Roger F Butterworth

Summary

Country: Canada

Publications

  1. ncbi Glutamate transporter and receptor function in disorders of ammonia metabolism
    R F Butterworth
    Neuroscience Research Unit, Hôpital Saint Luc C H U M, Montreal, Quebec, Canada
    Ment Retard Dev Disabil Res Rev 7:276-9. 2001
  2. pmc Role of nutrition in the management of hepatic encephalopathy in end-stage liver failure
    Chantal Bemeur
    Neuroscience Research Unit, CHUM, Saint Luc Hospital, University of Montreal, 1058 St Denis street, Montreal, QC, Canada
    J Nutr Metab 2010:489823. 2010
  3. pmc Inflammatory cascades driven by tumor necrosis factor-alpha play a major role in the progression of acute liver failure and its neurological complications
    Anne Chastre
    Neuroscience Research Unit, Hopital Saint Luc, CRCHUM, Montreal, Canada
    PLoS ONE 7:e49670. 2012
  4. doi Parkinsonism in cirrhosis: pathogenesis and current therapeutic options
    Roger F Butterworth
    Unité de Recherche en Neurosciences, Hôpital Saint Luc CHUM, Universite de Montreal, Montreal, Canada
    Metab Brain Dis 28:261-7. 2013
  5. ncbi Reprint of: Neuroinflammation in acute liver failure: mechanisms and novel therapeutic targets
    Roger F Butterworth
    Neuroscience Research Unit, Saint Luc Hospital, CHUM, University of Montreal, Montreal, Quebec, Canada
    Neurochem Int 60:715-22. 2012
  6. ncbi Role of circulating neurotoxins in the pathogenesis of hepatic encephalopathy: potential for improvement following their removal by liver assist devices
    Roger F Butterworth
    Neuroscience Research Unit, CHUM Hôpital Saint Luc, University of Montreal, Montreal, Quebec, Canada H2X 3J4
    Liver Int 23:5-9. 2003
  7. ncbi Pathophysiology of hepatic encephalopathy: a new look at ammonia
    Roger F Butterworth
    Neuroscience Research Unit, CHUM Hôpital Saint Luc, University of Montreal, 1058 St Denis street, Montreal, Quebec H2X 314, Canada
    Metab Brain Dis 17:221-7. 2002
  8. ncbi Molecular neurobiology of acute liver failure
    Roger F Butterworth
    Neuroscience Research Unit, Hôpital Saint Luc CHUM, Montreal, Quebec Canada
    Semin Liver Dis 23:251-8. 2003
  9. ncbi Neuronal cell death in hepatic encephalopathy
    Roger F Butterworth
    Neuroscience Research Unit, Hôpital Saint Luc CHUM, 1058 Saint Denis, Montreal, Quebec, Canada
    Metab Brain Dis 22:309-20. 2007
  10. doi Thiamine deficiency-related brain dysfunction in chronic liver failure
    Roger F Butterworth
    Neuroscience Research Unit, Saint Luc Hospital CHUM, University of Montreal, 1058, Saint Denis Street, Montreal, QC H2X 3J4, Canada
    Metab Brain Dis 24:189-96. 2009

Collaborators

Detail Information

Publications50

  1. ncbi Glutamate transporter and receptor function in disorders of ammonia metabolism
    R F Butterworth
    Neuroscience Research Unit, Hôpital Saint Luc C H U M, Montreal, Quebec, Canada
    Ment Retard Dev Disabil Res Rev 7:276-9. 2001
    ....
  2. pmc Role of nutrition in the management of hepatic encephalopathy in end-stage liver failure
    Chantal Bemeur
    Neuroscience Research Unit, CHUM, Saint Luc Hospital, University of Montreal, 1058 St Denis street, Montreal, QC, Canada
    J Nutr Metab 2010:489823. 2010
    ....
