Aly Karsan

Summary

Affiliation: British Columbia
Country: Canada

Publications

  1. pmc FADD negatively regulates lipopolysaccharide signaling by impairing interleukin-1 receptor-associated kinase 1-MyD88 interaction
    Rachel Zhande
    Department of Medical Biophysics, British Columbia Cancer Research Centre, University of British Columbia, 675 West 10th Ave, Vancouver, BC V5Z 1L3, Canada
    Mol Cell Biol 27:7394-404. 2007
  2. pmc Jagged1-mediated Notch activation induces epithelial-to-mesenchymal transition through Slug-induced repression of E-cadherin
    Kevin G Leong
    Department of Medical Biophysics, British Columbia Cancer Agency, Vancouver, British Columbia V5Z 1L3, Canada
    J Exp Med 204:2935-48. 2007
  3. pmc Slug is a direct Notch target required for initiation of cardiac cushion cellularization
    Kyle Niessen
    Department of Medical Biophysics, British Columbia Cancer Agency, Vancouver V5Z 1L3, Canada
    J Cell Biol 182:315-25. 2008
  4. pmc Heterogeneity of breast cancer stem cells as evidenced with Notch-dependent and Notch-independent populations
    Nelson K Y Wong
    Genome Sciences Centre, BC Cancer Agency Vancouver, BC, Canada Department of Pathology and Laboratory Medicine, University of British Columbia Vancouver, BC, Canada
    Cancer Med 1:105-13. 2012
  5. ncbi request reprint Analytical and preanalytical biases in serum proteomic pattern analysis for breast cancer diagnosis
    Aly Karsan
    Department of Pathology and Laboratory Medicine, British Columbia Cancer Agency, Vancouver, BC, Canada
    Clin Chem 51:1525-8. 2005
  6. doi request reprint Notch and integrin affinity: a sticky situation
    Aly Karsan
    Department of Pathology and Laboratory Medicine, British Columbia Cancer Agency, Vancouver, British Columbia V6K 2Z4, Canada
    Sci Signal 1:pe2. 2008
  7. doi request reprint Notch signaling in cardiac development
    Kyle Niessen
    Department of Medical Biophysics, British Columbia Cancer Research Centre, 675 W 10th Ave, Vancouver, BC, Canada V5Z 1L3
    Circ Res 102:1169-81. 2008
  8. ncbi request reprint Proteomic analysis of lipid microdomains from lipopolysaccharide-activated human endothelial cells
    Aly Karsan
    Department of Medical Biophysics and Pathology and Laboratory Medicine, British Columbia Cancer Agency, Vancouver, British Columbia, Canada V5Z 1L3
    J Proteome Res 4:349-57. 2005
  9. ncbi request reprint The role of notch in modeling and maintaining the vasculature
    Aly Karsan
    Department of Medical Biophysics, British Columbia Cancer Research Centre, Vancouver, BC, Canada
    Can J Physiol Pharmacol 83:14-23. 2005
  10. ncbi request reprint Quantitative proteomic analysis of sokotrasterol sulfate-stimulated primary human endothelial cells
    Aly Karsan
    Department of Medical Biophysics, British Columbia Cancer Agency, Vancouver, British Columbia V5Z 1L3, Canada
    Mol Cell Proteomics 4:191-204. 2005

Detail Information

Publications65

  1. pmc FADD negatively regulates lipopolysaccharide signaling by impairing interleukin-1 receptor-associated kinase 1-MyD88 interaction
    Rachel Zhande
    Department of Medical Biophysics, British Columbia Cancer Research Centre, University of British Columbia, 675 West 10th Ave, Vancouver, BC V5Z 1L3, Canada
    Mol Cell Biol 27:7394-404. 2007
    ..Reconstitution of FADD reversed the enhanced production of proinflammatory cytokines. Thus, FADD is a physiological negative regulator of IRAK1/MyD88-dependent responses in innate immune signaling...
