B Jeynes

Summary

Affiliation: Brock University
Country: Canada

Publications

  1. ncbi request reprint The possible role of capillary cerebral amyloid angiopathy in Alzheimer lesion development: a regional comparison
    Brian Jeynes
    Faculty of Applied Health Sciences, Department of Community Health Sciences, Brock University, St Catherines, ON, Canada, L2S 3A1
    Acta Neuropathol 112:417-27. 2006
  2. ncbi request reprint Evidence for altered LRP/RAGE expression in Alzheimer lesion pathogenesis
    B Jeynes
    Faculty of Applied Health Sciences, Brock University, St Catharine s, Ontario, Canada, L2S 3A1
    Curr Alzheimer Res 5:432-7. 2008
  3. doi request reprint Significant negative correlations between capillary expressed eNOS and Alzheimer lesion burden
    Brian Jeynes
    Faculty of Applied Health Sciences, Brock University, St Catharine s, Ontario, Canada
    Neurosci Lett 463:244-8. 2009
  4. doi request reprint The case for blood-brain barrier dysfunction in the pathogenesis of Alzheimer's disease
    Brian Jeynes
    Faculty of Applied Health Sciences, Brock University, St Catharine s, Ontario, Canada
    J Neurosci Res 89:22-8. 2011
  5. doi request reprint An investigation into the role of P-glycoprotein in Alzheimer's disease lesion pathogenesis
    Brian Jeynes
    Faculty of Applied Health Sciences, Brock University, St Catharine s, Ontario, Canada
    Neurosci Lett 487:389-93. 2011
  6. ncbi request reprint Neurofibrillary tangles and senile plaques in Alzheimer's brains are associated with reduced capillary expression of vascular endothelial growth factor and endothelial nitric oxide synthase
    John Provias
    Department of Pathology and Molecular Medicine Neuropathology, Hamilton Health Sciences, McMaster University, Ontario, Canada
    Curr Neurovasc Res 5:199-205. 2008
  7. pmc Is femur length the key height component in risk prediction of type 2 diabetes among adults?
    Jian Liu
    Department of Community Health Sciences, Brock University, St Catherines, Ontario, Canada
    Diabetes Care 32:739-40. 2009
  8. ncbi request reprint Correlation analysis of capillary APOE, VEGF and eNOS expression in Alzheimer brains
    John Provias
    Department of Pathology and Molecular Medicine Neuropathology, Hamilton Health Sciences, McMaster University, Hamilton, Ontario, Canada
    Curr Alzheimer Res 8:197-202. 2011

Collaborators

Detail Information

Publications8

  1. ncbi request reprint The possible role of capillary cerebral amyloid angiopathy in Alzheimer lesion development: a regional comparison
    Brian Jeynes
    Faculty of Applied Health Sciences, Department of Community Health Sciences, Brock University, St Catherines, ON, Canada, L2S 3A1
    Acta Neuropathol 112:417-27. 2006
    ..The data are also consistent with the concept that a focally dysfunctional blood-brain barrier (BBB) that is unable to regulate the influx/efflux of neurotoxic amyloid peptides may participate in the pathogenesis of AD lesions...
  2. ncbi request reprint Evidence for altered LRP/RAGE expression in Alzheimer lesion pathogenesis
    B Jeynes
    Faculty of Applied Health Sciences, Brock University, St Catharine s, Ontario, Canada, L2S 3A1
    Curr Alzheimer Res 5:432-7. 2008
    ..001]. These results suggest that alterations in the LRP-1 and RAGE mediated transport of Abeta take place in AD brains in lesion prone regions and may therefore contribute to SP lesion pathogenesis...
  3. doi request reprint Significant negative correlations between capillary expressed eNOS and Alzheimer lesion burden
    Brian Jeynes
    Faculty of Applied Health Sciences, Brock University, St Catharine s, Ontario, Canada
    Neurosci Lett 463:244-8. 2009
    ..Our results support the view that eNOS activity should be targeted for further investigation, and that factors involved in the regulation of NO production may be amenable to therapeutic intervention...
  4. doi request reprint The case for blood-brain barrier dysfunction in the pathogenesis of Alzheimer's disease
    Brian Jeynes
    Faculty of Applied Health Sciences, Brock University, St Catharine s, Ontario, Canada
    J Neurosci Res 89:22-8. 2011
    ..By allowing the influx of injurious materials or agents into the brain or by impeding or blocking the efflux of those materials and/or agents, BBB-related neuronopathies and their associated sequelae could, and do, ensue...
  5. doi request reprint An investigation into the role of P-glycoprotein in Alzheimer's disease lesion pathogenesis
    Brian Jeynes
    Faculty of Applied Health Sciences, Brock University, St Catharine s, Ontario, Canada
    Neurosci Lett 487:389-93. 2011
    ..These results also suggest that the levels of capillary P-gp may contribute to AD lesion development and that the role of P-gp is associated with that of LRP and RAGE...
  6. ncbi request reprint Neurofibrillary tangles and senile plaques in Alzheimer's brains are associated with reduced capillary expression of vascular endothelial growth factor and endothelial nitric oxide synthase
    John Provias
    Department of Pathology and Molecular Medicine Neuropathology, Hamilton Health Sciences, McMaster University, Ontario, Canada
    Curr Neurovasc Res 5:199-205. 2008
    ..01].These results suggest that diminished VEGF and eNOS activity in particularly lesion prone regions of AD brains may contribute to the pathogenesis of NFT and / or SP lesions...
  7. pmc Is femur length the key height component in risk prediction of type 2 diabetes among adults?
    Jian Liu
    Department of Community Health Sciences, Brock University, St Catherines, Ontario, Canada
    Diabetes Care 32:739-40. 2009
    ..To examine the diabetes risk association with femur length, standing height, and height without femur length (HWFL) (HWFL = standing height--femur length)...
  8. ncbi request reprint Correlation analysis of capillary APOE, VEGF and eNOS expression in Alzheimer brains
    John Provias
    Department of Pathology and Molecular Medicine Neuropathology, Hamilton Health Sciences, McMaster University, Hamilton, Ontario, Canada
    Curr Alzheimer Res 8:197-202. 2011
    ..The specific interrelationship between APOE, VEGF and eNOS activity at the BBB requires further investigation...