Spencer K Watson

Summary

Affiliation: British Columbia
Country: Canada

Publications

  1. pmc Large fragment Bst DNA polymerase for whole genome amplification of DNA from formalin-fixed paraffin-embedded tissues
    Sarit Aviel-Ronen
    Department of Pathology, University Health Network, 200 Elisabeth Street, Toronto, ON M5G 2C4, Canada
    BMC Genomics 7:312. 2006
  2. pmc Methods for high throughput validation of amplified fragment pools of BAC DNA for constructing high resolution CGH arrays
    Spencer K Watson
    Department of Cancer Genetics and Developmental Biology, BC Cancer Agency, 601 W, 10th Ave, Vancouver, BC, V5Z 1L3 Canada
    BMC Genomics 5:6. 2004
  3. ncbi request reprint Cytogenetically balanced translocations are associated with focal copy number alterations
    Spencer K Watson
    Cancer Genetics and Developmental Biology, British Columbia Cancer Research Centre, 675 West 10th Avenue, Vancouver, BC, Canada
    Hum Genet 120:795-805. 2007
  4. doi request reprint Minimum altered regions in early prostate cancer progression identified by high resolution whole genome tiling path BAC array comparative hybridization
    Spencer K Watson
    Department of Cancer Genetics and Developmental Biology, Vancouver, British Columbia, Canada
    Prostate 69:961-75. 2009
  5. ncbi request reprint A tiling resolution DNA microarray with complete coverage of the human genome
    Adrian S Ishkanian
    British Columbia Cancer Research Centre, 601 West 10th Avenue, Vancouver, British Columbia V5Z 1L3, Canada
    Nat Genet 36:299-303. 2004
  6. ncbi request reprint Skewed X-chromosome inactivation is associated with primary but not secondary ovarian failure
    Karla L Bretherick
    Department of Medical Genetics, University of British Columbia, Vancouver, British Columbia, Canada
    Am J Med Genet A 143:945-51. 2007
  7. ncbi request reprint An integrated mBAND and submegabase resolution tiling set (SMRT) CGH array analysis of focal amplification, microdeletions, and ladder structures consistent with breakage-fusion-bridge cycle events in osteosarcoma
    Gloria Lim
    Department of Laboratory Medicine and Pathobiology, University of Toronto, Toronto, Ontario, Canada
    Genes Chromosomes Cancer 42:392-403. 2005

Collaborators

Detail Information

Publications7

  1. pmc Large fragment Bst DNA polymerase for whole genome amplification of DNA from formalin-fixed paraffin-embedded tissues
    Sarit Aviel-Ronen
    Department of Pathology, University Health Network, 200 Elisabeth Street, Toronto, ON M5G 2C4, Canada
    BMC Genomics 7:312. 2006
    ..To date, MDA has been feasible only for genomic DNA isolated from fresh or snap-frozen tissue, and yields a representational distortion of less than threefold...
  2. pmc Methods for high throughput validation of amplified fragment pools of BAC DNA for constructing high resolution CGH arrays
    Spencer K Watson
    Department of Cancer Genetics and Developmental Biology, BC Cancer Agency, 601 W, 10th Ave, Vancouver, BC, V5Z 1L3 Canada
    BMC Genomics 5:6. 2004
    ..The AFP sequencing technique described in this study is a novel method designed to verify the identity of array spotting solution in a high throughput manner...
  3. ncbi request reprint Cytogenetically balanced translocations are associated with focal copy number alterations
    Spencer K Watson
    Cancer Genetics and Developmental Biology, British Columbia Cancer Research Centre, 675 West 10th Avenue, Vancouver, BC, Canada
    Hum Genet 120:795-805. 2007
    ..Our results reveal that imperfectly balanced translocations in tumor genomes are a phenomenon that occurs at frequencies much higher than previously demonstrated...
  4. doi request reprint Minimum altered regions in early prostate cancer progression identified by high resolution whole genome tiling path BAC array comparative hybridization
    Spencer K Watson
    Department of Cancer Genetics and Developmental Biology, Vancouver, British Columbia, Canada
    Prostate 69:961-75. 2009
    ..Carcinoma of the prostate (CaP) is a serious health problem. The altered molecular mechanisms that lead to this disease are poorly understood...
  5. ncbi request reprint A tiling resolution DNA microarray with complete coverage of the human genome
    Adrian S Ishkanian
    British Columbia Cancer Research Centre, 601 West 10th Avenue, Vancouver, British Columbia V5Z 1L3, Canada
    Nat Genet 36:299-303. 2004
    ..Our submegabase resolution tiling set for array CGH (SMRT array) allows comprehensive assessment of genomic integrity and thereby the identification of new genes associated with disease...
  6. ncbi request reprint Skewed X-chromosome inactivation is associated with primary but not secondary ovarian failure
    Karla L Bretherick
    Department of Medical Genetics, University of British Columbia, Vancouver, British Columbia, Canada
    Am J Med Genet A 143:945-51. 2007
    ..X-chromosome abnormalities undetectable by array, or reduced follicular pool due to an early trisomic rescue event, may explain the skewed XCI observed in POF patients presenting with primary amenorrhea...
  7. ncbi request reprint An integrated mBAND and submegabase resolution tiling set (SMRT) CGH array analysis of focal amplification, microdeletions, and ladder structures consistent with breakage-fusion-bridge cycle events in osteosarcoma
    Gloria Lim
    Department of Laboratory Medicine and Pathobiology, University of Toronto, Toronto, Ontario, Canada
    Genes Chromosomes Cancer 42:392-403. 2005
    ..In summary, this study has provided further support for the role of the BFB mechanism and fragile sites in facilitating gene amplification and chromosomal rearrangement in OS...