  2. pmc Jagged1-mediated Notch activation induces epithelial-to-mesenchymal transition through Slug-induced repression of E-cadherin
    Kevin G Leong
    Department of Medical Biophysics, British Columbia Cancer Agency, Vancouver, British Columbia V5Z 1L3, Canada
    J Exp Med 204:2935-48. 2007
    ..Our findings suggest that ligand-induced Notch activation, through the induction of Slug, promotes tumor growth and metastasis characterized by epithelial-to-mesenchymal transition and inhibition of anoikis...
  3. pmc Slug is a direct Notch target required for initiation of cardiac cushion cellularization
    Kyle Niessen
    Department of Medical Biophysics, British Columbia Cancer Agency, Vancouver V5Z 1L3, Canada
    J Cell Biol 182:315-25. 2008
    ..Collectively, our data suggest that combined expression of Slug and Snail is required for EMT in cardiac cushion morphogenesis...
  4. pmc Heterogeneity of breast cancer stem cells as evidenced with Notch-dependent and Notch-independent populations
    Nelson K Y Wong
    Genome Sciences Centre, BC Cancer Agency Vancouver, BC, Canada Department of Pathology and Laboratory Medicine, University of British Columbia Vancouver, BC, Canada
    Cancer Med 1:105-13. 2012
    ..Our findings thus provide direct evidence for a heterogeneous cancer stem cell pool, which will require combination therapies against multiple oncogenic pathways to eliminate the tumor-initiating cell population...
  5. ncbi request reprint Analytical and preanalytical biases in serum proteomic pattern analysis for breast cancer diagnosis
    Aly Karsan
    Department of Pathology and Laboratory Medicine, British Columbia Cancer Agency, Vancouver, BC, Canada
    Clin Chem 51:1525-8. 2005
  6. doi request reprint Notch and integrin affinity: a sticky situation
    Aly Karsan
    Department of Pathology and Laboratory Medicine, British Columbia Cancer Agency, Vancouver, British Columbia V6K 2Z4, Canada
    Sci Signal 1:pe2. 2008
    ..Because R-Ras is selectively distributed in vascular cells, these findings are of particular importance in understanding the effector functions of Notch in the vascular system...
  7. doi request reprint Notch signaling in cardiac development
    Kyle Niessen
    Department of Medical Biophysics, British Columbia Cancer Research Centre, 675 W 10th Ave, Vancouver, BC, Canada V5Z 1L3
    Circ Res 102:1169-81. 2008
    ..This review focuses on recently reported findings that elucidate mechanisms regulated by the Notch pathway during ventricular, atrioventricular canal, and outflow tract development...
  8. ncbi request reprint Proteomic analysis of lipid microdomains from lipopolysaccharide-activated human endothelial cells
    Aly Karsan
    Department of Medical Biophysics and Pathology and Laboratory Medicine, British Columbia Cancer Agency, Vancouver, British Columbia, Canada V5Z 1L3
    J Proteome Res 4:349-57. 2005
    ..This analysis sets the analytical foundation for an in-depth probing of LPS signaling in endothelial cells...
  9. ncbi request reprint The role of notch in modeling and maintaining the vasculature
    Aly Karsan
    Department of Medical Biophysics, British Columbia Cancer Research Centre, Vancouver, BC, Canada
    Can J Physiol Pharmacol 83:14-23. 2005
    ..Human diseases caused by Notch pathway members are also discussed...
  10. ncbi request reprint Quantitative proteomic analysis of sokotrasterol sulfate-stimulated primary human endothelial cells
    Aly Karsan
    Department of Medical Biophysics, British Columbia Cancer Agency, Vancouver, British Columbia V5Z 1L3, Canada
    Mol Cell Proteomics 4:191-204. 2005
    ..These findings are consistent with a role for sokotrasterol sulfate in endothelial sprouting...
  11. ncbi request reprint Notch activation results in phenotypic and functional changes consistent with endothelial-to-mesenchymal transformation
    Michela Noseda
    Department of Pathology and Laboratory Medicine, University of British Columbia, Vancouver, Canada
    Circ Res 94:910-7. 2004
    ....
