Annette M McWilliams

Summary

Affiliation: British Columbia
Country: Canada

Publications

  1. ncbi request reprint Lung cancer screening: a different paradigm
    Annette McWilliams
    British Columbia Cancer Agency, 600 West 10th Avenue, Vancouver, BC, V5Z 4E6 Canada
    Am J Respir Crit Care Med 168:1167-73. 2003
  2. doi request reprint Computed tomography-detected noncalcified pulmonary nodules: a review of evidence for significance and management
    Annette McWilliams
    Clinical Assistant Professor, University of British Columbia, British Columbia Cancer Agency, 675 West 10th Avenue, Vancouver, BC, V5Z 1L3 Canada
    Proc Am Thorac Soc 5:900-4. 2008
  3. ncbi request reprint Lung cancer screening using multi-slice thin-section computed tomography and autofluorescence bronchoscopy
    Annette M McWilliams
    British Columbia Cancer Agency, Vancouver, British Columbia, Canada
    J Thorac Oncol 1:61-8. 2006
  4. doi request reprint Early proximal lung cancer diagnosis and treatment
    A McWilliams
    University of British Columbia, British Columbia Cancer Agency and Vancouver General Hospital, 675 West 10th Avenue, Vancouver, BC, V5Z 1L3, Canada
    Eur Respir J 33:656-65. 2009
  5. pmc Evidence for dysanapsis using computed tomographic imaging of the airways in older ex-smokers
    A William Sheel
    School of Human Kinetics, University of British Columbia, BC, Canada
    J Appl Physiol 107:1622-8. 2009
  6. doi request reprint Perifissural nodules seen at CT screening for lung cancer
    Myeong I Ahn
    Department of Radiology, Vancouver General Hospital, 899 W 12th Ave, Vancouver, BC, Canada V5Z 1M9
    Radiology 254:949-56. 2010
  7. pmc Airway wall thickness assessed using computed tomography and optical coherence tomography
    Harvey O Coxson
    Department of Radiology, Vancouver General Hospital, 855 West 12th Avenue, Room 3350 JPN, Vancouver, BC, Canada
    Am J Respir Crit Care Med 177:1201-6. 2008
  8. pmc Small-airway obstruction and emphysema in chronic obstructive pulmonary disease
    John E McDonough
    University of British Columbia James Hogg Research Centre, St Paul s Hospital, Vancouver, BC, Canada
    N Engl J Med 365:1567-75. 2011
  9. doi request reprint Lung nodules: CT-guided placement of microcoils to direct video-assisted thoracoscopic surgical resection
    John R Mayo
    Department of Radiology, Vancouver General Hospital Site, University of British Columbia, Vancouver, BC, Canada
    Radiology 250:576-85. 2009
  10. doi request reprint Using laser Raman spectroscopy to reduce false positives of autofluorescence bronchoscopies: a pilot study
    Michael A Short
    Cancer Imaging Unit, Integrative Oncology Department, British Columbia Cancer Agency Research Centre, University of British Columbia, Vancouver, British Columbia, Canada
    J Thorac Oncol 6:1206-14. 2011

