Roger F Butterworth

Summary

Country: Canada

Publications

  1. ncbi Hepatic encephalopathy--a serious complication of alcoholic liver disease
    Roger F Butterworth
    Neuroscience Research Unit, CHUM Hôpital Saint Luc, University of Montreal, Montreal, Canada
    Alcohol Res Health 27:143-5. 2003
  2. ncbi Complications of cirrhosis III. Hepatic encephalopathy
    R F Butterworth
    Neuroscience Research Unit, CHUM Hôpital Saint Luc, University of Montreal, Quebec, Canada
    J Hepatol 32:171-80. 2000
  3. ncbi Glutamate transporters in hyperammonemia
    Roger F Butterworth
    Neuroscience Research Unit, Hopital Saint Luc du CHUM, University of Montreal, 1058 St Denis street, Que, H2X 3J4, Montreal, Canada
    Neurochem Int 41:81-5. 2002
  4. ncbi Brain edema in acute liver failure
    R F Butterworth
    Neuroscience Research Unit, Hopital Saint Luc du CHUM, University of Montreal, Montreal, Quebec, Canada
    Indian J Gastroenterol 22:S59-61. 2003
  5. ncbi Pathogenesis of hepatic encephalopathy: update on molecular mechanisms
    Roger F Butterworth
    Neuroscience Research Unit, Hopital Saint Luc du CHUM, University of Montreal, Montreal, Quebec, Canada
    Indian J Gastroenterol 22:S11-6. 2003
  6. ncbi Neurotransmitter dysfunction in hepatic encephalopathy: new approaches and new findings
    R F Butterworth
    Neuroscience Research Unit, Centre Hospitalier de l Universite de Montreal, Hopital Saint Luc, Quebec, Canada
    Metab Brain Dis 16:55-65. 2001
  7. ncbi Hepatic encephalopathy: a neuropsychiatric disorder involving multiple neurotransmitter systems
    R F Butterworth
    Neuroscience Research Unit, CHUM H pital Saint Luc, Montreal, Quebec, Canada
    Curr Opin Neurol 13:721-7. 2000
  8. ncbi Evidence for forebrain cholinergic neuronal loss in congenital ornithine transcarbamylase deficiency
    R F Butterworth
    Neuroscience Research Unit, CHUM Hôpital Saint Luc, Montreal, Quebec, Canada
    Metab Brain Dis 15:83-91. 2000
  9. ncbi Brain lactate synthesis in thiamine deficiency: a re-evaluation using 1H-13C nuclear magnetic resonance spectroscopy
    Darren Navarro
    Neuroscience Research Unit, CHUM Campus Saint Luc, University of Montreal, 1058 Saint Denis Street, Montreal, Province of Quebec H2X 3J4, Canada
    J Neurosci Res 79:33-41. 2005
  10. ncbi Differential effects of ammonia on the benzodiazepine modulatory site on the GABA-A receptor complex of human brain
    Samir Ahboucha
    Neuroscience Research Unit, CHUM Campus Saint Luc, 1058 St Denis, Montreal, Que, Canada H2X 3J4
    Neurochem Int 47:58-63. 2005

Collaborators

Detail Information

Publications88

  1. ncbi Hepatic encephalopathy--a serious complication of alcoholic liver disease
    Roger F Butterworth
    Neuroscience Research Unit, CHUM Hôpital Saint Luc, University of Montreal, Montreal, Canada
    Alcohol Res Health 27:143-5. 2003
    ....
  2. ncbi Complications of cirrhosis III. Hepatic encephalopathy
    R F Butterworth
    Neuroscience Research Unit, CHUM Hôpital Saint Luc, University of Montreal, Quebec, Canada
    J Hepatol 32:171-80. 2000
    ..A more widespread use of central nervous system-acting drugs awaits a more complete understanding of the precise neurotransmitter systems involved in the pathogenesis of HE in chronic liver failure...
  3. ncbi Glutamate transporters in hyperammonemia
    Roger F Butterworth
    Neuroscience Research Unit, Hopital Saint Luc du CHUM, University of Montreal, 1058 St Denis street, Que, H2X 3J4, Montreal, Canada
    Neurochem Int 41:81-5. 2002
    ....
  4. ncbi Brain edema in acute liver failure
    R F Butterworth
    Neuroscience Research Unit, Hopital Saint Luc du CHUM, University of Montreal, Montreal, Quebec, Canada
    Indian J Gastroenterol 22:S59-61. 2003
    ..Studies in experimental animals suggest that mild hypothermia or the use of L-ornithine-L-aspartate may be useful in the prevention of brain edema in these patients...
  5. ncbi Pathogenesis of hepatic encephalopathy: update on molecular mechanisms
    Roger F Butterworth
    Neuroscience Research Unit, Hopital Saint Luc du CHUM, University of Montreal, Montreal, Quebec, Canada
    Indian J Gastroenterol 22:S11-6. 2003
    ..Activation of these systems may lead to alterations of monoamine and amino acid neurotransmitter function and changes in cerebral blood flow in chronic liver failure...
