Stephen Lam

Summary

Affiliation: British Columbia
Country: Canada

Publications

  1. ncbi request reprint A randomized phase IIb trial of pulmicort turbuhaler (budesonide) in people with dysplasia of the bronchial epithelium
    Stephen Lam
    Department of Respiratory Medicine, British Columbia Cancer Agency and the University of British Columbia, Vancouver, British Columbia, Canada
    Clin Cancer Res 10:6502-11. 2004
  2. ncbi request reprint A phase I study of myo-inositol for lung cancer chemoprevention
    Stephen Lam
    Department of Respiratory Medicine, British Columbia Cancer Agency, British Columbia, Canada
    Cancer Epidemiol Biomarkers Prev 15:1526-31. 2006
  3. pmc In vivo optical coherence tomography imaging of preinvasive bronchial lesions
    Stephen Lam
    Cancer Imaging Department, British Columbia Cancer Agency and the University of British Columbia, Vancouver, British Columbia, Canada
    Clin Cancer Res 14:2006-11. 2008
  4. pmc Increased staining for phospho-Akt, p65/RELA and cIAP-2 in pre-neoplastic human bronchial biopsies
    Jay W Tichelaar
    Department of Environmental Health, University of Cincinnati College of Medicine, Cincinnati, OH 45267, USA
    BMC Cancer 5:155. 2005
  5. pmc Integrative genomic analyses identify BRF2 as a novel lineage-specific oncogene in lung squamous cell carcinoma
    William W Lockwood
    Department of Cancer Genetics and Developmental Biology, British Columbia Cancer Research Centre, Vancouver, British Columbia, Canada
    PLoS Med 7:e1000315. 2010
  6. pmc Genetic disruption of KEAP1/CUL3 E3 ubiquitin ligase complex components is a key mechanism of NF-kappaB pathway activation in lung cancer
    Kelsie L Thu
    Integrative Oncology Department, BC Cancer Research Centre, Vancouver, Canada
    J Thorac Oncol 6:1521-9. 2011
  7. doi request reprint Elevated expression of BIRC6 protein in non-small-cell lung cancers is associated with cancer recurrence and chemoresistance
    Xin Dong
    Department of Experimental Therapeutics, BC Cancer Agency, Cancer Research Centre, Vancouver, BC, Canada
    J Thorac Oncol 8:161-70. 2013
  8. pmc Transcriptome profiles of carcinoma-in-situ and invasive non-small cell lung cancer as revealed by SAGE
    Kim M Lonergan
    Genetics Unit, Integrative Oncology, British Columbia Cancer Research Centre, Vancouver, British Columbia, Canada
    PLoS ONE 5:e9162. 2010
  9. ncbi request reprint Surrogate end-point biomarker analysis in a retinol chemoprevention trial in current and former smokers with bronchial dysplasia
    Stephen Lam
    Department of Respiratory Therapy, British Columbia Cancer Agency, Vancouver, British Columbia V5Z 3J5, Canada
    Int J Oncol 23:1607-13. 2003
  10. ncbi request reprint High resolution analysis of non-small cell lung cancer cell lines by whole genome tiling path array CGH
    Cathie Garnis
    British Columbia Cancer Research Centre, Vancouver, BC, Canada
    Int J Cancer 118:1556-64. 2006

Research Grants

Detail Information

Publications63

  1. ncbi request reprint A randomized phase IIb trial of pulmicort turbuhaler (budesonide) in people with dysplasia of the bronchial epithelium
    Stephen Lam
    Department of Respiratory Medicine, British Columbia Cancer Agency and the University of British Columbia, Vancouver, British Columbia, Canada
    Clin Cancer Res 10:6502-11. 2004
    ..Preclinical studies suggest that inhaled budesonide may be an effective chemopreventive agent for lung cancer. We conducted a phase IIb study to determine the effects of inhaled budesonide in smokers with bronchial dysplasia...
