William W Lockwood

Summary

Affiliation: British Columbia
Country: Canada

Publications

  1. pmc DNA amplification is a ubiquitous mechanism of oncogene activation in lung and other cancers
    W W Lockwood
    Department of Cancer Genetics, British Columbia Cancer Research Centre, Vancouver, British Columbia, Canada
    Oncogene 27:4615-24. 2008
  2. ncbi request reprint Recent advances in array comparative genomic hybridization technologies and their applications in human genetics
    William W Lockwood
    Cancer Genetics and Developmental Biology, British Columbia Cancer Research Centre, Vancouver BC, Canada V5Z 1L3
    Eur J Hum Genet 14:139-48. 2006
  3. ncbi request reprint Whole genome tiling path array CGH analysis of segmental copy number alterations in cervical cancer cell lines
    William W Lockwood
    Department of Cancer Genetics and Developmental Biology, British Columbia Cancer Research Centre, Vancouver, BC, Canada
    Int J Cancer 120:436-43. 2007
  4. pmc Integrative genomic analyses identify BRF2 as a novel lineage-specific oncogene in lung squamous cell carcinoma
    William W Lockwood
    Department of Cancer Genetics and Developmental Biology, British Columbia Cancer Research Centre, Vancouver, British Columbia, Canada
    PLoS Med 7:e1000315. 2010
  5. pmc SIGMA: a system for integrative genomic microarray analysis of cancer genomes
    Raj Chari
    Department of Cancer Genetics and Developmental Biology, British Columbia Cancer Research Centre, Vancouver, BC, Canada
    BMC Genomics 7:324. 2006
  6. doi request reprint Integrative genomic and gene expression analysis of chromosome 7 identified novel oncogene loci in non-small cell lung cancer
    Jennifer M Campbell
    Department of Cancer Genetics and Developmental Biology, British Columbia Cancer Research Centre, 675 West 10th Avenue, Vancouver, BC V5Z1L3 Canada
    Genome 51:1032-9. 2008
  7. pmc An integrative multi-dimensional genetic and epigenetic strategy to identify aberrant genes and pathways in cancer
    Raj Chari
    Department of Integrative Oncology, BC Cancer Research Centre, Vancouver, BC, Canada
    BMC Syst Biol 4:67. 2010
  8. pmc Integrating the multiple dimensions of genomic and epigenomic landscapes of cancer
    Raj Chari
    Genetics Unit Department of Integrative Oncology, British Columbia Cancer Research Centre, Vancouver, BC, Canada
    Cancer Metastasis Rev 29:73-93. 2010
  9. pmc Genetic disruption of KEAP1/CUL3 E3 ubiquitin ligase complex components is a key mechanism of NF-kappaB pathway activation in lung cancer
    Kelsie L Thu
    Integrative Oncology Department, BC Cancer Research Centre, Vancouver, Canada
    J Thorac Oncol 6:1521-9. 2011
  10. pmc Integrative genomics identified RFC3 as an amplified candidate oncogene in esophageal adenocarcinoma
    William W Lockwood
    Integrative Oncology, British Columbia Cancer Research Centre, Vancouver, British Columbia, Canada
    Clin Cancer Res 18:1936-46. 2012