  6. ncbi Neurotransmitter dysfunction in hepatic encephalopathy: new approaches and new findings
    R F Butterworth
    Neuroscience Research Unit, Centre Hospitalier de l Universite de Montreal, Hopital Saint Luc, Quebec, Canada
    Metab Brain Dis 16:55-65. 2001
    ..In the case of GLT-1, PTBR, and nNOS, alterations in expression result from exposure to ammonia and/or manganese, two neurotoxic agents shown previously to be increased in brain in liver failure...
  7. ncbi Hepatic encephalopathy: a neuropsychiatric disorder involving multiple neurotransmitter systems
    R F Butterworth
    Neuroscience Research Unit, CHUM H pital Saint Luc, Montreal, Quebec, Canada
    Curr Opin Neurol 13:721-7. 2000
    ..Further elucidation of these neurotransmitter changes could provide novel pharmacological approaches in the treatment of hepatic encephalopathy...
  8. ncbi Evidence for forebrain cholinergic neuronal loss in congenital ornithine transcarbamylase deficiency
    R F Butterworth
    Neuroscience Research Unit, CHUM Hôpital Saint Luc, Montreal, Quebec, Canada
    Metab Brain Dis 15:83-91. 2000
    ..Loss of forebrain cholinergic neurons is consistent with the severe cognitive impairment characteristic of congenital OTC deficiency...
  9. ncbi Brain lactate synthesis in thiamine deficiency: a re-evaluation using 1H-13C nuclear magnetic resonance spectroscopy
    Darren Navarro
    Neuroscience Research Unit, CHUM Campus Saint Luc, University of Montreal, 1058 Saint Denis Street, Montreal, Province of Quebec H2X 3J4, Canada
    J Neurosci Res 79:33-41. 2005
    ..These results are consistent with the notion that focal lactate accumulation participates in the worsening of neurologic symptoms in thiamine-deficient patients...
  10. ncbi Differential effects of ammonia on the benzodiazepine modulatory site on the GABA-A receptor complex of human brain
    Samir Ahboucha
    Neuroscience Research Unit, CHUM Campus Saint Luc, 1058 St Denis, Montreal, Que, Canada H2X 3J4
    Neurochem Int 47:58-63. 2005
    ..These findings also suggest that positron emission tomography studies in cirrhotic patients using [11C]flumazenil may be underestimating GABA-A receptor sites depending upon the degree of hyperammonemia of the patient...
  11. doi Hypothermia attenuates oxidative/nitrosative stress, encephalopathy and brain edema in acute (ischemic) liver failure
    Wenlei Jiang
    Neuroscience Research Unit, Saint Luc Hospital, CHUM, Campus Saint Luc, University of Montreal, Montreal, Quebec, Canada
    Neurochem Int 55:124-8. 2009
    ....
  12. doi N-acetylcysteine attenuates cerebral complications of non-acetaminophen-induced acute liver failure in mice: antioxidant and anti-inflammatory mechanisms
    Chantal Bemeur
    University of Montreal, Montreal, Quebec, Canada
    Metab Brain Dis 25:241-9. 2010
    ..These findings demonstrate that the beneficial effects of NAC in experimental non-APAP-induced ALF involves both antioxidant and anti-inflammatory mechanisms...
  13. doi Antioxidant and anti-inflammatory effects of mild hypothermia in the attenuation of liver injury due to azoxymethane toxicity in the mouse
    Chantal Bemeur
    Neuroscience Research Unit, St Luc Hospital CHUM, University of Montreal, 1058 St Denis street, Montreal, Quebec, Canada, H2X 3J4
    Metab Brain Dis 25:23-9. 2010
    ..These findings demonstrate that the beneficial effects of mild hypothermia in experimental AOM-induced ALF involve both antioxidant and anti-inflammatory mechanisms...
  14. ncbi Dehydroascorbic acid normalizes several markers of oxidative stress and inflammation in acute hyperglycemic focal cerebral ischemia in the rat
    Chantal Bemeur
    Laboratoire de Neurobiologie, PEA A 423, Centre de Recherche du CHUM, Hôpital St Luc, 1058 St Denis, Montreal, Quebec, Canada H2X 3J4
    Neurochem Int 46:399-407. 2005
    ....
  15. ncbi Mild hypothermia prevents brain edema and attenuates up-regulation of the astrocytic benzodiazepine receptor in experimental acute liver failure
    Mireille Belanger
    Neuroscience Research Unit, C H U M Hôpital Saint Luc, 1058 St Denis, Montreal, Que, Canada
    J Hepatol 42:694-9. 2005
    ....
  16. pmc Inflammatory cascades driven by tumor necrosis factor-alpha play a major role in the progression of acute liver failure and its neurological complications
    Anne Chastre
    Neuroscience Research Unit, Hopital Saint Luc, CRCHUM, Montreal, Canada
    PLoS ONE 7:e49670. 2012
    ..The present study aimed to investigate the therapeutic value of etanercept, a TNF-α neutralizing molecule, on the progression of liver injury and HE in mice with ALF resulting from azoxymethane (AOM) hepatotoxicity...
