Research Topics
| Qin OuyangSummaryAffiliation: British Columbia Country: Canada Publications
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Detail Information
Publications
Age-associated accumulation of CMV-specific CD8+ T cells expressing the inhibitory killer cell lectin-like receptor G1 (KLRG1)Qin Ouyang
Section for Transplantation Immunology and Immunohematology, University of Tubingen, Germany
Exp Gerontol 38:911-20. 2003..The presence of clonal expansions of such virus-specific cells may shrink the available repertoire for other antigens and contribute to the increased incidence of infectious disease in the elderly...- Large numbers of dysfunctional CD8+ T lymphocytes bearing receptors for a single dominant CMV epitope in the very oldQin Ouyang
Tuebingen Ageing and Tumour Immunology Group, Section for Transplantation Immunology and Immunohematology, University of Tubingen, Tubingen, Germany
J Clin Immunol 23:247-57. 2003.... - Dysfunctional CMV-specific CD8(+) T cells accumulate in the elderlyQin Ouyang
Tubingen Ageing and Tumour Immunology Group, Section for Transplantation Immunology and Immunohematology, University of Tubingen, Tubingen, Germany
Exp Gerontol 39:607-13. 2004..This might account for the increased incidence of many infectious diseases in the elderly... - Compromised interferon gamma (IFN-gamma) production in the elderly to both acute and latent viral antigen stimulation: contribution to the immune risk phenotype?Qin Ouyang
Tubingen Ageing and Tumour Immunology Group, Section for Transplantation Immunology and Immunohaematology, Center for Medical Research, ZMF, University of Tubingen, Germany
Eur Cytokine Netw 13:392-4. 2002..Further longitudinal studies are needed to demonstrate whether cytokines such as IFN-g are also part of the IRP. Improving the definition of the IRP will help to understand and thus prevent or reverse age-associated immune dysfunction... - Development of an MHC-class I peptide selection assay combining nanoparticle technology and matrix-assisted laser desorption/ionisation mass spectrometryThomas Flad
Section for Transplantation Immunology and Immunohematology, University of Tuebingen, Germany
J Immunol Methods 283:205-13. 2003..The advantage of the system is that the bound peptides can be unambiguously identified without any prior modification (e.g. radioactive or fluorescence labelling), even from complex peptide mixtures... - An age-related increase in the number of CD8+ T cells carrying receptors for an immunodominant Epstein-Barr virus (EBV) epitope is counteracted by a decreased frequency of their antigen-specific responsivenessQin Ouyang
Tuebingen Ageing and Tumour Immunology Group, Center for Medical Research, ZMF, Waldhoernlestr 22, 72072, Tuebingen, Germany
Mech Ageing Dev 124:477-85. 2003..This may help to explain the increased incidence and case-fatality caused by viruses and intracellular pathogens in the elderly... - Expansion of peripheral CD8+ CD28- T cells in response to Epstein-Barr virus in patients with rheumatoid arthritisTatjana Klatt
Section for Transplantation-Immunology and Immunohematology, University Clinics, Tuebingen, Germany
J Rheumatol 32:239-51. 2005.... - [The expression of API2-MALT1 fusion gene and its influence on the cellular apoptosis and proliferation in gastrointestinal MALT lymphoma]Wen-Xiu Yang
Department of Pathology, West China Hospital, Sichuan University, Chengdu 610041, China
Sichuan Da Xue Xue Bao Yi Xue Ban 35:172-5. 2004..The expression of API2-MALT1 mRNA is unrelated to the cellular proliferation... - Identification of Novel HLA-A*0201-restricted epitopes in recent-onset type 1 diabetic subjects and antibody-positive relativesNathan E Standifer
Benaroya Research Institute at Virginia Mason, 1201 Ninth Ave, Room 260, Seattle WA, 98101, USA
Diabetes 55:3061-7. 2006..These data implicate peptides of ppIAPP, GFAP, and IGRP as CTL epitopes for a heterogenous CD8(+) T-cell response in type 1 subjects and antibody-positive relatives... - Recognition of HLA class I-restricted beta-cell epitopes in type 1 diabetesQin Ouyang
Department of Pathology and Laboratory Medicine, Child and Family Research Institute, University of British Columbia and British Columbia Children's Hospital, 4480 Oak St, Vancouver, British Columbia V6H 3V4, Canada
Diabetes 55:3068-74. 2006..These data suggest that many beta-cell epitopes are recognized by CTLs in recent-onset type 1 diabetic patients. These epitopes may be important in the pathogenesis of type 1 diabetes... 