  2. ncbi request reprint A phase I study of myo-inositol for lung cancer chemoprevention
    Stephen Lam
    Department of Respiratory Medicine, British Columbia Cancer Agency, British Columbia, Canada
    Cancer Epidemiol Biomarkers Prev 15:1526-31. 2006
    ..A phase I, open-label, multiple dose, dose-escalation clinical study was conducted to assess the safety, tolerability, maximum tolerated dose, and potential chemopreventive effect of myo-inositol in smokers with bronchial dysplasia...
  3. pmc In vivo optical coherence tomography imaging of preinvasive bronchial lesions
    Stephen Lam
    Cancer Imaging Department, British Columbia Cancer Agency and the University of British Columbia, Vancouver, British Columbia, Canada
    Clin Cancer Res 14:2006-11. 2008
    ..The objective of the study was to determine if OCT could characterize preneoplastic changes in the bronchial epithelium identified by autofluorescence bronchoscopy...
  4. pmc Increased staining for phospho-Akt, p65/RELA and cIAP-2 in pre-neoplastic human bronchial biopsies
    Jay W Tichelaar
    Department of Environmental Health, University of Cincinnati College of Medicine, Cincinnati, OH 45267, USA
    BMC Cancer 5:155. 2005
    ..The acquisition of anti-apoptotic signals is critical for the survival of cancer cells but the pathways involved are incompletely characterized in developing intra-epithelial neoplasia (IEN)...
  5. pmc Integrative genomic analyses identify BRF2 as a novel lineage-specific oncogene in lung squamous cell carcinoma
    William W Lockwood
    Department of Cancer Genetics and Developmental Biology, British Columbia Cancer Research Centre, Vancouver, British Columbia, Canada
    PLoS Med 7:e1000315. 2010
    ..Identification of the molecular differences between these tumor types will have a significant impact in designing novel therapies that can improve the treatment outcome...
  6. pmc Genetic disruption of KEAP1/CUL3 E3 ubiquitin ligase complex components is a key mechanism of NF-kappaB pathway activation in lung cancer
    Kelsie L Thu
    Integrative Oncology Department, BC Cancer Research Centre, Vancouver, Canada
    J Thorac Oncol 6:1521-9. 2011
    ..We investigated complex component gene disruption as a novel genetic mechanism of NF-κB activation in non-small cell lung cancer...
  7. doi request reprint Elevated expression of BIRC6 protein in non-small-cell lung cancers is associated with cancer recurrence and chemoresistance
    Xin Dong
    Department of Experimental Therapeutics, BC Cancer Agency, Cancer Research Centre, Vancouver, BC, Canada
    J Thorac Oncol 8:161-70. 2013
    ..In this study, we investigated whether BIRC6 expression can be used as a prognostic marker or potential therapeutic target for NSCLC...
  8. pmc Transcriptome profiles of carcinoma-in-situ and invasive non-small cell lung cancer as revealed by SAGE
    Kim M Lonergan
    Genetics Unit, Integrative Oncology, British Columbia Cancer Research Centre, Vancouver, British Columbia, Canada
    PLoS ONE 5:e9162. 2010
    ..Identification of biological pathways reflective of these progressive stages, and aberrantly expressed genes associated with these pathways, would conceivably enhance therapeutic approaches to this devastating disease...
  9. ncbi request reprint Surrogate end-point biomarker analysis in a retinol chemoprevention trial in current and former smokers with bronchial dysplasia
    Stephen Lam
    Department of Respiratory Therapy, British Columbia Cancer Agency, Vancouver, British Columbia V5Z 3J5, Canada
    Int J Oncol 23:1607-13. 2003
    ....
  10. ncbi request reprint High resolution analysis of non-small cell lung cancer cell lines by whole genome tiling path array CGH
    Cathie Garnis
    British Columbia Cancer Research Centre, Vancouver, BC, Canada
    Int J Cancer 118:1556-64. 2006
    ..In summary, our data demonstrate the unique information generated by high resolution analysis of NSCLC genomes and uncover the presence of genetic alterations prevalent in the different NSCLC subtypes...
