Edward J Mills

Summary

Affiliation: British Columbia
Country: Canada

Publications

  1. pmc Efficacy and safety of prostaglandin analogues in patients with predominantly primary open-angle glaucoma or ocular hypertension: a meta-analysis
    Oghenowede Eyawo
    Faculty of Health Sciences, Simon Fraser University, Vancouver, Canada
    Clin Ophthalmol 3:447-56. 2009
  2. pmc Survival of HIV-infected adolescents on antiretroviral therapy in Uganda: findings from a nationally representative cohort in Uganda
    Celestin Bakanda
    The AIDS Support Organization, Kampala, Uganda
    PLoS ONE 6:e19261. 2011
  3. pmc Combination antiretroviral therapy in population affected by conflict: outcomes from large cohort in northern Uganda
    Andrew Kiboneka
    The AIDS Support Organization TASO, Kampala, Uganda
    BMJ 338:b201. 2009
  4. pmc Modelling heterogeneity variances in multiple treatment comparison meta-analysis--are informative priors the better solution?
    Kristian Thorlund
    Department of Clinical Epidemiology and Biostatistics, McMaster University, Hamilton, ON, Canada
    BMC Med Res Methodol 13:2. 2013
  5. pmc Use of surgical task shifting to scale up essential surgical services: a feasibility analysis at facility level in Uganda
    Moses Galukande
    Department of Surgery, College of Health Sciences, Makerere University, Mulago Hill Road, Kampala, Uganda
    BMC Health Serv Res 13:292. 2013
  6. pmc Effect of selenium supplementation on CD4 T-cell recovery, viral suppression, morbidity and quality of life of HIV-infected patients in Rwanda: study protocol for a randomized controlled trial
    Julius Kamwesiga
    Rwanda Selenium Supplementation Clinical Trial Team, Kigali, Rwanda
    Trials 12:192. 2011
  7. pmc The HAART cell phone adherence trial (WelTel Kenya1): a randomized controlled trial protocol
    Richard T Lester
    Department of Medical Microbiology, University of Nairobi, UNITID Building, Nairobi, Kenya
    Trials 10:87. 2009
  8. pmc Incorporating multiple interventions in meta-analysis: an evaluation of the mixed treatment comparison with the adjusted indirect comparison
    Christopher O'Regan
    Department of Epidemiology, London School of Hygiene and Tropical Medicine, London, UK
    Trials 10:86. 2009
  9. pmc Stopping randomized trials early for benefit: a protocol of the Study Of Trial Policy Of Interim Truncation-2 (STOPIT-2)
    Matthias Briel
    Department of Clinical Epidemiology and Biostatistics, McMaster University, Hamilton, Canada
    Trials 10:49. 2009
  10. pmc The Cameroon mobile phone SMS (CAMPS) trial: a protocol for a randomized controlled trial of mobile phone text messaging versus usual care for improving adherence to highly active anti-retroviral therapy
    Lawrence Mbuagbaw
    Centre for the Development of Best Practices in Health CDBPH, Yaounde Central Hospital, Avenue Henri Dunant, Messa, PO Box 87, Yaounde, Cameroon
    Trials 12:5. 2011

Collaborators

Detail Information

Publications78

  1. pmc Efficacy and safety of prostaglandin analogues in patients with predominantly primary open-angle glaucoma or ocular hypertension: a meta-analysis
    Oghenowede Eyawo
    Faculty of Health Sciences, Simon Fraser University, Vancouver, Canada
    Clin Ophthalmol 3:447-56. 2009
    ..First-line therapy for primary open-angle glaucoma and ocular hypertension generally involves prostaglandin analogue therapy. The relative efficacy of differing prostaglandin therapy is disputed...
  2. pmc Survival of HIV-infected adolescents on antiretroviral therapy in Uganda: findings from a nationally representative cohort in Uganda
    Celestin Bakanda
    The AIDS Support Organization, Kampala, Uganda
    PLoS ONE 6:e19261. 2011
    ..Adolescents have been identified as a high-risk group for poor adherence to and defaulting from combination antiretroviral therapy (cART) care. However, data on outcomes for adolescents on cART in resource-limited settings remain scarce...
  3. pmc Combination antiretroviral therapy in population affected by conflict: outcomes from large cohort in northern Uganda
    Andrew Kiboneka
    The AIDS Support Organization TASO, Kampala, Uganda
    BMJ 338:b201. 2009
    ..To measure the clinical and immunological outcomes of HIV positive adult patients receiving combination antiretroviral therapy in conflict affected northern Uganda...
  4. pmc Modelling heterogeneity variances in multiple treatment comparison meta-analysis--are informative priors the better solution?