  17. doi Ammonia and proinflammatory cytokines modify expression of genes coding for astrocytic proteins implicated in brain edema in acute liver failure
    Anne Chastre
    Neuroscience Research Unit, St Luc Hospital CHUM, University of Montreal, Montreal, Quebec, Canada
    Metab Brain Dis 25:17-21. 2010
    ....
  18. doi eNOS gene deletion restores blood-brain barrier integrity and attenuates neurodegeneration in the thiamine-deficient mouse brain
    Elizabeth Beauchesne
    Neuroscience Research Unit, Saint Luc Hospital CHUM, Montreal, Quebec, Canada
    J Neurochem 111:452-9. 2009
    ..However, eNOS gene deletion only partially attenuated TD-related neuronal cell loss, suggesting the presence of mechanisms additional to BBB disruption in the pathogenesis of these changes...
  19. ncbi Selective alterations of brain osmolytes in acute liver failure: protective effect of mild hypothermia
    Claudia Zwingmann
    Neuroscience Research Unit, Hôpital Saint Luc CHUM, 1058 St Denis street, Montreal, Quebec, Canada H2X 3J4
    Brain Res 999:118-23. 2004
    ....
  20. doi Direct evidence for central proinflammatory mechanisms in rats with experimental acute liver failure: protective effect of hypothermia
    Wenlei Jiang
    Neuroscience Research Unit, Hôpital Saint Luc C H U M, University of Montreal, Montreal, Quebec, Canada
    J Cereb Blood Flow Metab 29:944-52. 2009
    ..Antiinflammatory agents could be beneficial in the management of these complications...
  21. doi Region-selective alterations of glucose oxidation and amino acid synthesis in the thiamine-deficient rat brain: a re-evaluation using 1H/13C nuclear magnetic resonance spectroscopy
    Darren Navarro
    Neuroscience Research Unit, CHUM Saint Luc Hospital, University of Montreal, Montreal, Quebec, Canada
    J Neurochem 106:603-12. 2008
    ..Glucose loading deteriorated TD-related decreases in TCA cycle flux, and concomitantly reduced synthesis of aspartate and glutamate in MT...
  22. ncbi Selectively increased expression of the astrocytic/endothelial glucose transporter protein GLUT1 in acute liver failure
    Mireille Belanger
    Neuroscience Research Unit, C H U M Hôpital Saint Luc, Montreal, Quebec, Canada
    Glia 53:557-62. 2006
    ....
  23. ncbi Mild hypothermia attenuates liver injury and improves survival in mice with acetaminophen toxicity
    Javier Vaquero
    Neuroscience Research Unit, Hôpital Saint Luc CHUM, Universite de Montreal, 1058 St Denis street, Montreal, Quebec, Canada
    Gastroenterology 132:372-83. 2007
    ..Therefore, we investigated the effects of body temperature on the progression of APAP-induced liver injury in mice...
  24. ncbi Effects of hypothermia on brain glucose metabolism in acute liver failure: a H/C-nuclear magnetic resonance study
    Nicolas Chatauret
    Neuroscience Research Unit, CHUM Hôpital, Saint Luc, Montreal, Quebec, Canada
    Gastroenterology 125:815-24. 2003
    ....
  25. doi Minocycline attenuates oxidative/nitrosative stress and cerebral complications of acute liver failure in rats
    Wenlei Jiang
    CHUM, University of Montreal, Quebec, Canada
    Neurochem Int 55:601-5. 2009
    ..These results indicate that the beneficial effect of minocycline on the neurological complications of ALF is mediated, at least in part, by reduction of oxidative/nitrosative stress...
  26. ncbi An interaction between benzodiazepines and neuroactive steroids at GABA A receptors in cultured hippocampal neurons
    Samir Ahboucha
    Neuroscience Research Unit, CHUM Hôpital Saint Luc, 1058 St Denis, Montreal, Quebec, Canada H2X 3J4
    Neurochem Int 48:703-7. 2006
    ..Our results may provide a rational basis for the use of benzodiazepine inverse agonists in the management and treatment of hepatic encephalopathy in patients with liver failure...
  27. doi Update of cell damage mechanisms in thiamine deficiency: focus on oxidative stress, excitotoxicity and inflammation
    Alan S Hazell
    Department of Medicine, University of Montreal, Quebec, Canada
    Alcohol Alcohol 44:141-7. 2009
    ....
  28. ncbi Neurobiological characterization of an azoxymethane mouse model of acute liver failure
    Mireille Belanger
    Neuroscience Research Unit, Hopital Saint Luc, CHUM, Montreal, Canada
    Neurochem Int 48:434-40. 2006
    ..These findings demonstrate that AOM treatment affords a simple, reproducible mouse model of ALF which may be suitable for the study of the effects of gene manipulation on the cerebral complications of ALF...
