Martin Hirst

Summary

Affiliation: British Columbia
Country: Canada

Publications

  1. ncbi request reprint Epigenomics: sequencing the methylome
    Martin Hirst
    Department of Microbiology and Immunology, Centre for High Throughput Biology, University of British Columbia, Vancouver, Canada
    Methods Mol Biol 973:39-54. 2013
  2. pmc LongSAGE profiling of nine human embryonic stem cell lines
    Martin Hirst
    Genome Sciences Centre, British Columbia Cancer Agency, Vancouver, British Columbia, Canada, V5Z 1L3
    Genome Biol 8:R113. 2007
  3. pmc Next generation sequencing based approaches to epigenomics
    Martin Hirst
    Genome Sciences Centre, Vancouver, BC, Canada
    Brief Funct Genomics 9:455-65. 2010
  4. doi request reprint Alternative expression analysis by RNA sequencing
    Malachi Griffith
    Genome Sciences Centre, British Columbia Cancer Agency, Vancouver, Canada
    Nat Methods 7:843-7. 2010
  5. pmc Genome-wide relationship between histone H3 lysine 4 mono- and tri-methylation and transcription factor binding
    A Gordon Robertson
    BC Cancer Agency Genome Sciences Centre, Vancouver, Canada
    Genome Res 18:1906-17. 2008
  6. pmc Next-generation tag sequencing for cancer gene expression profiling
    A Sorana Morrissy
    Genome Sciences Centre, Vancouver, British Columbia, Canada
    Genome Res 19:1825-35. 2009
  7. pmc The clonal and mutational evolution spectrum of primary triple-negative breast cancers
    Sohrab P Shah
    Department of Pathology and Laboratory Medicine, University of British Columbia, Vancouver, British Columbia V6T 2B5, Canada
    Nature 486:395-9. 2012
  8. doi request reprint Retinoblastoma-binding proteins 4 and 9 are important for human pluripotent stem cell maintenance
    Michael D O'Connor
    Terry Fox Laboratory, British Columbia Cancer Agency, Vancouver, BC, Canada
    Exp Hematol 39:866-79.e1. 2011
  9. doi request reprint Digital gene expression by tag sequencing on the illumina genome analyzer
    Sorana Morrissy
    BCCA Genome Sciences Centre, University of British Columbia, Vancouver, British Columbia, Canada
    Curr Protoc Hum Genet . 2010
  10. pmc Mutation discovery in regions of segmental cancer genome amplifications with CoNAn-SNV: a mixture model for next generation sequencing of tumors
    Anamaria Crisan
    Department of Molecular Oncology, BC Cancer Agency, Vancouver, British Columbia, Canada
    PLoS ONE 7:e41551. 2012