    Kristian Thorlund
    Department of Clinical Epidemiology and Biostatistics, McMaster University, Hamilton, ON, Canada
    BMC Med Res Methodol 13:2. 2013
    ..Relaxing the homogeneous variance assumption may be equally problematic due to reduced precision. To regain good precision, moderately informative variance priors or additional mathematical assumptions may be necessary...
  5. pmc Use of surgical task shifting to scale up essential surgical services: a feasibility analysis at facility level in Uganda
    Moses Galukande
    Department of Surgery, College of Health Sciences, Makerere University, Mulago Hill Road, Kampala, Uganda
    BMC Health Serv Res 13:292. 2013
    ..This study set out to assess the views of clinicians and managers on the use of task shifting as an effective way of alleviating shortages of skilled personnel at a facility level...
  6. pmc Effect of selenium supplementation on CD4 T-cell recovery, viral suppression, morbidity and quality of life of HIV-infected patients in Rwanda: study protocol for a randomized controlled trial
    Julius Kamwesiga
    Rwanda Selenium Supplementation Clinical Trial Team, Kigali, Rwanda
    Trials 12:192. 2011
    ..We aim to assess the effect of selenium supplementation on CD4 cell count, HIV viral load, opportunistic infections, and quality of life in HIV-infected patients in Rwanda...
  7. pmc The HAART cell phone adherence trial (WelTel Kenya1): a randomized controlled trial protocol
    Richard T Lester
    Department of Medical Microbiology, University of Nairobi, UNITID Building, Nairobi, Kenya
    Trials 10:87. 2009
    ..The objectives are to compare the effectiveness of cell phone-supported SMS messaging to standard care on adherence, quality of life, retention, and mortality in a population receiving antiretroviral therapy (ART) in Nairobi, Kenya...
  8. pmc Incorporating multiple interventions in meta-analysis: an evaluation of the mixed treatment comparison with the adjusted indirect comparison
    Christopher O'Regan
    Department of Epidemiology, London School of Hygiene and Tropical Medicine, London, UK
    Trials 10:86. 2009
    ..Several methodological options are now available. We aimed to determine the comparative validity of the adjusted indirect comparisons of RCTs with the mixed treatment comparison approach...
  9. pmc Stopping randomized trials early for benefit: a protocol of the Study Of Trial Policy Of Interim Truncation-2 (STOPIT-2)
    Matthias Briel
    Department of Clinical Epidemiology and Biostatistics, McMaster University, Hamilton, Canada
    Trials 10:49. 2009
    ..The aim of STOPIT-2 is to determine the magnitude and determinants of possible bias introduced by stopping RCTs early for benefit...
  10. pmc The Cameroon mobile phone SMS (CAMPS) trial: a protocol for a randomized controlled trial of mobile phone text messaging versus usual care for improving adherence to highly active anti-retroviral therapy
    Lawrence Mbuagbaw
    Centre for the Development of Best Practices in Health CDBPH, Yaounde Central Hospital, Avenue Henri Dunant, Messa, PO Box 87, Yaounde, Cameroon
    Trials 12:5. 2011
    ..This trial aims at testing the efficacy of weekly reminder and motivational text messages, compared to usual care in improving adherence to Highly Active Antiretroviral Treatment in patients attending a clinic in Yaoundé, Cameroon...
  11. pmc The first decade of antiretroviral therapy in Africa
    Nathan Ford
    Medecins Sans Frontieres, Geneva, Switzerland
    Global Health 7:33. 2011
    ....
  12. pmc Childhood physical abnormalities following paternal exposure to sulfur mustard gas in Iran: a case-control study
    Hassan Abolghasemi
    Urology and Nephrology Research Center, Shahid Beheshti University of Medical Sciences 9th Boostan Street, Pasdaran Avenue, Tehran, Iran
    Confl Health 4:13. 2010
    ..Mustard gas, a known chemical weapon, was used during the Iran-Iraq war of 1980-1988. We aimed to determine if exposure to mustard gas among men was significantly associated with abnormalities and disorders among progenies...
  13. pmc Ethics of conducting research in conflict settings
    Nathan Ford
    , Johannesburg, South Africa
    Confl Health 3:7. 2009
    ..Special attention needs to be placed on the feasibility and necessity of doing research in conflict-settings, and the harm-benefit ratio for potential research participants...
  14. ncbi Life expectancy of persons receiving combination antiretroviral therapy in low-income countries: a cohort analysis from Uganda
    Edward J Mills
    University of Ottawa, Ottawa, Ontario, Canada
    Ann Intern Med 155:209-16. 2011
    ..Little is known about the effect of combination antiretroviral therapy (cART) on life expectancy in sub-Saharan Africa...