  29. doi Evidence for oxidative/nitrosative stress in the pathogenesis of hepatic encephalopathy
    Chantal Bemeur
    Neuroscience Research Unit, Hôpital Saint Luc CHUM University of Montreal, Montreal, QC, Canada
    Metab Brain Dis 25:3-9. 2010
    ..However, evidence from studies in HE patients is limited. This review summarizes this evidence for a role of oxidative/nitrosative stress in relation to ammonia toxicity and to the pathogenesis of HE...
  30. ncbi Direct molecular and spectroscopic evidence for increased ammonia removal capacity of skeletal muscle in acute liver failure
    Nicolas Chatauret
    Neuroscience Research Unit, University of Montreal CHUM, Hopital Saint Luc, 1058 St Denis street, Montreal, Que, Canada H2X 3J4
    J Hepatol 44:1083-8. 2006
    ..To address this issue, glutamine synthetase expression and activities were measured in skeletal muscle of rats with acute liver failure resulting from hepatic devascularization...
  31. ncbi Effects of ammonia on high affinity glutamate uptake and glutamate transporter EAAT3 expression in cultured rat cerebellar granule cells
    Helen Chan
    Neuroscience Research Unit, Centre Hospitalier de l Universite de Montreal, Campus Saint Luc, 1058 St Denis St, Que, H2X 3J4, Montreal, Canada
    Neurochem Int 43:137-46. 2003
    ..Decrease of glutamate uptake in these cellular preparations may afford an additional regulatory mechanism aimed at controlling intracellular levels of glutamate and ultimately the releasable pool of glutamate in neurons...
  32. ncbi Mild hypothermia in the prevention of brain edema in acute liver failure: mechanisms and clinical prospects
    Nicolas Chatauret
    Neuroscience Research Unit, C H U M Hôpital Saint Luc, University of Montreal, Montreal, Quebec, Canada
    Metab Brain Dis 17:445-51. 2002
    ..Randomized controlled clinical trials of hypothermia are required to further evaluate its clinical impact...
  33. doi Altered expression of tight junction proteins and matrix metalloproteinases in thiamine-deficient mouse brain
    Elizabeth Beauchesne
    Neuroscience Research Unit, Saint Luc Hospital C H U M, Montreal, Quebec, Canada
    Neurochem Int 55:275-81. 2009
    ..They also suggest a role for MMP-9 in the initiation of changes to BBB integrity in TD...
  34. doi Thiamine deficiency-related brain dysfunction in chronic liver failure
    Roger F Butterworth
    Neuroscience Research Unit, Saint Luc Hospital CHUM, University of Montreal, 1058, Saint Denis Street, Montreal, QC H2X 3J4, Canada
    Metab Brain Dis 24:189-96. 2009
    ..These findings underscore the need for prompt, effective thiamine supplementation in all patients with chronic liver failure...
  35. doi Cerebral inflammation contributes to encephalopathy and brain edema in acute liver failure: protective effect of minocycline
    Wenlei Jiang
    Saint Luc Hospital, University of Montreal, Quebec, Canada
    J Neurochem 109:485-93. 2009
    ..These results offer the first direct evidence for central proinflammatory mechanisms in the pathogenesis of brain edema and its complications in ALF and suggest that anti-inflammatory agents may be beneficial in these patients...
  36. doi Liver-brain proinflammatory signalling in acute liver failure: role in the pathogenesis of hepatic encephalopathy and brain edema
    Chantal Bemeur
    Departement de Nutrition, Faculte de Medecine, Universite de Montreal, Montreal, QC, Canada
    Metab Brain Dis 28:145-50. 2013
    ....
  37. doi Pathogenesis of hepatic encephalopathy and brain edema in acute liver failure: role of glutamine redefined
    Paul Desjardins
    Neuroscience Research Unit, Saint Luc Hospital, CHUM, University of Montreal, Montreal, Quebec, Canada
    Neurochem Int 60:690-6. 2012
    ..While inhibitors of brain glutamine synthesis such as methionine sulfoximine, have been proposed for the prevention of brain edema in ALF, potential adverse effects have so far limited their applicability...
  38. doi Impaired oxidation of branched-chain amino acids in the medial thalamus of thiamine-deficient rats
    Darren Navarro
    Neuroscience Research Unit, CHUM Saint Luc Hospital, University of Montreal, 1058, Saint Denis Street, Montreal, QC, H2X 3J4, Canada
    Metab Brain Dis 23:445-55. 2008
    ..Impaired branched-chain ketoacid metabolism in rats may contribute to the neuronal dysfunction and ultimate thalamic neuronal cell death observed in thiamine deficiency...
  39. ncbi Glucose loading precipitates focal lactic acidosis in the vulnerable medial thalamus of thiamine-deficient rats
    Darren Navarro
    Neuroscience Research Unit, CHUM Campus Saint Luc, University of Montreal, 1058 Saint Denis Street, Montreal, Quebec, Canada
    Metab Brain Dis 23:115-22. 2008
    ..Alterations of brain pH could contribute to the pathogenesis of thalamic neuronal damage and consequent cerebral dysfunction in Wernicke's Encephalopathy...