  12. ncbi request reprint Notch4-induced inhibition of endothelial sprouting requires the ankyrin repeats and involves signaling through RBP-Jkappa
    Farrell MacKenzie
    Department of Pathology and Laboratory Medicine, University of British Columbia, Vancouver, BC, Canada
    Blood 104:1760-8. 2004
    ..Thus, Notch4-induced inhibition of sprouting requires the ankyrin repeats and appears to involve RBP-Jkappa-dependent and -independent signaling...
  13. pmc Differential regulation of transforming growth factor beta signaling pathways by Notch in human endothelial cells
    Yangxin Fu
    British Columbia Cancer Agency, University of British Columbia, Vancouver, British Columbia V5Z IL3, Canada
    J Biol Chem 284:19452-62. 2009
    ..This is the first evidence that Notch activation affects R-Smad expression and that cooperative induction of histone acetylation at specific promoters underlies the selective synergy between Notch and TGFbeta signaling pathways...
  14. pmc Notch activation induces endothelial cell cycle arrest and participates in contact inhibition: role of p21Cip1 repression
    Michela Noseda
    Department of Medical Biophysics, Vancouver, British Columbia, Canada V5Z 1L3
    Mol Cell Biol 24:8813-22. 2004
    ..We suggest that Notch activation contributes to contact inhibition of endothelial cells, in part through repression of p21Cip1 expression...
  15. ncbi request reprint Notch-dependent cell cycle arrest is associated with downregulation of minichromosome maintenance proteins
    Michela Noseda
    Department of Medical Biophysics, British Columbia Cancer Agency, Vancouver, Canada
    Circ Res 97:102-4. 2005
    ..Although the effects of the Notch pathway are cell-type specific and context-dependent, in cell types where Notch has an antiproliferative effect, downregulation of MCM proteins may be a common mechanism to inhibit DNA replication...
  16. ncbi request reprint Bacterial lipopolysaccharide directly induces angiogenesis through TRAF6-mediated activation of NF-kappaB and c-Jun N-terminal kinase
    Ingrid Pollet
    Department of Medical Biophyics, British Columbia Cancer Research Centre, 601 West 10th Ave, Vancouver, BC, Canada, V5Z 1L3
    Blood 102:1740-2. 2003
    ..Our findings thus demonstrate a direct endothelial-stimulatory role of LPS in initiating angiogenesis through activation of TRAF6-dependent signaling pathways...
  17. doi request reprint Notch activation promotes endothelial survival through a PI3K-Slug axis
    Linda Chang
    Genome Sciences Centre, British Columbia Cancer Agency, Vancouver, V5Z 1L3 BC, Canada
    Microvasc Res 89:80-5. 2013
    ..Notch activation can enhance or inhibit apoptosis but its role in maintaining the endothelium needs further delineation...
  18. doi request reprint SASH1 is a scaffold molecule in endothelial TLR4 signaling
    Shauna M Dauphinee
    Genome Sciences Centre, British Columbia Cancer Agency, Vancouver, British Columbia V5Z 1L3, Canada
    J Immunol 191:892-901. 2013
    ..Our findings suggest that SASH1 acts to assemble a signaling complex downstream of TLR4 to activate early endothelial responses to receptor activation. ..
  19. ncbi request reprint Notch initiates the endothelial-to-mesenchymal transition in the atrioventricular canal through autocrine activation of soluble guanylyl cyclase
    Alex C Y Chang
    Michael Smith Genome Sciences Centre, British Columbia Cancer Agency, Vancouver BC V5Z 1L3, Canada
    Dev Cell 21:288-300. 2011
    ..We thus show that the activation of sGC by NO through a Notch-dependent autocrine loop is necessary to drive early EndMT in the developing atrioventricular canal (AVC)...
  20. pmc Twist1 transcriptional targets in the developing atrio-ventricular canal of the mouse
    Pavle Vrljicak
    Terry Fox Laboratory, British Columbia Cancer Agency, Vancouver, Canada
    PLoS ONE 7:e40815. 2012
    ..Our findings support a role for TWIST1 in the differentiation of AVC mesenchyme post-EMT in the mouse, and suggest that TWIST1 can exert its function by direct DNA binding to activate valve specific gene expression...
