H L Holland

Summary

Affiliation: Brock University
Country: Canada

Publications

  1. ncbi request reprint Microbial transformations
    H L Holland
    Department of Chemistry, Brock University, St Catharines, ON L2S 3A1, Canada
    Curr Opin Chem Biol 2:77-84. 1998
  2. ncbi request reprint Microbial hydroxylation of acetylaminosteroids
    H L Holland
    Department of Chemistry, Brock University, St Catharines, Ontario, Canada
    Steroids 63:484-95. 1998
  3. ncbi request reprint C-H activation
    H L Holland
    Department of Chemistry, Brock University, Saint Catharines Ontario L2S3A1, Canada
    Curr Opin Chem Biol 3:22-7. 1999
  4. ncbi request reprint Enantioselective synthesis and pharmacological evaluation of a new type of verapamil analog with hypotensive and calcium antagonist activities
    H L Holland
    Department of Chemistry, Brock University, St Catharines, Ontario, Canada
    Pharm Res 16:281-7. 1999
  5. ncbi request reprint Recent advances in applied and mechanistic aspects of the enzymatic hydroxylation of steroids by whole-cell biocatalysts
    H L Holland
    Department of Chemistry, Brock University, St Catharines, ON, Canada
    Steroids 64:178-86. 1999
  6. ncbi request reprint Biotransformation of beta-ketosulfides to produce chiral beta-hydroxysulfoxides
    H L Holland
    Department of Chemistry, Brock University, ON L2S 3A1, St Catharines, Canada
    J Ind Microbiol Biotechnol 30:292-301. 2003
  7. ncbi request reprint Biotransformation of organic sulfides--IV. Formation of chiral benzyl alkyl and phenyl alkyl sulfoxides by Helminthosporium species NRRL 4671
    H L Holland
    Department of Chemistry, Brock University, St Catharines, Ontario, Canada
    Bioorg Med Chem 2:647-52. 1994
  8. ncbi request reprint Fungal biotransformation of organophosphines
    H L Holland
    Department of Chemistry, Brock University, St Catharines, Ontario, Canada
    Xenobiotica 23:519-24. 1993
  9. ncbi request reprint Enzymatic hydroxylation reactions
    H L Holland
    Department of Chemistry, Brock University, St Catherines, ON L2S 3A1, Canada
    Curr Opin Biotechnol 11:547-53. 2000

Detail Information

Publications9

  1. ncbi request reprint Microbial transformations
    H L Holland
    Department of Chemistry, Brock University, St Catharines, ON L2S 3A1, Canada
    Curr Opin Chem Biol 2:77-84. 1998
    ..Methodological development such as the application of novel immobilisation techniques or the use of non-aqueous solvents continues to enhance the usefulness of microbial biocatalysts...
  2. ncbi request reprint Microbial hydroxylation of acetylaminosteroids
    H L Holland
    Department of Chemistry, Brock University, St Catharines, Ontario, Canada
    Steroids 63:484-95. 1998
    ....
  3. ncbi request reprint C-H activation
    H L Holland
    Department of Chemistry, Brock University, Saint Catharines Ontario L2S3A1, Canada
    Curr Opin Chem Biol 3:22-7. 1999
    ....
  4. ncbi request reprint Enantioselective synthesis and pharmacological evaluation of a new type of verapamil analog with hypotensive and calcium antagonist activities
    H L Holland
    Department of Chemistry, Brock University, St Catharines, Ontario, Canada
    Pharm Res 16:281-7. 1999
    ..The syntheses and evaluation for cardiovascular activity in the rat of both enantiomers of a verapamil analog in which the cyano group has been replaced by hydroxyl...
  5. ncbi request reprint Recent advances in applied and mechanistic aspects of the enzymatic hydroxylation of steroids by whole-cell biocatalysts
    H L Holland
    Department of Chemistry, Brock University, St Catharines, ON, Canada
    Steroids 64:178-86. 1999
    ..Mechanistic factors that control the regiochemistry and stereochemistry of steroid hydroxylation are also discussed...
  6. ncbi request reprint Biotransformation of beta-ketosulfides to produce chiral beta-hydroxysulfoxides
    H L Holland
    Department of Chemistry, Brock University, ON L2S 3A1, St Catharines, Canada
    J Ind Microbiol Biotechnol 30:292-301. 2003
    ..Fungal biotransformations using Helminthosporium sp. and M. isabellina resulted in the opposite sulfoxide configurations of various beta-hydroxysulfoxide products...
  7. ncbi request reprint Biotransformation of organic sulfides--IV. Formation of chiral benzyl alkyl and phenyl alkyl sulfoxides by Helminthosporium species NRRL 4671
    H L Holland
    Department of Chemistry, Brock University, St Catharines, Ontario, Canada
    Bioorg Med Chem 2:647-52. 1994
    ..The data so obtained have been used to define the preparatively useful limits of S-oxidation of phenyl alkyl sulfides and benzyl alkyl sulfides by biotransformation using Helminthosporium...
  8. ncbi request reprint Fungal biotransformation of organophosphines
    H L Holland
    Department of Chemistry, Brock University, St Catharines, Ontario, Canada
    Xenobiotica 23:519-24. 1993
    ..4. Incubation of ethylmethylphenyl phosphine with M. isabellina gave the corresponding S(-) phosphine oxide in a 92% yield with an enantiomeric purity of 13%...
  9. ncbi request reprint Enzymatic hydroxylation reactions
    H L Holland
    Department of Chemistry, Brock University, St Catherines, ON L2S 3A1, Canada
    Curr Opin Biotechnol 11:547-53. 2000
    ....