  15. ncbi Providing antiretroviral care in conflict settings
    Edward J Mills
    BC Centre for Excellence in HIV AIDS, Vancouver, BC, Canada
    Curr HIV/AIDS Rep 6:201-9. 2009
    ..Emerging guidelines from United Nations bodies now support the expansion of cART in settings of conflict...
  16. pmc Antifungal treatment for invasive Candida infections: a mixed treatment comparison meta-analysis
    Edward J Mills
    Faculty of Health Sciences, Simon Fraser University, Burnaby, Canada
    Ann Clin Microbiol Antimicrob 8:23. 2009
    ..Treatment guidelines vary on optimal treatment strategies. We aimed to determine the effects of different antifungal therapies on global response rates, mortality and safety...
  17. doi Association of aging and survival in a large HIV-infected cohort on antiretroviral therapy
    Celestin Bakanda
    The AIDS Support Organization Headquarters, Kampala, Uganda
    AIDS 25:701-5. 2011
    ..To examine if there is a significant difference in survival between elderly (>50 years) and nonelderly adult patients receiving combination antiretroviral therapy in Uganda between 2004 and 2010...
  18. doi Male sex and the risk of mortality among individuals enrolled in antiretroviral therapy programs in Africa: a systematic review and meta-analysis
    Eric Druyts
    Faculty of Health Sciences, University of Ottawa, Ottawa, Ontario, Canada
    AIDS 27:417-25. 2013
    ..HIV/AIDS has historically had a sex and gender-focused approach to prevention and care. Some evidence suggests that HIV-positive men have worse treatment outcomes than their women counterparts in Africa...
  19. doi Mortality by baseline CD4 cell count among HIV patients initiating antiretroviral therapy: evidence from a large cohort in Uganda
    Edward J Mills
    Faculty of Health Sciences, University of Ottawa, Canada
    AIDS 25:851-5. 2011
    ..Funders have been reticent to recommend earlier initiation of treatment. We aimed to examine the effect of baseline CD4 cell count on mortality using data from HIV patients receiving combination antiretroviral therapy (cART) in Uganda...
  20. pmc Adherence to HAART: a systematic review of developed and developing nation patient-reported barriers and facilitators
    Edward J Mills
    Centre for International Health and Human Rights Studies, Toronto, Ontario, Canada
    PLoS Med 3:e438. 2006
    ..We systematically reviewed the literature to determine patient-reported barriers and facilitators to adhering to antiretroviral therapy...
  21. ncbi Adherence to antiretroviral therapy in sub-Saharan Africa and North America: a meta-analysis
    Edward J Mills
    Centre for International Health and Human Rights Studies, Toronto, Ontario, Canada
    JAMA 296:679-90. 2006
    ..Concerns about incomplete adherence among patients living in poverty have been an important consideration in expanding the access to antiretroviral therapy in sub-Saharan Africa...
  22. pmc Male gender predicts mortality in a large cohort of patients receiving antiretroviral therapy in Uganda
    Edward J Mills
    Faculty of Health Sciences, University of Ottawa, Ottawa, Canada
    J Int AIDS Soc 14:52. 2011
    ....
  23. doi Does ratification of human-rights treaties have effects on population health?
    Alexis Palmer
    Faculty of Health Sciences, Simon Fraser University, Vancouver, BC, Canada
    Lancet 373:1987-92. 2009
    ....
  24. pmc Naturopathic care for chronic low back pain: a randomized trial
    Orest Szczurko
    Division of Clinical Epidemiology, Canadian College of Naturopathic Medicine, Toronto, Ontario, Canada
    PLoS ONE 2:e919. 2007
    ..Chronic low back pain represents a substantial cost to employers through benefits coverage and days missed due to incapacity. We sought to explore the effectiveness of Naturopathic care on chronic low back pain...
  25. doi Long-term health care interruptions among HIV-positive patients in Uganda
    Edward J Mills
    University of Ottawa, Ottawa, Ontario, Canada
    J Acquir Immune Defic Syndr 63:e23-7. 2013
    ..We examined risk factors for health care interruptions and loss to follow-up within a cohort receiving ART in Uganda...
  26. doi HIV/AIDS in African militaries: an ecological analysis
    Oumar Ba
    Faculty of Health Sciences, Simon Fraser University, Vancouver, Canada
    Med Confl Surviv 24:88-100. 2008
    ..4). Population levels predicted military prevalence rates (P < or = 0.001). HIV/AIDS prevalence rates in most African militaries are significantly elevated compared to their host communities...
