Gulisa Turashvili

Summary

Affiliation: British Columbia
Country: Canada

Publications

  1. ncbi Differentiation of tumours of ductal and lobular origin: II. Genomics of invasive ductal and lobular breast carcinomas
    Gulisa Turashvili
    Laboratory of Molecular Pathology and Institute of Pathology, Palacky University, Hnevotinska 3, Olomouc, 77515, Czech Republic
    Biomed Pap Med Fac Univ Palacky Olomouc Czech Repub 149:63-8. 2005
  2. doi Nucleic acid quantity and quality from paraffin blocks: defining optimal fixation, processing and DNA/RNA extraction techniques
    Gulisa Turashvili
    The Centre of Translation and Applied Genomics, BC Cancer Agency, Provincial Health Services Authority, Vancouver, BC, Canada V5Z 4E6
    Exp Mol Pathol 92:33-43. 2012
  3. pmc Human mammary cancer progression model recapitulates methylation events associated with breast premalignancy
    Nancy Dumont
    Department of Pathology and Comprehensive Cancer Center, University of California at San Francisco, 513 Parnassus Avenue, San Francisco, California, 94143 0511, USA
    Breast Cancer Res 11:R87. 2009
  4. pmc Inter-observer reproducibility of HER2 immunohistochemical assessment and concordance with fluorescent in situ hybridization (FISH): pathologist assessment compared to quantitative image analysis
    Gulisa Turashvili
    Molecular Oncology and Breast Cancer Program, British Columbia Cancer Research Centre, Vancouver, BC, Canada
    BMC Cancer 9:165. 2009
  5. doi Are columnar cell lesions the earliest histologically detectable non-obligate precursor of breast cancer?
    Gulisa Turashvili
    Molecular Oncology and Breast Cancer Program, BC Cancer Research Centre, 675 W 10th Avenue, V5Z 1L3 Vancouver, British Columbia, Canada
    Virchows Arch 452:589-98. 2008
  6. doi The clonal and mutational evolution spectrum of primary triple-negative breast cancers
    Sohrab P Shah
    Department of Pathology and Laboratory Medicine, University of British Columbia, Vancouver, British Columbia V6T 2B5, Canada
    Nature 486:395-9. 2012
  7. pmc Integrative analysis of genome-wide loss of heterozygosity and monoallelic expression at nucleotide resolution reveals disrupted pathways in triple-negative breast cancer
    Gavin Ha
    Department of Molecular Oncology, British Columbia Cancer Agency, Vancouver, British Columbia V5Z 1L3, Canada
    Genome Res 22:1995-2007. 2012
  8. doi Insulin-like growth factor receptor (IGF-1R) in breast cancer subtypes
    Rinat Yerushalmi
    Division of Medical Oncology, BC Cancer Agency, Cancer Agency, 600 W 10th Avenue, Vancouver, BC V5Z 4E6, Canada
    Breast Cancer Res Treat 132:131-42. 2012
  9. doi Columnar cell lesions, mammographic density and breast cancer risk
    Gulisa Turashvili
    Molecular Oncology and Breast Cancer Program, BC Cancer Research Centre, 675 W 10th Avenue, Vancouver, Canada
    Breast Cancer Res Treat 115:561-71. 2009
  10. pmc Mll5 is required for normal spermatogenesis
    Damian B Yap
    Department of Molecular Oncology, British Columbia Cancer Research Centre, Vancouver, British Columbia, Canada
    PLoS ONE 6:e27127. 2011

