
    Kathy Michaud
    Department of Psychology, Carleton University, Ottawa, Ont, Canada
    Stress 11:177-97. 2008
    ..Nevertheless, there are ample data suggesting that stressful events, through their actions on cortisol levels and reactivity, may influence psychological and physical pathology...
  62. ncbi Effects of acute or chronic omega-3 and omega-6 polyunsaturated fatty acid treatment on behavioral, neuroendocrine and cytokine changes elicited by exogenous interleukin-1beta challenge
    Maia Miguelez
    Institute of Neuroscience, University of Carleton, Neuroscience Building, Rm 333, Ottawa, Ontario, Canada K1S 5B6
    J Neuroimmunol 181:19-28. 2006
    ....
  63. ncbi Validation of a simple, ethologically relevant paradigm for assessing anxiety in mice
    Zul Merali
    Institute of Mental Health Research, Royal Ottawa Hospital, and Department of Cellular and Molecular Medicine, University of Ottawa, Ontario, Canada
    Biol Psychiatry 54:552-65. 2003
    ....
  64. ncbi Regulation of dopaminergic loss by Fas in a 1-methyl-4-phenyl-1,2,3,6-tetrahydropyridine model of Parkinson's disease
    Shawn Hayley
    Ottawa Health Research Institute, Neuroscience Group, Ottawa, Ontario, Canada K1H 8M5
    J Neurosci 24:2045-53. 2004
    ..Despite the reduced terminals, dopamine levels were not further suppressed by MPTP treatment in mutant mice, raising the possibility of a compensatory response in basal ganglia function in Fas-deficient mice...
  65. doi Anhedonia and altered cardiac atrial natriuretic peptide following chronic stressor and endotoxin treatment in mice
    Boubacar Pasto Wann
    Institute of Neuroscience, Department of Psychology, Carleton University, Ottawa, Ontario, Canada K1S5B6
    Psychoneuroendocrinology 35:233-40. 2010
    ..These findings are consistent with the view that chronic stressors and inflammatory immune activation may represent a common denominator subserving the frequent comorbidity between these illnesses...
  66. ncbi Stress, coping, uplifts, and quality of life in subtypes of depression: a conceptual frame and emerging data
    Arun V Ravindran
    Department of Psychiatry, Royal Ottawa Hospital, Department of Psychology, Ottawa, Ontario, Canada
    J Affect Disord 71:121-30. 2002
    ....
  67. doi GABAA receptor promoter hypermethylation in suicide brain: implications for the involvement of epigenetic processes
    Michael O Poulter
    Molecular Brain Research Group, Robarts Research Institute, Department of Physiology and Pharmacology University of Western Ontario, London, Ontario, Canada
    Biol Psychiatry 64:645-52. 2008
    ..Epigenetic mechanisms may be involved in the reprogramming of gene expression in response to stressful stimuli. This investigation determined whether epigenetic phenomena might similarly be associated with suicide/depression...
  68. doi Central ghrelin signaling mediates the metabolic response of C57BL/6 male mice to chronic social defeat stress
    Z R Patterson
    Department of Neuroscience, Carleton University, 1125 Colonel By Drive, Ottawa, Ontario, K1S 5B6, Canada
    Endocrinology 154:1080-91. 2013
    ....
  69. doi Stressor exposure of male and female juvenile mice influences later responses to stressors: modulation of GABAA receptor subunit mRNA expression
    S Jacobson-Pick
    Department of Neuroscience, Carleton University, Ottawa, Canada K1S5B6
    Neuroscience 215:114-26. 2012
    ..Nevertheless, these GABA(A) sex-specific subunit variations may be tied to the differences in anxiety in males and females...
  70. ncbi Attenuation of MPTP-induced neurotoxicity and behavioural impairment in NSE-XIAP transgenic mice
    S J Crocker
    Neuroscience Research Institute, University of Ottawa, Ottawa, Ontario K1H 8M5, Canada
    Neurobiol Dis 12:150-61. 2003
    ..Taken together, these findings suggest that strategies to enhance neuronal expression of XIAP may provide therapeutic benefit for the treatment of neurodegeneration in Parkinson's disease...