Detail Information

Publications61

  1. ncbi request reprint Epigenomics: sequencing the methylome
    Martin Hirst
    Department of Microbiology and Immunology, Centre for High Throughput Biology, University of British Columbia, Vancouver, Canada
    Methods Mol Biol 973:39-54. 2013
    ..The sequence reads are subsequently aligned to a reference genome and subjected to specialized analytical tools to extract the underlying methylation signature. This chapter will outline these emerging techniques...
  2. pmc LongSAGE profiling of nine human embryonic stem cell lines
    Martin Hirst
    Genome Sciences Centre, British Columbia Cancer Agency, Vancouver, British Columbia, Canada, V5Z 1L3
    Genome Biol 8:R113. 2007
    ....
  3. pmc Next generation sequencing based approaches to epigenomics
    Martin Hirst
    Genome Sciences Centre, Vancouver, BC, Canada
    Brief Funct Genomics 9:455-65. 2010
    ..We will discuss these in terms of library preparation, sequence platforms and analysis techniques...
  4. doi request reprint Alternative expression analysis by RNA sequencing
    Malachi Griffith
    Genome Sciences Centre, British Columbia Cancer Agency, Vancouver, Canada
    Nat Methods 7:843-7. 2010
    ..Alternative expression annotation databases, source code, a data viewer and other resources to facilitate analysis are available at http://www.alexaplatform.org/alexa_seq/...
  5. pmc Genome-wide relationship between histone H3 lysine 4 mono- and tri-methylation and transcription factor binding
    A Gordon Robertson
    BC Cancer Agency Genome Sciences Centre, Vancouver, Canada
    Genome Res 18:1906-17. 2008
    ....
  6. pmc Next-generation tag sequencing for cancer gene expression profiling
    A Sorana Morrissy
    Genome Sciences Centre, Vancouver, British Columbia, Canada
    Genome Res 19:1825-35. 2009
    ....
  7. pmc The clonal and mutational evolution spectrum of primary triple-negative breast cancers
    Sohrab P Shah
    Department of Pathology and Laboratory Medicine, University of British Columbia, Vancouver, British Columbia V6T 2B5, Canada
    Nature 486:395-9. 2012
    ..Taken together, our results show that understanding the biology and therapeutic responses of patients with TNBC will require the determination of individual tumour clonal genotypes...
  8. doi request reprint Retinoblastoma-binding proteins 4 and 9 are important for human pluripotent stem cell maintenance
    Michael D O'Connor
    Terry Fox Laboratory, British Columbia Cancer Agency, Vancouver, BC, Canada
    Exp Hematol 39:866-79.e1. 2011
    ..Here we sought to identify new candidate PS cell regulators to facilitate future improvements in their generation, expansion, and differentiation...
  9. doi request reprint Digital gene expression by tag sequencing on the illumina genome analyzer
    Sorana Morrissy
    BCCA Genome Sciences Centre, University of British Columbia, Vancouver, British Columbia, Canada
    Curr Protoc Hum Genet . 2010
    ..2009)...
  10. pmc Mutation discovery in regions of segmental cancer genome amplifications with CoNAn-SNV: a mixture model for next generation sequencing of tumors
    Anamaria Crisan
    Department of Molecular Oncology, BC Cancer Agency, Vancouver, British Columbia, Canada
    PLoS ONE 7:e41551. 2012
    ..Our results indicate that in genomically unstable tumors, copy number annotation for SNV detection will be critical to fully characterize the mutational landscape of cancer genomes...
  11. pmc JointSNVMix: a probabilistic model for accurate detection of somatic mutations in normal/tumour paired next-generation sequencing data
    Andrew Roth
    Department of Molecular Oncology, BC Cancer Agency, BC, Canada
    Bioinformatics 28:907-13. 2012
    ....
  12. pmc ARID1A mutations in endometriosis-associated ovarian carcinomas
    Kimberly C Wiegand
    British Columbia Cancer Agency, Vancouver, Canada
    N Engl J Med 363:1532-43. 2010
    ..Ovarian clear-cell and endometrioid carcinomas may arise from endometriosis, but the molecular events involved in this transformation have not been described...
  13. doi request reprint Preparation and analysis of microRNA libraries using the Illumina massively parallel sequencing technology
    Ryan D Morin
    BC Cancer Agency, Genome Sciences Centre, Vancouver, BC, Canada
    Methods Mol Biol 650:173-99. 2010
    ..We describe a detailed procedure for the preparation of small RNA libraries for Illumina sequencing. We further comment on approaches for analyzing the resultant sequence data for measuring microRNA abundance...
  14. doi request reprint De novo transcriptome assembly with ABySS
