Research Topics
| N KlarSummaryAffiliation: Cancer Care Ontario Country: Canada Publications
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Detail Information
Publications
Current and future challenges in the design and analysis of cluster randomization trialsN Klar
Division of Preventive Oncology, Cancer Care Ontario, Toronto, Ontario, M5G 2L7, Canada
Stat Med 20:3729-40. 2001..Brief mention is also made of issues related to economic analysis and to the planning and conduct of meta-analyses for cluster randomization trials. Recommendations for reporting are also discussed...- Methods for modelling change in cluster randomization trialsNeil Klar
Division of Preventive Oncology, Cancer Care Ontario, Toronto, Ontario, Canada M5G 2L7
Stat Med 23:2341-57. 2004..The discussion is illustrated using data from a school-based smoking prevention trial... - Breast screening outcomes in women with and without a family history of breast and/or ovarian cancerE E Halapy
Division of Preventive Oncology, Cancer Care Ontario, 620 University Avenue, Toronto, ON M5G 2L7, Canada
J Med Screen 11:32-8. 2004..To compare breast screening outcomes between women with a moderate or strong family history of breast and/or ovarian cancer with those without such a history... - Accounting for expected attrition in the planning of community intervention trialsMonica Taljaard
Ottawa Health Research Institute, Clinical Epidemiology Program, The Ottawa Hospital, Ottawa, Canada
Stat Med 26:2615-28. 2007..To aid in the planning of future trials, we recommend that estimates for tau be reported in published community intervention trials... - Colorectal screening is associated with reduced colorectal cancer risk: a case-control study within the population-based Ontario Familial Colorectal Cancer RegistryMichelle Cotterchio
Division of Preventive Oncology, Cancer Care Ontario, 620 University Avenue, M5G 2L7, Ontario, Toronto, Canada
Cancer Causes Control 16:865-75. 2005..This is the first study to evaluate the association between colonic screening and colorectal cancer risk among Canadians... - Comparison of papanicolaou (Pap) test rates across Ontario and factors associated with cervical screeningGordon Fehringer
Division of Preventive Oncology, Cancer Care Ontario, Toronto, ON
Can J Public Health 96:140-4. 2005..A positive association was observed between Pap test rates and the presence of a teaching hospital. Data quality issues limit the ability to monitor cervical screening. A provincial registry would address these issues... - Accuracy of breast screening among women with and without a family history of breast and/or ovarian cancerErika Halapy
Division of Preventive Oncology, Cancer Care Ontario, 620 University Avenue, Toronto, Ontario M5G 2L7, Canada
Breast Cancer Res Treat 90:299-305. 2005..To compare interval cancer rates, sensitivity and specificity of breast cancer screening between women with moderate or strong family history and women without a family history... - Accuracy of cancer family histories: comparison of two breast cancer syndromesKatherine A Schneider
Population Sciences, Dana Farber Cancer Institute, Boston, MA 02115, USA
Genet Test 8:222-8. 2004..Our data suggest that it may not be necessary to confirm breast cancer diagnoses routinely; however, documentation of other cancer types remains important for appropriate risk assessment and follow-up... - Methods for the statistical analysis of binary data in split-cluster designsAllan Donner
Department of Epidemiology and Biostatistics, University of Western Ontario, London, Ontario N6A 5C1, Canada
Biometrics 60:919-25. 2004.... - Antidepressant medication use and non-Hodgkin's lymphoma risk: no associationSaira Bahl
Division of Preventive Oncology, Cancer Care Ontario, Toronto, Ontario, Canada
Am J Epidemiol 160:566-75. 2004..These findings do not support an increased risk of non-Hodgkin's lymphoma with antidepressant medication use... 
Pitfalls of and controversies in cluster randomization trialsAllan Donner
Department of Epidemiology and Biostatistics, University of Western Ontario, London, Canada
Am J Public Health 94:416-22. 2004..We discuss several topics related to these issues, with emphasis on the choices that must be made in the planning stages of a trial and on some potential pitfalls to be avoided...- Sample size re-estimation in cluster randomization trialsStephen Lake
Department of Biostatistics, Harvard School of Public Health, 655 Huntington Avenue, Boston, MA 02115, USA
Stat Med 21:1337-50. 2002..The effect of this design on the power, significance level and sample size is analysed via simulation and is shown to provide a flexible and practical approach to cluster randomization trials... - The merits of breaking the matches: a cautionary taleAllan Donner
Department of Epidemiology and Biostatistics, Schulich School of Medicine, University of Western Ontario, London, Canada
Stat Med 26:2036-51. 2007.... - Group sequential methods for cluster randomization trials with binary outcomesGuang Yong Zou
Department of Epidemiology and Biostatistics, Schulich School of Medicine and Dentistry, University of Western Ontario, London, Ontario, Canada
Clin Trials 2:479-87. 2005.... - A blended knowledge translation initiative to improve colorectal cancer staging [ISRCTN56824239]Frances C Wright
Sunnybrook and Women s College Health Sciences Centre, University of Toronto, Toronto, ON, M4N 3M5, Canada
BMC Health Serv Res 6:4. 2006.... - A non-iterative confidence interval estimating procedure for the intraclass kappa statistic with multinomial outcomesGuangyong Zou
Robarts Clinical Trials, Robarts Research Institute, 100 Perth Drive, London, Ontario, Canada N6A 5K8
Biom J 47:682-90. 2005..The procedure is illustrated with two examples from previously published medical studies... - Issues in the meta-analysis of cluster randomized trialsAllan Donner
Department of Epidemiology and Biostatistics, The University of Western Ontario, London, Ontario, N6A 5C1, Canada
Stat Med 21:2971-80. 2002..In this paper we review and comment on a selected number of these issues, including problems of study heterogeneity, difficulties in estimating design effects from individual trials and the choice of statistical methods... - Predictors of self-reported confidence ratings for adult recall of early life sun exposureAnne-Sharon Relova
Division of Preventive Oncology, Cancer Care Ontario, Toronto, Ontario, Canada
Am J Epidemiol 162:183-92. 2005..91; 12-18 years: odds ratio = 1.32), which suggests an absence of recall bias for reported time spent outdoors... - A population-based study of Ashkenazi Jewish women's attitudes toward genetic discrimination and BRCA1/2 testingLisa Soleymani Lehmann
Massachusetts General Hospital, General Medicine Division, currently at Brigham and Women's Hospital, Division of General Medicine and Harvard Medical School, Division of Medical Ethics, Boston, Massachusetts 02115, USA
Genet Med 4:346-52. 2002..Women who are highly educated are more concerned about genetic discrimination. There is significant variation among Jewish women's interest in breast cancer susceptibility testing... 
Imputation strategies for missing continuous outcomes in cluster randomized trialsMonica Taljaard
Ottawa Health Research Institute, Clinical Epidemiology Program, Ottawa Hospital, 1053 Carling Avenue, Ottawa, Ontario, Canada
Biom J 50:329-45. 2008..Within-cluster multiple imputation is shown to be the least powerful among the procedures considered...