E C Vamvakas

Summary

Affiliation: Canadian Blood Services
Country: Canada

Publications

  1. ncbi Exposure to allogeneic plasma and risk of postoperative pneumonia and/or wound infection in coronary artery bypass graft surgery
    Eleftherios C Vamvakas
    Department of Pathology, New York University School of Medicine, New York, New York, USA
    Transfusion 42:107-13. 2002
  2. ncbi Is white blood cell reduction equivalent to antibody screening in preventing transmission of cytomegalovirus by transfusion? A review of the literature and meta-analysis
    Eleftherios C Vamvakas
    Canadian Blood Services, Ottawa, Canada
    Transfus Med Rev 19:181-99. 2005
  3. ncbi Uses and sources of data on long-term survival after blood transfusion
    Eleftherios C Vamvakas
    Department of Pathology, New York University School of Medicine, New York, NY, USA
    Transfus Med Rev 17:194-208. 2003
  4. ncbi Platelet transfusion and adverse outcomes
    Eleftherios C Vamvakas
    Canadian Blood Services, Department of Pathology and Laboratory Medicine, University of Ottawa, Ottawa, ON K1 G 4 J5, Canada
    Lancet 364:1736-8. 2004
  5. ncbi Evidence-based practice of transfusion medicine: is it possible and what do the words mean?
    Eleftherios C Vamvakas
    Division of Medical, Scientific and Research Affairs, Canadian Blood Services, Ottawa, Canada
    Transfus Med Rev 18:267-78. 2004
  6. ncbi White-blood-cell-containing allogeneic blood transfusion, postoperative infection and mortality: a meta-analysis of observational 'before-and-after' studies
    E C Vamvakas
    Canadian Blood Services and Department of Pathology and Laboratory Medicine, University of Ottawa Faculty of Medicine, Ottawa, Ontario, Canada
    Vox Sang 86:111-9. 2004
  7. ncbi White-blood-cell-containing allogeneic blood transfusion and postoperative infection or mortality: an updated meta-analysis
    E C Vamvakas
    Department of Pathology and Laboratory Medicine, University of Ottawa Faculty of Medicine, Ottawa, ON K1G 4J4, Canada
    Vox Sang 92:224-32. 2007
  8. ncbi Meta-analysis of randomized controlled trials comparing the risk of postoperative infection between recipients of allogeneic and autologous blood transfusion
    E C Vamvakas
    Department of Pathology, New York University School of Medicine, New York, NY 10016, USA
    Vox Sang 83:339-46. 2002
  9. ncbi Pneumonia as a complication of blood product transfusion in the critically ill: transfusion-related immunomodulation (TRIM)
    Eleftherios C Vamvakas
    Medical, Scientific and Research Affairs, Canadian Blood Services, University of Ottawa Faculty of Medicine, Ottawa, Ontario, Canada
    Crit Care Med 34:S151-9. 2006
  10. ncbi The development of West Nile virus safety policies by Canadian blood services: guiding principles and a comparison between Canada and the United States
    Eleftherios C Vamvakas
    Canadian Blood Services; Department of Pathology and Laboratory Medicine, University of Ottawa Faculty of Medicine, ON, Canada
    Transfus Med Rev 20:97-109. 2006

