Research Topics
Genomes and GenesSpecies | Jeffrey AtkinsonSummaryAffiliation: Brock University Country: Canada Publications
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Publications
Tocopherols and tocotrienols in membranes: a critical reviewJeffrey Atkinson
Department of Chemistry and Centre for Biotechnology, Brock University, 500 Glenridge Avenue, St Catharines, Ontario, Canada
Free Radic Biol Med 44:739-64. 2008..We hope that it will assist researchers when designing new experiments and when critically assessing the results, in turn providing a more thorough understanding of the biochemistry of tocols...- The location and behavior of alpha-tocopherol in membranesJeffrey Atkinson
Department of Chemistry, Brock University, St Catharines, Ont, Canada
Mol Nutr Food Res 54:641-51. 2010..Physical methodologies are then described to elucidate the nature of the interaction of alpha-tocopherol with PUFA and to establish that the vitamin and PUFA-containing phospholipids co-localize in non-raft domains... - Fluorescent tocopherols as probes of inter-vesicular transfer catalyzed by the alpha-tocopherol transfer proteinJeffrey K Atkinson
Department of Chemistry and Centre for Biotechnology, Brock University, St Catharines, Ontario, Canada
Ann N Y Acad Sci 1031:324-7. 2004..The presence of hTTP substantially increases the rate of AO-alpha-tocopherol transfer over the uncatalyzed spontaneous rate... - The contribution of surface residues to membrane binding and ligand transfer by the ?-tocopherol transfer protein (?-TTP)Wen Xiao Zhang
Department of Chemistry, Brock University, St Catharines, Ontario, Canada L2S3A1
J Mol Biol 405:972-88. 2011..Mutation of selected basic residues (R192H, K211A, and K217A) had little effect on transfer rates, indicating no significant involvement of nonspecific electrostatic interactions with membranes... - Preparation of fluorescent tocopherols for use in protein binding and localization with the alpha-tocopherol transfer proteinPhillip Nava
Department of Chemistry and Centre for Biotechnology, Brock University, St. Catharines, Ont, Canada L2S 3A1
Bioorg Med Chem 14:3721-36. 2006..Thus, compounds have been prepared that allow the investigation of the rate of alpha-TTP-mediated inter-membrane transfer of alpha-tocopherol and to investigate the mechanism of alpha-TTP function at membranes of different composition... - Ligand specificity in the CRAL-TRIO protein familyCandace Panagabko
Department of Chemistry and Centre for Biotechnology, Brock University, St. Catharines, Ontario, Canada, L2S 3A1
Biochemistry 42:6467-74. 2003..Further, ligand promiscuity observed within this family suggests that caution should be exercised when suggesting protein function(s) from measurements utilizing a single ligand... - Molecular determinants of heritable vitamin E deficiencySamantha Morley
Department of Chemistry and Centre for Biotechnology, Brock University, St Catharines, Ontario, Canada, L2S 3A1
Biochemistry 43:4143-9. 2004..These findings suggest the possibility that the AVED syndrome may not arise from an inability of TTP to bind or to transfer alpha tocopherol, but rather from defects in other activities of the protein... - Inhibition of oxidative metabolism of tocopherols with omega-N-heterocyclic derivatives of vitamin EStephan Ohnmacht
Department of Chemistry and Centre for Biotechnology, Brock University, 500 Glenridge Avenue, St Catharines, Ont, Canada L2S 3A1
Bioorg Med Chem 16:7631-8. 2008..05). Thus, 1 may be a useful adjuvant to the therapeutic use of non-alpha-tocopherols... - Effect of bilayer phospholipid composition and curvature on ligand transfer by the alpha-tocopherol transfer proteinWen Xiao Zhang
Department of Chemistry, Centre for Biotechnology, Brock University, 500 Glenridge Ave, St Catharines, ON L2S 3A1, Canada
Lipids 44:631-41. 2009..These results point to hydrophobic features of alpha-TTP dominating the binding energy between protein and membrane... - Synthesis and characterization of BODIPY-alpha-tocopherol: a fluorescent form of vitamin ERyan West
Department of Chemistry and Centre for Biotechnology, Brock University, St Catharines, Ontario, Canada L2S 3A1
J Org Chem 75:2883-92. 2010.... - Assignment of the 1H and 13C NMR of tocotrienolsStephan Ohnmacht
Department of Chemistry and Centre for Biotechnology, Brock University, St Catharines, Ontario, L2S 3A1, Canada
Magn Reson Chem 46:287-94. 2008..Herein we report multidimensional NMR data (HSQC, COSY, ADEQUATE(1,1), C--H HMBC, and NOESY) that have allowed us to assign the identity of almost all the resonances for alpha-, beta-, gamma-, and delta-tocotrienol... - Expression and refolding of recombinant human alpha-tocopherol transfer protein capable of specific alpha-tocopherol bindingCandace Panagabko
Department of Chemistry and Centre for Biotechnology, Brock University, St. Catharines, Ontario, Canada
Protein Expr Purif 24:395-403. 2002..The resulting purification scheme provides recombinant alpha-TTP in good yield and purity for investigation of both its structure and its binding affinities for different ligands including natural and synthetic tocols... - Preparation and biological assessment of hydroxycinnamic acid amides of polyaminesSolomon Fixon-Owoo
Department of Chemistry, Brock University, St.Catharines, L2S3A1, Ontario, Canada
Phytochemistry 63:315-34. 2003..We conclude from this work that while the coumaric acid polyamine conjugates are active when directly applied to neuroreceptors, they show no overt toxicity when ingested by insect larvae...