  3. pmc Inflammatory cascades driven by tumor necrosis factor-alpha play a major role in the progression of acute liver failure and its neurological complications
    Anne Chastre
    Neuroscience Research Unit, Hopital Saint Luc, CRCHUM, Montreal, Canada
    PLoS ONE 7:e49670. 2012
    ..The present study aimed to investigate the therapeutic value of etanercept, a TNF-α neutralizing molecule, on the progression of liver injury and HE in mice with ALF resulting from azoxymethane (AOM) hepatotoxicity...
  4. doi Parkinsonism in cirrhosis: pathogenesis and current therapeutic options
    Roger F Butterworth
    Unité de Recherche en Neurosciences, Hôpital Saint Luc CHUM, Universite de Montreal, Montreal, Canada
    Metab Brain Dis 28:261-7. 2013
    ..However, reports of post-transplant residual extrapyramidal symptoms suggest an element of irreversibility in some cases...
  5. ncbi Reprint of: Neuroinflammation in acute liver failure: mechanisms and novel therapeutic targets
    Roger F Butterworth
    Neuroscience Research Unit, Saint Luc Hospital, CHUM, University of Montreal, Montreal, Quebec, Canada
    Neurochem Int 60:715-22. 2012
    ..Translation of these findings to the clinic has the potential to provide rational targeted approaches to the prevention and treatment of these complications in the near future...
  6. ncbi Role of circulating neurotoxins in the pathogenesis of hepatic encephalopathy: potential for improvement following their removal by liver assist devices
    Roger F Butterworth
    Neuroscience Research Unit, CHUM Hôpital Saint Luc, University of Montreal, Montreal, Quebec, Canada H2X 3J4
    Liver Int 23:5-9. 2003
    ..In this regard, the Molecular Adsorbents Recirculating System (MARS) appears to offer distinct advantages over hepatocyte-based systems...
  7. ncbi Pathophysiology of hepatic encephalopathy: a new look at ammonia
    Roger F Butterworth
    Neuroscience Research Unit, CHUM Hôpital Saint Luc, University of Montreal, 1058 St Denis street, Montreal, Quebec H2X 314, Canada
    Metab Brain Dis 17:221-7. 2002
    ....
  8. ncbi Molecular neurobiology of acute liver failure
    Roger F Butterworth
    Neuroscience Research Unit, Hôpital Saint Luc CHUM, Montreal, Quebec Canada
    Semin Liver Dis 23:251-8. 2003
    ..Further elucidation of the molecular mechanisms responsible for brain edema and encephalopathy in acute liver failure will undoubtedly lead to novel treatment strategies for these complications...
  9. ncbi Neuronal cell death in hepatic encephalopathy
    Roger F Butterworth
    Neuroscience Research Unit, Hôpital Saint Luc CHUM, 1058 Saint Denis, Montreal, Quebec, Canada
    Metab Brain Dis 22:309-20. 2007
    ..These findings suggest that some of the purported "sequelae" of liver transplantation (gait ataxia, memory loss, confusion) could reflect preexisting neuropathology...
  10. doi Thiamine deficiency-related brain dysfunction in chronic liver failure
    Roger F Butterworth
    Neuroscience Research Unit, Saint Luc Hospital CHUM, University of Montreal, 1058, Saint Denis Street, Montreal, QC H2X 3J4, Canada
    Metab Brain Dis 24:189-96. 2009
    ..These findings underscore the need for prompt, effective thiamine supplementation in all patients with chronic liver failure...
  11. doi Experimental models of hepatic encephalopathy: ISHEN guidelines
    Roger F Butterworth
    Neuroscience Research Unit, St Luc Hospital CHUM, University of Montreal, Montreal, QC, Canada
    Liver Int 29:783-8. 2009
    ..More attention could be paid in the future to in vitro models involving the neurovascular unit, microglia and neuronal co-cultures in relation to HE pathogenesis...
  12. doi Neuroinflammation in acute liver failure: mechanisms and novel therapeutic targets
    Roger F Butterworth
    Neuroscience Research Unit, Saint Luc Hospital CHUM, University of Montreal, Montreal, Quebec, Canada
    Neurochem Int 59:830-6. 2011
    ..Translation of these findings to the clinic has the potential to provide rational targeted approaches to the prevention and treatment of these complications in the near future...