  21. doi request reprint MicroRNA-146a disrupts hematopoietic differentiation and survival
    Daniel T Starczynowski
    British Columbia Cancer Agency Research Centre, 675 West 10th Avenue, Vancouver, BC, Canada
    Exp Hematol 39:167-178.e4. 2011
    ..The aim of this study was to investigate the in vivo consequences of expressing one of the LPS-induced miRNA, miR-146a, in bone marrow cells...
  22. ncbi request reprint Lipopolysaccharide initiates a TRAF6-mediated endothelial survival signal
    Fred Wong
    Department of Pathology and Laboratory Medicine, British Columbia Cancer Agency, Vancouver, BC, Canada V5Z 1L3
    Blood 103:4520-6. 2004
    ..Activation of PI3K signals a critical antiapoptotic pathway in response to LPS in endothelial cells, whereas ERK1/2 does not. Thus TRAF6 acts as a bifurcation point of the LPS-initiated death and survival signals in endothelial cells...
  23. ncbi request reprint Vascular endothelial growth factor receptor-2 induces survival of hematopoietic progenitor cells
    Bruno Larrivee
    Department of Medicine, University of British Columbia, Vancouver, British Columbia V6T 1Z4, Canada
    J Biol Chem 278:22006-13. 2003
    ..Thus, the role of VEGFR-2 in hematopoiesis is likely to maintain survival of hematopoietic progenitors through the activation of antiapoptotic pathways...
  24. pmc Differentiation of vascular smooth muscle cells from local precursors during embryonic and adult arteriogenesis requires Notch signaling
    Linda Chang
    Genome Sciences Centre, British Columbia Cancer Agency, Vancouver, BC, Canada V5Z 1L3
    Proc Natl Acad Sci U S A 109:6993-8. 2012
    ..Thus, Notch activity is required in the differentiation of a Tie1(+) local precursor to VSMC in a spatiotemporal fashion across all vascular beds...
  25. doi request reprint Notch-dependent regulation of the ischemic vasodilatory response--brief report
    Alex C Y Chang
    Michael Smith Genome Sciences Centre, British Columbia Cancer Agency, Vancouver, BC, V5Z 1L3, Canada
    Arterioscler Thromb Vasc Biol 33:510-2. 2013
    ..We tested the hypothesis that endothelial cell-Notch function is required for NO induction and vasodilation, in response to ischemia in the adult vasculature...
  26. ncbi request reprint Endothelial-specific Notch blockade inhibits vascular function and tumor growth through an eNOS-dependent mechanism
    Alexandre Patenaude
    Authors Affiliations Genome Sciences Centre Integrative Oncology Program Department of Pathology and Laboratory Medicine, British Columbia Cancer Agency and Department of Pathology and Laboratory Medicine, University of British Columbia, Vancouver, British Columbia, Canada
    Cancer Res 74:2402-11. 2014
    ..This study uncovers a novel mechanism of nitric oxide production in endothelial cells in tumors, with implications for understanding the peculiar character of tumor blood vessels...
  27. ncbi request reprint Smooth Muscle alpha-actin is a direct target of Notch/CSL
    Michela Noseda
    Department of Medical Biophysics, British Columbia Cancer Agency, Vancouver, Canada
    Circ Res 98:1468-70. 2006
    ..This is the first evidence of the requirement for Notch activation in the regulation of SMA expression...
  28. ncbi request reprint Notch4 inhibits endothelial apoptosis via RBP-Jkappa-dependent and -independent pathways
    Farrell MacKenzie
    Department of Pathology and Laboratory Medicine, University of British Columbia, Vancouver, British Columbia V6T 2B5, Canada
    J Biol Chem 279:11657-63. 2004
    ..Our findings demonstrate that Notch4 activation inhibits apoptosis through multiple pathways and provides one mechanism to explain the remarkable capacity of endothelial cells to withstand apoptosis...
