Research Topics
Species | Cheryl M McCormickSummaryAffiliation: Brock University Country: Canada Publications
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Publications
HPA function in adolescence: role of sex hormones in its regulation and the enduring consequences of exposure to stressorsCheryl M McCormick
Behavioural Neuroscience, Center for Neuroscience and Department of Psychology, Brock University, St Catharines ON, Canada
Pharmacol Biochem Behav 86:220-33. 2007..However, the effects reported appear to be stressor-specific and sex-specific. Such research may contribute toward understanding the increased risk for drug abuse and psychopathology that occurs over adolescence in people...- Effects of chronic social stress in adolescence on anxiety and neuroendocrine response to mild stress in male and female ratsC M McCormick
Neuroscience Program, Brock University, St Catharines, ON, Canada L2S 3A1
Behav Brain Res 187:228-38. 2008..In sum, modest effects of adolescent social stress were observable several weeks after the stress exposure, indicating that sex-specific developmental trajectories and vulnerability to anxiety may be shaped by experiences in adolescence... - Individual differences in cortisol levels and performance on a test of executive function in men and womenC M McCormick
Neuroscience Program, Bates College, Lewiston, ME 04240, USA
Physiol Behav 91:87-94. 2007..Our results suggest that individual differences in cortisol levels among participants upon arrival to a test situation influence performance on a task involving the prefrontal cortex... - Locomotor activity to nicotine and Fos immunoreactivity in the paraventricular nucleus of the hypothalamus in adolescent socially-stressed ratsCheryl M McCormick
Centre for Neuroscience, Brock University, St Catharines ON, Canada L2S 3A1
Pharmacol Biochem Behav 86:92-102. 2007..These results add to evidence that adolescents are uniquely vulnerable to stressors due to ongoing brain development, and also indicate that effects are sex- and stressor-specific... - Social instability in adolescence alters the central and peripheral hypothalamic-pituitary-adrenal responses to a repeated homotypic stressor in male and female ratsC M McCormick
Neuroscience Program, Brock University, St Catharines, Ontario, Canada
J Neuroendocrinol 19:116-26. 2007..The resultant increase in exposure to glucocorticoids over adolescence may alter ongoing brain development and increase vulnerability to psychopathology... - Long-lasting, sex- and age-specific effects of social stressors on corticosterone responses to restraint and on locomotor responses to psychostimulants in ratsCheryl M McCormick
Neuroscience Program, Bates College, Lewiston, ME, USA
Horm Behav 48:64-74. 2005..However, in terms of behavioral sensitivity to drugs of abuse, females may be more susceptible to stressors during adolescence than adulthood, although the reverse appears to be true for HPA function... - Stress during adolescence enhances locomotor sensitization to nicotine in adulthood in female, but not male, ratsCheryl M McCormick
Neuroscience Program, Bates College, Lewiston, ME 04240, USA
Horm Behav 46:458-66. 2004..Thus, during adolescence, social stressors can have long-lasting effects, and the effects appear to differ for males and females... 