  13. doi Metal toxicity, liver disease and neurodegeneration
    Roger F Butterworth
    Neuroscience Research Unit, St Luc Hospital CHUM, University of Montreal, 1058, Saint Denis, Montreal, QC, H2X 3J4, Canada
    Neurotox Res 18:100-5. 2010
    ..Management and treatment of hepatocerebral disorders include chelation therapy (Wilson's Disease), the use of ammonia-lowering agents (lactulose, antibiotics, ornithine aspartate) and liver transplantation...
  14. doi Altered glial-neuronal crosstalk: cornerstone in the pathogenesis of hepatic encephalopathy
    Roger F Butterworth
    Neuroscience Research Unit, St Luc Hospital CHUM, University of Montreal, Montreal, QC, Canada
    Neurochem Int 57:383-8. 2010
    ....
  15. doi Hepatic encephalopathy: a central neuroinflammatory disorder?
    Roger F Butterworth
    Neuroscience Research Unit, Hopital Saint Luc, Centre Hospitalier de l Universite de Montreal, Montreal, Quebec, Canada
    Hepatology 53:1372-6. 2011
    ..The prevention of central proinflammatory processes will undoubtedly herald a new chapter in the development of agents for the prevention and treatment of the central nervous system complications of liver failure...
  16. ncbi Increased densities of binding sites for the peripheral-type benzodiazepine receptor ligand [3H]PK 11195 in congenital ornithine transcarbamylase-deficient sparse fur mouse
    V L Rao
    Neuroscience Research Unit, Hôpital St Luc University of Montreal, Quebec, Canada
    Pediatr Res 34:777-80. 1993
    ..The positron emission tomography ligand 11C-PK 11195 could find an application in the assessment of end organ dysfunction in this disorder...
  17. ncbi Mild hypothermia prevents cerebral edema and CSF lactate accumulation in acute liver failure
    N Chatauret
    Neuroscience Research Unit, Hopital Saint-Luc du CHUM, University of Montreal, Quebec, Canada
    Metab Brain Dis 16:95-102. 2001
    ..Mild hypothermia could be beneficial in the prevention of severe encephalopathy and brain edema in patients with ALF awaiting liver transplantation...
  18. ncbi Alterations in expression of genes coding for key astrocytic proteins in acute liver failure
    P Desjardins
    Neuroscience Research Unit, , 1058 St-Denis Street, Montreal, Quebec H2X 3J4, Canada
    J Neurosci Res 66:967-71. 2001
    ..Therapeutic measures currently used to prevent and treat brain edema and encephalopathy in patients with acute liver failure include mild hypothermia and the ammonia-lowering agent L-ornithine-L-aspartate...
  19. ncbi Neurotransmitter dysfunction in hepatic encephalopathy: new approaches and new findings
    R F Butterworth
    Neuroscience Research Unit, Centre Hospitalier de l Universite de Montreal, Hopital Saint Luc, Quebec, Canada
    Metab Brain Dis 16:55-65. 2001
    ..In the case of GLT-1, PTBR, and nNOS, alterations in expression result from exposure to ammonia and/or manganese, two neurotoxic agents shown previously to be increased in brain in liver failure...
  20. ncbi Brain edema in acute liver failure
    R F Butterworth
    Neuroscience Research Unit, Hopital Saint Luc du CHUM, University of Montreal, Montreal, Quebec, Canada
    Indian J Gastroenterol 22:S59-61. 2003
    ..Studies in experimental animals suggest that mild hypothermia or the use of L-ornithine-L-aspartate may be useful in the prevention of brain edema in these patients...
  21. ncbi Evidence for forebrain cholinergic neuronal loss in congenital ornithine transcarbamylase deficiency
    R F Butterworth
    Neuroscience Research Unit, CHUM Hôpital Saint Luc, Montreal, Quebec, Canada
    Metab Brain Dis 15:83-91. 2000
    ..Loss of forebrain cholinergic neurons is consistent with the severe cognitive impairment characteristic of congenital OTC deficiency...