Collaborators

Detail Information

Publications21

  1. ncbi Differentiation of tumours of ductal and lobular origin: II. Genomics of invasive ductal and lobular breast carcinomas
    Gulisa Turashvili
    Laboratory of Molecular Pathology and Institute of Pathology, Palacky University, Hnevotinska 3, Olomouc, 77515, Czech Republic
    Biomed Pap Med Fac Univ Palacky Olomouc Czech Repub 149:63-8. 2005
    ..However, future approaches will need to include methods for high throughput clinical validation and the ability to analyze microscopic samples...
  2. doi Nucleic acid quantity and quality from paraffin blocks: defining optimal fixation, processing and DNA/RNA extraction techniques
    Gulisa Turashvili
    The Centre of Translation and Applied Genomics, BC Cancer Agency, Provincial Health Services Authority, Vancouver, BC, Canada V5Z 4E6
    Exp Mol Pathol 92:33-43. 2012
    ....
  3. pmc Human mammary cancer progression model recapitulates methylation events associated with breast premalignancy
    Nancy Dumont
    Department of Pathology and Comprehensive Cancer Center, University of California at San Francisco, 513 Parnassus Avenue, San Francisco, California, 94143 0511, USA
    Breast Cancer Res 11:R87. 2009
    ....
  4. pmc Inter-observer reproducibility of HER2 immunohistochemical assessment and concordance with fluorescent in situ hybridization (FISH): pathologist assessment compared to quantitative image analysis
    Gulisa Turashvili
    Molecular Oncology and Breast Cancer Program, British Columbia Cancer Research Centre, Vancouver, BC, Canada
    BMC Cancer 9:165. 2009
    ..Our study compares HER2 scoring by histopathologists with automated quantitation of staining, and determines the concordance of IHC scores with FISH results...
  5. doi Are columnar cell lesions the earliest histologically detectable non-obligate precursor of breast cancer?
    Gulisa Turashvili
    Molecular Oncology and Breast Cancer Program, BC Cancer Research Centre, 675 W 10th Avenue, V5Z 1L3 Vancouver, British Columbia, Canada
    Virchows Arch 452:589-98. 2008
    ..The relationship and natural history of CCLs to invasive ductal carcinoma is enigmatic, but they may prove of clinical relevance when detected by screening mammography...
  6. doi The clonal and mutational evolution spectrum of primary triple-negative breast cancers
    Sohrab P Shah
    Department of Pathology and Laboratory Medicine, University of British Columbia, Vancouver, British Columbia V6T 2B5, Canada
    Nature 486:395-9. 2012
    ..Taken together, our results show that understanding the biology and therapeutic responses of patients with TNBC will require the determination of individual tumour clonal genotypes...
  7. pmc Integrative analysis of genome-wide loss of heterozygosity and monoallelic expression at nucleotide resolution reveals disrupted pathways in triple-negative breast cancer
    Gavin Ha
    Department of Molecular Oncology, British Columbia Cancer Agency, Vancouver, British Columbia V5Z 1L3, Canada
    Genome Res 22:1995-2007. 2012
    ..Finally, we show how inference of LOH can be used to interpret allele frequencies of somatic mutations and postulate on temporal ordering of mutations in the evolutionary history of these tumors...
  8. doi Insulin-like growth factor receptor (IGF-1R) in breast cancer subtypes
    Rinat Yerushalmi
    Division of Medical Oncology, BC Cancer Agency, Cancer Agency, 600 W 10th Avenue, Vancouver, BC V5Z 4E6, Canada
    Breast Cancer Res Treat 132:131-42. 2012
    ..Results may have relevance to the development of therapeutics targeting IGF-1R...
  9. doi Columnar cell lesions, mammographic density and breast cancer risk
    Gulisa Turashvili
    Molecular Oncology and Breast Cancer Program, BC Cancer Research Centre, 675 W 10th Avenue, Vancouver, Canada
    Breast Cancer Res Treat 115:561-71. 2009
    ..We hypothesized that CCLs may be related to breast composition, in particular breast density, in non-tumour containing breast tissue...
  10. pmc Mll5 is required for normal spermatogenesis
    Damian B Yap
    Department of Molecular Oncology, British Columbia Cancer Research Centre, Vancouver, British Columbia, Canada
    PLoS ONE 6:e27127. 2011
    ..Mll5 deficient male mice are infertile and here we analyse the consequences of Mll5 deficiency for spermatogenesis...
  11. pmc The testosterone-dependent and independent transcriptional networks in the hypothalamus of Gpr54 and Kiss1 knockout male mice are not fully equivalent