  27. ncbi Cardiovascular events associated with smoking cessation pharmacotherapies: a network meta-analysis
    Edward J Mills
    Stanford Prevention Research Center, Stanford University, Stanford, CA E J M, K T, J J P Faculty of Health Sciences, University of Ottawa, Ottawa, ON, Canada E J M, S E, P W and Department of Clinical Epidemiology and Biostatistics, McMaster University, Hamilton, ON, Canada K T
    Circulation 129:28-41. 2014
    ..We aimed to examine whether the 3 licensed smoking cessation therapies-nicotine replacement therapy, bupropion, and varenicline-were associated with an increased risk of cardiovascular disease events using a network meta-analysis...
  28. doi The prognostic value of baseline CD4(+) cell count beyond 6 months of antiretroviral therapy in HIV-positive patients in a resource-limited setting
    Edward J Mills
    Faculty of Health Sciences, University of Ottawa, Ottawa, Canada
    AIDS 26:1425-9. 2012
    ..We examined whether initial CD4 cell count maintains a strong prognostic value among patients with at least 6 months follow-up after the initiation of ART...
  29. doi Clinical and immunological outcomes of a national paediatric cohort receiving combination antiretroviral therapy in Uganda
    Andrew Kiboneka
    The AIDS Support Organization, Kampala, Uganda
    AIDS 22:2493-9. 2008
    ..We aimed to evaluate clinical and immunological outcomes of paediatric patients receiving combination antiretroviral therapy (cART) enrolled in The AIDS Support Organization (TASO) Uganda national HIV/AIDS programme...
  30. doi Efficacy and safety of pegylated interferon alfa-2a or alfa-2b plus ribavirin for the treatment of chronic hepatitis C in children and adolescents: a systematic review and meta-analysis
    Eric Druyts
    Faculty of Health Sciences, University of Ottawa, Ottawa, Canada
    Clin Infect Dis 56:961-7. 2013
    ..A systematic review and meta-analysis were conducted to examine the efficacy and safety of pegylated interferon (peg-IFN) alfa-2a and peg-IFN alfa-2b plus ribavirin (RBV) in children and adolescents with chronic hepatitis C virus (HCV)...
  31. pmc Increased mortality among HIV-positive men on antiretroviral therapy: survival differences between sexes explained by late initiation in Uganda
    Steve Kanters
    Faculty of Health Science, Simon Fraser University, Burnaby, BC, Canada Faculty of Health Sciences, University of Ottawa, Ottawa, ON, Canada
    HIV AIDS (Auckl) 5:111-9. 2013
    ..We also specifically examined the role of antenatal services in favoring women's access to HIV care...
  32. doi Cohort profile: the MUg Observational Cohort
    Anna Funk
    Faculty of Health Sciences, University of Ottawa, Ottawa, Ontario, Canada and The Mildmay Centre, Kampala, Uganda
    Int J Epidemiol 41:1594-1594f. 2012
    ..Data comprise demographic, behavioural and clinical variables. Collaborations and enquiries relating to the MUg observational cohort are encouraged, and can be addressed to Dr Edward Mills at edward.mills@uottowa.ca...
  33. ncbi A wake-up call for global access to salvage HIV drug regimens
    Edward J Mills
    British Columbia Centre for Excellence in HIV AIDS, Vancouver, BC, Canada
    Lancet 370:1885-7. 2007
  34. pmc Density of healthcare providers and patient outcomes: evidence from a nationally representative multi-site HIV treatment program in Uganda
    Celestin Bakanda
    The AIDS Support Organization, Headquarters, Kampala, Uganda
    PLoS ONE 6:e16279. 2011
    ..We examined the association between density of healthcare providers and patient outcomes using a large nationally representative cohort of patients receiving combination antiretroviral therapy (cART) in Uganda...
  35. doi CD4(+) T-cell recovery after initiation of antiretroviral therapy in a resource-limited setting: a prospective cohort analysis
    Steve Kanters
    Faculty of Health Sciences, University of Ottawa, Ottawa, ON, Canada
    Antivir Ther 19:31-9. 2014
    ..CD4(+) T-cell count recovery after antiretroviral therapy (ART) initiation is associated with improved health outcomes. It is unknown how the CD4(+) T-cell counts of African HIV patients recover following ART initiation...
  36. doi Earlier initialization of highly active antiretroviral therapy is associated with long-term survival and is cost-effective: findings from a deterministic model of a 10-year Ugandan cohort
    Fergal P Mills
    Faculty of Health Sciences, University of Ottawa, Ottawa, Canada Médecins Sans Frontiers, Geneva, Switzerland
    J Acquir Immune Defic Syndr 61:364-9. 2012
    ..We examined costs of this shift using data from Uganda for almost 10 years...