Collaborators

Detail Information

Publications25

  1. ncbi request reprint Lung cancer screening: a different paradigm
    Annette McWilliams
    British Columbia Cancer Agency, 600 West 10th Avenue, Vancouver, BC, V5Z 4E6 Canada
    Am J Respir Crit Care Med 168:1167-73. 2003
    ..1%. CT scan alone would have missed 29% of the cancers. This screening paradigm shift has the additional potential of reducing the number of initial CT scans by at least 25% with further savings in follow-up investigations and treatment...
  2. doi request reprint Computed tomography-detected noncalcified pulmonary nodules: a review of evidence for significance and management
    Annette McWilliams
    Clinical Assistant Professor, University of British Columbia, British Columbia Cancer Agency, 675 West 10th Avenue, Vancouver, BC, V5Z 1L3 Canada
    Proc Am Thorac Soc 5:900-4. 2008
    ..The role of PET in evaluating these nodules needs further exploration. Serial follow-up for 24 months in a high-risk cohort appears reasonable based on present data, but further longitudinal information is required...
  3. ncbi request reprint Lung cancer screening using multi-slice thin-section computed tomography and autofluorescence bronchoscopy
    Annette M McWilliams
    British Columbia Cancer Agency, Vancouver, British Columbia, Canada
    J Thorac Oncol 1:61-8. 2006
    ..Our hypothesis is that the use of a two-step strategy, using a sputum biomarker, may increase the detection rate of lung cancer by identifying individuals at highest risk...
  4. doi request reprint Early proximal lung cancer diagnosis and treatment
    A McWilliams
    University of British Columbia, British Columbia Cancer Agency and Vancouver General Hospital, 675 West 10th Avenue, Vancouver, BC, V5Z 1L3, Canada
    Eur Respir J 33:656-65. 2009
    ..The present article will deal with various issues regarding early detection, staging and treatment of centrally located early stage, mostly squamous type, lung cancer...
  5. pmc Evidence for dysanapsis using computed tomographic imaging of the airways in older ex-smokers
    A William Sheel
    School of Human Kinetics, University of British Columbia, BC, Canada
    J Appl Physiol 107:1622-8. 2009
    ..In males and females matched for lung size women had significantly smaller airway luminal areas. The larger conducting airways in females are significantly smaller than those of males even after controlling for lung size...
  6. doi request reprint Perifissural nodules seen at CT screening for lung cancer
    Myeong I Ahn
    Department of Radiology, Vancouver General Hospital, 899 W 12th Ave, Vancouver, BC, Canada V5Z 1M9
    Radiology 254:949-56. 2010
    ..Although PFNs may show increased size at follow-up CT, the authors in this study found none that had developed into lung cancer; this suggests that the malignancy potential of PFNs is low. (c) RSNA, 2010...
  7. pmc Airway wall thickness assessed using computed tomography and optical coherence tomography
    Harvey O Coxson
    Department of Radiology, Vancouver General Hospital, 855 West 12th Avenue, Room 3350 JPN, Vancouver, BC, Canada
    Am J Respir Crit Care Med 177:1201-6. 2008
    ..Optical coherence tomography (OCT) is a promising new micron-scale resolution imaging technique that can image small airways 2 mm in diameter or less...
  8. pmc Small-airway obstruction and emphysema in chronic obstructive pulmonary disease
    John E McDonough
    University of British Columbia James Hogg Research Centre, St Paul s Hospital, Vancouver, BC, Canada
    N Engl J Med 365:1567-75. 2011
    ..We wanted to determine whether there was a relationship between small-airway obstruction and emphysematous destruction in COPD...
  9. doi request reprint Lung nodules: CT-guided placement of microcoils to direct video-assisted thoracoscopic surgical resection
    John R Mayo
    Department of Radiology, Vancouver General Hospital Site, University of British Columbia, Vancouver, BC, Canada
    Radiology 250:576-85. 2009
    ....
  10. doi request reprint Using laser Raman spectroscopy to reduce false positives of autofluorescence bronchoscopies: a pilot study
    Michael A Short
    Cancer Imaging Unit, Integrative Oncology Department, British Columbia Cancer Agency Research Centre, University of British Columbia, Vancouver, British Columbia, Canada
    J Thorac Oncol 6:1206-14. 2011
    ....
  11. ncbi request reprint A randomized phase IIb trial of pulmicort turbuhaler (budesonide) in people with dysplasia of the bronchial epithelium
    Stephen Lam
    Department of Respiratory Medicine, British Columbia Cancer Agency and the University of British Columbia, Vancouver, British Columbia, Canada
    Clin Cancer Res 10:6502-11. 2004
    ..Preclinical studies suggest that inhaled budesonide may be an effective chemopreventive agent for lung cancer. We conducted a phase IIb study to determine the effects of inhaled budesonide in smokers with bronchial dysplasia...
  12. doi request reprint Combining field imaging endoscopy with point analysis spectroscopy for improving early lung cancer detection
    Haishan Zeng
    BC Cancer Research Centre, Vancouver, BC, Canada V5Z 1L3
    Conf Proc IEEE Eng Med Biol Soc 2008:1849-50. 2008
    ..Preliminary Raman spectroscopy results will be reported at the conference...
  13. ncbi request reprint Integrated endoscopy system for simultaneous imaging and spectroscopy for early lung cancer detection
    Haishan Zeng
    Cancer Imaging Department, BC Cancer Agency, 601 West 10th Avenue, Vancouver, British Columbia V5Z 1L3, Canada