  11. ncbi request reprint Using laser Raman spectroscopy to reduce false positives of autofluorescence bronchoscopies: a pilot study
    Michael A Short
    Cancer Imaging Unit, Integrative Oncology Department, British Columbia Cancer Agency Research Centre, University of British Columbia, Vancouver, British Columbia, Canada
    J Thorac Oncol 6:1206-14. 2011
    ....
  12. doi request reprint Surfactant protein D and bronchial dysplasia in smokers at high risk of lung cancer
    Don D Sin
    St Paul s Hospital, 1081 Burrard Street, Vancouver, BC, Canada
    Chest 134:582-8. 2008
    ..Surfactant dysfunction has been implicated in both lung cancer and COPD. This study evaluated the relationship between surfactant protein D (SP-D) and the progression of bronchial dysplasia in heavy smokers...
  13. doi request reprint Patient-derived first generation xenografts of non-small cell lung cancers: promising tools for predicting drug responses for personalized chemotherapy
    Xin Dong
    Department of Cancer Endocrinology, BC Cancer Agency, University of British Columbia, Vancouver, British Columbia, Canada
    Clin Cancer Res 16:1442-51. 2010
    ..In this study, first generation subrenal capsule xenografts of primary NSCLCs were examined for (a) determining responses to conventional chemotherapeutic regimens and (b) selecting regimens most effective for individual patients...
  14. pmc Automated sputum cytometry for detection of intraepithelial neoplasias in the lung
    Gerald Li
    Integrative Oncology Department, BC Cancer Research Centre, Vancouver, Canada
    Anal Cell Pathol (Amst) 35:187-201. 2012
    ..Our novel sputum biomarker, the Combined Score (CS), uses automated image cytometric analysis of ploidy and nuclear morphology to detect subtle intraepithelial changes that often precede lung tumours...
  15. ncbi request reprint Nuclear morphometry as a biomarker for bronchial intraepithelial neoplasia: correlation with genetic damage and cancer development
    Martial Guillaud
    Department of Cancer Imaging, Vancouver, British Columbia, Canada
    Cytometry A 63:34-40. 2005
    ..The objective of this study was to quantitate morphologic changes of intraepitherlial neoplasia and validate its utility through correlation with histopathology, allelic loss, and cancer development...
  16. ncbi request reprint Development and preliminary results of an endoscopic Raman probe for potential in vivo diagnosis of lung cancers
    Michael A Short
    Cancer Imagin Department, British Columbia Cancer Research Centre, Vancouver, B C, Canada
    Opt Lett 33:711-3. 2008
    ..Preliminary clinical tests show that clear and reliable Raman spectra can be obtained...
  17. ncbi request reprint Lung cancer screening: a different paradigm
    Annette McWilliams
    British Columbia Cancer Agency, 600 West 10th Avenue, Vancouver, BC, V5Z 4E6 Canada
    Am J Respir Crit Care Med 168:1167-73. 2003
    ..1%. CT scan alone would have missed 29% of the cancers. This screening paradigm shift has the additional potential of reducing the number of initial CT scans by at least 25% with further savings in follow-up investigations and treatment...
  18. pmc A sequence-based approach to identify reference genes for gene expression analysis
    Raj Chari
    Department of Integrative Oncology, British Columbia Cancer Agency Research Centre, Vancouver, BC, Canada
    BMC Med Genomics 3:32. 2010
    ..Alternatively, as sequencing-based technologies provide digital quantitative output, absolute quantification ensues, and reference gene identification becomes more accurate...
  19. ncbi request reprint Gain of a region on 7p22.3, containing MAD1L1, is the most frequent event in small-cell lung cancer cell lines
    Bradley P Coe
    British Columbia Cancer Research Centre, Vancouver, BC, Canada
    Genes Chromosomes Cancer 45:11-9. 2006
    ..Intriguingly, MAD1L1 has been implicated to have tumor-suppressing functions. Our data suggest a more complex role for this gene, as MAD1L1 is the most frequent copy number gain in SCLC cell lines...