Collaborators

Detail Information

Publications21

  1. pmc DNA amplification is a ubiquitous mechanism of oncogene activation in lung and other cancers
    W W Lockwood
    Department of Cancer Genetics, British Columbia Cancer Research Centre, Vancouver, British Columbia, Canada
    Oncogene 27:4615-24. 2008
    ..Our findings suggest that amplification is far more common a mechanism of oncogene activation than previously believed and that specific regions of the genome are hotspots of amplification...
  2. ncbi request reprint Recent advances in array comparative genomic hybridization technologies and their applications in human genetics
    William W Lockwood
    Cancer Genetics and Developmental Biology, British Columbia Cancer Research Centre, Vancouver BC, Canada V5Z 1L3
    Eur J Hum Genet 14:139-48. 2006
    ....
  3. ncbi request reprint Whole genome tiling path array CGH analysis of segmental copy number alterations in cervical cancer cell lines
    William W Lockwood
    Department of Cancer Genetics and Developmental Biology, British Columbia Cancer Research Centre, Vancouver, BC, Canada
    Int J Cancer 120:436-43. 2007
    ..This work represents the highest resolution look at a cervical cancer genome to date and offers definitive characterization of the alteration status of these cancer cell lines...
  4. pmc Integrative genomic analyses identify BRF2 as a novel lineage-specific oncogene in lung squamous cell carcinoma
    William W Lockwood
    Department of Cancer Genetics and Developmental Biology, British Columbia Cancer Research Centre, Vancouver, British Columbia, Canada
    PLoS Med 7:e1000315. 2010
    ..Identification of the molecular differences between these tumor types will have a significant impact in designing novel therapies that can improve the treatment outcome...
  5. pmc SIGMA: a system for integrative genomic microarray analysis of cancer genomes
    Raj Chari
    Department of Cancer Genetics and Developmental Biology, British Columbia Cancer Research Centre, Vancouver, BC, Canada
    BMC Genomics 7:324. 2006
    ..However, tools for direct mining and analysis of array CGH data are limited. Hence, there is a great need for analytical and display software tailored to cross platform integrative analysis of cancer genomes...
  6. doi request reprint Integrative genomic and gene expression analysis of chromosome 7 identified novel oncogene loci in non-small cell lung cancer
    Jennifer M Campbell
    Department of Cancer Genetics and Developmental Biology, British Columbia Cancer Research Centre, 675 West 10th Avenue, Vancouver, BC V5Z1L3 Canada
    Genome 51:1032-9. 2008
    ..The detection of gene activation in multiple cohorts of samples strongly supports the presence of key genes involved in lung cancer that are distinct from the EGFR and MET loci on chromosome 7...
  7. pmc An integrative multi-dimensional genetic and epigenetic strategy to identify aberrant genes and pathways in cancer
    Raj Chari
    Department of Integrative Oncology, BC Cancer Research Centre, Vancouver, BC, Canada
    BMC Syst Biol 4:67. 2010
    ..This has afforded the potential for large scale integration of genome and transcriptome data generated from a variety of technology platforms to acquire a better understanding of cancer...
  8. pmc Integrating the multiple dimensions of genomic and epigenomic landscapes of cancer
    Raj Chari
    Genetics Unit Department of Integrative Oncology, British Columbia Cancer Research Centre, Vancouver, BC, Canada
    Cancer Metastasis Rev 29:73-93. 2010
    ....
  9. pmc Genetic disruption of KEAP1/CUL3 E3 ubiquitin ligase complex components is a key mechanism of NF-kappaB pathway activation in lung cancer
    Kelsie L Thu
    Integrative Oncology Department, BC Cancer Research Centre, Vancouver, Canada
    J Thorac Oncol 6:1521-9. 2011
    ..We investigated complex component gene disruption as a novel genetic mechanism of NF-κB activation in non-small cell lung cancer...
  10. pmc Integrative genomics identified RFC3 as an amplified candidate oncogene in esophageal adenocarcinoma
    William W Lockwood
    Integrative Oncology, British Columbia Cancer Research Centre, Vancouver, British Columbia, Canada
    Clin Cancer Res 18:1936-46. 2012
    ..We employed an integrative genomics approach to identify novel genes involved in EAC biology that may serve as useful clinical markers...
  11. ncbi request reprint High resolution analysis of non-small cell lung cancer cell lines by whole genome tiling path array CGH
    Cathie Garnis