  37. doi Intensive statin therapy compared with moderate dosing for prevention of cardiovascular events: a meta-analysis of >40 000 patients
    Edward J Mills
    Faculty of Health Sciences, University of Ottawa, Ottawa, Ontario, Canada V5Z 4B4 K1n6X1
    Eur Heart J 32:1409-15. 2011
    ..There is widespread interest in whether intensive dosing of statins yields larger treatment effects. We aimed to determine if intensive dosing is clinically important using a meta-analysis of randomized clinical trials (RCTs)...
  38. pmc The financial cost of doctors emigrating from sub-Saharan Africa: human capital analysis
    Edward J Mills
    Faculty of Health Sciences, University of Ottawa, Canada
    BMJ 343:d7031. 2011
    ..To estimate the lost investment of domestically educated doctors migrating from sub-Saharan African countries to Australia, Canada, the United Kingdom, and the United States...
  39. pmc Design, analysis, and presentation of crossover trials
    Edward J Mills
    Faculty of Health Sciences, Simon Fraser University, Burnaby, Canada
    Trials 10:27. 2009
    ..Although crossover trials enjoy wide use, standards for analysis and reporting have not been established. We reviewed methodological aspects and quality of reporting in a representative sample of published crossover trials...
  40. pmc Boceprevir and telaprevir for the treatment of chronic hepatitis C genotype 1 infection: an indirect comparison meta-analysis
    Curtis L Cooper
    Division of Infectious Diseases, Faculty of Medicine, University of Ottawa, Ottawa
    Ther Clin Risk Manag 8:105-30. 2012
    ..The aim of this study was to examine the relative efficacy and safety of boceprevir and telaprevir, when used in combination with pegylated interferon alpha and ribavirin, using an indirect comparison meta-analysis...
  41. pmc Metastatic renal cell cancer treatments: an indirect comparison meta-analysis
    Edward J Mills
    Faculty of Health Sciences, Simon Fraser University, Vancouver, Canada
    BMC Cancer 9:34. 2009
    ..New treatment options may provide improved progression-free survival (PFS). We aimed to determine the relative effectiveness of new therapies in this field...
  42. ncbi Epidemiology and reporting of randomized trials employing re-randomization of patient groups: a systematic survey
    Edward J Mills
    Department of Clinical Epidemiology and Biostatistics, McMaster University, 1200 Main Street West, Hamilton, Ontario, Canada
    Contemp Clin Trials 28:268-75. 2007
    ....
  43. doi A users' guide to understanding therapeutic substitutions
    Edward J Mills
    Faculty of Health Sciences, University of Ottawa, 43 Templeton Street, Ottawa, Canada K1N6X1 Centre for Clinical Epidemiology and Evaluation C2E2, University of British Columbia, 828 West 10th Ave, Research Pavilion, Vancouver, Canada, V5Z 1M9 Electronic address
    J Clin Epidemiol 67:305-13. 2014
    ..This article uses a problem-based format to address the biological mechanism, validity, and results of a scenario in which therapeutic substitutions may be considered...
  44. doi Micronutrient deficiency and treatment adherence in a randomized controlled trial of micronutrient supplementation in ART-naïve persons with HIV
    Louise Balfour
    CIHR Canadian HIV Trials Network CTN, Vancouver, British Columbia, Canada Division of Infectious Diseases, Department of Medicine, University of Ottawa at The Ottawa Hospital, Ottawa, Ontario, Canada
    PLoS ONE 9:e85607. 2014
    ..The MAINTAIN study is an on-going RCT comparing high-dose micronutrient and anti-oxidant supplementation versus recommended daily allowance (RDA) vitamins in slowing HIV immune deficiency progression in ART-naïve people with HIV infection...
  45. doi Why the findings of published multiple treatment comparison meta-analyses of biologic treatments for rheumatoid arthritis are different: an overview of recurrent methodological shortcomings
    Kristian Thorlund
    Department of Clinical Epidemiology and Biostatistics, McMaster University, Hamilton, Ontario, Canada
    Ann Rheum Dis 72:1524-35. 2013
    ....
  46. ncbi How to use an article reporting a multiple treatment comparison meta-analysis
    Edward J Mills
    Faculty of Health Sciences, University of Ottawa, Room 031, Thompson Hall, 35 University Private, Ottawa, ON, K1N 7K4, Canada
    JAMA 308:1246-53. 2012
    ..This article uses the existing Users' Guides format to address study validity, interpretation of results, and application to a patient scenario...