  20. pmc Effect of active smoking on the human bronchial epithelium transcriptome
    Raj Chari
    Department of Cancer Genetics and Developmental Biology, British Columbia Cancer Research Centre, Vancouver, BC, Canada
    BMC Genomics 8:297. 2007
    ....
  21. ncbi request reprint High-resolution chromosome arm 5p array CGH analysis of small cell lung carcinoma cell lines
    Bradley P Coe
    British Columbia Cancer Research Centre, Vancouver, British Columbia, Canada
    Genes Chromosomes Cancer 42:308-13. 2005
    ....
  22. pmc Divergent genomic and epigenomic landscapes of lung cancer subtypes underscore the selection of different oncogenic pathways during tumor development
    William W Lockwood
    Department of Integrative Oncology, British Columbia Cancer Research Centre, Vancouver, British Columbia, Canada
    PLoS ONE 7:e37775. 2012
    ..Together, our findings suggest that AC and SqCC develop through distinct pathogenetic pathways that have significant implication in our approach to the clinical management of NSCLC...
  23. pmc Lung adenocarcinoma of never smokers and smokers harbor differential regions of genetic alteration and exhibit different levels of genomic instability
    Kelsie L Thu
    Department of Integrative Oncology, British Columbia Cancer Research Centre, Vancouver, British Columbia, Canada
    PLoS ONE 7:e33003. 2012
    ..Collectively, our findings provide evidence that these lung tumors are globally and genetically different, which implies they are likely driven by distinct molecular mechanisms...
  24. pmc Integrating the multiple dimensions of genomic and epigenomic landscapes of cancer
    Raj Chari
    Genetics Unit Department of Integrative Oncology, British Columbia Cancer Research Centre, Vancouver, BC, Canada
    Cancer Metastasis Rev 29:73-93. 2010
    ....
  25. ncbi request reprint Involvement of multiple developmental genes on chromosome 1p in lung tumorigenesis
    Cathie Garnis
    British Columbia Cancer Research Centre, Vancouver, BC V5Z 1L3, Canada
    Hum Mol Genet 14:475-82. 2005
    ..Importantly, this implication of pathways known only to be activated in fetal lung development lends support to the proposed model of lung cancer ontology whereby tumors arise from dysregulated pleuripotent stem cells...
  26. doi request reprint The xc- cystine/glutamate antiporter as a potential therapeutic target for small-cell lung cancer: use of sulfasalazine
    Jun Guan
    Department of Cancer Endocrinology, BC Cancer Agency, Research Centre, Vancouver, BC, Canada
    Cancer Chemother Pharmacol 64:463-72. 2009
    ..To determine whether the xc- cystine transporter could be a useful therapeutic target for small-cell lung cancer (SCLC)...
  27. pmc Human cancer long non-coding RNA transcriptomes
    Ewan A Gibb
    British Columbia Cancer Agency Research Centre, Vancouver, British Columbia, Canada
    PLoS ONE 6:e25915. 2011
    ..Our findings show extensive, tissue-specific lncRNA expression in normal tissues and highly aberrant lncRNA expression in human cancers. Here, we present a first generation atlas for lncRNA profiling in cancer...
  28. pmc Airway wall thickness assessed using computed tomography and optical coherence tomography
    Harvey O Coxson
    Department of Radiology, Vancouver General Hospital, 855 West 12th Avenue, Room 3350 JPN, Vancouver, BC, Canada
    Am J Respir Crit Care Med 177:1201-6. 2008
    ..Optical coherence tomography (OCT) is a promising new micron-scale resolution imaging technique that can image small airways 2 mm in diameter or less...
  29. pmc TRAF6 is an amplified oncogene bridging the RAS and NF-κB pathways in human lung cancer
    Daniel T Starczynowski
    British Columbia Cancer Agency, Vancouver, British Columbia, Canada
    J Clin Invest 121:4095-105. 2011
    ..Our findings show that TRAF6 is an oncogene that is important for RAS-mediated oncogenesis and provide a mechanistic explanation for the previously apparent importance of constitutive NF-κB activation in RAS-driven lung cancers...