  29. ncbi request reprint Identification of sokotrasterol sulfate as a novel proangiogenic steroid
    Siun Murphy
    Department of Medical Biophysics, British Columbia Cancer Agency, 675 West 10th Ave, Vancouver, British Columbia V5Z 1L3, Canada
    Circ Res 99:257-65. 2006
    ..Our findings indicate that sokotrasterol sulfate and its analogs can promote angiogenesis in vitro and in vivo and could potentially be used for promoting neovascularization to relieve the sequelae of vasoocclusive diseases...
  30. doi request reprint Involvement of endothelial progenitor cells in tumor vascularization
    Alexandre Patenaude
    Pathology and Laboratory Medicine and Genome Sciences Centre, British Columbia Cancer Agency Research Centre, 675 West 10th Avenue, V5Z 1L3 British Columbia, Vancouver, Canada
    Microvasc Res 79:217-23. 2010
    ..This review focuses on studies reporting or precluding the importance of EPC in tumor vasculogenesis. The putative sources of these cells and difficulties associated with their detection are discussed...
  31. pmc RUNX3 maintains the mesenchymal phenotype after termination of the Notch signal
    Yangxin Fu
    British Columbia Cancer Research Centre, University of British Columbia, Vancouver, British Columbia, Canada
    J Biol Chem 286:11803-13. 2011
    ..Taken together, our results suggest that induction of RUNX3 may be a mechanism to maintain Notch-transformed mesenchymal cells during heart development...
  32. ncbi request reprint A Notch-dependent transcriptional hierarchy promotes mesenchymal transdifferentiation in the cardiac cushion
    Alex C Y Chang
    Michael Smith Genome Sciences Centre, British Columbia Cancer Agency, Vancouver, Canada
    Dev Dyn 243:894-905. 2014
    ..These novel signaling pathways downstream of Notch are potentially relevant to valve development. Developmental Dynamics 243:894-905, 2014. © 2014 Wiley Periodicals, Inc. ..
  33. pmc Activated Notch4 inhibits angiogenesis: role of beta 1-integrin activation
    Kevin G Leong
    Department of Experimental Medicine, University of British Columbia and British Columbia Cancer Agency, Vancouver, British Columbia V5Z 1L3, Canada
    Mol Cell Biol 22:2830-41. 2002
    ..Our findings suggest that constitutive Notch4 activation in endothelial cells inhibits angiogenesis in part by promoting beta 1-integrin-mediated adhesion to the underlying matrix...
  34. pmc Genomic analysis distinguishes phases of early development of the mouse atrio-ventricular canal
    Pavle Vrljicak
    Terry Fox Laboratory, British Columbia Cancer Agency, Vancouver, British Columbia, Canada V5Z 1L3
    Physiol Genomics 40:150-7. 2010
    ..These results identify molecular signatures that distinguish different phases of early heart valve formation allowing gene expression and function to be further investigated...
  35. doi request reprint Innate immune signaling in the myelodysplastic syndromes
    Daniel T Starczynowski
    Genome Sciences Centre, British Columbia Cancer Research Centre, 675 West 10th Avenue, Vancouver, BC, Canada
    Hematol Oncol Clin North Am 24:343-59. 2010
    ..Increased activation of the innate immune pathway may contribute to dysregulated hematopoiesis, dysplasia, and clonal expansion in myelodysplastic syndromes...
  36. ncbi request reprint Activation of vascular endothelial growth factor receptor-2 in bone marrow leads to accumulation of myeloid cells: role of granulocyte-macrophage colony-stimulating factor
    Bruno Larrivee
    Department of Experimental Medicine, University of British Columbia, Vancouver, Canada
    J Immunol 175:3015-24. 2005
    ..Our findings indicate that VEGF signaling through VEGFR-2 promotes myelopoiesis through GM-CSF-dependent and -independent mechanisms...
  37. doi request reprint Genome-wide identification of human microRNAs located in leukemia-associated genomic alterations
    Daniel T Starczynowski
    British Columbia Cancer Agency Research Centre, Vancouver, BC, Canada
    Blood 117:595-607. 2011
    ..This detailed genomic and small RNA analysis points to a subset of miRNAs that may play a role in myeloid malignancies...