  71. doi Decomposing identity: differential relationships between several aspects of ethnic identity and the negative effects of perceived discrimination among First Nations adults in Canada
    Amy Bombay
    Department of Psychology, Carleton University, Ottawa, Canada
    Cultur Divers Ethnic Minor Psychol 16:507-16. 2010
    ..The data underscore the importance of examining different aspects of identity and gender differences in determining the role of ethnic identity in the well-being of minority populations...
  72. doi Religiosity as identity: toward an understanding of religion from a social identity perspective
    Renate Ysseldyk
    Carleton University, Ottawa, Ontario, Canada
    Pers Soc Psychol Rev 14:60-71. 2010
    ..Consideration of religion's dual function as a social identity and a belief system may facilitate greater understanding of the variability in its importance across individuals and groups...
  73. doi Forgiveness and the appraisal-coping process in response to relationship conflicts: implications for depressive symptoms
    Renate Ysseldyk
    Department of Psychology, Carleton University, Ottawa, Ontario, Canada
    Stress 12:152-66. 2009
    ..It is suggested that the relation between forgiveness and diminished distress operates primarily by guiding individuals' appraisals of the conflict and by diminishing the reliance on emotion-focused coping...
  74. doi Animation-based education as a gambling prevention tool: correcting erroneous cognitions and reducing the frequency of exceeding limits among slots players
    Michael J A Wohl
    Department of Psychology, Carleton University, Ottawa, ON, Canada
    J Gambl Stud 26:469-86. 2010
    ..Some effects waned over a 30-day period suggesting booster sessions may be required for long term sustainability. The effectiveness of animation-based education as a prevention tool and the need for adjunctive measures is discussed...
  75. doi Neuroendocrine and neurochemical impact of aggressive social interactions in submissive and dominant mice: implications for stress-related disorders
    Marie Claude Audet
    Institute of Neurosciences, Carleton University, Ottawa, Ontario, Canada
    Int J Neuropsychopharmacol 13:361-72. 2010
    ..However, given that 5-HT changes occur irrespective of social rank, these data suggest that a toll is taken on both submissive and dominant mice, leaving them vulnerable to stress-related pathology...
  76. ncbi Neurochemical and behavioral responses to inflammatory immune stressors
    Julie Gibb
    Institute of Neurosciences, Carleton University, Ottawa, Ontario, Canada
    Front Biosci (Schol Ed) 1:275-95. 2009
    ..Together, these findings indicate that activation of the inflammatory immune system may favor the evolution of psychological disturbances...
  77. doi Lipopolysaccharide and a social stressor influence behaviour, corticosterone and cytokine levels: divergent actions in cyclooxygenase-2 deficient mice and wild type controls
    Shawn Hayley
    Institute of Neuroscience, Carleton University, 1125 Colonel By Drive, Ottawa, Ontario, Canada K1S 5B6
    J Neuroimmunol 197:29-36. 2008
    ..g., in the case of TNF-alpha, IL-6 and corticosterone). Evidently, COX-2 deletion may have either pro- or anti-inflammatory actions, depending upon the psychosocial context in which immune activation occurs...
  78. ncbi Relations between trauma experiences and psychological, physical and neuroendocrine functioning among Somali refugees: mediating role of coping with acculturation stressors
    Kimberly Matheson
    Department of Psychology, Carleton University, Ottawa, ON, Canada
    J Immigr Minor Health 10:291-304. 2008
    ..Evidently, refugees were at risk for stress-related dysfunction long after migrating, and the diminished capacity to cope with acculturation challenges was particularly important in this regard...
  79. ncbi Psychosocial stress evoked by a virtual audience: relation to neuroendocrine activity
    Owen Kelly
    Carleton University, Institute of Neuroscience, Ontario, Canada
    Cyberpsychol Behav 10:655-62. 2007
    ..These data suggest that VR technology may be amenable to evaluating the impact of psychosocial stressors such as the TSST...
  80. ncbi Cortisol rise following awakening among problem gamblers: dissociation from comorbid symptoms of depression and impulsivity
    Michael Jeremy Adam Wohl
    Department of Psychology, Carleton University, 1125 Colonel By Drive, B550 Loeb Building, Ottawa, ON, Canada, K1S 5B6
    J Gambl Stud 24:79-90. 2008
    ..Furthermore, the sustained morning cortisol elevations may be indicative of allostatic overload, and could potentially be a harbinger for potential health risks among problematic gamblers...