Motivational and situational factors and the relationship between testosterone dynamics and human aggression during competitionJustin M Carré
Department of Psychology, Brock University, Canada
Biol Psychol 84:346-53. 2010..These results indicate that costly aggressive behaviour is intrinsically rewarding, perhaps to regulate future interactions, and that testosterone may be a physiological marker of such reward value...- An animal model of social instability stress in adolescence and risk for drugs of abuseCheryl M McCormick
Canada Research Chair in Behavioural Neuroscience, Department of Psychology and Centre for Neuroscience, Brock University, St Catharines, ON, Canada
Physiol Behav 99:194-203. 2010..Elevated exposure to glucocorticoids over the course of adolescence confers sex-specific changes in behavioural responses to drugs of abuse, which may be of relevance for understanding risk factors in people... - Changes in hyporesponsiveness to acute amphetamine and age differences in tyrosine hydroxylase immunoreactivity in the brain over adolescence in male and female ratsIva Z Mathews
Department of Psychology and Neuroscience Program, Brock University, St Catharines, Ontario, Canada L2S 3A1
Dev Psychobiol 51:417-28. 2009..Thus, adolescents may have an increased threshold of behavioral activation that can be overcome with either a higher dose or with repeated amphetamine treatment, and may be related to changes in the dopamine system over development... - Increased depressive behaviour in females and heightened corticosterone release in males to swim stress after adolescent social stress in ratsIva Z Mathews
Psychology Department, Brock University, 500 Glenridge Avenue, St Catharines, Ontario, Canada
Behav Brain Res 190:33-40. 2008.... - Female and male rats in late adolescence differ from adults in amphetamine-induced locomotor activity, but not in conditioned place preference for amphetamineIva Z Mathews
Department of Psychology, Brock University, St Catharines, Ontario, Canada
Behav Pharmacol 18:641-50. 2007..These data suggest that differences in neural systems underlying some behavioural responses to amphetamine continue to mature postpubertally into late adolescence in a sex-specific manner... - Testosterone responses to competition predict future aggressive behaviour at a cost to reward in menJustin M Carré
Psychology Department, Brock University, St Catharines, Ontario, Canada
Psychoneuroendocrinology 34:561-70. 2009..These findings suggest that situational changes in testosterone concentrations modulate future aggressive behaviour in men... - Estimating aggression from emotionally neutral faces: which facial cues are diagnostic?Justin M Carré
Department of Psychology, Brock University, St Catharines, Ontario L2S 3A1, Canada
Perception 39:356-77. 2010..Together, these experiments suggest that the facial width-to-height ratio is an honest signal of propensity for aggressive behaviour... - Social instability stress in adolescent male rats alters hippocampal neurogenesis and produces deficits in spatial location memory in adulthoodCheryl M McCormick
Department of Psychology, Brock University, St Catharines, Ontario, Canada
Hippocampus 22:1300-12. 2012.... - State, not trait, neuroendocrine function predicts costly reactive aggression in men after social exclusion and inclusionShawn N Geniole
Department of Psychology, Brock University, St Catharines, Ontario, Canada
Biol Psychol 87:137-45. 2011..4%, F(1,)(55)=3.53, p=0.07), but no significant effects were observed in either group alone. The findings add to evidence that individual differences in state neuroendocrine function map onto variability in human social behaviour... - Investigations of HPA function and the enduring consequences of stressors in adolescence in animal modelsCheryl M McCormick
Department of Psychology and Centre for Neuroscience, Brock University, St Catharines, ON, Canada
Brain Cogn 72:73-85. 2010..The effects of adolescent stress depend on a number of factors, including the age, gender, the duration of stress exposure, the type of stressor, and the time between stress exposure and testing... - Hippocampal cell proliferation and spatial memory performance after social instability stress in adolescence in female ratsCheryl M McCormick
Department of Psychology, Brock University, Canada
Behav Brain Res 208:23-9. 2010..The lasting memory reduction and reduced cell proliferation/survival in SS rats is consistent with the hypothesis that ongoing development of the hippocampus renders the adolescent particularly vulnerable to chronic social stress... 