  30. ncbi request reprint miR-101 DNA copy loss is a prominent subtype specific event in lung cancer
    Kelsie L Thu
    BC Cancer Research Centre, Vancouver, British Columbia, Canada
    J Thorac Oncol 6:1594-8. 2011
    ..miR-101 is encoded at two loci in the human genome: 1p31.3 (miR-101-1) and 9p24.1 (miR-101-2). We sought to investigate miR-101 locus-specific deletions and genomic loss in the major subtypes of lung cancer...
  31. pmc EZH2 promotes E2F-driven SCLC tumorigenesis through modulation of apoptosis and cell-cycle regulation
    Roland Hubaux
    Integrative Oncology, British Columbia Cancer Research Centre, Vancouver, British Columbia, Canada
    J Thorac Oncol 8:1102-6. 2013
    ..Given the therapeutic potential of EZH2 as a target, we sought to delineate the downstream consequences of EZH2 disruption to identify the cellular mechanisms by which EZH2 promotes tumorigenesis in SCLC...
  32. pmc Pro-surfactant protein B as a biomarker for lung cancer prediction
    Don D Sin
    Don D Sin, Stephen Lam, and Anthony Tam, University of British Columbia Don D Sin and Anthony Tam, Institute of Heart and Lung Health, James Hogg Research Center, St Paul s Hospital Stephen Lam and Xiaobo Duan, British Columbia Cancer Agency, Vancouver, British Columbia C Martin Tammemagi, Brock University, St Catharines, Ontario, Canada Matt J Barnett, Ziding Feng, and Gary E Goodman, Fred Hutchinson Cancer Research Center, Seattle, WA Heidi Auman, Canary Foundation, Palo Alto, CA and Ziding Feng, Samir Hanash, and Ayumu Taguchi, University of Texas MD Anderson Cancer Center, Houston, TX
    J Clin Oncol 31:4536-43. 2013
    ..We conducted a study to determine the independent predictive potential of pro-SFTPB in identifying individuals who are subsequently diagnosed with lung cancer...
  33. ncbi request reprint Identification of novel lung genes in bronchial epithelium by serial analysis of gene expression
    Kim M Lonergan
    Cancer Genetics and Developmental Biology, Department of Cancer Imaging, Canada s Michael Smith Genome Sciences Centre, British Columbia Cancer Research Centre, Vancouver, BC, Canada
    Am J Respir Cell Mol Biol 35:651-61. 2006
    ....
  34. pmc Molecular features in arsenic-induced lung tumors
    Roland Hubaux
    British Columbia Cancer Research Centre, 675 West 10th Avenue, Vancouver, BC V5Z 1L3, Canada
    Mol Cancer 12:20. 2013
    ..In this article, we review the current knowledge on the various mechanisms of arsenic carcinogenicity and the specific roles of this metalloid in signaling pathways leading to lung cancer...
  35. doi request reprint Confocal fluorescence microendoscopy of bronchial epithelium
    Pierre M Lane
    British Columbia Cancer Research Center, Cancer Imaging Department, 675 West 10th Avenue, Vancouver, BC V5Z 1 L3, Canada
    J Biomed Opt 14:024008. 2009
    ..However, further improvements in the miniature objective lens are required to provide sufficient axial resolution for accurate classification of preneoplastic lesions...
  36. ncbi request reprint Near-infrared Raman spectroscopy for optical diagnosis of lung cancer
    Zhiwei Huang
    Photomedicine and Optics Research Laboratory, Cancer Imaging Department, British Columbia Cancer Research Centre, 601 West 10th Avenue, Vancouver, B C V5Z 1L3, Canada
    Int J Cancer 107:1047-52. 2003
    ..0001). The results of this exploratory study indicate that NIR Raman spectroscopy provides significant potential for the noninvasive diagnosis of lung cancers in vivo based on the optic evaluation of biomolecules...
