Genomes and Genes
Affiliation: British Columbia
- Post translational activation of latent transforming growth factor beta (L-TGF-beta): clinical implicationsN Khalil
Department of Medicine, Vancouver Hospital, University of British Columbia, Canada
Histol Histopathol 16:541-51. 2001..The recognition of mechanisms that activate L-TGF-beta1 in vivo offers the possibility of interfering with the activation of L-TGF-beta1 for therapeutic purposes...
- Regulation of the effects of TGF-beta 1 by activation of latent TGF-beta 1 and differential expression of TGF-beta receptors (T beta R-I and T beta R-II) in idiopathic pulmonary fibrosisN Khalil
University of Manitoba, Winnipeg, Manitoba, Canada
Thorax 56:907-15. 2001..TGF-beta latency binding protein 1 (LTBP-1), which facilitates the release and activation of L-TGF-beta 1, is also important in the biology of TGF-beta 1...
- Differential expression of transforming growth factor-beta type I and II receptors by pulmonary cells in bleomycin-induced lung injury: correlation with repair and fibrosisNasreen Khalil
Manitoba Institute of Cell Biology, University of Manitoba, Winnipeg, Canada
Exp Lung Res 28:233-50. 2002..Ourfindings suggest that during bleomycin-induced pulmonary fibrosis, the effects of TGF-beta1 on cells may be regulated by the expression of TbetaRs...
- Release of biologically active TGF-beta from airway smooth muscle cells induces autocrine synthesis of collagenA Coutts
Department of Medicine and Manitoba Institute of Cell Biology, University of Manitoba, Winnipeg, Manitoba R3E 0V9
Am J Physiol Lung Cell Mol Physiol 280:L999-1008. 2001..The autocrine induction of collagen expression by ASMCs may contribute to the irreversible fibrosis and remodeling seen in the airways of some asthmatics...
- Activation of rat alveolar macrophage-derived latent transforming growth factor beta-1 by plasmin requires interaction with thrombospondin-1 and its cell surface receptor, CD36T Yehualaeshet
Departments of Medicine, Manitoba Institute of Cell Biology, University of Manitoba, Winnipeg, Manitoba, Canada
Am J Pathol 155:841-51. 1999..These findings suggest that activation of L-TGF-beta1 by plasmin occurs at the cell surface of activated alveolar macrophages and requires a TSP-1/CD36 interaction...
- Increase in the beta chain of hepatocyte growth factor (HGF beta) precedes c-met expression after bleomycin-induced lung injury in the ratDeborah Douglas
Department of Medicine and the Vancouver General Hospital, University of British Columbia, Vancouver, British Columbia, Canada
Exp Lung Res 28:301-14. 2002..These findings suggest that HGF may regulate its own receptor on AECs and is an important mitogen for AECs 4 days after bleomycin administration...
- TGF-beta1 increases proliferation of airway smooth muscle cells by phosphorylation of map kinasesGang Chen
Division of Respiratory Medicine, Department of Medicine, The University of British Columbia, The Vancouver Coastal Health Research Institute, Vancouver, BC V6H 3Z6, Canada
Respir Res 7:2. 2006..In the present study, we determined the role of phosphorylated MAPKs in TGF-beta1 induced ASMC proliferation...
- Proliferation of pulmonary interstitial fibroblasts is mediated by transforming growth factor-beta1-induced release of extracellular fibroblast growth factor-2 and phosphorylation of p38 MAPK and JNKNasreen Khalil
Respiratory Division, Department of Medicine, University of British Columbia
J Biol Chem 280:43000-9. 2005....
- Angiotensin II type 1 receptor blocker inhibits pulmonary injuryG B John Mancini
Department of Medicine, Division of Cardiology, University of British Columbia and Vancouver Coastal Research Institute, Vancouver, Canada
Clin Invest Med 28:118-26. 2005..The purpose of this study was to evaluate the effects of an angiotensin II type 1 receptor blocker, valsartan, on systemic, cellular, and fibrotic consequences of pulmonary injury induced by the anti-neoplastic antibiotic, bleomycin...
- Idiopathic pulmonary fibrosis: current understanding of the pathogenesis and the status of treatmentNasreen Khalil
Respiratory Division, Vancouver Coastal Health Research Institute, Vancouver, BC
CMAJ 171:153-60. 2004..There is no known effective treatment for IPF, but lung transplantation improves survival...
- Release of biologically active TGF-beta1 by alveolar epithelial cells results in pulmonary fibrosisYing Dong Xu
Division of Respiratory Medicine, Department of Medicine, The University of British Columbia, Vancouver, BC V6H 3Z6, Canada
Am J Physiol Lung Cell Mol Physiol 285:L527-39. 2003..Collagens I, III, IV, and V and fibronectin were increased in explants treated with pMX-L-s223,225-TGF-beta1. The findings in the current study suggest that IPF may be a disorder of epithelial cells and not inflammatory cells...
- GM-CSF increases airway smooth muscle cell connective tissue expression by inducing TGF-beta receptorsGang Chen
Department of Medicine, Vancouver Hospital and Health Sciences Centre, University of British Columbia, Vancouver, British Columbia V6Z 3Z6, Canada
Am J Physiol Lung Cell Mol Physiol 284:L548-56. 2003..In conclusion, GM-CSF increases the responsiveness of ASMC to TGF-beta1-mediated connective tissue expression by induction of TbetaRs, which is inhibited by corticosteroids...
- In vitro wounding of airway smooth muscle cell monolayers increases expression of TGF-beta receptorsGang Chen
Division of Respiratory Medicine, Department of Medicine, Vancouver Hospital and Health Sciences Centre, The University of British Columbia, 655 West 12th Avenue, Vancouver, BC, Canada V5Z 4R4
Respir Physiol Neurobiol 132:341-6. 2002..These results suggest that ASMC injury may play an important role in airway fibrosis mediated by TGF-beta1, which can be prevented by the use of corticosteroids...
- Environmental, inhaled and ingested causes of pulmonary fibrosisNasreen Khalil
Department of Medicine, Respiratory Division, Vancouver General Hospital, V5Z 1M9, The University of British Columbia, Canada
Toxicol Pathol 35:86-96. 2007..Prevention or removal of the inciting agent is critical to the treatment of these disorders and in some instances corticosteroids may be of help...