Facing aggression: cues differ for female versus male facesShawn N Geniole
Department of Psychology, Brock University, St Catharines, Ontario, Canada
PLoS ONE 7:e30366. 2012..In contrast, all four variables are highly inter-correlated in male faces, likely because these cues in male faces serve as "honest signals"...- Peripheral and central sex steroids have differential effects on the HPA axis of male and female ratsCheryl M McCormick
Neuroscience Program, Department of Psychology, Bates College, Lewiston, Maine 04240, USA
Stress 5:235-47. 2002..The results suggest that sexual dimorphisms influence HPA function even when males and females are given equivalent physiological doses of gonadal steroids, and that the relevant sexual dimorphisms involve both the periphery and the CNS... - Role of medial prefrontal cortex dopamine in age differences in response to amphetamine in rats: locomotor activity after intra-mPFC injections of dopaminergic ligandsIva Z Mathews
Department of Psychology and Centre for Neuroscience, Brock University, St Catharines, Ontario L2S 3A1, Canada
Dev Neurobiol 72:1415-21. 2012..These results suggest that insufficient activation of mPFC D1 receptors may underlie the reduced activity at the low dose of amphetamine in early adolescent compared to adult rats... - Enduring deficits in contextual and auditory fear conditioning after adolescent, not adult, social instability stress in male ratsMark D Morrissey
Department of Psychology and Neuroscience Program, Brock University, St Catharines, ON, Canada
Neurobiol Learn Mem 95:46-56. 2011..Social instability stress in adulthood had no effect on any measure of fear conditioning. The results support the hypothesis that adolescence is a time of heightened vulnerability to stressors... - Adolescent development, hypothalamic-pituitary-adrenal function, and programming of adult learning and memoryCheryl M McCormick
Department of Psychology and Centre for Neuroscience, Brock University, St Catharines ON, Canada
Prog Neuropsychopharmacol Biol Psychiatry 34:756-65. 2010.... - Intermittent physical stress during early- and mid-adolescence differentially alters rats' anxiety- and depression-like behaviors in adulthoodMeaghan M Wilkin
Department of Psychology, Queen s University, 62 Arch Street, Kingston, ON, USA
Behav Neurosci 126:344-60. 2012..By contrast, stress in mid-adolescence might have more predominant effects on risk-taking behavior (indexed by increases in open-arm activity), a possibility that merits further investigation... - Aggressive behavior and change in salivary testosterone concentrations predict willingness to engage in a competitive taskJustin M Carré
Department of Psychology, Brock University, St Catharines ON, Canada
Horm Behav 54:403-9. 2008..02). These results indicate that situation-specific aggressive behavior and testosterone responsiveness are functionally relevant predictors of future social behavior... - Stress, depression, cortisol, and periodontal diseaseAmy E Rosania
Department of Psychology, Bates College, Lewiston, ME 04240, USA
J Periodontol 80:260-6. 2009..This cross-sectional pilot study explored the associations between psychologic factors, markers of periodontal disease, psychoneuroimmunologic variables, and behavior... - Chronic social stress in adolescence influenced both amphetamine conditioned place preference and locomotor sensitizationI Z Mathews
Department of Psychology, Brock University, 500 Glenridge Ave, St Catharines, ON, Canada
Dev Psychobiol 50:451-9. 2008.... - Facial structure is a reliable cue of aggressive behaviorJustin M Carré
Department of Psychology, Brock University, St Catharines, Ontario, Canada
Psychol Sci 20:1194-8. 2009..These findings suggest that the facial width-to-height ratio may be a cue used to predict propensity for aggression in others... - Individual differences in activity predict locomotor activity and conditioned place preference to amphetamine in both adolescent and adult ratsIva Z Mathews
Department of Psychology and Neuroscience Program, Brock University, St Catharines, ON, Canada
Pharmacol Biochem Behav 95:63-71. 2010..Thus, in contrast to enhanced psychostimulant sensitivity in high novelty-seekers, rats higher in general activity are less sensitive to amphetamine conditioned place preference... - In your face: facial metrics predict aggressive behaviour in the laboratory and in varsity and professional hockey playersJustin M Carré
Department of Psychology, Brock University, 500 Glenridge Avenue, St Catharines, Ontario, Canada L2S 3A1
Proc Biol Sci 275:2651-6. 2008..Together, these findings suggest that the sexually dimorphic facial width-to-height ratio may be an 'honest signal' of propensity for aggressive behaviour... - Effect of neonatal ovariectomy and estradiol treatment on corticosterone release in response to stress in the adult female ratCheryl M McCormick