Collaborators

Detail Information

Publications42

  1. ncbi Exposure to allogeneic plasma and risk of postoperative pneumonia and/or wound infection in coronary artery bypass graft surgery
    Eleftherios C Vamvakas
    Department of Pathology, New York University School of Medicine, New York, New York, USA
    Transfusion 42:107-13. 2002
    ..A relationship may exist between the immunomodulatory effects of allogeneic blood transfusion and the volume of transfused allogeneic plasma and/or the number of transfused plasma-containing units...
  2. ncbi Is white blood cell reduction equivalent to antibody screening in preventing transmission of cytomegalovirus by transfusion? A review of the literature and meta-analysis
    Eleftherios C Vamvakas
    Canadian Blood Services, Ottawa, Canada
    Transfus Med Rev 19:181-99. 2005
    ..22-0.79; P < .05). Thus, a meta-analysis of the available controlled studies indicates that CMV-seronegative blood components are more efficacious than WBC-reduced blood components in preventing transfusion-acquired CMV infection...
  3. ncbi Uses and sources of data on long-term survival after blood transfusion
    Eleftherios C Vamvakas
    Department of Pathology, New York University School of Medicine, New York, NY, USA
    Transfus Med Rev 17:194-208. 2003
    ..A population-based study that includes several US counties has to be undertaken to generate the information needed for public policy decisions in the future...
  4. ncbi Platelet transfusion and adverse outcomes
    Eleftherios C Vamvakas
    Canadian Blood Services, Department of Pathology and Laboratory Medicine, University of Ottawa, Ottawa, ON K1 G 4 J5, Canada
    Lancet 364:1736-8. 2004
  5. ncbi Evidence-based practice of transfusion medicine: is it possible and what do the words mean?
    Eleftherios C Vamvakas
    Division of Medical, Scientific and Research Affairs, Canadian Blood Services, Ottawa, Canada
    Transfus Med Rev 18:267-78. 2004
    ....
  6. ncbi White-blood-cell-containing allogeneic blood transfusion, postoperative infection and mortality: a meta-analysis of observational 'before-and-after' studies
    E C Vamvakas
    Canadian Blood Services and Department of Pathology and Laboratory Medicine, University of Ottawa Faculty of Medicine, Ottawa, Ontario, Canada
    Vox Sang 86:111-9. 2004
    ....
  7. ncbi White-blood-cell-containing allogeneic blood transfusion and postoperative infection or mortality: an updated meta-analysis
    E C Vamvakas
    Department of Pathology and Laboratory Medicine, University of Ottawa Faculty of Medicine, Ottawa, ON K1G 4J4, Canada
    Vox Sang 92:224-32. 2007
    ..Because no further RCTs are underway, a final meta-analysis of all available RCTs was conducted...
  8. ncbi Meta-analysis of randomized controlled trials comparing the risk of postoperative infection between recipients of allogeneic and autologous blood transfusion
    E C Vamvakas
    Department of Pathology, New York University School of Medicine, New York, NY 10016, USA
    Vox Sang 83:339-46. 2002
    ....
  9. ncbi Pneumonia as a complication of blood product transfusion in the critically ill: transfusion-related immunomodulation (TRIM)
    Eleftherios C Vamvakas
    Medical, Scientific and Research Affairs, Canadian Blood Services, University of Ottawa Faculty of Medicine, Ottawa, Ontario, Canada
    Crit Care Med 34:S151-9. 2006
    ..CONCLUSIONS: No overwhelming clinical evidence has been presented to establish the existence of a TRIM effect that relates allogeneic blood transfusion to postoperative infection...
  10. ncbi The development of West Nile virus safety policies by Canadian blood services: guiding principles and a comparison between Canada and the United States
    Eleftherios C Vamvakas
    Canadian Blood Services; Department of Pathology and Laboratory Medicine, University of Ottawa Faculty of Medicine, ON, Canada
    Transfus Med Rev 20:97-109. 2006
    ..This review discusses the guiding principles affecting CBS policy development and compares CBS WNV safety policies to policies adopted in the United States...
  11. ncbi Meta-analysis of randomized controlled trials investigating the risk of postoperative infection in association with white blood cell-containing allogeneic blood transfusion: the effects of the type of transfused red blood cell product and surgical setting
    Eleftherios C Vamvakas
    Department of Pathology, New York University School of Medicine, New York, NY, USA
    Transfus Med Rev 16:304-14. 2002
    ..To determine whether such a deleterious immunomodulatory effect of ABT exists, additional RCTs transfusing non-buffy-coat-reduced RBCs to the treatment arm should be conducted...
  12. ncbi Allogeneic blood transfusion and postoperative duration of mechanical ventilation
    E C Vamvakas
    Department of Pathology, New York University School of Medicine, New York, NY 10016, USA
    Transfusion 41:885-92. 2001
    ..In patients having open heart surgery, allogeneic blood transfusion (ABT) may be related to an enhanced inflammatory response and impaired pulmonary function, resulting in the need for prolonged mechanical ventilation...