  47. doi Comparisons of high-dose and combination nicotine replacement therapy, varenicline, and bupropion for smoking cessation: a systematic review and multiple treatment meta-analysis
    Edward J Mills
    Department of Clinical Epidemiology and Biostatistics, McMaster University, Hamilton, Ontario, Canada
    Ann Med 44:588-97. 2012
    ..This review compared the effect of high-dose nicotine replacement therapy (NRT) and combinations of NRT for increasing smoking abstinence rates compared to standard-dose NRT patch, varenicline, and bupropion on smoking abstinence...
  48. doi Low-dose aspirin and cancer mortality: a meta-analysis of randomized trials
    Edward J Mills
    Faculty of Health Sciences, University of Ottawa, Ontario, Canada
    Am J Med 125:560-7. 2012
    ..We aimed to determine whether cancer mortality also is reduced by low-dose aspirin in the shorter term...
  49. pmc Differences in clinical outcomes among hepatitis C genotype 1-infected patients treated with peginterferon alpha-2a or peginterferon alpha-2b plus ribavirin: a meta-analysis
    Eric Druyts
    Faculty of Health Sciences, University of Ottawa, Ottawa, ON, Canada
    Clin Exp Gastroenterol 5:11-21. 2012
    ....
  50. doi Design and methods of the MAINTAIN study: a randomized controlled clinical trial of micronutrient and antioxidant supplementation in untreated HIV infection
    Neera Singhal
    Department of Medicine, University of Ottawa at Ottawa Hospital Research Institute, Ottawa, Ontario, Canada
    Contemp Clin Trials 31:604-11. 2010
    ..We discuss here the study design and methods, often used for evaluation of complementary and adjunctive treatments for health maintenance in HIV infection, which are common interventions...
  51. doi Risk of resistance to highly active antiretroviral therapy among HIV-positive injecting drug users: a meta-analysis
    Daniel Werb
    British Columbia Centre for Excellence in HIV AIDS, University of British Columbia, 608 1081 Burrard Street, Vancouver, BC, Canada
    Lancet Infect Dis 10:464-9. 2010
    ..Therapeutic guidelines should consider reassessment of this issue...
  52. pmc Multiple treatment comparison meta-analyses: a step forward into complexity
    Edward J Mills
    Faculty of Health Sciences, University of Ottawa, Ottawa, ON, Canada
    Clin Epidemiol 3:193-202. 2011
    ..We conclude that MTC meta-analysis is a useful tool in the context of comparative effectiveness and requires further study, as its utility and transparency will likely predict its uptake by the research and clinical community...
  53. doi Liver transplant outcomes in HIV-infected patients: a systematic review and meta-analysis with synthetic cohort
    Curtis Cooper
    The Ottawa Hospital Division of Infectious Diseases, University of Ottawa, Canada
    AIDS 25:777-86. 2011
    ..We aimed to evaluate the effectiveness of liver transplantation in HIV-hepatitis co-infected patients using a meta-analysis and individual patient data meta-analysis as a synthetic cohort...
  54. doi The effectiveness of anti-illicit-drug public-service announcements: a systematic review and meta-analysis
    Dan Werb
    British Columbia Centre for Excellence in HIV AIDS, Vancouver, Canada
    J Epidemiol Community Health 65:834-40. 2011
    ..Anti-illicit-drug public-service announcements (PSAs) have become a cornerstone of drug policy in the USA. However, studies of the effectiveness of these interventions have not been subjected to a systematic evaluation...
  55. ncbi What drives the comparative effectiveness of biologics vs methotrexate in rheumatoid arthritis? Meta-regression and graphical inspection of suspected clinical factors
    Steve Kanters
    Department of Population and Public Health, University of British Columbia, Vancouver, BC, Faculty of Medicine, University of Ottawa, Ottawa, ON, Canada, Stanford Prevention Research Center, Stanford University, Palo Alto, CA, USA and Department of Clinical Epidemiology and Biostatistics, McMaster University, Hamilton, ON, Canada Department of Population and Public Health, University of British Columbia, Vancouver, BC, Faculty of Medicine, University of Ottawa, Ottawa, ON, Canada, Stanford Prevention Research Center, Stanford University, Palo Alto, CA, USA and Department of Clinical Epidemiology and Biostatistics, McMaster University, Hamilton, ON, Canada
    Rheumatology (Oxford) 53:1264-73. 2014
    ..The aim of this study was to explore which clinical factors and patient characteristics are associated with the magnitude of comparative efficacy between biologics vs MTX in RA patients with inadequate response to MTX...
  56. ncbi Years of life lost to incarceration: inequities between Aboriginal and non-Aboriginal Canadians
    Akwasi Owusu-Bempah
    Faculty of Health Sciences, University of Ottawa, 25 University Private, Ottawa, Ontario K1N 6 N5, Canada
    BMC Public Health 14:585. 2014
    ..Aboriginal representation in Canadian correctional institutions has increased rapidly over the past decade. We calculated "years of life lost to incarceration" for Aboriginal and non-Aboriginal Canadians...
