Alexandre Bureau

Summary

Country: Canada

Publications

  1. doi request reprint Follow-up of a major psychosis linkage site in 13q13-q14 reveals significant association in both case-control and family samples
    Alexandre Bureau
    Centre de Recherche de l Institut Universitaire en Santé Mentale de Québec, Universite Laval, Quebec, Canada
    Biol Psychiatry 74:444-50. 2013
  2. pmc Application of microarray outlier detection methodology to psychiatric research
    Carl Ernst
    McGill Group for Suicide Studies, McGill University, Montreal, Canada
    BMC Psychiatry 8:29. 2008
  3. ncbi request reprint Identifying SNPs predictive of phenotype using random forests
    Alexandre Bureau
    Department of Human Genetics, Oscient Pharmaceuticals, Waltham, Massachusetts, USA
    Genet Epidemiol 28:171-82. 2005
  4. doi request reprint Latent class model with familial dependence to address heterogeneity in complex diseases: adapting the approach to family-based association studies
    Alexandre Bureau
    Centre de Recherche Universite Laval Robert Giffard, Quebec City, Quebec, Canada
    Genet Epidemiol 35:182-9. 2011
  5. ncbi request reprint Estimating interaction between genetic and environmental risk factors: efficiency of sampling designs within a cohort
    Alexandre Bureau
    Centre de Recherche Universite Laval Robert Giffard, Universite Laval, Quebec, Canada
    Epidemiology 19:83-93. 2008
  6. doi request reprint Using disease symptoms to improve detection of linkage under genetic heterogeneity
    Alexandre Bureau
    Centre de Recherche Universite Laval Robert Giffard, Quebec City, Quebec, Canada
    Genet Epidemiol 32:476-86. 2008
  7. doi request reprint A new strategy for linkage analysis under epistasis taking into account genetic heterogeneity
    Alexandre Bureau
    Centre de Recherche, Université Laval Robert Giffard, Quebec, Que, Canada
    Hum Hered 68:231-42. 2009
  8. doi request reprint Detection of phenotype modifier genes using two-locus linkage analysis in complex disorders such as major psychosis
    Alexandre Bureau
    Centre de Recherche de l Institut Universitaire en Santé Mentale de Québec, Universite Laval, Quebec, Quebec, Canada
    Hum Hered 73:195-207. 2012
  9. doi request reprint Replication of linkage with bipolar disorder on chromosome 16p in the Eastern Quebec population
    Chantal Mérette
    Department of Psychiatry, Laval University, Quebec, Canada
    Am J Med Genet B Neuropsychiatr Genet 147:737-44. 2008
  10. pmc Chromosome 13q13-q14 locus overlaps mood and psychotic disorders: the relevance for redefining phenotype
    Michel Maziade
    Department of Psychiatry, Laval University, Quebec, QC, Canada
    Eur J Hum Genet 17:1034-42. 2009