  13. ncbi Why have meta-analyses of randomized controlled trials of the association between non-white-blood-cell-reduced allogeneic blood transfusion and postoperative infection produced discordant results?
    E C Vamvakas
    Department of Pathology and Laboratory Medicine, Faculty of Medicine, University of Ottawa, Ottawa, ON, Canada
    Vox Sang 93:196-207. 2007
    ..Intention-to-treat and as-treated comparisons produced concordant results...
  14. ncbi Face-to-face interviewing in predonation screening: lack of effect on detected human immunodeficiency virus and hepatitis C virus infections
    Sheila F O'Brien
    Canadian Blood Services, Ottawa, Ontario, Canada
    Transfusion 46:1380-7. 2006
    ..The impact of face-to-face interviewing and of the format of the Donor Health Assessment Questionnaire (DHAQ) have not been evaluated...
  15. ncbi WBC-containing allogeneic blood transfusion and mortality: a meta-analysis of randomized controlled trials
    Eleftherios C Vamvakas
    Department of Pathology, New York University School of Medicine, New York, New York, USA
    Transfusion 43:963-73. 2003
    ..A meta-analysis was undertaken to examine whether this finding can be generalized across clinical settings and/or transfused RBC components...
  16. ncbi The Canadian blood donor health assessment questionnaire: lessons from history, application of cognitive science principles, and recommendations for change
    Sheila F O'Brien
    Department of Epidemiology and Community Medicine, University of Ottawa, Ottawa ON, Canada
    Transfus Med Rev 21:205-22. 2007
    ..Thus, we believe that redesigning the DHAQ will improve the quality and accuracy of the donors' answers to screening questions...
  17. ncbi Hepatitis B virus DNA-positive, hepatitis B surface antigen-negative blood donations intercepted by anti-hepatitis B core antigen testing: the Canadian Blood Services experience
    Sheila F O'Brien
    National Epidemiology and Surveillance, Canadian Blood Services, 1800 Alta Vista Drive, Ottawa, Ontario, Canada
    Transfusion 47:1809-15. 2007
    ..The benefit of introducing anti-hepatitis B core antigen (HBc) screening for intercepting potentially infectious donations missed by hepatitis B surface antigen (HBsAg) screening in Canada was studied...
  18. ncbi Current incidence and estimated residual risk of transfusion-transmitted infections in donations made to Canadian Blood Services
    Sheila F O'Brien
    Canadian Blood Services, and the Department of Epidemiology and Community Medicine, University of Ottawa, Ottawa, Ontario, Canada
    Transfusion 47:316-25. 2007
    ..Thus, available RR estimates for Canada need to be updated...
  19. ncbi Predictive ability of sequential surveys in determining donor loss from increasingly stringent variant Creutzfeldt-Jakob disease deferral policies
    Sheila F O'Brien
    Canadian Blood Services, Ottawa, Ontario, Canada
    Transfusion 46:461-8. 2006
    ..This study examines the ability of sequential surveys to predict actual travel deferrals and the operational validity of travel questions...
  20. ncbi RBC transfusion and postoperative length of stay in the hospital or the intensive care unit among patients undergoing coronary artery bypass graft surgery: the effects of confounding factors
    E C Vamvakas
    Department of Pathology, New York University School of Medicine, New York, NY 10016, USA
    Transfusion 40:832-9. 2000
    ..Data on the independent association between perioperative allogeneic blood transfusion (ABT) and postoperative length of stay at the hospital or in the intensive care unit (ICU) are sparse...
  21. ncbi The relative safety of pooled whole-blood-derived platelets prepared by the buffy-coat method versus single-donor (apheresis) platelets
    Eleftherios C Vamvakas
    Department of Pathology and Laboratory Medicine, Cedars Sinai Medical Center, Los Angeles, CA 90048, USA
    Clin Lab 56:263-79. 2010
    ..The latter cannot protect from vCJD and potentially also from some other emerging TTIs; moreover, they have recently been associated with an increased risk of bleeding...
  22. ncbi Relative safety of pooled whole blood-derived versus single-donor (apheresis) platelets in the United States: a systematic review of disparate risks
    Eleftherios C Vamvakas
    Department of Pathology and Laboratory Medicine, Cedars Sinai Medical Center, Los Angeles, California 90048, USA
    Transfusion 49:2743-58. 2009
    ....
  23. ncbi Scientific background on the risk engendered by reducing the lifetime blood donation deferral period for men who have sex with men
    Eleftherios C Vamvakas
    Department of Pathology and Laboratory Medicine, Cedars Sinai Medical Center, Los Angeles, CA 90048, USA
    Transfus Med Rev 23:85-102. 2009
    ....
  24. ncbi Blood still kills: six strategies to further reduce allogeneic blood transfusion-related mortality
    Eleftherios C Vamvakas
    Department of Pathology and Laboratory Medicine, Cedars Sinai Medical Center, Los Angeles, CA, USA
    Transfus Med Rev 24:77-124. 2010
    ....
  25. ncbi Four-year survival of transfusion recipients identified by hepatitis C lookback
    Eleftherios C Vamvakas
    Bloodbank and Transfusion Service, New York University Medical Center, New York, NY 10016, USA
    Transfusion 42:691-7. 2002