  81. pmc Cyclin-dependent kinase 5 is a mediator of dopaminergic neuron loss in a mouse model of Parkinson's disease
    Patrice D Smith
    Neuroscience Group, Ottawa Health Research Institute, Ottawa, ON, Canada K1H 8M5
    Proc Natl Acad Sci U S A 100:13650-5. 2003
    ..We propose that cdk5 is a key regulator in the degeneration of dopaminergic neurons in Parkinson's disease...
  82. ncbi Working and reference memory in seizure-prone and seizure-resistant rats: impact of amygdala kindling
    Dan C McLntyre
    Department of Psychology, Institute for Neuroscience, Carleton University, Ottawa, ON, Canada
    Behav Neurosci 118:314-23. 2004
    ....
  83. ncbi Amygdala amino acid and monoamine levels in genetically Fast and Slow kindling rat strains during massed amygdala kindling: a microdialysis study
    Rick S Shin
    Department of Psychology, Life Sciences Research Building, Carleton University, Ottawa, Ontario, K1S 5B6, Canada
    Eur J Neurosci 20:185-94. 2004
    ....
  84. ncbi Multiple mechanisms of cytokine action in neurodegenerative and psychiatric states: neurochemical and molecular substrates
    Shawn Hayley
    Institute of Neuroscience, Carleton University, Ottawa, Ontario, Canada
    Curr Pharm Des 11:947-62. 2005
    ..Attention is also devoted to the possibility that cytokines may sensitize neuroinflammatory pathways that, in turn, favour long-term pathology...
  85. doi Sex differences in hormonal responses to a social stressor in chronic major depression
    Kevin K Chopra
    Centre for Addiction and Mental Health, Toronto, Ontario, Canada
    Psychoneuroendocrinology 34:1235-41. 2009
    ..The current study evaluated cortisol stress responses to a social challenge in chronic major depressive disorder (CMDD)...
  86. ncbi Systems of coping associated with dysphoria, anxiety and depressive illness: a multivariate profile perspective
    Kimberly Matheson
    Department of Psychology and Institute of Neuroscience, Carleton University, Ottawa, Ont, Canada
    Stress 6:223-34. 2003
    ..It is suggested that a multidimensional approach may prove useful in understanding coping as a dynamic system, and may have implications for clinical intervention...
  87. ncbi Impact of life-long macronutrient choice on neuroendocrine and cognitive functioning in aged mice: differential effects in stressor-reactive and stressor-resilient mouse strains
    Beth M Tannenbaum
    Institute of Neuroscience, Carleton University, Ottawa, Ontario, Canada K1S 5B6
    Brain Res 985:187-97. 2003
    ..These data suggest that the adverse effects of fat consumption need to be considered in the context of genetically determined vulnerability/resilience factors...
  88. ncbi Coping with employment uncertainty: a comparison of employed and unemployed workers
    Janet Mantler
    Department of Psychology, Carleton University, Ottawa, ON, Canada
    J Occup Health Psychol 10:200-9. 2005
    ....
  89. ncbi Parental bonding and depressive affect: the mediating role of coping resources
    Kimberly Matheson
    Department of Psychology and Institute of Neuroscience, Carleton University, Canada
    Br J Soc Psychol 44:371-95. 2005
    ....
  90. ncbi Differential impact of audiogenic stressors on Lewis and Fischer rats: behavioral, neurochemical, and endocrine variations
    David S Michaud
    Consumer and Clinical Radiation Protection Bureau, Health Canada, Ottawa, Ontario, Canada
    Neuropsychopharmacology 28:1068-81. 2003
    ..Behaviorally, the Fischer rats displayed an active stress response, whereas the Lewis strain adopted freezing as a defensive style. The role of CRH in the genesis of the overall strain-dependent response to stressors is discussed...
  91. ncbi Stress and cytokine-elicited neuroendocrine and neurotransmitter sensitization: implications for depressive illness
    Shawn Hayley
    Institute of Neuroscience, Carleton University, Canada
    Stress 6:19-32. 2003
    ..It is suggested that by virtue of these neurochemical changes, cytokines may have both immediate and proactive effects on mood states...