  38. doi request reprint Copy number alterations at polymorphic loci may be acquired somatically in patients with myelodysplastic syndromes
    Daniel T Starczynowski
    Genome Sciences Centre, British Columbia Cancer Agency, Vancouver, BC, Canada
    Leuk Res 35:444-7. 2011
    ....
  39. doi request reprint Heterotrimeric Gi/Go proteins modulate endothelial TLR signaling independent of the MyD88-dependent pathway
    Shauna M Dauphinee
    Genome Sciences Centre, Vancouver, British Columbia, Canada
    Am J Physiol Heart Circ Physiol 301:H2246-53. 2011
    ..Taken together, the data presented here suggest that heterotrimeric G proteins are widely involved in TLR pathways along a signaling cascade that is distinct from MyD88-TRAF6...
  40. pmc TRAF6 is an amplified oncogene bridging the RAS and NF-κB pathways in human lung cancer
    Daniel T Starczynowski
    British Columbia Cancer Agency, Vancouver, British Columbia, Canada
    J Clin Invest 121:4095-105. 2011
    ..Our findings show that TRAF6 is an oncogene that is important for RAS-mediated oncogenesis and provide a mechanistic explanation for the previously apparent importance of constitutive NF-κB activation in RAS-driven lung cancers...
  41. ncbi request reprint Erythropoietin promotes survival of primary human endothelial cells through PI3K-dependent, NF-kappaB-independent upregulation of Bcl-xL
    Rachel Zhande
    Department of Pathology and Laboratory Medicine, University of British Columbia Vancouver, BC, Canada
    Am J Physiol Heart Circ Physiol 292:H2467-74. 2007
    ..Thus EPO promotes survival of endothelial cells through PI3K-dependent Bcl-x(L)-induction and BIM regulation, as well as through a separate mechanism involving the ERK pathway...
  42. pmc Correlation of clinical response and response duration with miR-145 induction by lenalidomide in CD34(+) cells from patients with del(5q) myelodysplastic syndrome
    Christopher P Venner
    Leukemia Bone Marrow Transplant Program, Division of Hematology, University of British Columbia, Vancouver, BC, Canada
    Haematologica 98:409-13. 2013
    ..Lenalidomide selectively abrogated progenitor activity in cells depleted of miR-143 and miR-145 supporting a key role for miR-143/145 in the sensitivity to lenalidomide of del(5q) myelodysplastic syndrome patients...
  43. ncbi request reprint Lipopolysaccharide signals an endothelial apoptosis pathway through TNF receptor-associated factor 6-mediated activation of c-Jun NH2-terminal kinase
    Christopher Hull
    Department of Pathology and Laboratory Medicine, British Columbia Cancer Agency, Canada
    J Immunol 169:2611-8. 2002
    ..JNK inhibition blocks caspase activation, but the reverse is not true. Hence, JNK activation lies upstream of caspase activation in response to LPS stimulation...
  44. doi request reprint Co-ordinating Notch, BMP, and TGF-β signaling during heart valve development
    Victoria C Garside
    Terry Fox Laboratory, BC Cancer Agency, 675 West 10th Avenue, Vancouver, BC, Canada
    Cell Mol Life Sci 70:2899-917. 2013
    ..Here, we discuss BMP, TGF-β, and Notch signaling pathways during mouse cardiac cushion formation and how they together produce a coordinated EMT response in the developing mouse valves. ..
  45. ncbi request reprint The morphogenic function of E-cadherin-mediated adherens junctions in epithelial ovarian carcinoma formation and progression
    Colleen Wu
    Department of Cellular and Physiological Sciences, Life Science Center University of British Columbia, Vancouver, BC, Canada
    Differentiation 76:193-205. 2008
    ....
  46. doi request reprint Identification of miR-145 and miR-146a as mediators of the 5q- syndrome phenotype
    Daniel T Starczynowski
    British Columbia Cancer Agency Research Centre, Vancouver, British Columbia, Canada
    Nat Med 16:49-58. 2010
    ..Thus, inappropriate activation of innate immune signals in HSPCs phenocopies several clinical features of 5q- syndrome...