Identification and functional characterization of 2 variant alleles of the telomerase RNA template gene (TERC) in a patient with dyskeratosis congenitaHinh Ly
Department of Pathology and Laboratory Medicine, Emory University, Atlanta, GA, USA
Blood 106:1246-52. 2005....- Basic biology and clinical impact of immunosenescenceWolfgang M Wagner
, , , 72072, , Germany
Biogerontology 5:63-6. 2004 - Basic biology and clinical impact of immunosenescenceRaquel Tarazona
Department of Immunology, University Hospital Reina Sofia, , , , Spain
Exp Gerontol 37:183-9. 2002..We briefly summarise some of the highlights of the meeting here, and bring together in this special issue a collection of peer-reviewed papers reflecting the broad approach to immunosenescence currently being applied... - [Effects of NaBT and NSAIDs on colorectal adenoma-carcinoma cells]Zhihong Zhang
Department of Gastroenterology, West China Hospital, Sichuan University, Chengdu 610041, China
Sichuan Da Xue Xue Bao Yi Xue Ban 34:544-5, 593. 2003..CONCLUSION: NaBT and the two NSAIDs could inhibit the cell proliferation when used separately, and a combination of butyrate with aspirin or NS-398 could enhance the inhibitory effects... - Immunosenescence in MontecatiniGraham Pawelec
Center for Medical Research, , , , Germany Author for correspondence (e-mail: fax: +49-7071-294677
Biogerontology 4:121-3. 2003 - Pathways to a robust immune response in the elderlyGraham Pawelec
Second Department of Internal Medicine, University of Tubingen Medical School, Waldhornlestr 22, D 72076 Tubingen, Germany
Immunol Allergy Clin North Am 23:1-13. 2003.... - [The growth inhibition of colorectal adenoma cells by sulindac and its mechanisms]Libin Huang
Department of Gastroenterology, West China Hospital, Sichuan University, Chengdu 610041, China
Hua Xi Yi Ke Da Xue Xue Bao 33:101-3. 2002..05). CONCLUSION: These data suggested that sulindac could inhibit the growth of the colorectal adenoma cells, and its mechanisms might be related to suppressing proliferation and inducing apoptosis... - The abl/bcr gene product as a novel leukemia-specific antigen: peptides spanning the fusion region of abl/bcr can be recognized by both CD4+ and CD8+ T lymphocytesWolfgang M Wagner
Section for Transplantation Immunology and Immunohaematology, Second Department of Internal Medicine, Tübingen University Medical School, Tubingen, Germany
Cancer Immunol Immunother 52:89-96. 2003..Because abl/bcr is expressed in the majority of CML patients, it may represent a highly leukemia-specific antigen with potential use in immunotherapy... - Is human immunosenescence clinically relevant? Looking for 'immunological risk phenotypes'Graham Pawelec
Tubingen Ageing and Tumour Immunology Group, Center for Medical Research, Waldhornlestrasse 22, D 72072 Tubingen, Germany
Trends Immunol 23:330-2. 2002 - [The effects of butyrates and non-steroidal anti-inflammatory agents on HT-29 colonic carcinoma cells]Zhihong Zhang
Department of Gastroenterology, The First Affiliated Hospital, Western China University of Medical Sciences, Chengdu 610041, China
Zhonghua Nei Ke Za Zhi 41:153-5. 2002..CONCLUSIONS: Butyrates and NSAIDs could induce apoptosis individually. Combination with the two drugs could enhance the above effects by down-regulating cyclooxygenase-2 expression... - Telomere length in human natural killer cell subsetsQin Ouyang
Terry Fox Laboratory, BC Cancer Research Centre, 675 West 10th Avenue, Vancouver, BC, Canada, V5Z 1L3
Ann N Y Acad Sci 1106:240-52. 2007..Telomere attrition in NK cells is a plausible cause for diminished NK cell function in the elderly...