  92. ncbi Dissociating anorexia and anhedonia elicited by interleukin-1beta: antidepressant and gender effects on responding for "free chow" and "earned" sucrose intake
    Zul Merali
    Institute of Mental Health Research, Royal Ottawa Hospital, Ottawa, Canada
    Psychopharmacology (Berl) 165:413-8. 2003
    ..Analysis of the behavioral effects of interleukin-1beta (IL-1beta), and their modification by antidepressants, is complicated since the anorexic and anhedonic effects of the cytokine are not readily dissociated from one another...
  93. ncbi Changes in extracellular levels of amygdala amino acids in genetically fast and slow kindling rat strains
    Rick S Shin
    Institute of Neuroscience, Department of Psychology, Life Sciences Research Building, Carleton University, 1125 Colonel By Drive, Ottawa, Ontario K1S 5B6, Canada
    Brain Res 946:31-42. 2002
    ....
  94. ncbi Involvement of interferon-gamma in microglial-mediated loss of dopaminergic neurons
    Matthew P Mount
    Ottawa Health Research Institute, Neuroscience Group, Ottawa, Ontario, Canada K1H 8M5
    J Neurosci 27:3328-37. 2007
    ..Finally, levels of IFN-gamma message increased in microglia in response to rotenone. Together, these data suggest that IFN-gamma participates in death of dopaminergic neurons by regulating microglial activity...
  95. ncbi Differential involvement of amygdaloid CRH system(s) in the salience and valence of the stimuli
    Zul Merali
    Institute of Mental Health Research, Royal Ottawa Hospital, University of Ottawa, 1145 Carling Avenue, K1Z 7K4, Ottawa, ON, Canada
    Prog Neuropsychopharmacol Biol Psychiatry 27:1201-12. 2003
    ..We suggest that the CRH responses at the CeA may be involved in a preparatory capacity and, as such, may accompany a range of emotionally significant stimuli, be they appetitive or aversive...
  96. ncbi Individual differences in sucrose consumption in the rat: motivational and neurochemical correlates of hedonia
    K Brennan
    Institute of Neuroscience, Carleton University, School of Psychology, University of Ottawa, Ottawa, Ontario, Canada
    Psychopharmacology (Berl) 157:269-76. 2001
    ....
  97. doi Activation of gastrin-releasing peptide receptors at the infralimbic cortex elicits gastrin-releasing peptide release at the basolateral amygdala: implications for conditioned fear
    Z Merali
    School of Psychology, University of Ottawa, Ottawa, Ontario, Canada K1N 6N5
    Neuroscience 243:97-103. 2013
    ..Together these findings provide further evidence for the involvement of GRP in fear and anxiety-related disorders...
  98. ncbi Role of bombesin-related peptides in the control of food intake
    Z Merali
    School of Psychology, University of Ottawa, Ottawa, Ontario, K1N 6N5
    Neuropeptides 33:376-86. 1999
    ..Hence, pharmacological targeting of these systems may be of therapeutic value...
  99. pmc Hypersensitivity of DJ-1-deficient mice to 1-methyl-4-phenyl-1,2,3,6-tetrahydropyrindine (MPTP) and oxidative stress
    Raymond H Kim
    Campbell Family Institute for Breast Cancer Research, Department of Medical Biophysics, University of Toronto, Toronto, ON, Canada M5G 2C1
    Proc Natl Acad Sci U S A 102:5215-20. 2005
    ..Thus, DJ-1 protects against neuronal oxidative stress, and loss of DJ-1 may lead to Parkinson's disease by conferring hypersensitivity to dopaminergic insults...
  100. ncbi Calpain-regulated p35/cdk5 plays a central role in dopaminergic neuron death through modulation of the transcription factor myocyte enhancer factor 2
    Patrice D Smith
    Ottawa Health Research Institute, Ottawa, Ontario, K1H 8M5, Canada
    J Neurosci 26:440-7. 2006
    ..Together, these data indicate that calpain-p35-p25/cdk5-mediated inactivation of MEF2 plays a critical role in dopaminergic loss in vivo...
  101. ncbi Inhibition of calpains prevents neuronal and behavioral deficits in an MPTP mouse model of Parkinson's disease
    Stephen J Crocker
    Neuroscience Research Group, Ottawa Health Research Institute, Canada
    J Neurosci 23:4081-91. 2003
    ..Taken together, our findings provide a potentially novel correlation between calpain proteolytic activity in an MPTP model of PD and the etiology of neuronal loss in PD in humans...