  47. doi request reprint Reduction in multi-lineage and erythroid progenitors distinguishes myelodysplastic syndromes from non-malignant cytopenias
    Suzanne M Vercauteren
    Department of Pathology and Laboratory Medicine, Vancouver General Hospital, Vancouver, Canada
    Leuk Res 33:1636-42. 2009
    ..In conclusion, a defect in early hematopoietic progenitor activity, in particular erythroid activity, distinguishes MDS from non-MDS...
  48. pmc Interleukin-3, but not granulocyte-macrophage colony-stimulating factor and interleukin-5, inhibits apoptosis of human basophils through phosphatidylinositol 3-kinase: requirement of NF-kappaB-dependent and -independent pathways
    Xueyan Zheng
    iCAPTURE Center, McDonald Research Laboratory, University of British Columbia, St Paul s Hospital, 1081 Burrard Street, Vancouver, BC, Canada V6Z 1Y6
    Immunology 107:306-15. 2002
    ....
  49. pmc Barnacle: detecting and characterizing tandem duplications and fusions in transcriptome assemblies
    Lucas Swanson
    Canada s Michael Smith Genome Sciences Centre, British Columbia Cancer Agency, Vancouver, Canada
    BMC Genomics 14:550. 2013
    ..Chimeric transcripts, including partial and internal tandem duplications (PTDs, ITDs) and gene fusions, are important in the detection, prognosis, and treatment of human cancers...
  50. ncbi request reprint Tissue distribution of endothelial cells in vivo following intravenous injection
    Bruno Larrivee
    Departments of Medical Biophysics, British Columbia Cancer Agency, Vancouver, British Columbia, Canada
    Exp Hematol 34:1741-5. 2006
    ..However, the in vivo homing properties of mature endothelial cells are still unclear. In this paper, we studied the kinetics and specificity of endothelial homing to sites of angiogenesis...
  51. ncbi request reprint Isolation and culture of primary endothelial cells
    Bruno Larrivee
    Department of Medicine, University of British Columbia, Vancouver, Canada
    Methods Mol Biol 290:315-29. 2005
    ....
  52. ncbi request reprint Role of the microenvironment in promoting angiogenesis in acute myeloid leukemia
    Craig Litwin
    Department of Pathology and Laboratory Medicine, University of British Columbia, Vancouver, BC, Canada
    Am J Hematol 70:22-30. 2002
    ..This suggests that angiogenesis in AML likely represents a response to microenvironmental factors in vivo, rather than being an intrinsic property of leukemic cells...
  53. ncbi request reprint Recent insights into the role of Notch signaling in tumorigenesis
    Kevin G Leong
    Department of Medical Biophysics, British Columbia Cancer Agency, Vancouver, BC, Canada
    Blood 107:2223-33. 2006
    ..In addition, cellular mechanisms that potentially explain the complex role of Notch in tumorigenesis are discussed...
  54. ncbi request reprint Lipopolysaccharide signaling in endothelial cells
    Shauna M Dauphinee
    Department of Medical Biophysics, British Columbia Cancer Agency, Vancouver, British Columbia, Canada
    Lab Invest 86:9-22. 2006
    ..This review will focus on the signaling pathways initiated by LPS binding to the TLR4 receptor in endothelial cells and the coordinated regulation of this pathway...
  55. pmc Constitutively overexpressed 21 kDa protein in Hodgkin lymphoma and aggressive non-Hodgkin lymphomas identified as cytochrome B5b (CYB5B)
    Derek Murphy
    Centre for Translational and Applied Genomics, British Columbia Cancer Agency, Provincial Health Services Authority Laboratories, 600 West 10th Avenue, Vancouver, British Columbia, V5Z 4E6, Canada
    Mol Cancer 9:14. 2010
    ....
  56. doi request reprint Mouse models of myelodysplastic syndromes
    Joanna Wegrzyn
    Genome Sciences Centre, Department of Pathology and Laboratory Medicine, University of British Columbia, Vancouver, British Columbia, Canada
    Leuk Res 35:853-62. 2011
    ..In addition, we describe progress in xenotransplantation models of MDS and discuss questions that remain to be answered...