    ..These figures were 20 percent lower than the figures reported previously from Olmsted County, Minnesota...
  26. ncbi Possible mechanisms of allogeneic blood transfusion-associated postoperative infection
    Eleftherios C Vamvakas
    Blood Bank and Transfusion Service, RRG-17, New York University Medical Center, 400 East 34th Street, New York, NY 10016, USA
    Transfus Med Rev 16:144-60. 2002
    ....
  27. ncbi Meta-analysis of the studies of bleeding complications of platelets pathogen-reduced with the Intercept system
    E C Vamvakas
    Department of Pathology and Laboratory Medicine, Cedars Sinai Medical Center, Los Angeles, CA 90048, USA
    Vox Sang 102:302-16. 2012
    ....
  28. ncbi Risk of transmission of Creutzfeldt-Jakob disease by transfusion of blood, plasma, and plasma derivatives
    E C Vamvakas
    Department of Pathology, New York Department of Veterans Affairs Medical Center and New York University School of Medicine, New York, New York 10016, USA
    J Clin Apher 14:135-43. 1999
    ....
  29. ncbi Transfusion-related mortality: the ongoing risks of allogeneic blood transfusion and the available strategies for their prevention
    Eleftherios C Vamvakas
    Department of Pathology and Laboratory Medicine, Cedars Sinai Medical Center, Los Angeles, CA, USA
    Blood 113:3406-17. 2009
    ....
  30. ncbi Proceedings of a consensus conference: the screening of blood donors for variant CJD
    Morris A Blajchman
    Canadian Blood Services, Hamilton, Ontario, Canada
    Transfus Med Rev 18:73-92. 2004
    ..This contentious issue is of potential considerable importance to transfusion medicine personnel worldwide, as well as to future recipients of allogeneic blood components...
  31. ncbi Allogeneic blood transfusion and postoperative duration of mechanical ventilation: effects of red cell supernatant, platelet supernatant, plasma components and total transfused fluid
    E C Vamvakas
    Department of Pathology, New York University School of Medicine, New York, New York, USA
    Vox Sang 82:141-9. 2002
    ..Transfused red blood cell (RBC) supernatant, platelet supernatant or plasma components, may exercise varying effects on pulmonary function, because these fluids differ in their content of soluble biological-response modifiers...
  32. ncbi Rationale for randomized controlled trials and for intention-to-treat analysis in transfusion medicine: are they one and the same?
    E C Vamvakas
    Department of Pathology and Laboratory Medicine, Cedars Sinai Medical Center, Los Angeles, CA, USA
    Vox Sang 95:165-73. 2008
    ..Nonetheless, the rationale for ITT can be reversed in equivalence and non-inferiority trials where the finding of no difference is the objective of the research; thus, both ITT and AT analyses should be presented in these settings...
  33. ncbi The prognostic significance of specific arterial lesions in acute renal allograft rejection
    V Nickeleit
    Department of Pathology, Massachusetts General Hospital, Boston 02114, USA
    J Am Soc Nephrol 9:1301-8. 1998
    ..Grading systems for therapeutic trials and clinical management should emphasize scoring of specific vascular lesions...
  34. ncbi Is human herpesvirus-8 transmitted by transfusion?
    Eleftherios C Vamvakas
    Department of Pathology and Laboratory Medicine, Cedars Sinai Medical Center, Los Angeles, CA 90048, USA
    Transfus Med Rev 24:1-14. 2010
    ....
  35. ncbi Meta-analysis of clinical studies of the purported deleterious effects of "old" (versus "fresh") red blood cells: are we at equipoise?
    Eleftherios C Vamvakas
    Department of Pathology and Laboratory Medicine, Cedars Sinai Medical Center, Los Angeles, California 90048, USA
    Transfusion 50:600-10. 2010
    ..Such suspicion is required for intentionally exposing patients enrolled in randomized controlled trials (RCTs) to the known or probable--but rare--risks of old RBCs, to document (and prevent) purported common adverse effects of old RBCs...
  36. ncbi Assessment of the quality of clinical research
    Eleftherios C Vamvakas
    Department of Pathology, New York University School of Medicine, New York, New York, USA
    Vox Sang 83:397-401. 2002
  37. ncbi Transfusion-related immunomodulation (TRIM): an update
    Eleftherios C Vamvakas
    Department of Pathology and Laboratory Medicine, University of Ottawa, Faculty of Medicine, Canada
    Blood Rev 21:327-48. 2007
    ....
  38. ncbi Ten-year survival of transfusion recipients identified by hepatitis C lookback
    Eleftherios C Vamvakas
    Transfusion 43:418-9. 2003
  39. ncbi The continuing risk of transfusion-transmitted infections
    Morris A Blajchman
    McMaster University, Hamilton, ON, Canada
    N Engl J Med 355:1303-5. 2006
  40. ncbi Deleterious clinical effects of transfusion immunomodulation: proven beyond a reasonable doubt
    Eleftherios C Vamvakas
    Transfusion 46:492-4; author reply 494-5. 2006
  41. ncbi Platelet transfusion and postoperative infection in cardiac surgery
    Eleftherios C Vamvakas
    Transfusion 47:352-4; author reply 354-6. 2007
  42. ncbi Specialized therapeutic hemapheresis: present and future
    Alvaro A Pineda
    Division of Transfusion Medicine, Mayo Clinic, Rochester, Minnesota, USA
    Vox Sang 83:41-4. 2002