Collaborators

Detail Information

Publications19

  1. doi request reprint Follow-up of a major psychosis linkage site in 13q13-q14 reveals significant association in both case-control and family samples
    Alexandre Bureau
    Centre de Recherche de l Institut Universitaire en Santé Mentale de Québec, Universite Laval, Quebec, Canada
    Biol Psychiatry 74:444-50. 2013
    ..We previously reported a genome-wide significant linkage for major psychosis in chromosome 13q13-q14...
  2. pmc Application of microarray outlier detection methodology to psychiatric research
    Carl Ernst
    McGill Group for Suicide Studies, McGill University, Montreal, Canada
    BMC Psychiatry 8:29. 2008
    ..While microarrays generate a substantial amount of false positive and spurious results, some of the extreme expression values may be valid and could represent true biological findings...
  3. ncbi request reprint Identifying SNPs predictive of phenotype using random forests
    Alexandre Bureau
    Department of Human Genetics, Oscient Pharmaceuticals, Waltham, Massachusetts, USA
    Genet Epidemiol 28:171-82. 2005
    ..SNPs and SNP pairs highly associated with asthma tend to have the highest importance index value, but predictive importance and association do not always coincide...
  4. doi request reprint Latent class model with familial dependence to address heterogeneity in complex diseases: adapting the approach to family-based association studies
    Alexandre Bureau
    Centre de Recherche Universite Laval Robert Giffard, Quebec City, Quebec, Canada
    Genet Epidemiol 35:182-9. 2011
    ..The analysis using the posterior probability of membership to an LC detected an association in the JARID2 gene as significant as that for ASD (P = 3 × 10(-5)) but with a larger effect size (odds ratio = 2.17 vs. 1.55)...
  5. ncbi request reprint Estimating interaction between genetic and environmental risk factors: efficiency of sampling designs within a cohort
    Alexandre Bureau
    Centre de Recherche Universite Laval Robert Giffard, Universite Laval, Quebec, Canada
    Epidemiology 19:83-93. 2008
    ..It was possible to estimate the interaction effect with precision close to that of the full cohort when using case-cohort or nested case-control samples containing fewer than half the subjects of the cohort...
  6. doi request reprint Using disease symptoms to improve detection of linkage under genetic heterogeneity
    Alexandre Bureau
    Centre de Recherche Universite Laval Robert Giffard, Quebec City, Quebec, Canada
    Genet Epidemiol 32:476-86. 2008
    ....
  7. doi request reprint A new strategy for linkage analysis under epistasis taking into account genetic heterogeneity
    Alexandre Bureau
    Centre de Recherche, Université Laval Robert Giffard, Quebec, Que, Canada
    Hum Hered 68:231-42. 2009
    ..We propose a complete three-step strategy for parametric linkage analysis under epistasis and heterogeneity in extended pedigrees...
  8. doi request reprint Detection of phenotype modifier genes using two-locus linkage analysis in complex disorders such as major psychosis
    Alexandre Bureau
    Centre de Recherche de l Institut Universitaire en Santé Mentale de Québec, Universite Laval, Quebec, Quebec, Canada
    Hum Hered 73:195-207. 2012
    ....
  9. doi request reprint Replication of linkage with bipolar disorder on chromosome 16p in the Eastern Quebec population
    Chantal Mérette
    Department of Psychiatry, Laval University, Quebec, Canada
    Am J Med Genet B Neuropsychiatr Genet 147:737-44. 2008
    ....
  10. pmc Chromosome 13q13-q14 locus overlaps mood and psychotic disorders: the relevance for redefining phenotype
    Michel Maziade
    Department of Psychiatry, Laval University, Quebec, QC, Canada
    Eur J Hum Genet 17:1034-42. 2009
    ..Our data suggest a susceptibility locus in 13q13-q14 that is shared by schizophrenia and mood disorder. That locus would be additional to another well documented and more distal 13q locus where the G72/G30 gene is mapped...
  11. pmc Association of polyaminergic loci with anxiety, mood disorders, and attempted suicide
    Laura M Fiori
    McGill Group for Suicide Studies, Douglas Mental Health University Institute, McGill University, Montreal, Quebec, Canada
    PLoS ONE 5:e15146. 2010
    ..Studies have identified associations between genetic variants in spermidine/spermine N1-acetyltransferase (SAT1) and both anxiety and suicide, and several polymorphisms appear to play important roles in determining gene expression...
  12. doi request reprint Global gene expression profiling of the polyamine system in suicide completers
    Laura M Fiori
    McGill Group for Suicide Studies, Douglas Mental Health University Institute, McGill University, Montreal, Quebec, Canada
    Int J Neuropsychopharmacol 14:595-605. 2011
    ..This study provides a broader view of the nature and extent of the dysregulation of the polyamine system in suicide, and highlights the importance of this system in the neurobiology of suicide...
  13. pmc Symptom dimensions as alternative phenotypes to address genetic heterogeneity in schizophrenia and bipolar disorder
    Aurelie Labbe
    Department of Epidemiology, Biostatistics and Occupational Health, McGill University, Montreal, Quebec, Canada
    Eur J Hum Genet 20:1182-8. 2012
    ..Our results support the view that dissecting phenotypic heterogeneity by modeling symptom dimensions may provide new insights into the genetics of SZ and BP...
  14. pmc Mapping complex traits using Random Forests
    Alexandre Bureau
    Genome Therapeutics Corporation, Waltham, Massachusetts 02453, USA
    BMC Genet 4:S64. 2003
    ..Random Forest was able to identify a few of the major genes influencing the phenotypes, such as baseline HDL and triglycerides, but failed to identify the major genes regulating baseline glucose levels...
  15. doi request reprint High-density polymorphisms analysis of 23 candidate genes for association with bone mineral density
    Sylvie Giroux
    Centre de Recherche de l Hôpital St François d Assise du Centre Hospitalier Universitaire de Québec, Quebec, Canada G1L 3L5
    Bone 47:975-81. 2010
    ..The results reported in this study suggest a role for CSF3R in the determination of bone density in women...
  16. doi request reprint Association with replication between estrogen-related receptor gamma (ESRRgamma) polymorphisms and bone phenotypes in women of European ancestry
    Latifa Elfassihi
    Centre de Recherche de l Hôpital St François d Assise du Centre Hospitalier Universitaire de Québec, Quebec, Canada
    J Bone Miner Res 25:901-11. 2010
    ..All SNPs involved in the associations were analyzed in two other sample sets with significant results in the same direction. These results suggest involvement of ESRRgamma in the determination of bone density in women...
  17. doi request reprint Profiling brain expression of the spermidine/spermine N1-acetyltransferase 1 (SAT1) gene in suicide
    Timothy A Klempan
    McGill Group for Suicide Studies, Douglas Hospital, McGill University, Montreal, Quebec, Canada
    Am J Med Genet B Neuropsychiatr Genet 150:934-43. 2009
    ....
  18. pmc Homozygous deletion of the very low density lipoprotein receptor gene causes autosomal recessive cerebellar hypoplasia with cerebral gyral simplification
    Kym M Boycott
    Department of Medical Genetics, Alberta Children s Hospital and University of Calgary, Alberta, Canada
    Am J Hum Genet 77:477-83. 2005
    ..To our knowledge, this syndrome represents the first human lipoprotein receptor malformation syndrome and the second human disease associated with a reelin pathway defect...
  19. ncbi request reprint Evidence for a novel glaucoma locus at chromosome 3p21-22
    Paul N Baird
    Centre for Eye Research Australia, University of Melbourne, 32 Gisborne Street, East Melbourne, VIC 3002, Australia
    Hum Genet 117:249-57. 2005
    ..These findings provide evidence of a new autosomal dominant glaucoma locus on the short arm of chromosome 3...