  57. pmc The effects of excluding treatments from network meta-analyses: survey
    Edward J Mills
    Faculty of Health Sciences, University of Ottawa, Ottawa, Canada
    BMJ 347:f5195. 2013
    ..To examine whether the exclusion of individual treatment comparators, including placebo/no treatment, affects the results of network meta-analysis...
  58. pmc Sample size and power considerations in network meta-analysis
    Kristian Thorlund
    Department of Clinical Epidemiology and Biostatistics, Faculty of Health Sciences, McMaster University, 1280 Main Street West, Hamilton, Ontario, Canada L8S 4 K1
    Syst Rev 1:41. 2012
    ..This issue, however, has so far only received little attention in network meta-analysis. To date, no approaches have been proposed for evaluating the adequacy of the sample size, and thus power, in a treatment network...
  59. doi Primary prevention of cardiovascular mortality and events with statin treatments: a network meta-analysis involving more than 65,000 patients
    Edward J Mills
    Department of Clinical Epidemiology and Biostatistics, McMaster University, Hamilton, Ontario, Canada
    J Am Coll Cardiol 52:1769-81. 2008
    ..This study aimed to evaluate the effectiveness of 3-hydroxy-3-methyl-glutaryl-CoA reductase inhibitors (statins) in primary prevention of cardiovascular events...
  60. pmc Estimating the power of indirect comparisons: a simulation study
    Edward J Mills
    Faculty of Health Sciences, University of Ottawa, Ottawa, Canada
    PLoS ONE 6:e16237. 2011
    ..While indirect methods have grown in popularity and acceptance, little is known about the fragility of confidence interval estimations and hypothesis testing relying on this method...
  61. pmc Tuberculosis mortality in HIV-infected individuals: a cross-national systematic assessment
    Christopher Au-Yeung
    BC Centre for Excellence in HIV AIDS, Vancouver, Canada
    Clin Epidemiol 3:21-9. 2011
    ..Tuberculosis (TB) is a leading cause of death in human immunodeficiency virus (HIV)-positive individuals. We sought to compare mortality rates in TB/HIV co-infected individuals globally and by country/territory...
  62. ncbi Migration and transmission of blood-borne infections among injection drug users: understanding the epidemiologic bridge
    Beth Rachlis
    BC Centre for Excellence in HIV AIDS, St Paul s Hospital, Vancouver, British Columbia, Canada
    Drug Alcohol Depend 90:107-19. 2007
    ..We also discuss the potential policy implications of addressing prevention and care issues in mobile drug using populations...
  63. doi HIV status in discordant couples in sub-Saharan Africa: a systematic review and meta-analysis
    Oghenowede Eyawo
    Faculty of Health Sciences, Simon Fraser University, Vancouver, BC, Canada
    Lancet Infect Dis 10:770-7. 2010
    ..We investigated serodiscordance in stable relationships to establish the gender balance of index-case infections...
  64. doi Stopping randomized trials early for benefit and estimation of treatment effects: systematic review and meta-regression analysis
    Dirk Bassler
    Department of Clinical Epidemiology and Biostatistics, McMaster University, Hamilton, Ontario, Canada
    JAMA 303:1180-7. 2010
    ..Theory and simulation suggest that randomized controlled trials (RCTs) stopped early for benefit (truncated RCTs) systematically overestimate treatment effects for the outcome that precipitated early stopping...
  65. pmc In the era of systematic reviews, does the size of an individual trial still matter
    Gordon H Guyatt
    Department of Clinical Epidemiology and Biostatistics, McMaster University, Hamilton, Ontario, Canada
    PLoS Med 5:e4. 2008
    ..Others point out that small trials can still be potentially misleading...
  66. doi Naturopathic treatment of rotator cuff tendinitis among Canadian postal workers: a randomized controlled trial
    Orest Szczurko
    Canadian College of Naturopathic Medicine, Toronto, Ontario, Canada
    Arthritis Rheum 61:1037-45. 2009
    ..To explore the effectiveness of naturopathic care (NC) on rotator cuff tendinitis using a prospective randomized clinical trial design...
  67. pmc The Cameroon Mobile Phone SMS (CAMPS) trial: a randomized trial of text messaging versus usual care for adherence to antiretroviral therapy
    Lawrence Mbuagbaw
    Centre for the Development of Best Practices in Health CDBPH, Yaounde Central Hospital, Yaounde, Centre, Cameroon
    PLoS ONE 7:e46909. 2012
    ..This trial investigates the use of motivational mobile phone text messages (SMS) to improve adherence to antiretroviral therapy (ART) over six months...