  40. ncbi The neurosteroid system: an emerging therapeutic target for hepatic encephalopathy
    Samir Ahboucha
    Neuroscience Research Unit, CHUM Campus Saint Luc, 1058 St Denis, Montreal, Quebec, Canada
    Metab Brain Dis 22:291-308. 2007
    ..In HE, it has been well documented that neurotransmission and gene expression alterations occur during the progression of the disease. This review summarizes findings of relevance for the involvement of NS in human and experimental HE...
  41. doi Selective increase of neuronal cyclooxygenase-2 (COX-2) expression in vulnerable brain regions of rats with experimental Wernicke's encephalopathy: effect of nimesulide
    Baoying Gu
    Neuroscience Research Unit, CHUM Campus Saint Luc, 1058 St Denis street, Montreal, Quebec, Canada, H2X 3J4
    Metab Brain Dis 23:175-87. 2008
    ..These findings suggest that newly synthesized prostanoids exert a neuroprotective role in TD...
  42. ncbi Mechanisms of brain edema in acute liver failure and impact of novel therapeutic interventions
    Javier Vaquero
    Neuroscience Research Unit, Hôpital Saint Luc CHUM, Universite de Montreal, Montreal, H2X3J4, QC, Canada
    Neurol Res 29:683-90. 2007
    ....
  43. ncbi Pathophysiology of hepatic encephalopathy: a new look at GABA from the molecular standpoint
    Samir Ahboucha
    Neuroscience Research Unit, CHUM Hôpital Saint Luc, Montreal, Quebec, Canada
    Metab Brain Dis 19:331-43. 2004
    ..While the role of endogenous benzodiazepines remains controversial, the presence of neurosteroids with GABA agonist properties affords a plausible explanation for increased GABAergic tone in HE...
  44. doi IL-1 or TNF receptor gene deletion delays onset of encephalopathy and attenuates brain edema in experimental acute liver failure
    Chantal Bemeur
    Neuroscience Research Unit, Hôpital Saint Luc CHUM, University of Montreal, Montreal, Quebec, Canada
    Neurochem Int 56:213-5. 2010
    ..These findings further support a role for selective brain-derived cytokines in the pathogenesis of the cerebral complications in acute liver failure and suggest that anti-inflammatory strategies could be beneficial in their prevention...
  45. doi Up-regulation of caveolin-1 and blood-brain barrier breakdown are attenuated by N-acetylcysteine in thiamine deficiency
    Elizabeth Beauchesne
    Department of Medicine, University of Montreal, Montreal, Quebec, Canada
    Neurochem Int 57:830-7. 2010
    ..These findings demonstrate a role for caveolin-1 in TD pathogenesis, and suggest that oxidative stress contributes to BBB alterations in TD via modulation of this pathway...
  46. doi Parkinsonism in cirrhosis: pathogenesis and current therapeutic options
    Roger F Butterworth
    Unité de Recherche en Neurosciences, Hôpital Saint Luc CHUM, Universite de Montreal, Montreal, Canada
    Metab Brain Dis 28:261-7. 2013
    ..However, reports of post-transplant residual extrapyramidal symptoms suggest an element of irreversibility in some cases...
  47. ncbi Selective loss of expression of glutamate GluR2/R3 receptor subunits in cerebellar tissue from a patient with olivopontocerebellar atrophy
    Gregoire Dirson
    Neuroscience Research Unit, Hĵpital Saint Luc du CHUM University of Montreal, Canada
    Metab Brain Dis 17:77-82. 2002
    ....
  48. doi Altered glial-neuronal crosstalk: cornerstone in the pathogenesis of hepatic encephalopathy
    Roger F Butterworth
    Neuroscience Research Unit, St Luc Hospital CHUM, University of Montreal, Montreal, QC, Canada
    Neurochem Int 57:383-8. 2010
    ....
  49. ncbi Keeping cool in acute liver failure: rationale for the use of mild hypothermia
    Javier Vaquero
    Neuroscience Research Unit, Hôpital Saint Luc C H U M, 1058 St Denis street, Montreal, QC, Canada H2X 3J4
    J Hepatol 43:1067-77. 2005
    ..Randomized controlled clinical trials are now needed to adequately assess its efficacy, safety, clinical impact on global outcomes and to provide the guidelines for its use in ALF...
  50. ncbi Increased brain serotonin turnover correlates with the degree of shunting and hyperammonemia in rats following variable portal vein stenosis
    Violina Lozeva
    Neuroscience Research Unit, Hôpital Saint Luc CHUM, 1058 St Denis St, Montreal, Que, Canada H2X 3J4
    J Hepatol 40:742-8. 2004
    ..Brain monoamines have been implicated in the pathogenesis of HE. We examined the relationship between monoamine dysfunction and the degree of portal-systemic shunting (PSS) in rats with varying degrees of PSS...
  51. ncbi Increased brain concentrations of endogenous (non-benzodiazepine) GABA-A receptor ligands in human hepatic encephalopathy
    Samir Ahboucha
    Neuroscience Research Unit, CHUM Campus Saint Luc, Montreal, Quebec, Canada
    Metab Brain Dis 19:241-51. 2004
    ..These findings suggest the presence of nonbenzodiazepine substances (possibly neurosteroids) with positive allosteric modulatory properties at the GABA-A receptor complex in brain in hepatic encephalopathy...