  22. ncbi Hepatic encephalopathy: a neuropsychiatric disorder involving multiple neurotransmitter systems
    R F Butterworth
    Neuroscience Research Unit, CHUM H pital Saint Luc, Montreal, Quebec, Canada
    Curr Opin Neurol 13:721-7. 2000
    ..Further elucidation of these neurotransmitter changes could provide novel pharmacological approaches in the treatment of hepatic encephalopathy...
  23. ncbi Effect of sodium benzoate on cerebral and hepatic energy metabolites in spf mice with congenital hyperammonemia
    L Ratnakumari
    Research Centre, Hopital Sainte Justine, Montreal, Quebec, Canada
    Biochem Pharmacol 45:137-46. 1993
    ..Hence, the spf/Y mouse may be the ideal animal model for studying the pharmacology of sodium benzoate in hyperammonemic disorders at both the cerebral and hepatic levels...
  24. ncbi Alterations of neurotransmitter-related gene expression in human and experimental portal-systemic encephalopathy
    R F Butterworth
    Neuroscience Research Unit, Centre Hospitalier de l Universite de Montreal, Quebec, Canada
    Metab Brain Dis 13:337-49. 1998
    ..Further elucidation of the consequences of neurotransmitter-related gene expression could identify new pathophysiologic mechanisms and result in new approaches to the prevention of PSE in chronic liver disease in humans...
  25. ncbi Portacaval anastomosis causes selective alterations of peripheral-type benzodiazepine receptor expression in rat brain and peripheral tissues
    P Desjardins
    Neuroscience Research Unit, CHUM Campus Saint Luc, Montreal, Quebec, Canada
    Neurochem Int 35:293-9. 1999
    ..In brain, activation of PTBR could result in an increase in the production of neurosteroids with potent inhibitory action in the CNS, which could contribute to the pathogenesis of portal-systemic encephalopathy...
  26. ncbi Complications of cirrhosis III. Hepatic encephalopathy
    R F Butterworth
    Neuroscience Research Unit, CHUM Hôpital Saint Luc, University of Montreal, Quebec, Canada
    J Hepatol 32:171-80. 2000
    ..A more widespread use of central nervous system-acting drugs awaits a more complete understanding of the precise neurotransmitter systems involved in the pathogenesis of HE in chronic liver failure...
  27. ncbi The astrocytic ("peripheral-type") benzodiazepine receptor: role in the pathogenesis of portal-systemic encephalopathy
    R F Butterworth
    University of Montreal, Neuroscience Research Unit, Hospital St Luc, Quebec, Canada
    Neurochem Int 36:411-6. 2000
    ..Accumulation of such substances in the brain in chronic liver failure could explain the neural inhibition characteristics of PSE...
  28. ncbi Mechanisms of neuronal cell death in Wernicke's encephalopathy
    A S Hazell
    Neuroscience Research Unit, Centre Hospitalier de l Université de Montréal Campus Saint Luc, Quebec, Canada
    Metab Brain Dis 13:97-122. 1998
    ..Additional studies are still required to identify the site of the initial cellular insult and to explain the predilection of diencephalic and brainstem structures due to thiamine deficiency...
  29. ncbi Effects of congenital hyperammonemia on the cerebral and hepatic levels of the intermediates of energy metabolism in spf mice
    L Ratnakumari
    Service of Medical Genetics, Hopital Sainte Justine, Montreal, Quebec, Canada
    Biochem Biophys Res Commun 184:746-51. 1992
    ..The spf mouse may, therefore, be an ideal model for the study of the neurotoxic effects of ammonia in chronic hyperammonemic syndromes...
  30. ncbi Selective down-regulation of the astrocyte glutamate transporters GLT-1 and GLAST within the medial thalamus in experimental Wernicke's encephalopathy
    A S Hazell
    Neuroscience Research Unit, Hopital Saint Luc, CHUM, University of Montreal, Montreal, Quebec, Canada
    J Neurochem 78:560-8. 2001
    ....
  31. ncbi Mild hypothermia prevents cerebral edema in acute liver failure
    R F Butterworth
    Neuroscience Research Unit, CHUM H pital Saint-Luc, Montreal, , Canada
    J Hepatobiliary Pancreat Surg 8:16-9. 2001
    ..Mild hypothermia offers a potentially useful bridge therapy in patients with acute liver failure who are awaiting liver transplantation...
