Yvonne Y Li

Summary

Affiliation: British Columbia
Country: Canada

Publications

  1. ncbi request reprint Selective targeting of indel-inferred differences in spatial structures of homologous proteins
    Yvonne Y Li
    CIHR MSFHR Strategic Training Program in Bioinformatics, University of British Columbia, 570 West 7th Avenue, Vancouver, British Columbia, V5Z 4S6, Canada
    J Bioinform Comput Biol 4:403-14. 2006
  2. pmc Improving the specificity of high-throughput ortholog prediction
    Debra L Fulton
    Department of Molecular Biology and Biochemistry, Simon Fraser University, Burnaby, BC, Canada
    BMC Bioinformatics 7:270. 2006
  3. ncbi request reprint A large-scale computational approach to drug repositioning
    Yvonne Y Li
    Canada s Michael Smith Genome Sciences Centre, 570 West 7th Avenue, Vancouver, British Columbia, V5Z 4S6, Canada
    Genome Inform 17:239-47. 2006
  4. pmc A computational approach to finding novel targets for existing drugs
    Yvonne Y Li
    Canada s Michael Smith Genome Sciences Centre, British Columbia Cancer Agency, Vancouver, British Columbia, Canada
    PLoS Comput Biol 7:e1002139. 2011
  5. doi request reprint Ab initio parameterization of YFF1, a universal force field for drug-design applications
    Olexandr Ya Yakovenko
    Genome Sciences Centre, BC Cancer Agency, Suite 100 570 West 7th Avenue, Vancouver, British Columbia, Canada
    J Mol Model 18:663-73. 2012
  6. pmc Evolution of an adenocarcinoma in response to selection by targeted kinase inhibitors
    Steven Jm Jones
    Genome Sciences Centre, British Columbia Cancer Agency, 570 West 7th Avenue, Vancouver, BC, V5Z 4S6, Canada
    Genome Biol 11:R82. 2010

Detail Information

Publications7

  1. ncbi request reprint Selective targeting of indel-inferred differences in spatial structures of homologous proteins
    Yvonne Y Li
    CIHR MSFHR Strategic Training Program in Bioinformatics, University of British Columbia, 570 West 7th Avenue, Vancouver, British Columbia, V5Z 4S6, Canada
    J Bioinform Comput Biol 4:403-14. 2006
    ..While experimental evidence is required to verify our results, our findings thus far appear to support this approach as a new strategy for the development of antagonists against pathogenic targets having close human homologs...
  2. pmc Improving the specificity of high-throughput ortholog prediction
    Debra L Fulton
    Department of Molecular Biology and Biochemistry, Simon Fraser University, Burnaby, BC, Canada
    BMC Bioinformatics 7:270. 2006
    ..In addition, there is an increasing interest in identifying orthologs most likely to have retained similar function...
  3. ncbi request reprint A large-scale computational approach to drug repositioning
    Yvonne Y Li
    Canada s Michael Smith Genome Sciences Centre, 570 West 7th Avenue, Vancouver, British Columbia, V5Z 4S6, Canada
    Genome Inform 17:239-47. 2006
    ..Our results highlight the promising nature of the inverse docking method for identifying potential novel therapeutic uses for existing drugs...
  4. pmc A computational approach to finding novel targets for existing drugs
    Yvonne Y Li
    Canada s Michael Smith Genome Sciences Centre, British Columbia Cancer Agency, Vancouver, British Columbia, Canada
    PLoS Comput Biol 7:e1002139. 2011
    ..Novel interactions discovered may lead to the drug being repositioned as a therapeutic treatment for its off-target's associated disease, added insight into the drug's mechanism of action, and added insight into the drug's side effects...
  5. doi request reprint Ab initio parameterization of YFF1, a universal force field for drug-design applications
    Olexandr Ya Yakovenko
    Genome Sciences Centre, BC Cancer Agency, Suite 100 570 West 7th Avenue, Vancouver, British Columbia, Canada
    J Mol Model 18:663-73. 2012
    ..1 kcal mol(-1). Although the primary goal of this work was to parameterize nonbonded interactions, bonded parameters were also derived, by fitting to PM6 semiempirically optimized geometries of approximately 20,000 compounds...
  6. pmc Evolution of an adenocarcinoma in response to selection by targeted kinase inhibitors
    Steven Jm Jones
    Genome Sciences Centre, British Columbia Cancer Agency, 570 West 7th Avenue, Vancouver, BC, V5Z 4S6, Canada
    Genome Biol 11:R82. 2010
    ..We investigated the utility of massively parallel sequencing to characterize an adenocarcinoma of the tongue, before and after treatment...