Annette M McWilliams
Affiliation: British Columbia
- Lung cancer screening: a different paradigmAnnette McWilliams
British Columbia Cancer Agency, 600 West 10th Avenue, Vancouver, BC, V5Z 4E6 Canada
Am J Respir Crit Care Med 168:1167-73. 2003..1%. CT scan alone would have missed 29% of the cancers. This screening paradigm shift has the additional potential of reducing the number of initial CT scans by at least 25% with further savings in follow-up investigations and treatment...
- Computed tomography-detected noncalcified pulmonary nodules: a review of evidence for significance and managementAnnette McWilliams
Clinical Assistant Professor, University of British Columbia, British Columbia Cancer Agency, 675 West 10th Avenue, Vancouver, BC, V5Z 1L3 Canada
Proc Am Thorac Soc 5:900-4. 2008..The role of PET in evaluating these nodules needs further exploration. Serial follow-up for 24 months in a high-risk cohort appears reasonable based on present data, but further longitudinal information is required...
- Lung cancer screening using multi-slice thin-section computed tomography and autofluorescence bronchoscopyAnnette M McWilliams
British Columbia Cancer Agency, Vancouver, British Columbia, Canada
J Thorac Oncol 1:61-8. 2006..Our hypothesis is that the use of a two-step strategy, using a sputum biomarker, may increase the detection rate of lung cancer by identifying individuals at highest risk...
- Early proximal lung cancer diagnosis and treatmentA McWilliams
University of British Columbia, British Columbia Cancer Agency and Vancouver General Hospital, 675 West 10th Avenue, Vancouver, BC, V5Z 1L3, Canada
Eur Respir J 33:656-65. 2009..The present article will deal with various issues regarding early detection, staging and treatment of centrally located early stage, mostly squamous type, lung cancer...
- Evidence for dysanapsis using computed tomographic imaging of the airways in older ex-smokersA William Sheel
School of Human Kinetics, University of British Columbia, BC, Canada
J Appl Physiol (1985) 107:1622-8. 2009..In males and females matched for lung size women had significantly smaller airway luminal areas. The larger conducting airways in females are significantly smaller than those of males even after controlling for lung size...
- Perifissural nodules seen at CT screening for lung cancerMyeong I Ahn
Department of Radiology, Vancouver General Hospital, 899 W 12th Ave, Vancouver, BC, Canada V5Z 1M9
Radiology 254:949-56. 2010..To describe and characterize the potential for malignancy of noncalcified lung nodules adjacent to fissures that are often found in current or former heavy smokers who undergo computed tomography (CT) for lung cancer screening...
- Airway wall thickness assessed using computed tomography and optical coherence tomographyHarvey O Coxson
Department of Radiology, Vancouver General Hospital, 855 West 12th Avenue, Room 3350 JPN, Vancouver, BC, Canada
Am J Respir Crit Care Med 177:1201-6. 2008..Optical coherence tomography (OCT) is a promising new micron-scale resolution imaging technique that can image small airways 2 mm in diameter or less...
- Small-airway obstruction and emphysema in chronic obstructive pulmonary diseaseJohn E McDonough
University of British Columbia James Hogg Research Centre, St Paul s Hospital, Vancouver, BC, Canada
N Engl J Med 365:1567-75. 2011..We wanted to determine whether there was a relationship between small-airway obstruction and emphysematous destruction in COPD...
- Lung nodules: CT-guided placement of microcoils to direct video-assisted thoracoscopic surgical resectionJohn R Mayo
Department of Radiology, Vancouver General Hospital Site, University of British Columbia, Vancouver, BC, Canada
Radiology 250:576-85. 2009....
- Using laser Raman spectroscopy to reduce false positives of autofluorescence bronchoscopies: a pilot studyMichael A Short
Cancer Imaging Unit, Integrative Oncology Department, British Columbia Cancer Agency Research Centre, University of British Columbia, Vancouver, British Columbia, Canada
J Thorac Oncol 6:1206-14. 2011....
- A randomized phase IIb trial of pulmicort turbuhaler (budesonide) in people with dysplasia of the bronchial epitheliumStephen Lam
Department of Respiratory Medicine, British Columbia Cancer Agency and the University of British Columbia, Vancouver, British Columbia, Canada
Clin Cancer Res 10:6502-11. 2004..Preclinical studies suggest that inhaled budesonide may be an effective chemopreventive agent for lung cancer. We conducted a phase IIb study to determine the effects of inhaled budesonide in smokers with bronchial dysplasia...
- Combining field imaging endoscopy with point analysis spectroscopy for improving early lung cancer detectionHaishan Zeng
BC Cancer Research Centre, Vancouver, BC, Canada V5Z 1L3
Conf Proc IEEE Eng Med Biol Soc 2008:1849-50. 2008..Preliminary Raman spectroscopy results will be reported at the conference...
- Integrated endoscopy system for simultaneous imaging and spectroscopy for early lung cancer detectionHaishan Zeng
Cancer Imaging Department, BC Cancer Agency, 601 West 10th Avenue, Vancouver, British Columbia V5Z 1L3, Canada
Opt Lett 29:587-9. 2004..The system has been successfully tested in a clinic, demonstrating a practical approach to improve both diagnostic sensitivity and specificity at the same time...