  52. ncbi Expression of superoxide dismutase in hyperglycemic focal cerebral ischemia in the rat
    Chantal Bemeur
    Laboratoire de Neurobiologie, Centre de Recherche du CHUM, Hôpital St Luc, A 466, 1058 St Denis St, Montreal, Quebec, Canada H2X 3J4
    Neurochem Int 45:1167-74. 2004
    ....
  53. doi Hepatic encephalopathy: a central neuroinflammatory disorder?
    Roger F Butterworth
    Neuroscience Research Unit, Hopital Saint Luc, Centre Hospitalier de l Universite de Montreal, Montreal, Quebec, Canada
    Hepatology 53:1372-6. 2011
    ..The prevention of central proinflammatory processes will undoubtedly herald a new chapter in the development of agents for the prevention and treatment of the central nervous system complications of liver failure...
  54. ncbi Selective increase of brain lactate synthesis in experimental acute liver failure: results of a [H-C] nuclear magnetic resonance study
    Claudia Zwingmann
    Neuroscience Research Unit, CHUM Hôpital Saint Luc, Montreal, Quebec, Canada
    Hepatology 37:420-8. 2003
    ..Future NMR spectroscopic studies using stable isotopes and real-time measurements of metabolic rates could be valuable in the elucidation of the cerebral metabolic consequences of ALF in humans...
  55. ncbi Reduced expression of astrocytic glycine transporter (Glyt-1) in acute liver failure
    Claudia Zwingmann
    Neuroscience Research Unit, CHUM Hôpital Saint Luc, Montreal, Quebec, Canada
    Metab Brain Dis 17:263-73. 2002
    ..The use of NMDA receptor antagonists, aimed specifically at the glycine modulatory site, could offer novel approaches to the prevention and treatment of HE in ALF...
  56. ncbi Primary cultures of rat astrocytes respond to thiamine deficiency-induced swelling by downregulating aquaporin-4 levels
    Helen Chan
    Division of Experimental Medicine, McGill University, Montreal, Que, Canada
    Neurosci Lett 366:231-4. 2004
    ....
  57. ncbi Role of endogenous benzodiazepine ligands and their GABA-A--associated receptors in hepatic encephalopathy
    Samir Ahboucha
    Neuroscience Research Unit, CHUM Hôpital Saint Luc, Montreal, Quebec, Canada
    Metab Brain Dis 20:425-37. 2005
    ....
  58. doi Neuroinflammation in acute liver failure: mechanisms and novel therapeutic targets
    Roger F Butterworth
    Neuroscience Research Unit, Saint Luc Hospital CHUM, University of Montreal, Montreal, Quebec, Canada
    Neurochem Int 59:830-6. 2011
    ..Translation of these findings to the clinic has the potential to provide rational targeted approaches to the prevention and treatment of these complications in the near future...
  59. ncbi Mild hypothermia for the treatment of acute liver failure--what are we waiting for?
    Javier Vaquero
    Neuroscience Research Unit, Hopital Saint Luc, University of Montreal, Montreal, QC, Canada
    Nat Clin Pract Gastroenterol Hepatol 4:528-9. 2007
  60. ncbi Increased concentrations of histamine and its metabolite, tele-methylhistamine and down-regulation of histamine H3 receptor sites in autopsied brain tissue from cirrhotic patients who died in hepatic coma
    Violina Lozeva
    Neuroscience Research Unit, Centre Hospitalier de l Universite de Montreal, Hopital Saint Luc, 1058 St Denis St, Montreal, Quebec, Canada H2X 3J4
    J Hepatol 39:522-7. 2003
    ....
  61. ncbi Loss of expression of glial fibrillary acidic protein in acute hyperammonemia
    Mireille Belanger
    Neuroscience Research Unit, Hopital Saint Luc du CHUM, University of Montreal, 1058 St Denis street, Que, H2X 3J4, Montreal, Canada
    Neurochem Int 41:155-60. 2002
    ..These findings suggest a role for GFAP in cell volume regulation and that loss of GFAP expression could contribute to the pathogenesis of brain edema in acute hyperammonemic syndromes...
  62. ncbi The neurosteroid system: implication in the pathophysiology of hepatic encephalopathy
    Samir Ahboucha
    Neuroscience Research Unit, Hôpital Saint Luc CHUM, 1058 St Denis, Montreal, Quebec, Canada H2X 3J4
    Neurochem Int 52:575-87. 2008
    ..This review summarizes findings consistent with the involvement of NS in human and experimental HE...
  63. ncbi Cell-selective effects of ammonia on glutamate transporter and receptor function in the mammalian brain
    Helen Chan
    Division of Experimental Medicine, McGill University, Montreal, Que, Canada
    Neurochem Int 43:525-32. 2003
    ..Therapeutic measures aimed at these targets could result in effective measures for the prevention of CNS consequences in hyperammonemic syndromes...