    Opt Lett 29:587-9. 2004
    ..The system has been successfully tested in a clinic, demonstrating a practical approach to improve both diagnostic sensitivity and specificity at the same time...
  14. pmc In vivo optical coherence tomography imaging of preinvasive bronchial lesions
    Stephen Lam
    Cancer Imaging Department, British Columbia Cancer Agency and the University of British Columbia, Vancouver, British Columbia, Canada
    Clin Cancer Res 14:2006-11. 2008
    ..The objective of the study was to determine if OCT could characterize preneoplastic changes in the bronchial epithelium identified by autofluorescence bronchoscopy...
  15. ncbi request reprint Development and preliminary results of an endoscopic Raman probe for potential in vivo diagnosis of lung cancers
    Michael A Short
    Cancer Imagin Department, British Columbia Cancer Research Centre, Vancouver, B C, Canada
    Opt Lett 33:711-3. 2008
    ..Preliminary clinical tests show that clear and reliable Raman spectra can be obtained...
  16. ncbi request reprint A phase I study of myo-inositol for lung cancer chemoprevention
    Stephen Lam
    Department of Respiratory Medicine, British Columbia Cancer Agency, British Columbia, Canada
    Cancer Epidemiol Biomarkers Prev 15:1526-31. 2006
    ..A phase I, open-label, multiple dose, dose-escalation clinical study was conducted to assess the safety, tolerability, maximum tolerated dose, and potential chemopreventive effect of myo-inositol in smokers with bronchial dysplasia...
  17. ncbi request reprint The effects of radiation dose and CT manufacturer on measurements of lung densitometry
    Ren Yuan
    Department of Radiology, Vancouver General Hospital, 855 West Twelfth Ave, Room 3350 JPN, Vancouver, BC, Canada
    Chest 132:617-23. 2007
    ..To evaluate the effect of radiation dose and scanner manufacturer on quantitative CT scan measurements of lung morphology in smokers...
  18. ncbi request reprint Lung cancer screening
    Annette McWilliams
    British Columbia Cancer Agency, Vancouver, Canada
    Curr Opin Pulm Med 11:272-7. 2005
    ..Advances in imaging technologies and biomarker research offer hope that the incidence and mortality of lung cancer can be reduced by screening similar to what have been achieved for cancer of the cervix, breast, and colon...
  19. doi request reprint Surfactant protein D and bronchial dysplasia in smokers at high risk of lung cancer
    Don D Sin
    St Paul s Hospital, 1081 Burrard Street, Vancouver, BC, Canada
    Chest 134:582-8. 2008
    ..Surfactant dysfunction has been implicated in both lung cancer and COPD. This study evaluated the relationship between surfactant protein D (SP-D) and the progression of bronchial dysplasia in heavy smokers...
  20. ncbi request reprint Early detection and chemoprevention of lung cancer
    Tawimas Shaipanich
    Department of Respiratory Medicine, British Columbia Cancer Agency, Vancouver, Canada
    Respirology 11:366-72. 2006
    ..The current status of chemoprevention is summarized. The case for using a two-step screening strategy is also discussed...
  21. doi request reprint Confocal fluorescence microendoscopy of bronchial epithelium
    Pierre M Lane
    British Columbia Cancer Research Center, Cancer Imaging Department, 675 West 10th Avenue, Vancouver, BC V5Z 1 L3, Canada
    J Biomed Opt 14:024008. 2009
    ..However, further improvements in the miniature objective lens are required to provide sufficient axial resolution for accurate classification of preneoplastic lesions...
  22. doi request reprint Detection sensitivity of a commercial lung nodule CAD system in a series of pathologically proven lung cancers
    Myrna C B Godoy
    Department of Radiology, St Paul s Hospital, University of British Columbia, Vancouver, British Columbia, Canada
    J Thorac Imaging 23:1-6. 2008
    ..To evaluate the performance of a commercially available computer-aided detection (CAD) system in a series of pathologically proven lung cancers...
  23. ncbi request reprint New approaches to lung cancer prevention
    Annette McWilliams
    Lung Tumor Group, British Columbia Cancer Agency, University of British Columbia, 600 West 10th Avenue, Vancouver, BC, Canada V5Z 4E6
    Curr Oncol Rep 4:487-94. 2002
    ..More accurate surrogate endpoint biomarkers are becoming available for phase II trials of new agents. A number of promising agents are currently being tested in phase II and III trials for prevention of lung cancer...
  24. ncbi request reprint Near-infrared Raman spectroscopy for optical diagnosis of lung cancer
    Zhiwei Huang
    Photomedicine and Optics Research Laboratory, Cancer Imaging Department, British Columbia Cancer Research Centre, 601 West 10th Avenue, Vancouver, B C V5Z 1L3, Canada
    Int J Cancer 107:1047-52. 2003
    ..0001). The results of this exploratory study indicate that NIR Raman spectroscopy provides significant potential for the noninvasive diagnosis of lung cancers in vivo based on the optic evaluation of biomolecules...
  25. ncbi request reprint Effect of formalin fixation on the near-infrared Raman spectroscopy of normal and cancerous human bronchial tissues
    Zhiwei Huang
    Cancer Imaging Department, British Columbia Cancer Research Centre, 601 West 10th Avenue, Vancouver, BC, Canada V5Z 1L3
    Int J Oncol 23:649-55. 2003
    ..If only fixed tissue is available, thorough rinsing of specimens in phosphate-buffered saline (PBS) before spectral measurements may help reduce the formalin fixation artifacts on tissue Raman spectra...