  68. pmc Anti-tumor necrosis factor (TNF) drugs for the treatment of psoriatic arthritis: an indirect comparison meta-analysis
    Kristian Thorlund
    Department of Clinical Epidemiology and Biostatistics, McMaster University, Hamilton, Ontario, Canada
    Biologics 6:417-27. 2012
    ....
  69. doi Calculating additive treatment effects from multiple randomized trials provides useful estimates of combination therapies
    Edward J Mills
    Faculty of Health Sciences, University of Ottawa, 43 Templeton Street, Ottawa, Ontario, Canada
    J Clin Epidemiol 65:1282-8. 2012
    ..We discuss here the prerequisites and methods of applying additivity assumptions in synthesizing the evidence from randomized trials and multiple treatment meta-analyses...
  70. pmc Health system determinants of infant, child and maternal mortality: A cross-sectional study of UN member countries
    Katherine A Muldoon
    British Columbia Centre for Excellence in HIV AIDS, St, Paul s Hospital, 1081 Burrard Street, Vancouver, British Columbia, Canada
    Global Health 7:42. 2011
    ..abstract:..
  71. pmc Adverse events associated with nicotine replacement therapy (NRT) for smoking cessation. A systematic review and meta-analysis of one hundred and twenty studies involving 177,390 individuals
    Edward J Mills
    Faculty of Health Sciences, University of Ottawa, Ottawa, Canada
    Tob Induc Dis 8:8. 2010
    ..Although expectations of mild adverse effects have been observed to be independent predictors of reduced motivation to use NRT, adverse effects associated with NRT have not been precisely quantified...
  72. pmc Predictive value of CD4 cell count nadir on long-term mortality in HIV-positive patients in Uganda
    Sarah Bray
    Interdisciplinary School of Health Sciences, Faculty of Health Sciences, University of Ottawa, Ottawa, Canada
    HIV AIDS (Auckl) 4:135-40. 2012
    ..The lowest level that their CD4 cell count reaches, the nadir, may have long-term consequences in terms of mortality. We examined this health state in a large cohort of HIV+ patients in Uganda...
  73. doi Treatment outcomes of patients on second-line antiretroviral therapy in resource-limited settings: a systematic review and meta-analysis
    Olawale Ajose
    Clinton Health Access Initiative, Dar es Salaam, Tanzania
    AIDS 26:929-38. 2012
    ..We carried out a systematic review in order to summarize reported rates and reasons for virological failure among people on second-line therapy in resource-limited settings...
  74. doi Safety of task-shifting for male medical circumcision: a systematic review and meta-analysis
    Nathan Ford
    Centre for Infectious Disease Epidemiology and Research, University of Cape Town, Cape Town, South Africa
    AIDS 26:559-66. 2012
    ..We undertook a systematic review and meta-analysis to review the safety of task-shifting for circumcision in Africa...
  75. pmc Engaging Men in Prevention and Care for HIV/AIDS in Africa
    Edward J Mills
    Faculty of Health Sciences, University of Ottawa, Ottawa, Canada
    PLoS Med 9:e1001167. 2012
    ..Ed Mills and colleagues argue that a more balanced approach to gender is needed so that both men and women are involved in HIV treatment and prevention...
  76. pmc Equitable access to HCV care in HIV-HCV co-infection can be achieved despite barriers to health care provision
    Curtis L Cooper
    The University of Ottawa Division of Infectious Diseases Viral Hepatitis Program, Ottawa, Canada
    Ther Clin Risk Manag 6:207-12. 2010
    ..SVR is diminished in HIV-HCV co-infection independent of language barrier, race, immigration status, or socioeconomic status...
  77. pmc Gender differences in clinical, immunological, and virological outcomes in highly active antiretroviral-treated HIV-HCV coinfected patients
    Joel Emery
    The Ottawa Hospital Division of Infectious Diseases, University of Ottawa, Ottawa, Canada
    Patient Prefer Adherence 4:97-103. 2010
    ..The influence of biological sex on human immunodeficiency virus (HIV) antiretroviral treatment outcome is not well described in HIV-hepatitis C (HCV) coinfection...
  78. pmc Pharmacotherapies for chronic obstructive pulmonary disease: a multiple treatment comparison meta-analysis
    Edward J Mills
    Faculty of Health Sciences, University of Ottawa, Ottawa, Ontario, Canada
    Clin Epidemiol 3:107-29. 2011
    ..Since current guidelines cannot make strong recommendations yet, our aim was to determine the relative efficacy of existing treatments and combinations to reduce the risk for COPD exacerbations...