N Khalil

Summary

Affiliation: British Columbia
Country: Canada

Publications

  1. ncbi Post translational activation of latent transforming growth factor beta (L-TGF-beta): clinical implications
    N Khalil
    Department of Medicine, Vancouver Hospital, University of British Columbia, Canada
    Histol Histopathol 16:541-51. 2001
  2. pmc Regulation of the effects of TGF-beta 1 by activation of latent TGF-beta 1 and differential expression of TGF-beta receptors (T beta R-I and T beta R-II) in idiopathic pulmonary fibrosis
    N Khalil
    University of Manitoba, Winnipeg, Manitoba, Canada
    Thorax 56:907-15. 2001
  3. ncbi Differential expression of transforming growth factor-beta type I and II receptors by pulmonary cells in bleomycin-induced lung injury: correlation with repair and fibrosis
    Nasreen Khalil
    Manitoba Institute of Cell Biology, University of Manitoba, Winnipeg, Canada
    Exp Lung Res 28:233-50. 2002
  4. ncbi Release of biologically active TGF-beta from airway smooth muscle cells induces autocrine synthesis of collagen
    A Coutts
    Department of Medicine and Manitoba Institute of Cell Biology, University of Manitoba, Winnipeg, Manitoba R3E 0V9
    Am J Physiol Lung Cell Mol Physiol 280:L999-1008. 2001
  5. pmc Activation of rat alveolar macrophage-derived latent transforming growth factor beta-1 by plasmin requires interaction with thrombospondin-1 and its cell surface receptor, CD36
    T Yehualaeshet
    Departments of Medicine, Manitoba Institute of Cell Biology, University of Manitoba, Winnipeg, Manitoba, Canada
    Am J Pathol 155:841-51. 1999
  6. ncbi Increase in the beta chain of hepatocyte growth factor (HGF beta) precedes c-met expression after bleomycin-induced lung injury in the rat
    Deborah Douglas
    Department of Medicine and the Vancouver General Hospital, University of British Columbia, Vancouver, British Columbia, Canada
    Exp Lung Res 28:301-14. 2002
  7. pmc TGF-beta1 increases proliferation of airway smooth muscle cells by phosphorylation of map kinases
    Gang Chen
    Division of Respiratory Medicine, Department of Medicine, The University of British Columbia, The Vancouver Coastal Health Research Institute, Vancouver, BC V6H 3Z6, Canada
    Respir Res 7:2. 2006
  8. ncbi Proliferation of pulmonary interstitial fibroblasts is mediated by transforming growth factor-beta1-induced release of extracellular fibroblast growth factor-2 and phosphorylation of p38 MAPK and JNK
    Nasreen Khalil
    Respiratory Division, Department of Medicine, University of British Columbia
    J Biol Chem 280:43000-9. 2005
  9. ncbi Angiotensin II type 1 receptor blocker inhibits pulmonary injury
    G B John Mancini
    Department of Medicine, Division of Cardiology, University of British Columbia and Vancouver Coastal Research Institute, Vancouver, Canada
    Clin Invest Med 28:118-26. 2005
  10. pmc Idiopathic pulmonary fibrosis: current understanding of the pathogenesis and the status of treatment
    Nasreen Khalil
    Respiratory Division, Vancouver Coastal Health Research Institute, Vancouver, BC
    CMAJ 171:153-60. 2004