  57. ncbi request reprint Notch signaling in the developing cardiovascular system
    Kyle Niessen
    Dept of Medical Biophysics, British Columbia Cancer Agency, Vancouver, BC, Canada V5Z 1L3
    Am J Physiol Cell Physiol 293:C1-11. 2007
    ..This article focuses on the role of the Notch pathway in the developing cardiovascular system and congenital human cardiovascular diseases...
  58. doi request reprint High-resolution whole genome tiling path array CGH analysis of CD34+ cells from patients with low-risk myelodysplastic syndromes reveals cryptic copy number alterations and predicts overall and leukemia-free survival
    Daniel T Starczynowski
    Department of Medical Biophysics, British Columbia Cancer Agency, Vancouver, Canada
    Blood 112:3412-24. 2008
    ..002) and was less frequently associated with transformation to acute myeloid leukemia (P = .033). This study suggests a potential role for the use of aCGH in the clinical workup of MDS patients...
  59. ncbi request reprint A clinically validated diagnostic second-generation sequencing assay for detection of hereditary BRCA1 and BRCA2 mutations
    Ian E Bosdet
    Cancer Genetics Laboratory, BC Cancer Agency, Vancouver, British Columbia, Canada Department of Pathology and Laboratory Medicine, University of British Columbia, Vancouver, British Columbia, Canada
    J Mol Diagn 15:796-809. 2013
    ..The results demonstrate that this method is suitable for sensitive, automatable, high-throughput sequence variant detection in the clinical laboratory. ..
  60. pmc Vascularization predicts overall survival and risk of transformation in follicular lymphoma
    Pedro Farinha
    Pathology, British Columbia Cancer Agency Center for Lymphoid Cancer, Vancouver, Canada
    Haematologica 95:2157-60. 2010
    ..05, P=0.001 and P=0.01, respectively) and IPI and TVD(90) predicted risk of transformation (P=0.008 and P=0.08, respectively). Increased angiogenesis is an independent marker of inferior survival and may promote transformation...
  61. ncbi request reprint Roles of reactive oxygen species in angiopoietin-1/tie-2 receptor signaling
    Rania Harfouche
    Critical Care and Respiratory Divisions, Royal Victoria Hospital and Meakins Christie Laboratories, McGill University, Montreal, Quebec, Canada
    FASEB J 19:1728-30. 2005
    ....
  62. ncbi request reprint Minimal contribution of marrow-derived endothelial precursors to tumor vasculature
    Bruno Larrivee
    Department of Medicine, University of British Columbia, Canada
    J Immunol 175:2890-9. 2005
    ..Furthermore, we show that VEGF-A stimulation of hemopoietic cells does not significantly alter this process...
  63. ncbi request reprint Angiopoietin-1 activates both anti- and proapoptotic mitogen-activated protein kinases
    Rania Harfouche
    Critical Care Division, Royal Victoria Hospital, 687 Ave West, Montreal, Quebec, Canada H3A 1A1
    FASEB J 17:1523-5. 2003
    ..The strong antiapoptotic effects of the ERK and the PI-3 kinase pathways mask the proapoptotic function of p38 MAPKs resulting in net attenuation of apoptosis by Ang-1...
  64. ncbi request reprint Quantitative analysis of the low molecular weight serum proteome using 18O stable isotope labeling in a lung tumor xenograft mouse model
    Brian L Hood
    Laboratory of Proteomics and Analytical Technologies, National Cancer Institute at Frederick, SAIC Frederick, Inc, Frederick, Maryland 21702, USA
    J Am Soc Mass Spectrom 16:1221-30. 2005
    ..The methodology adopted in this work provides the means for future quantitative measurements in comparative animal models of disease and in human disease cohorts...
  65. ncbi request reprint Notch and minichromosome maintenance (MCM) proteins: integration of two ancestral pathways in cell cycle control
    Michela Noseda
    Department of Medicine, Cardiology, Baylor College of Medicine, Houston, Texas, USA
    Cell Cycle 5:2704-9. 2006
    ..Here, we review the canonical pathway mediated by Notch receptors and discuss recent findings connecting the Notch pathway with the ancestral MCM complex during cell cycle progression...