  37. doi request reprint Detection sensitivity of a commercial lung nodule CAD system in a series of pathologically proven lung cancers
    Myrna C B Godoy
    Department of Radiology, St Paul s Hospital, University of British Columbia, Vancouver, British Columbia, Canada
    J Thorac Imaging 23:1-6. 2008
    ..To evaluate the performance of a commercially available computer-aided detection (CAD) system in a series of pathologically proven lung cancers...
  38. ncbi request reprint Key issues in lung cancer chemoprevention trials of new agents
    Stephen Lam
    Lung Tumour Group, The British Columbia Cancer Agency and The University of British Columbia, West 10 Avenue, Vancouver, BC V5Z 4E6, Canada
    Recent Results Cancer Res 163:182-95; discussion 264-6. 2003
    ..Novel imaging methods such as confocal micro-endoscopy and spiral CT-directed endoscopic biopsies are under development to evaluate the response of chemopreventive agents on peripheral pre-neoplastic lesions in small airways...
  39. ncbi request reprint A randomized phase IIb trial of anethole dithiolethione in smokers with bronchial dysplasia
    Stephen Lam
    Department of Respiratory Medicine, British Columbia Cancer Agency and the University of British Columbia, Vancouver, Canada
    J Natl Cancer Inst 94:1001-9. 2002
    ..We conducted a phase IIb study to determine the effects of ADT in smokers with bronchial dysplasia...
  40. pmc DNA methylation is globally disrupted and associated with expression changes in chronic obstructive pulmonary disease small airways
    Emily A Vucic
    1 Department of Integrative Oncology, British Columbia Cancer Research Centre, Vancouver, British Columbia, Canada
    Am J Respir Cell Mol Biol 50:912-22. 2014
    ....
  41. doi request reprint Fluorescence and navigational bronchoscopy
    Annette McWilliams
    Department of Integrative Oncology, British Columbia Cancer Agency, 6 108, 675 West 10th Avenue, Vancouver, British Columbia V5Z 1L3, Canada
    Thorac Surg Clin 23:153-61. 2013
    ..These tools may provide a safer alternative method to CT-guided transthoracic lung biopsy for peripheral lung lesions that are not pleural based...
  42. pmc Genomic deregulation of the E2F/Rb pathway leads to activation of the oncogene EZH2 in small cell lung cancer
    Bradley P Coe
    Integrative Oncology Department, BC Cancer Research Centre, Vancouver, Canada
    PLoS ONE 8:e71670. 2013
    ..In conclusion, our data confirm the role of EZH2 as a critical oncogene in SCLC, and lend support to the prioritization of EZH2 as a potential therapeutic target in clinical disease. ..
  43. ncbi request reprint A framework for quantitative assessment of Ki67 distribution in preneoplastic bronchial epithelial lesions
    Mehrnoush Khojasteh
    Department of Cancer Imaging, British Columbia Cancer Research Center, Vancouver, British Columbia, Canada
    Anal Quant Cytol Histol 34:120-38. 2012
    ..We sought to develop a robust, objective means of quantitatively evaluating Ki67 immunostaining for lung precancerous lesions...
  44. ncbi request reprint Lung cancer screening
    Annette McWilliams
    British Columbia Cancer Agency, Vancouver, Canada
    Curr Opin Pulm Med 11:272-7. 2005
    ..Advances in imaging technologies and biomarker research offer hope that the incidence and mortality of lung cancer can be reduced by screening similar to what have been achieved for cancer of the cervix, breast, and colon...
  45. ncbi request reprint In vitro model for studying malignancy associated changes
    Xiao Rong Sun
    Cancer Imaging Department, British Columbia Cancer Agency, Vancouver, Canada
    Anal Cell Pathol 25:95-102. 2003
    ..This study provides evidence in support to the hypothesis that MAC are induced by a soluble factor(s) released by malignant cells. Colour figure can be viewed on http://www.esacp.org/acp/2003/25-2/sun.htm..