    Leah M Prentice
    Molecular Oncology and Breast Cancer Program, British Columbia Cancer Research Centre, 675 West 10th Avenue, Vancouver, BC, V5Z 1L3, Canada
    BMC Genomics 12:209. 2011
    ..The transcriptional networks regulated by these proteins in the hypothalamus have yet to be explored by genome-wide methods...
  12. pmc ARID1A mutations in endometriosis-associated ovarian carcinomas
    Kimberly C Wiegand
    British Columbia Cancer Agency, Vancouver, Canada
    N Engl J Med 363:1532-43. 2010
    ..Ovarian clear-cell and endometrioid carcinomas may arise from endometriosis, but the molecular events involved in this transformation have not been described...
  13. doi A method for quantifying normal human mammary epithelial stem cells with in vivo regenerative ability
    Peter Eirew
    Terry Fox Laboratory, British Columbia Cancer Agency, 675 West Tenth Avenue, Vancouver, British Columbia, Canada
    Nat Med 14:1384-9. 2008
    ..This new assay procedure sets the stage for investigations of mechanisms regulating normal human mammary stem cells (and possibly stem cells in other tissues) and their relationship to human cancer stem cell populations...
  14. doi P-cadherin expression as a prognostic biomarker in a 3992 case tissue microarray series of breast cancer
    Gulisa Turashvili
    Molecular Oncology Department, BC Cancer Research Centre, Vancouver, BC, Canada
    Mod Pathol 24:64-81. 2011
    ..P-cadherin positivity is associated with high-grade tumor subtypes and well-established markers of poor prognosis, and may represent a promising antibody therapeutic target...
  15. pmc JointSNVMix: a probabilistic model for accurate detection of somatic mutations in normal/tumour paired next-generation sequencing data
    Andrew Roth
    Department of Molecular Oncology, BC Cancer Agency, BC, Canada
    Bioinformatics 28:907-13. 2012
    ....
  16. doi Mutational evolution in a lobular breast tumour profiled at single nucleotide resolution
    Sohrab P Shah
    Molecular Oncology, BC Cancer Agency, 675 West 10th Avenue, Vancouver V5Z 1L3, Canada
    Nature 461:809-13. 2009
    ..Taken together, our data show that single nucleotide mutational heterogeneity can be a property of low or intermediate grade primary breast cancers and that significant evolution can occur with disease progression...
  17. ncbi A novel myoepithelial/progenitor cell marker in the breast?
    Zdenek Kolar
    Virchows Arch 450:607-9. 2007
  18. ncbi Novel immunohistochemical markers for the differentiation of lobular and ductal invasive breast carcinomas
    Gulisa Turashvili
    Laboratory of Molecular Pathology, Department of Pathology, Faculty of Medicine and Dentistry, Palacky University, Olomouc, Czech Republic
    Biomed Pap Med Fac Univ Palacky Olomouc Czech Repub 151:59-64. 2007
    ..The aim of our study was to identify the diagnostic usefulness of novel markers in the differentiation of these tumor types...
  19. pmc Novel markers for differentiation of lobular and ductal invasive breast carcinomas by laser microdissection and microarray analysis
    Gulisa Turashvili
    Laboratory of Molecular Pathology, Institute of Pathology, Palacky University, Olomouc, Czech Republic
    BMC Cancer 7:55. 2007
    ..The aim of our study was to identify gene expression profiles of IDC and ILC in relation to normal breast epithelial cells...
  20. ncbi Wnt signaling pathway in mammary gland development and carcinogenesis
    Gulisa Turashvili
    Laboratory of Molecular Pathology, Institute of Pathology, Palacky University, Olomouc, Czech Republic
    Pathobiology 73:213-23. 2006
    ..Further research is required to determine how Wnt signaling is involved in the development of different histological types of breast cancer and whether it promotes the viability of cancer stem cells or not...
  21. ncbi Differentiation of tumours of ductal and lobular origin: I. Proteomics of invasive ductal and lobular breast carcinomas
    Gulisa Turashvili
    Laboratory of Molecular Pathology and Institute of Pathology, Palacky University, Hnevotinska 3, Olomouc, 77515, Czech Republic
    Biomed Pap Med Fac Univ Palacky Olomouc Czech Repub 149:57-62. 2005
    ..1, a member of the NK-class of homeodomain, is highly restricted and is found primarily in lobular carcinoma. Some histological and immunohistochemical characteristics of pleomorphic lobular carcinoma are also discussed...