  64. ncbi Neuronal cell death in hepatic encephalopathy
    Roger F Butterworth
    Neuroscience Research Unit, Hôpital Saint Luc CHUM, 1058 Saint Denis, Montreal, Quebec, Canada
    Metab Brain Dis 22:309-20. 2007
    ..These findings suggest that some of the purported "sequelae" of liver transplantation (gait ataxia, memory loss, confusion) could reflect preexisting neuropathology...
  65. ncbi Role of circulating neurotoxins in the pathogenesis of hepatic encephalopathy: potential for improvement following their removal by liver assist devices
    Roger F Butterworth
    Neuroscience Research Unit, CHUM Hôpital Saint Luc, University of Montreal, Montreal, Quebec, Canada H2X 3J4
    Liver Int 23:5-9. 2003
    ..In this regard, the Molecular Adsorbents Recirculating System (MARS) appears to offer distinct advantages over hepatocyte-based systems...
  66. doi Metal toxicity, liver disease and neurodegeneration
    Roger F Butterworth
    Neuroscience Research Unit, St Luc Hospital CHUM, University of Montreal, 1058, Saint Denis, Montreal, QC, H2X 3J4, Canada
    Neurotox Res 18:100-5. 2010
    ..Management and treatment of hepatocerebral disorders include chelation therapy (Wilson's Disease), the use of ammonia-lowering agents (lactulose, antibiotics, ornithine aspartate) and liver transplantation...
  67. ncbi Induction of astrocytic cyclooxygenase-2 in epileptic patients with hippocampal sclerosis
    Paul Desjardins
    Neuroscience Research Unit, C H U M, Hopital Saint Luc, 1058 St Denis street, Montreal, Que, Canada H2X 3J4
    Neurochem Int 42:299-303. 2003
    ....
  68. ncbi The "peripheral-type" benzodiazepine (omega 3) receptor in hyperammonemic disorders
    Paul Desjardins
    Neuroscience Research Unit, Hopital Saint Luc du CHUM, University of Montreal, 1058 St Denis street, Que, H2X 3J4, Montreal, Canada
    Neurochem Int 41:109-14. 2002
    ..Preliminary reports suggest that positron emission tomography (PET) studies using [11C]-PK11195 may be useful for the assessment of the neurological consequences of chronic liver failure...
  69. ncbi Molecular neurobiology of acute liver failure
    Roger F Butterworth
    Neuroscience Research Unit, Hôpital Saint Luc CHUM, Montreal, Quebec Canada
    Semin Liver Dis 23:251-8. 2003
    ..Further elucidation of the molecular mechanisms responsible for brain edema and encephalopathy in acute liver failure will undoubtedly lead to novel treatment strategies for these complications...
  70. ncbi Pathophysiology of hepatic encephalopathy: a new look at ammonia
    Roger F Butterworth
    Neuroscience Research Unit, CHUM Hôpital Saint Luc, University of Montreal, 1058 St Denis street, Montreal, Quebec H2X 314, Canada
    Metab Brain Dis 17:221-7. 2002
    ....
  71. doi Experimental models of hepatic encephalopathy: ISHEN guidelines
    Roger F Butterworth
    Neuroscience Research Unit, St Luc Hospital CHUM, University of Montreal, Montreal, QC, Canada
    Liver Int 29:783-8. 2009
    ..More attention could be paid in the future to in vitro models involving the neurovascular unit, microglia and neuronal co-cultures in relation to HE pathogenesis...
  72. ncbi Role of mitochondrial dysfunction and oxidative stress in the pathogenesis of selective neuronal loss in Wernicke's encephalopathy
    Paul Desjardins
    Neuroscience Research Unit, CHUM Hopital St Luc, University of Montreal, Montreal, Quebec, Canada
    Mol Neurobiol 31:17-25. 2005
    ..Reactive oxygen species production results in decreased expression of astrocytic glutamate transporters and decreased activities of alpha-KGDH, resulting in an amplification of cell death mechanisms in thiamine deficiency...
  73. ncbi Reduced plasma dehydroepiandrosterone sulfate levels are significantly correlated with fatigue severity in patients with primary biliary cirrhosis
    Samir Ahboucha
    Neuroscience Research Unit, CHUM Hôpital Saint Luc, 1058 St Denis, Montreal, Quebec 2X 3J4, Canada
    Neurochem Int 52:569-74. 2008
    ....
  74. ncbi The brain glutamate system in liver failure
    Javier Vaquero
    Neuroscience Research Unit, Hôpital Saint Luc CHUM, University of Montreal, Montreal, QC, Canada
    J Neurochem 98:661-9. 2006
    ..A better understanding of the cause and precise nature of the alterations of the brain glutamate system in liver failure could lead to new therapeutic avenues for the cerebral complications of liver disease...
  75. ncbi Acute liver failure: a critical appraisal of available animal models
    Mireille Belanger
    Neuroscience Research Unit, C H U M Hôpital Saint Luc, Montreal, Quebec, Canada
    Metab Brain Dis 20:409-23. 2005
    ..Despite the high prevalence of viral hepatitis worldwide, very few satisfactory viral models of ALF are available. Established and newly developed models of ALF are reviewed...