  46. doi request reprint New and current clinical imaging techniques to study chronic obstructive pulmonary disease
    Harvey O Coxson
    Providence Heart and Lung Institute, St Paul s Hospital, Vancouver, British Columbia, Canada
    Am J Respir Crit Care Med 180:588-97. 2009
    ..In this article, we provide an overview of these imaging modalities in the context of COPD and discuss their strengths as well as their limitations for providing quantitative COPD phenotypes...
  47. pmc MicroRNA gene dosage alterations and drug response in lung cancer
    Katey S S Enfield
    British Columbia Cancer Research Centre, Vancouver, BC, Canada
    J Biomed Biotechnol 2011:474632. 2011
    ....
  48. pmc Validation of airway wall measurements by optical coherence tomography in porcine airways
    Anthony M D Lee
    Department of Integrative Oncology Imaging Unit, British Columbia Cancer Agency Research Centre, Vancouver, British Columbia, Canada
    PLoS ONE 9:e100145. 2014
    ..We believe this study sets the groundwork for quantitatively monitoring pathogenesis and interventions in the airways using OCT. ..
  49. ncbi request reprint Early detection and chemoprevention of lung cancer
    Tawimas Shaipanich
    Department of Respiratory Medicine, British Columbia Cancer Agency, Vancouver, Canada
    Respirology 11:366-72. 2006
    ..The current status of chemoprevention is summarized. The case for using a two-step screening strategy is also discussed...
  50. doi request reprint In vivo lung microvasculature visualized in three dimensions using fiber-optic color Doppler optical coherence tomography
    Anthony M D Lee
    British Columbia Cancer Research Centre, Department of Integrative Oncology Imaging Unit, Vancouver, British Columbia V5Z 1L3, Canada
    J Biomed Opt 18:50501. 2013
    ..In a second example, a smaller vessel (∼80  μm diameter) that is indistinguishable in the structural OCT image is fully visualized in 3-D using CDOCT...
  51. pmc Probability of cancer in pulmonary nodules detected on first screening CT
    Annette McWilliams
    Vancouver General Hospital, Vancouver, BC, Canada
    N Engl J Med 369:910-9. 2013
    ..We conducted a population-based prospective study to determine factors predicting the probability that lung nodules detected on the first screening low-dose CT scans are malignant or will be found to be malignant on follow-up...
  52. pmc Arsenic, asbestos and radon: emerging players in lung tumorigenesis
    Roland Hubaux
    British Columbia Cancer Research Centre, Vancouver, BC, V5Z 1L3, Canada
    Environ Health 11:89. 2012
    ..A better understanding of the mode of action of these carcinogens will facilitate the prevention and management of lung cancer related to such environmental hazards...
  53. ncbi request reprint New approaches to lung cancer prevention
    Annette McWilliams
    Lung Tumor Group, British Columbia Cancer Agency, University of British Columbia, 600 West 10th Avenue, Vancouver, BC, Canada V5Z 4E6
    Curr Oncol Rep 4:487-94. 2002
    ..More accurate surrogate endpoint biomarkers are becoming available for phase II trials of new agents. A number of promising agents are currently being tested in phase II and III trials for prevention of lung cancer...
  54. ncbi request reprint Side population in human lung cancer cell lines and tumors is enriched with stem-like cancer cells
    Maria M Ho
    Department of Cancer Genetics and Developmental Biology, British Columbia Cancer Agency, Vancouver, British Columbia, Canada
    Cancer Res 67:4827-33. 2007
    ..These findings indicate that SP is an enriched source of lung tumor-initiating cells with stem cell properties and may be an important target for effective therapy and a useful tool to investigate the tumorigenic process...
