David J Johnson
Affiliation: Canadian Food Inspection Agency
- Probabilistic hazard assessment of environmentally occurring pharmaceuticals toxicity to fish, daphnids and algae by ECOSAR screeningHans Sanderson
Center for Toxicology, University of Guelph, Bovey Building, Gordon Street, Guelph, Ont, Canada N1G 2W1
Toxicol Lett 144:383-95. 2003..are still uncertain. (Q)SAR's can be important prioritization tools for subsequent experimental risk assessment of pharmaceuticals in surface waters, due to the prevalent lack of ecotoxicological data...
- Toxicity and hazard of selective serotonin reuptake inhibitor antidepressants fluoxetine, fluvoxamine, and sertraline to algaeDavid J Johnson
Centre for Toxicology, Bovey Administrative Building, University of Guelph, Guelph, Ontario, Canada N1G 2W1
Ecotoxicol Environ Saf 67:128-39. 2007....
- Exposure assessment and microcosm fate of selected selective serotonin reuptake inhibitorsDavid J Johnson
Centre for Toxicology, Department of Environmental Biology, University of Guelph, Ont, Canada
Regul Toxicol Pharmacol 42:313-23. 2005..Partitioning into other environmental compartments such as this may act as a reservoir from which SSRIs may be re-released into surface waters and indicates the potential susceptibility of benthos...
- Effects of a mixture of tetracyclines to Lemna gibba and Myriophyllum sibiricum evaluated in aquatic microcosmsRichard A Brain
Centre for Toxicology, Department of Environmental Biology, University of Guelph, Guelph, Ontario, Canada N1G 2W1
Environ Pollut 138:425-42. 2005..gibba) and submerged (M. sibiricum) species of macrophytes. A hazard quotient assessment of the lowest EC10 value indicated significant risk, exceeding the critical HQ value, but not the lowest EC25 value...
- Ranking and prioritization of environmental risks of pharmaceuticals in surface watersHans Sanderson
Centre for Toxicology, University of Guelph, Bovey Building, Guelph, Ont, Canada N1G 2W1
Regul Toxicol Pharmacol 39:158-83. 2004..Data available: http://www.uoguelph.ca/~hsander/...
- Structural and functional responses of plankton to a mixture of four tetracyclines in aquatic microcosmsChristian J Wilson
Centre for Toxicology and Department of Environmental Biology, University of Guelph, Guelph, Ontario, N1G 2W1 Canada
Environ Sci Technol 38:6430-9. 2004..The effects observed occurred at considerably greater concentrations than are currently measured in the environment, indicating minimal risk to aquatic organisms...
- Toxicity and hazard of a mixture of SSRIs to zooplankton communities evaluated in aquatic microcosmsBrian D Laird
Centre for Toxicology, Canadian Network of Toxicology Centres CNTC, University of Guelph, Guelph, ON, Canada N1G 2W1
Chemosphere 69:949-54. 2007..51 nM) yielded HQs at least two orders of magnitude below 1. Therefore, mixtures of SSRIs do not appear to present a hazard to zooplankton communities at environmentally relevant concentrations...
- Aquatic microcosm assessment of the effects of tylosin on Lemna gibba and Myriophyllum spicatumRichard A Brain
Centre for Toxicology, Department of Environmental Biology, University of Guelph, Guelph, ON, Canada N1G 2W1
Environ Pollut 133:389-401. 2005..spicatum or L. gibba. A hazard quotient assessment indicated that tylosin poses little risk to either species of macrophyte, with an HQ value calculated to be nearly three orders of magnitude below 1 (0.002)...
- Microcosm evaluation of the effects of an eight pharmaceutical mixture to the aquatic macrophytes Lemna gibba and Myriophyllum sibiricumRichard A Brain
Department of Environmental Biology, Centre for Toxicology, University of Guelph, Guelph, Ont, N1G 2W1, Canada
Aquat Toxicol 70:23-40. 2004..sibiricum exposed to similar mixtures of pharmaceutical compounds. For M. sibiricum and L. gibba, respective minimum differences of 5 and 1%, were detectable, however, these effect sizes are not considered ecologically significant...
- Toxicity classification and evaluation of four pharmaceuticals classes: antibiotics, antineoplastics, cardiovascular, and sex hormonesHans Sanderson
University of Guelph, Centre for Toxicology, Bovey Building, Ontario, Canada N1G 2W1
Toxicology 203:27-40. 2004..Data for the individual compounds are accessible via...
- Dissipation of oxytetracycline, chlortetracycline, tetracycline and doxycycline using HPLC-UV and LC/MS/MS under aquatic semi-field microcosm conditionsHans Sanderson
University of Guelph, Centre for Toxicology, Bovey Building, Guelph, Ont, N1G 2W1, Canada
Chemosphere 60:619-29. 2005..DT50 for products were less than 1.2 days. Formation of 4-epi-anh-tetracyclines, occurred at neutral to weak alkaline conditions...
- Effects of 25 pharmaceutical compounds to Lemna gibba using a seven-day static-renewal testRichard A Brain
Centre for Toxicology, Department of Environmental Biology, Bovey Administrative Building, University of Guelph, Guelph, Ontario N1G 2W1, Canada
Environ Toxicol Chem 23:371-82. 2004..Wet mass was consistently the most sensitive endpoint above 100 microg/L; conversely, frond number was the most sensitive below 100 microg/L. Pigment endpoints were significantly less sensitive than growth endpoints...
- Effects of pharmaceutical mixtures in aquatic microcosmsSean M Richards
Department of Biological and Environmental Sciences, University of Tennessee at Chattanooga, Chattanooga, Tennessee 37403, USA
Environ Toxicol Chem 23:1035-42. 2004..Although the present data do not suggest that ibuprofen, fluoxetine, and ciprofloxacin are individually causing adverse effects in surface-water environments, questions remain about additive responses from mixtures...
- Aquatic persistence of eight pharmaceuticals in a microcosm studyMonica W Lam
Department of Chemistry, University of Toronto, 80 St George Street, Toronto, Ontario M5S 3H6, Canada
Environ Toxicol Chem 23:1431-40. 2004..Observed photoproducts of several of the pharmaceuticals remained photoreactive, which led to further degradation in irradiated surface waters...