  76. ncbi Normal coupling of brain benzodiazepine and neurosteroid modulatory sites on the GABA-A receptor complex in human hepatic encephalopathy
    Samir Ahboucha
    Neuroscience Research Unit, CHUM Campus Saint Luc, 1058 St Denis, Que, H2X 3J4, Montreal, Canada
    Neurochem Int 43:551-6. 2003
    ....
  77. ncbi Increased brain endothelial nitric oxide synthase expression in thiamine deficiency: relationship to selective vulnerability
    Milarca Kruse
    Neuroscience Research Unit, CHUM Campus Saint Luc, University of Montreal, 1058, Saint Denis Street, Montreal, Que, Canada H2X 3J4
    Neurochem Int 45:49-56. 2004
    ....
  78. ncbi Ammonia induces MK-801-sensitive nitration and phosphorylation of protein tyrosine residues in rat astrocytes
    Freimut Schliess
    Clinic for Gastroenterology, Hepatology and Infectiology, Heinrich Heine University, Dusseldorf, Germany
    FASEB J 16:739-41. 2002
    ..The production of reactive nitrogen intermediates and protein tyrosine nitration may alter astrocyte function and contribute to ammonia neurotoxicity...
  79. ncbi Increased levels of pregnenolone and its neuroactive metabolite allopregnanolone in autopsied brain tissue from cirrhotic patients who died in hepatic coma
    Samir Ahboucha
    Neuroscience Research Unit, CHUM Hôpital Saint Luc Quebec, Canada H2X 3J4
    Neurochem Int 49:372-8. 2006
    ..These findings suggest that increased levels of allopregnanolone rather than "endogenous benzodiazepines" offer a cogent explanation for the phenomenon of "increased GABAergic tone" previously proposed in HE...
  80. ncbi Effect of albumin dialysis on intracranial pressure increase in pigs with acute liver failure: a randomized study
    Sambit Sen
    Liver Failure Group, The UCL Institute of Hepatology, Division of Medicine, Royal Free and University College Medical School, London
    Crit Care Med 34:158-64. 2006
    ....
  81. ncbi Neurobiology of ammonia
    Vicente Felipo
    Department of Neurobiology, Laboratory of Neurobiology, Instituto de Investigaciones Citologicas, Amadeo de Saboya 4, Fundacion Valenciana de Investigaciones Biomedicas, 46010 Valencia, Spain
    Prog Neurobiol 67:259-79. 2002
    ..Therapy in hyperammonemic syndromes continues to rely on ammonia-lowering strategies via peripheral mechanisms (reduction of ammonia production in the gastrointestinal tract, increased ammonia removal by muscle)...
  82. ncbi Lack of assessment of body temperature in mice with acetaminophen toxicity
    Javier Vaquero
    Hepatology 44:279-80. 2006
  83. ncbi Hepatic encephalopathy
    Roger F Butterworth
    Neuroscience Research Unit, CHUM Hôpital Saint Luc, Montreal, Canada
    Alcohol Res Health 27:240-6. 2003
    ..Treatment of patients with HE involves measures to lower ammonia levels in the blood, medications to counteract ammonia's effects on brain cell function, devices to compensate for liver dysfunction, and liver transplantation...
  84. ncbi Pathogenesis of hepatic encephalopathy: new insights from neuroimaging and molecular studies
    Roger F Butterworth
    J Hepatol 39:278-85. 2003
  85. ncbi Region selective alterations of soluble guanylate cyclase content and modulation in brain of cirrhotic patients
    Regina Corbalán
    Laboratory of Neurobiology, Instituto de Investigaciones Citologicas, Fundacion Valenciana de Investigaciones Biomedicas, Spain
    Hepatology 36:1155-62. 2002
    ....
  86. ncbi Increased brain concentrations of a neuroinhibitory steroid in human hepatic encephalopathy
    Samir Ahboucha
    Ann Neurol 58:169-70. 2005
  87. ncbi Manganese distribution in the brain and neurobehavioral changes following inhalation exposure of rats to three chemical forms of manganese
    Louise Normandin
    Department of Environmental and Occupational Health, Faculty of Medicine, Universite de Montreal, CP 6128, Succursale Centre Ville, Montreal, Que, Canada H3C 3J7
    Neurotoxicology 25:433-41. 2004
    ..Exposure to Mn phosphate/sulfate mixture caused a decrease in the total ambulatory count related to locomotor activity. Our results confirm that Mn species and solubility have an influence on the brain distribution of Mn in rats...
  88. ncbi Mitochondrial dysfunction in acute hyperammonemia
    Vicente Felipo
    Instituto Investigaciones Citologicas de la Fundacion Valenciana de Investigaciones Biomedicas, Valencia, Spain
    Neurochem Int 40:487-91. 2002
    ..Alterations of mitochondrial function could contribute to the neuronal dysfunction characteristic of acute hyperammonemic syndromes...