  55. ncbi request reprint Integrated endoscopy system for simultaneous imaging and spectroscopy for early lung cancer detection
    Haishan Zeng
    Cancer Imaging Department, BC Cancer Agency, 601 West 10th Avenue, Vancouver, British Columbia V5Z 1L3, Canada
    Opt Lett 29:587-9. 2004
    ..The system has been successfully tested in a clinic, demonstrating a practical approach to improve both diagnostic sensitivity and specificity at the same time...
  56. ncbi request reprint Effect of formalin fixation on the near-infrared Raman spectroscopy of normal and cancerous human bronchial tissues
    Zhiwei Huang
    Cancer Imaging Department, British Columbia Cancer Research Centre, 601 West 10th Avenue, Vancouver, BC, Canada V5Z 1L3
    Int J Oncol 23:649-55. 2003
    ..If only fixed tissue is available, thorough rinsing of specimens in phosphate-buffered saline (PBS) before spectral measurements may help reduce the formalin fixation artifacts on tissue Raman spectra...
  57. pmc The relationship between stage 1 and 2 non-small cell lung cancer and lung function in men and women
    Samir Malhotra
    Respiratory Division, Department of Medicine, University of British Columbia, British Columbia, Canada
    BMC Pulm Med 6:2. 2006
    ..Using a large tissue registry, we sought to determine the relationship between FEV1 and subtypes of NSCLC and determine whether this relationship is modified by gender...
  58. ncbi request reprint Increase of sensitivity of sputum cytology using high-resolution image cytometry: field study results
    Branko Palcic
    British Columbia Cancer Agency, 191 828 West 10th Street, Vancouver, British Columbia V5Z 1L8, Canada
    Cytometry 50:168-76. 2002
    ..Cytometry (Clin. Cytometry) 50:168-176, 2002...
  59. ncbi request reprint Establishment in severe combined immunodeficiency mice of subrenal capsule xenografts and transplantable tumor lines from a variety of primary human lung cancers: potential models for studying tumor progression-related changes
    Jean Claude Cutz
    Department of Cancer Endocrinology, BC Cancer Agency, Vancouver, British Columbia, Canada
    Clin Cancer Res 12:4043-54. 2006
    ..With a view to establishing such models, we developed and evaluated xenografts of a variety of human lung cancers...
  60. pmc What to do when a smoker's CT scan is "normal"?: Implications for lung cancer screening
    Joanna H Zurawska
    Department of Medicine, Division of Respiratory Medicine, University of British Columbia, BC, Canada
    Chest 141:1147-52. 2012
    ..In this article, we offer a possible low-cost strategy to risk-stratify smokers on the basis of spirometry measurements and emphysema scoring by radiologists on CT scans...
  61. ncbi request reprint The effects of radiation dose and CT manufacturer on measurements of lung densitometry
    Ren Yuan
    Department of Radiology, Vancouver General Hospital, 855 West Twelfth Ave, Room 3350 JPN, Vancouver, BC, Canada
    Chest 132:617-23. 2007
    ..To evaluate the effect of radiation dose and scanner manufacturer on quantitative CT scan measurements of lung morphology in smokers...
  62. doi request reprint EarlyCDT-Lung: an immunobiomarker test as an aid to early detection of lung cancer
    Stephen Lam
    Department of Pulmonary Medicine, British Columbia Cancer Agency, Vancouver, Canada
    Cancer Prev Res (Phila) 4:1126-34. 2011
    ..These studies confirm the value of an autoantibody assay, EarlyCDT-Lung, as an aid to detecting lung cancer in patients at high risk of the disease...
  63. ncbi request reprint Construction and optimization of chromosome arm-specific comparative genomic hybridization arrays for identifying genetic alterations in preinvasive lung cancers
    Cathie Garnis
    British Columbia Cancer Research Centre, Vancouver, BC, Canada
    Chest 125:104S-5S. 2004

Research Grants1

  1. A Phase II Trial of ACAPHA in Former Smokers with IEN.
    Stephen Lam; Fiscal Year: 2006
    ..It will also provide new information on the use of novel biomarkers as surrogate endpoints for assessing the effect of chemoprevention. ..