M Cotterchio

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..We developed an implementation guideline to answer the question: What interventions have been shown to increase the uptake of cancer screening by individuals, specifically for breast, cervical, and colorectal cancers?..

..Our primary outcome, screening completion, was calculated as the overall median post-intervention absolute percentage point (PP) change in completed screening tests...

..To evaluate whether phytoestrogen intake is associated with reduced breast cancer risk, using a novel phytoestrogen database...

..Some heterogeneity exists in the risk factor profiles of ER+PR+ and ER-PR- premenopausal breast cancer; however, risk factor profiles did not differ markedly for postmenopausal breast cancer...

..This finding that phytoestrogen intake may reduce colorectal cancer risk is important, because dietary intake is potentially modifiable...

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..Intriguing evidence to date suggests that the aetiology of a subgroup of human breast cancers and lymphomas may have viral involvement, and this warrants further investigation...

..Our results suggest a reduction in breast cancer risk associated with any regular NSAID use. NSAID use is a modifiable factor, and any protective effect attributed to its use could be of great public health importance...

..This is the first study to evaluate the association between colonic screening and colorectal cancer risk among Canadians...

..These findings do not support an increased risk of non-Hodgkin's lymphoma with antidepressant medication use...

..03) status. These findings support the hypothesis that prolonged cigarette smoking is associated with increased risk of colorectal cancer and that this risk may be modified by variation in carcinogen metabolism genes...

..If verified, this finding has important implications with regard to breast cancer prevention since diet is a potentially modifiable factor...

..Colorectal cancer screening awareness and education programs need to consider targeting persons most likely to present with late stage colorectal cancer...

..The low prevalence of colorectal cancer screening among the target population suggests the need for an increased awareness of the public health importance of colorectal cancer screening...

..The objective of this study was to determine colorectal cancer (CRC) risk associated with mutations in the MYH gene...

..In conclusion, individuals with a first-degree kin with breast cancer may have a modest increased risk for CRC compared to individuals without...

..No confounding or effect modification was identified in multivariate modeling. Our findings do not support the hypothesis that women who use antihistamines are at a greater breast cancer risk than those who do not...

..Possible pancreatic cancer risk factors were evaluated within the population-based Ontario Pancreas Cancer Study...

..74 to 0.84). Breast cancer risk tended to decrease with increasing duration of NSAID use and was generally lowest for >or=7 years of use, and both acetylsalicylic acid and non-acetylsalicylic acid use were associated with reduced risks...

..CONCLUSION: These findings suggest that hormonal factors associated with greater exposure to estrogen and/or progesterone may be associated with decreased risk for gastric cancer...

..Hence, the intake of supplements should be taken into consideration in clinical or epidemiological studies for more accurate estimation of phytoestrogen intakes...

..To assess the validity and reliability of the most recent adaptation of Block's full-diet food-frequency questionnaire (FFQ) among a sample of Canadian women...

..Some evidence suggests that vitamin D may reduce breast cancer risk. Despite the biological interaction between vitamin D and calcium, few studies have evaluated their joint effects on breast cancer risk...

..To measure and compare dietary vitamin D intake among women in Ontario using a modified Block 1998 (US) food frequency questionnaire (FFQ) before and after modification for Canadian-specific vitamin D food fortification...

..To determine factors that influence awareness of, and readiness to undergo, fecal occult blood testing (FOBT) for colorectal cancer (CRC) screening...

..29-0.63). There was no association observed between a history of asthma and pancreas cancer risk. Findings are of great importance to understanding the biological mechanisms involved in pancreas cancer development...

..A positive association was observed between Pap test rates and the presence of a teaching hospital. Data quality issues limit the ability to monitor cervical screening. A provincial registry would address these issues...

..OR estimates did not change, but CI were widened and statistical significance lost, after adjustment for factors associated with breast cancer risk...

..The richest sources of specific phytoestrogens, including coumestrol, were identified. The database will improve phytoestrogen intake estimation in future epidemiological and clinical studies particularly in Western populations...

..There was no trend in risk with increasing follow-up. Our data support the hypothesis that reduced levels of endogenous oestrogen may be protective for breast cancer in women...

..Familial risk associated with MSI-High tumors is primarily driven by the Amsterdam-criteria patients. MSI-Low tumors may represent a distinct subtype of colorectal cancer with respect to certain epidemiologic variables studied here...

..Results confirm findings from previous studies that diazepam use does not increase the risk for breast cancer and also suggest no association with the use of other benzodiazepine compounds...

..It is useful to collect proxy information on such variables as medical history, parity, colonic screening and vitamin use, whereas oral contraceptive use and previous weight are not well reported...

..These two MYH gene mutations may account for a substantial fraction of hereditary colorectal cancer...

..Total abdominal colectomy with ileorectal anastomosis (TAC-IR) may be considered for young patients or those with a colorectal cancer family history to prevent metachronous lesions and facilitate surveillance...

..i.): 1.07-1.26; P = 5.05 x 10(-4)). A summary across all seven studies at the 8q24 locus was highly significant (OR = 1.17, c.i.: 1.12-1.23; P = 3.16 x 10(-11)). This locus has also been implicated in prostate cancer...

..This North American population-based map will be a useful resource for future genetic studies...

..The objective of the current study was to evaluate the adequacy and detection rates of SurePath after its implementation in Ontario...

..They also highlight the need to understand the phenomenon underlying the possibly increasing rates of disorders in younger birth cohorts, so that outreach strategies can be modified to accommodate differences in younger women...

..This work assessed associations between colorectal cancer risk and postmenopausal/contraceptive hormones; subgroup analyses included women with a clinically defined family history of cancer...

..Evidence to date does not support a change in the current use of antidepressant medications...

..In conclusion, strenuous recreational activity early in life may increase the risk of ovarian cancer, whereas more recent recreational activity may reduce the risk...

..Ontario women were surveyed about their use of NVNM supplements, including those for women's health, and characteristics associated with use were examined...

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..Family studies have served as a cornerstone of genetic research on colorectal cancer...

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