- In vivo optical coherence tomography imaging of preinvasive bronchial lesionsStephen Lam
Cancer Imaging Department, British Columbia Cancer Agency and the University of British Columbia, Vancouver, British Columbia, Canada
Clin Cancer Res 14:2006-11. 2008..The objective of the study was to determine if OCT could characterize preneoplastic changes in the bronchial epithelium identified by autofluorescence bronchoscopy...
- Development and preliminary results of an endoscopic Raman probe for potential in vivo diagnosis of lung cancersMichael A Short
Cancer Imagin Department, British Columbia Cancer Research Centre, Vancouver, B C, Canada
Opt Lett 33:711-3. 2008..Preliminary clinical tests show that clear and reliable Raman spectra can be obtained...
- A phase I study of myo-inositol for lung cancer chemopreventionStephen Lam
Department of Respiratory Medicine, British Columbia Cancer Agency, British Columbia, Canada
Cancer Epidemiol Biomarkers Prev 15:1526-31. 2006..A phase I, open-label, multiple dose, dose-escalation clinical study was conducted to assess the safety, tolerability, maximum tolerated dose, and potential chemopreventive effect of myo-inositol in smokers with bronchial dysplasia...
- The effects of radiation dose and CT manufacturer on measurements of lung densitometryRen Yuan
Department of Radiology, Vancouver General Hospital, 855 West Twelfth Ave, Room 3350 JPN, Vancouver, BC, Canada
Chest 132:617-23. 2007..To evaluate the effect of radiation dose and scanner manufacturer on quantitative CT scan measurements of lung morphology in smokers...
- Lung cancer screeningAnnette McWilliams
British Columbia Cancer Agency, Vancouver, Canada
Curr Opin Pulm Med 11:272-7. 2005..Advances in imaging technologies and biomarker research offer hope that the incidence and mortality of lung cancer can be reduced by screening similar to what have been achieved for cancer of the cervix, breast, and colon...
- Surfactant protein D and bronchial dysplasia in smokers at high risk of lung cancerDon D Sin
St Paul s Hospital, 1081 Burrard Street, Vancouver, BC, Canada
Chest 134:582-8. 2008..Surfactant dysfunction has been implicated in both lung cancer and COPD. This study evaluated the relationship between surfactant protein D (SP-D) and the progression of bronchial dysplasia in heavy smokers...
- Early detection and chemoprevention of lung cancerTawimas Shaipanich
Department of Respiratory Medicine, British Columbia Cancer Agency, Vancouver, Canada
Respirology 11:366-72. 2006..The current status of chemoprevention is summarized. The case for using a two-step screening strategy is also discussed...
- Confocal fluorescence microendoscopy of bronchial epitheliumPierre M Lane
British Columbia Cancer Research Center, Cancer Imaging Department, 675 West 10th Avenue, Vancouver, BC V5Z 1 L3, Canada
J Biomed Opt 14:024008. 2009..However, further improvements in the miniature objective lens are required to provide sufficient axial resolution for accurate classification of preneoplastic lesions...
- Detection sensitivity of a commercial lung nodule CAD system in a series of pathologically proven lung cancersMyrna C B Godoy
Department of Radiology, St Paul s Hospital, University of British Columbia, Vancouver, British Columbia, Canada
J Thorac Imaging 23:1-6. 2008..To evaluate the performance of a commercially available computer-aided detection (CAD) system in a series of pathologically proven lung cancers...
- New approaches to lung cancer preventionAnnette McWilliams
Lung Tumor Group, British Columbia Cancer Agency, University of British Columbia, 600 West 10th Avenue, Vancouver, BC, Canada V5Z 4E6
Curr Oncol Rep 4:487-94. 2002..More accurate surrogate endpoint biomarkers are becoming available for phase II trials of new agents. A number of promising agents are currently being tested in phase II and III trials for prevention of lung cancer...
- Near-infrared Raman spectroscopy for optical diagnosis of lung cancerZhiwei Huang
Photomedicine and Optics Research Laboratory, Cancer Imaging Department, British Columbia Cancer Research Centre, 601 West 10th Avenue, Vancouver, B C V5Z 1L3, Canada
Int J Cancer 107:1047-52. 2003..0001). The results of this exploratory study indicate that NIR Raman spectroscopy provides significant potential for the noninvasive diagnosis of lung cancers in vivo based on the optic evaluation of biomolecules...
- Effect of formalin fixation on the near-infrared Raman spectroscopy of normal and cancerous human bronchial tissuesZhiwei Huang
Cancer Imaging Department, British Columbia Cancer Research Centre, 601 West 10th Avenue, Vancouver, BC, Canada V5Z 1L3
Int J Oncol 23:649-55. 2003..If only fixed tissue is available, thorough rinsing of specimens in phosphate-buffered saline (PBS) before spectral measurements may help reduce the formalin fixation artifacts on tissue Raman spectra...