Collaborators

Detail Information

Publications14

  1. ncbi Post translational activation of latent transforming growth factor beta (L-TGF-beta): clinical implications
    N Khalil
    Department of Medicine, Vancouver Hospital, University of British Columbia, Canada
    Histol Histopathol 16:541-51. 2001
    ..The recognition of mechanisms that activate L-TGF-beta1 in vivo offers the possibility of interfering with the activation of L-TGF-beta1 for therapeutic purposes...
  2. pmc Regulation of the effects of TGF-beta 1 by activation of latent TGF-beta 1 and differential expression of TGF-beta receptors (T beta R-I and T beta R-II) in idiopathic pulmonary fibrosis
    N Khalil
    University of Manitoba, Winnipeg, Manitoba, Canada
    Thorax 56:907-15. 2001
    ..TGF-beta latency binding protein 1 (LTBP-1), which facilitates the release and activation of L-TGF-beta 1, is also important in the biology of TGF-beta 1...
  3. ncbi Differential expression of transforming growth factor-beta type I and II receptors by pulmonary cells in bleomycin-induced lung injury: correlation with repair and fibrosis
    Nasreen Khalil
    Manitoba Institute of Cell Biology, University of Manitoba, Winnipeg, Canada
    Exp Lung Res 28:233-50. 2002
    ..Ourfindings suggest that during bleomycin-induced pulmonary fibrosis, the effects of TGF-beta1 on cells may be regulated by the expression of TbetaRs...
  4. ncbi Release of biologically active TGF-beta from airway smooth muscle cells induces autocrine synthesis of collagen
    A Coutts
    Department of Medicine and Manitoba Institute of Cell Biology, University of Manitoba, Winnipeg, Manitoba R3E 0V9
    Am J Physiol Lung Cell Mol Physiol 280:L999-1008. 2001
    ..The autocrine induction of collagen expression by ASMCs may contribute to the irreversible fibrosis and remodeling seen in the airways of some asthmatics...
  5. pmc Activation of rat alveolar macrophage-derived latent transforming growth factor beta-1 by plasmin requires interaction with thrombospondin-1 and its cell surface receptor, CD36
    T Yehualaeshet
    Departments of Medicine, Manitoba Institute of Cell Biology, University of Manitoba, Winnipeg, Manitoba, Canada
    Am J Pathol 155:841-51. 1999
    ..These findings suggest that activation of L-TGF-beta1 by plasmin occurs at the cell surface of activated alveolar macrophages and requires a TSP-1/CD36 interaction...
  6. ncbi Increase in the beta chain of hepatocyte growth factor (HGF beta) precedes c-met expression after bleomycin-induced lung injury in the rat
    Deborah Douglas
    Department of Medicine and the Vancouver General Hospital, University of British Columbia, Vancouver, British Columbia, Canada
    Exp Lung Res 28:301-14. 2002
    ..These findings suggest that HGF may regulate its own receptor on AECs and is an important mitogen for AECs 4 days after bleomycin administration...
  7. pmc TGF-beta1 increases proliferation of airway smooth muscle cells by phosphorylation of map kinases
    Gang Chen
    Division of Respiratory Medicine, Department of Medicine, The University of British Columbia, The Vancouver Coastal Health Research Institute, Vancouver, BC V6H 3Z6, Canada
    Respir Res 7:2. 2006
    ..In the present study, we determined the role of phosphorylated MAPKs in TGF-beta1 induced ASMC proliferation...
  8. ncbi Proliferation of pulmonary interstitial fibroblasts is mediated by transforming growth factor-beta1-induced release of extracellular fibroblast growth factor-2 and phosphorylation of p38 MAPK and JNK
    Nasreen Khalil
    Respiratory Division, Department of Medicine, University of British Columbia
    J Biol Chem 280:43000-9. 2005
    ....
  9. ncbi Angiotensin II type 1 receptor blocker inhibits pulmonary injury
    G B John Mancini
    Department of Medicine, Division of Cardiology, University of British Columbia and Vancouver Coastal Research Institute, Vancouver, Canada
    Clin Invest Med 28:118-26. 2005
    ..The purpose of this study was to evaluate the effects of an angiotensin II type 1 receptor blocker, valsartan, on systemic, cellular, and fibrotic consequences of pulmonary injury induced by the anti-neoplastic antibiotic, bleomycin...
  10. pmc Idiopathic pulmonary fibrosis: current understanding of the pathogenesis and the status of treatment
    Nasreen Khalil
    Respiratory Division, Vancouver Coastal Health Research Institute, Vancouver, BC
    CMAJ 171:153-60. 2004
    ..There is no known effective treatment for IPF, but lung transplantation improves survival...
  11. ncbi Release of biologically active TGF-beta1 by alveolar epithelial cells results in pulmonary fibrosis
    Ying Dong Xu
    Division of Respiratory Medicine, Department of Medicine, The University of British Columbia, Vancouver, BC V6H 3Z6, Canada
    Am J Physiol Lung Cell Mol Physiol 285:L527-39. 2003
    ..Collagens I, III, IV, and V and fibronectin were increased in explants treated with pMX-L-s223,225-TGF-beta1. The findings in the current study suggest that IPF may be a disorder of epithelial cells and not inflammatory cells...
  12. ncbi GM-CSF increases airway smooth muscle cell connective tissue expression by inducing TGF-beta receptors
    Gang Chen
    Department of Medicine, Vancouver Hospital and Health Sciences Centre, University of British Columbia, Vancouver, British Columbia V6Z 3Z6, Canada
    Am J Physiol Lung Cell Mol Physiol 284:L548-56. 2003
    ..In conclusion, GM-CSF increases the responsiveness of ASMC to TGF-beta1-mediated connective tissue expression by induction of TbetaRs, which is inhibited by corticosteroids...
  13. ncbi In vitro wounding of airway smooth muscle cell monolayers increases expression of TGF-beta receptors
    Gang Chen
    Division of Respiratory Medicine, Department of Medicine, Vancouver Hospital and Health Sciences Centre, The University of British Columbia, 655 West 12th Avenue, Vancouver, BC, Canada V5Z 4R4
    Respir Physiol Neurobiol 132:341-6. 2002
    ..These results suggest that ASMC injury may play an important role in airway fibrosis mediated by TGF-beta1, which can be prevented by the use of corticosteroids...
  14. ncbi Environmental, inhaled and ingested causes of pulmonary fibrosis
    Nasreen Khalil
    Department of Medicine, Respiratory Division, Vancouver General Hospital, V5Z 1M9, The University of British Columbia, Canada
    Toxicol Pathol 35:86-96. 2007
    ..Prevention or removal of the inciting agent is critical to the treatment of these disorders and in some instances corticosteroids may be of help...