  32. ncbi Role of manganese in the pathogenesis of portal-systemic encephalopathy
    G P Layrargues
    Liver Unit, Clinical Research Center, CHUM, Montreal, Quebec, Canada
    Metab Brain Dis 13:311-7. 1998
    ..Future studies should be aimed at evaluating the effects of manganese chelation and/or of treatment of the dopaminergic deficit on neurological symptomatology in these patients...
  33. ncbi Brain GABA and benzodiazepine receptors in hepatic encephalopathy
    R F Butterworth
    Laboratory of Neurochemistry, , , Montreal, Quebec, Canada H2X 3J4
    Rev Invest Clin 42:137-40. 1990
    ..Results of several studies using agonists and antagonists of both types of benzodiazepine receptors are discussed in this review...
  34. ncbi Pathophysiology of hepatic encephalopathy: studies in autopsied brain tissue from hepatic coma patients
    R F Butterworth
    Laboratory of Neurochemistry, , , Montreal, Quebec, Canada H2X 3J4
    Rev Invest Clin 42:131-6. 1990
    ....
  35. ncbi Evidence for cholinergic neuronal loss in brain in congenital ornithine transcarbamylase deficiency
    L Ratnakumari
    Department of Medical Genetics, Hopital Ste Justine, Montreal, Que, Canada
    Neurosci Lett 178:63-5. 1994
    ..Possible pathogenetic mechanisms responsible for the cholinergic neuronal loss in congenital OTC deficiency include neurotoxic effects of ammonia and accumulation of quinolinic acid...
  36. ncbi Evidence for a serotonin transporter deficit in experimental acute liver failure
    A Michalak
    Neuroscience Research Unit, , University of Montreal, 1058 St. Denis Street, Montreal, Que, Canada H2X 3J4
    Neurochem Int 38:163-68. 2001
    ..Pharmacological manipulation of the brain serotonin system could afford a novel therapeutic approach to the prevention of the neuropsychiatric symptoms characteristic of acute liver failure in humans...
  37. doi Indomethacin improves locomotor deficit and reduces brain concentrations of neuroinhibitory steroids in rats following portacaval anastomosis
    S Ahboucha
    Neuroscience Research Unit, Universite de Montreal, CHUM Hôpital Saint Luc, Montreal, QC, Canada
    Neurogastroenterol Motil 20:949-57. 2008
    ..Pharmacological approaches using agents that either reduce neurosteroid synthesis or modulate the neurosteroid site on GABA-A receptor could offer new therapeutic tools for the management and treatment of HE...
  38. ncbi Mechanisms of selective neuronal cell death due to thiamine deficiency
    K Todd
    Neuroscience Research Unit, Centre Hospitalier de l Universite de Montreal, Quebec, Canada
    Ann N Y Acad Sci 893:404-11. 1999
    ..Recent evidence of early microglial activation and increased free radical production suggest that oxidative stress processes play an important early role in the brain damage associated with thiamine deficiency...
  39. ncbi Assessment of bioaccumulation and neurotoxicity in rats with portacaval anastomosis and exposed to manganese phosphate: a pilot study
    F Salehi
    Human Toxicology Research Group and Department of Environmental and Occupational Medicine, University of Montreal, Quebec, Canada
    Inhal Toxicol 13:1151-63. 2001
    ..05) for the EXP group. Assessment of the locomotor activities did not reveal any significant difference. This study constitutes a first step toward our understanding of the potential adverse effects of Mn in sensitive populations...
  40. ncbi Thiamine deficiency results in metabolic acidosis and energy failure in cerebellar granule cells: an in vitro model for the study of cell death mechanisms in Wernicke's encephalopathy
    P Pannunzio
    Neuroscience Research Unit, Hopital Saint Luc, Universite de Montreal, Montreal, Quebec, Canada
    J Neurosci Res 62:286-92. 2000
    ....