    British Columbia Cancer Research Centre, Vancouver, BC, Canada
    Int J Cancer 118:1556-64. 2006
    ..In summary, our data demonstrate the unique information generated by high resolution analysis of NSCLC genomes and uncover the presence of genetic alterations prevalent in the different NSCLC subtypes...
  12. pmc Divergent genomic and epigenomic landscapes of lung cancer subtypes underscore the selection of different oncogenic pathways during tumor development
    William W Lockwood
    Department of Integrative Oncology, British Columbia Cancer Research Centre, Vancouver, British Columbia, Canada
    PLoS ONE 7:e37775. 2012
    ..Together, our findings suggest that AC and SqCC develop through distinct pathogenetic pathways that have significant implication in our approach to the clinical management of NSCLC...
  13. pmc Lung adenocarcinoma of never smokers and smokers harbor differential regions of genetic alteration and exhibit different levels of genomic instability
    Kelsie L Thu
    Department of Integrative Oncology, British Columbia Cancer Research Centre, Vancouver, British Columbia, Canada
    PLoS ONE 7:e33003. 2012
    ..Collectively, our findings provide evidence that these lung tumors are globally and genetically different, which implies they are likely driven by distinct molecular mechanisms...
  14. pmc TRAF6 is an amplified oncogene bridging the RAS and NF-κB pathways in human lung cancer
    Daniel T Starczynowski
    British Columbia Cancer Agency, Vancouver, British Columbia, Canada
    J Clin Invest 121:4095-105. 2011
    ..Our findings show that TRAF6 is an oncogene that is important for RAS-mediated oncogenesis and provide a mechanistic explanation for the previously apparent importance of constitutive NF-κB activation in RAS-driven lung cancers...
  15. doi request reprint miR-101 DNA copy loss is a prominent subtype specific event in lung cancer
    Kelsie L Thu
    BC Cancer Research Centre, Vancouver, British Columbia, Canada
    J Thorac Oncol 6:1594-8. 2011
    ..miR-101 is encoded at two loci in the human genome: 1p31.3 (miR-101-1) and 9p24.1 (miR-101-2). We sought to investigate miR-101 locus-specific deletions and genomic loss in the major subtypes of lung cancer...
  16. ncbi request reprint Genomic analyses identify gene candidates for acquired irinotecan resistance in melanoma cells
    Kai Gao
    Department of Dermatology and Skin Science, Jack Bell Research Centre, Vancouver Coastal Health Research Institute, University of British Columbia, Vancouver, Canada
    Int J Oncol 32:1343-9. 2008
    ..In addition, genes located at 14q23.3-31.1 would be promising targets to overcome acquired CPT-resistance in melanoma...
  17. doi request reprint Evolving strategies for global gene expression analysis of cancer
    Bradley P Coe
    British Columbia Cancer Research Centre, Vancouver, British Columbia, Canada
    J Cell Physiol 217:590-7. 2008
    ....
  18. doi request reprint Comparative genomic hybridization on BAC arrays
    Bradley P Coe
    British Columbia Cancer Research Centre, BC, Canada
    Methods Mol Biol 556:7-19. 2009
    ..In this chapter, we describe in detail the technical procedure required to perform copy number analysis of genomes with BAC aCGH...
  19. pmc Cyclin E1 is amplified and overexpressed in osteosarcoma
    William W Lockwood
    British Columbia Cancer Research Center, Vancouver, British Columbia, Canada
    J Mol Diagn 13:289-96. 2011
    ..Fluorescence in situ hybridization and immunohistochemical analysis confirmed the findings. Overexpression of cyclin E1 has potential prognostic and therapeutic implications that are discussed herein...
  20. pmc Computational methods for the analysis of array comparative genomic hybridization
    Raj Chari
    Cancer Genetics and Developmental Biology, British Columbia Cancer Research Centre, Vancouver BC, Canada V5Z 1L3
    Cancer Inform 2:48-58. 2007
    ..Here we explain the principles behind array image processing, data visualization and genomic profile analysis, review currently available software packages, and raise considerations for future software development...
  21. pmc PIK3CA mutations and copy number gains in human lung cancers
    Hiromasa Yamamoto
    Hamon Center for Therapeutic Oncology Research, University of Texas Southwestern Medical Center at Dallas, 6000 Harry Hines Boulevard, Dallas, TX 75390 8593, USA
    Cancer Res 68:6913-21. 2008
    ..PIK3CA mutations or gains are present in a subset of lung cancers and are of functional importance...