Art F Y Poon

Summary

Affiliation: British Columbia
Country: Canada

Publications

  1. ncbi Reconstructing the dynamics of HIV evolution within hosts from serial deep sequence data
    Art F Y Poon
    BC Centre for Excellence in HIV AIDS, Vancouver, British Columbia, Canada
    PLoS Comput Biol 8:e1002753. 2012
  2. ncbi Phylogenetic analysis of population-based and deep sequencing data to identify coevolving sites in the nef gene of HIV-1
    Art F Y Poon
    British Columbia Centre for Excellence in HIV AIDS, Vancouver, British Columbia, Canada
    Mol Biol Evol 27:819-32. 2010
  3. ncbi Dates of HIV infection can be estimated for seroprevalent patients by coalescent analysis of serial next-generation sequencing data
    Art F Y Poon
    BC Centre for Excellence in HIV AIDS, Vancouver, Canada
    AIDS 25:2019-26. 2011
  4. ncbi Factors influencing the sensitivity and specificity of conventional sequencing in human immunodeficiency virus type 1 tropism testing
    David J H F Knapp
    BC Centre for Excellence in HIV AIDS, Vancouver, British Columbia, Canada
    J Clin Microbiol 51:444-51. 2013
  5. ncbi In vitro selection of clinically relevant bevirimat resistance mutations revealed by "deep" sequencing of serially passaged, quasispecies-containing recombinant HIV-1
    David J H F Knapp
    BC Centre for Excellence in HIV AIDS, 603 1081 Burrard St, Vancouver, BC, Canada
    J Clin Microbiol 49:201-8. 2011
  6. ncbi Prolonged and substantial discordance in prevalence of raltegravir-resistant HIV-1 in plasma versus PBMC samples revealed by 454 "deep" sequencing
    Guinevere Q Lee
    BC Centre for Excellence in HIV AIDS, Vancouver, BC, Canada
    PLoS ONE 7:e46181. 2012
  7. ncbi Silent mutations are selected in HIV-1 reverse transcriptase and affect enzymatic efficiency
    P Richard Harrigan
    BC Centre for Excellence in HIV AIDS, Vancouver, British Columbia, Canada
    AIDS 22:2501-8. 2008
  8. ncbi Transmitted drug resistance in the CFAR network of integrated clinical systems cohort: prevalence and effects on pre-therapy CD4 and viral load
    Art F Y Poon
    BC Centre for Excellence in HIV AIDS, Vancouver, British Columbia, Canada
    PLoS ONE 6:e21189. 2011
  9. ncbi Compensatory mutations are repeatable and clustered within proteins
    Brad H Davis
    Department of Zoology, University of British Columbia, Vancouver, British Columbia, Canada V6T 1Z4
    Proc Biol Sci 276:1823-7. 2009

Collaborators

Detail Information

Publications9

  1. ncbi Reconstructing the dynamics of HIV evolution within hosts from serial deep sequence data
    Art F Y Poon
    BC Centre for Excellence in HIV AIDS, Vancouver, British Columbia, Canada
    PLoS Comput Biol 8:e1002753. 2012
    ..We observed highly patient-specific distributions and time-scales of mutation accumulation, implying that the role of a fitness valley is contingent on the genotype of the transmitted variant...
  2. ncbi Phylogenetic analysis of population-based and deep sequencing data to identify coevolving sites in the nef gene of HIV-1
    Art F Y Poon
    British Columbia Centre for Excellence in HIV AIDS, Vancouver, British Columbia, Canada
    Mol Biol Evol 27:819-32. 2010
    ..Phylogenetic reconstruction from these data revealed correlated substitutions at Y120/Q125 or N157/S169 repeated across multiple lineages in every host, indicating convergent within-host evolution shaped by epistatic interactions...
  3. ncbi Dates of HIV infection can be estimated for seroprevalent patients by coalescent analysis of serial next-generation sequencing data
    Art F Y Poon
    BC Centre for Excellence in HIV AIDS, Vancouver, Canada
    AIDS 25:2019-26. 2011
    ..To reconstruct dates of HIV infection by the coalescent analysis of longitudinal next-generation sequencing (NGS) data...
  4. ncbi Factors influencing the sensitivity and specificity of conventional sequencing in human immunodeficiency virus type 1 tropism testing
    David J H F Knapp
    BC Centre for Excellence in HIV AIDS, Vancouver, British Columbia, Canada
    J Clin Microbiol 51:444-51. 2013
    ..75; P << 0.001); however, concordance in tropism inference was only 83%. Input copy number and PCR replication are important factors in minority species detection in samples with significant heterogeneity...
  5. ncbi In vitro selection of clinically relevant bevirimat resistance mutations revealed by "deep" sequencing of serially passaged, quasispecies-containing recombinant HIV-1
    David J H F Knapp
    BC Centre for Excellence in HIV AIDS, 603 1081 Burrard St, Vancouver, BC, Canada
    J Clin Microbiol 49:201-8. 2011
    ....
  6. ncbi Prolonged and substantial discordance in prevalence of raltegravir-resistant HIV-1 in plasma versus PBMC samples revealed by 454 "deep" sequencing
    Guinevere Q Lee
    BC Centre for Excellence in HIV AIDS, Vancouver, BC, Canada
    PLoS ONE 7:e46181. 2012
    ..Overall, our observations suggested that plasma and PBMC hosted drastically different HIV-1 populations even after a prolonged exposure to raltegravir selection pressure...
  7. ncbi Silent mutations are selected in HIV-1 reverse transcriptase and affect enzymatic efficiency
    P Richard Harrigan
    BC Centre for Excellence in HIV AIDS, Vancouver, British Columbia, Canada
    AIDS 22:2501-8. 2008
    ..Missense mutations in HIV-1 reverse transcriptase are frequently selected in response to therapy; we examined whether silent mutations were also selected for by HIV therapy...
  8. ncbi Transmitted drug resistance in the CFAR network of integrated clinical systems cohort: prevalence and effects on pre-therapy CD4 and viral load
    Art F Y Poon
    BC Centre for Excellence in HIV AIDS, Vancouver, British Columbia, Canada
    PLoS ONE 6:e21189. 2011
    ....
  9. ncbi Compensatory mutations are repeatable and clustered within proteins
    Brad H Davis
    Department of Zoology, University of British Columbia, Vancouver, British Columbia, Canada V6T 1Z4
    Proc Biol Sci 276:1823-7. 2009
    ..These results suggest that compensatory evolution at the protein level is partially predictable and may be convergent...