  41. ncbi Regional amino acid neurotransmitter changes in brains of spf/Y mice with congenital ornithine transcarbamylase deficiency
    L Ratnakumari
    Service of Medical Genetics, Hopital Ste Justine, Montreal, Quebec, Canada
    Metab Brain Dis 9:43-51. 1994
    ..Increased brain content of the excitatory amino acid aspartate could be responsible for the seizures frequently encountered in congenital OTC deficiency...
  42. ncbi Brain histamine in experimental acute liver failure: effects of L-histidine loading
    V Lozeva-Thomas
    Neuroscience Research Unit, Centre Hospitalier de l Universite de Montreal, Campus St Luc, H2X 3J4 Montreal, Quebec, Canada
    Inflamm Res 53:S55-6. 2004
  43. ncbi Increased neuronal cell survival after L-deprenyl treatment in experimental thiamine deficiency
    K G Todd
    Neuroscience Research Unit, Andre Viallet Clinical Research Centre, Hôpital St Luc University of Montreal, Quebec, Canada
    J Neurosci Res 52:240-6. 1998
    ..The neuroprotective effects of l-deprenyl in thiamine deficiency induced brain damage most likely result from its properties other than its effects as an MAO-B inhibitor...
  44. ncbi Thiamine deficiency and Wernicke's encephalopathy in AIDS
    R F Butterworth
    Laboratory of Neurochemistry, , , University of Montreal, Quebec, Canada
    Metab Brain Dis 6:207-12. 1991
    ....
  45. ncbi Regional alterations of thiamine phosphate esters and of thiamine diphosphate-dependent enzymes in relation to function in experimental Wernicke's encephalopathy
    M Heroux
    Neuroscience Research Unit, Hôpital Saint Luc University of Montreal, Quebec, Canada
    Neurochem Res 20:87-93. 1995
    ....
  46. ncbi Developmental deficiency of the cholinergic system in congenitally hyperammonemic spf mice: effect of acetyl-L-carnitine
    L Ratnakumari
    Division of Medical Genetics, Sainte Justine Hospital, Montreal, Quebec, Canada
    J Pharmacol Exp Ther 274:437-43. 1995
    ..These data are suggestive of a neurotrophic property of ALCAR during cholinergic deficiency caused by congenital hyperammonemia...
  47. ncbi Reversible alterations of cerebral gamma-aminobutyric acid in pyrithiamine-treated rats: implications for the pathogenesis of Wernicke's encephalopathy
    M Heroux
    Laboratory of Neurochemistry, Andre Viallet Clinical Research Centre, Hopital Saint Luc, University of Montreal, Quebec, Canada
    J Neurochem 51:1221-6. 1988
    ..Similar mechanisms may play a role in the pathogenesis of the reversible symptoms of Wernicke's encephalopathy in man...
  48. ncbi Central muscarinic cholinergic M1 and M2 receptor changes in congenital ornithine transcarbamylase deficiency
    L Ratnakumari
    Department of Medical Genetics, Hopital Sainte Justine, Montreal, Quebec, Canada
    Pediatr Res 40:25-8. 1996
    ..These findings support the presence of a central muscarinic cholinergic lesion in congenital OTC deficiency...
  49. ncbi Activities of monoamine oxidase-A and -B are altered in the brains of congenitally hyperammonemic sparse-fur (spf) mice
    V L Rao
    Neuroscience Research Unit, André Viallet Clinical Research Center University of Montreal, Hopital Saint Luc, Que, Canada
    Neurosci Lett 170:27-30. 1994
    ..Altered monoaminergic function could be a key factor in the pathogenesis of neurological dysfunction in congenital hyperammonemias...
  50. doi Neuroactive steroids and fatigue severity in patients with primary biliary cirrhosis and hepatitis C
    S Ahboucha
    Neuroscience Research Unit, Universite de Montreal, Montreal, QC, Canada
    Neurogastroenterol Motil 20:671-9. 2008
    ..The present preliminary findings suggest that increased inhibition through GABA-A receptors due to the accumulation of neuroinhibitory steroids may represent an important pathophysiological mechanism of fatigue in chronic liver diseases...