Department of Psychology, Centre for Neurosciences, Brock University, Niagara Region, 500 Glenridge Avenue, St Catharines, Ont, Canada L2S 3A1
Stress 14:82-7. 2011..Thus, evidently there are organizational effects of the sex hormonal milieu of the neonatal female, although this is a modest effect compared to previous reports in males... - Low doses of amphetamine lead to immediate and lasting locomotor sensitization in adolescent, not adult, male ratsIva Z Mathews
Department of Psychology, Brock University, St Catharines, ON, Canada L2S3A1
Pharmacol Biochem Behav 97:640-6. 2011..The results suggest that the rapid adaptations to drug exposures in adolescence have greater consequences than identical treatment in adulthood, and highlight the unique vulnerability of adolescents to brief, low dose drug exposure... - Effects of neonatal corticosterone treatment on maze performance and HPA axis in juvenile ratsC M McCormick
Neuroscience Program and Department of Psychology, Bates College, Lewiston, ME 04240, USA
Physiol Behav 74:371-9. 2001..The results also suggest that there is a critical or sensitive period for corticosterone treatment in that early treatment was more effective than later treatment... - Neonatal isolation alters stress hormone and mesolimbic dopamine release in juvenile ratsCheryl M McCormick
Neuroscience Program and Department of Psychology, Bates College, Lewiston, ME 04240, USA
Pharmacol Biochem Behav 73:77-85. 2002..These data indicate that the effects of neonatal isolation persist postweaning and that the effects are most evident in response to stress as opposed to under baseline conditions... - Effects of prenatal protein malnutrition and neonatal stress on CNS responsivenessP Kehoe
Neuroscience Program, Trinity College, Hartford, CT, USA
Brain Res Dev Brain Res 132:23-31. 2001.... - Corticosterone release in response to repeated, short episodes of neonatal isolation: evidence of sensitizationC M McCormick
Neuroscience Program, Bates College, Lewiston, Maine 04240, USA
Int J Dev Neurosci 16:175-85. 1998..Thus, daily episodes of isolation potentiate the hypothalamic-pituitary-adrenal response to stress... - Sleep deprivation lowers reactive aggression and testosterone in menKimberly A Cote
Psychology Department, Brock University, St Catharines, Ontario, L2S 3A1, Canada
Biol Psychol 92:249-56. 2013..This is the first experimental study to demonstrate that sleep deprivation lowers reactive aggression in men. Testosterone, but not cortisol, played a role in the relationship between sleep and reactive aggression in men... - Deficits in male sexual behavior in adulthood after social instability stress in adolescence in ratsCheryl M McCormick
Department of Psychology, 500 Glenridge Ave, St Catharines, Ontario, Canada L2S 3A1
Horm Behav 63:5-12. 2013..The results suggest that developmental history contributes to individual differences in reproductive behavior, and that stress exposures in adolescence may be a factor in sexual sluggishness... - Caveats of chronic exogenous corticosterone treatments in adolescent rats and effects on anxiety-like and depressive behavior and hypothalamic-pituitary-adrenal (HPA) axis functionPatti Waters
Department of Psychology and Centre for Neuroscience, Brock University, St Catharines, Ontario, Canada
Biol Mood Anxiety Disord 1:4. 2011..abstract:.. - Acute corticosterone replacement reinstates performance on spatial and nonspatial memory tasks 3 months after adrenalectomy despite degeneration in the dentate gyrusC M McCormick
Department of Psychology, Bates College, Lewiston, Maine 04240, USA
Behav Neurosci 111:518-31. 1997..CORT did not affect INC and SHAM rats. Thus, the adverse effects of ADX on memory may not be due to damage in the dentate, and the effects of CORT replacement may operate outside the hippocampus... - Prenatal protein malnutrition in rats alters the c-Fos response of neurons in the anterior cingulate and medial prefrontal region to behavioral stressDouglas L Rosene
Department of Anatomy and Neurobiology, Boston University School of Medicine, Boston, MA 02118, USA
Nutr Neurosci 7:281-9. 2004..These results suggest that neurons in anterior cingulate and medial prefrontal regions respond excessively to restraint stress in prenatally malnourished rats... - 3alpha,5alpha-THP mediates progestins' effects to protect against adrenalectomy-induced cell death in the dentate gyrus of female and male ratsMadeline E Rhodes
Department of Psychology, University at Albany-SUNY, Social Science 220, 1400 Washington Avenue, Albany, NY 12222, USA
Pharmacol Biochem Behav 78:505-12. 2004..Together, these data suggest that progestins can protect against ADX-induced cell death and that the actions of the progesterone metabolite, 3alpha,5alpha-THP, may underlie these effects...