    Inanc Birol
    Genome Sciences Centre, Vancouver, BC V5Z 4S6, Canada
    Bioinformatics 25:2872-7. 2009
    ..One can deduce gene expression levels using sequence coverage as a surrogate, identify coding changes or discover novel isoforms or transcripts. Especially for discovery of novel events, de novo assembly of transcriptomes is desirable...
  15. doi request reprint Complete genomic landscape of a recurring sporadic parathyroid carcinoma
    Katayoon Kasaian
    Canada s Michael Smith Genome Sciences Centre, British Columbia Cancer Agency, Vancouver, British Columbia, Canada
    J Pathol 230:249-60. 2013
    ..The key somatic mutations identified in this study can serve as novel diagnostic markers as well as therapeutic targets...
  16. pmc Locus co-occupancy, nucleosome positioning, and H3K4me1 regulate the functionality of FOXA2-, HNF4A-, and PDX1-bound loci in islets and liver
    Brad G Hoffman
    Department of Cancer Endocrinology, British Columbia Cancer Agency, Vancouver, British Columbia V5Z 1L3, Canada
    Genome Res 20:1037-51. 2010
    ..Finally, we apply these approaches to generate novel insights into how FOXA2, PDX1, and HNF4A cooperate to drive islet- and liver-specific gene expression...
  17. pmc Transcriptome analysis for Caenorhabditis elegans based on novel expressed sequence tags
    Heesun Shin
    Molecular Biology and Biochemistry, Simon Fraser University, Burnaby, BC, Canada
    BMC Biol 6:30. 2008
    ..This work also demonstrates the successful and efficient application of a next generation sequencing methodology...
  18. pmc SNVMix: predicting single nucleotide variants from next-generation sequencing of tumors
    Rodrigo Goya
    Department of Molecular Oncology Breast Cancer Research Program, British Columbia Cancer Research Centre, Vancouver, BC, Canada
    Bioinformatics 26:730-6. 2010
    ..Although tools exist for SNV discovery from NGS data, none are specifically suited to work with data from tumors, where altered ploidy and tumor cellularity impact the statistical expectations of SNV discovery...
  19. pmc Integrative analysis of genome-wide loss of heterozygosity and monoallelic expression at nucleotide resolution reveals disrupted pathways in triple-negative breast cancer
    Gavin Ha
    Department of Molecular Oncology, British Columbia Cancer Agency, Vancouver, British Columbia V5Z 1L3, Canada
    Genome Res 22:1995-2007. 2012
    ..Finally, we show how inference of LOH can be used to interpret allele frequencies of somatic mutations and postulate on temporal ordering of mutations in the evolutionary history of these tumors...
  20. pmc Integrated genome and transcriptome sequencing identifies a novel form of hybrid and aggressive prostate cancer
    Chunxiao Wu
    Vancouver Prostate Centre and Department of Urologic Sciences, University of British Columbia, Vancouver, BC, Canada
    J Pathol 227:53-61. 2012
    ..Overall, this work highlights the importance of integrated analyses of genome, exome and transcriptome sequences for basic tumour biology, sequence-based molecular pathology and personalized oncology...
  21. pmc In-depth characterization of the microRNA transcriptome in a leukemia progression model
    Florian Kuchenbauer
    Terry Fox Laboratory, BC Cancer Agency, Vancouver, British Columbia V5Z 1L3, Canada
    Genome Res 18:1787-97. 2008
    ..Finally, 55 novel miRNAs species were identified in our data set, adding further complexity to the emerging world of small RNAs...
  22. pmc Frequent mutation of histone-modifying genes in non-Hodgkin lymphoma
    Ryan D Morin
    Canada s Michael Smith Genome Sciences Centre, BC Cancer Agency, Vancouver, British Columbia V5Z 1L3, Canada
    Nature 476:298-303. 2011
    ..Our analysis suggests a previously unappreciated disruption of chromatin biology in lymphomagenesis...
  23. pmc Application of massively parallel sequencing to microRNA profiling and discovery in human embryonic stem cells
    Ryan D Morin
    Genome Sciences Centre, BC Cancer Agency, Vancouver, British Columbia V5Z 1L3, Canada
    Genome Res 18:610-21. 2008
    ..Included among the high-ranked predicted gene targets are those implicated in differentiation, cell cycle control, programmed cell death, and transcriptional regulation...
  24. doi request reprint Recurrent somatic DICER1 mutations in nonepithelial ovarian cancers
    Alireza Heravi-Moussavi
    British Columbia Cancer Research Centre, Vancouver, BC, Canada
    N Engl J Med 366:234-42. 2012
    ..Mutation carriers are at risk for nonepithelial ovarian tumors, notably sex cord-stromal tumors...
  25. pmc deFuse: an algorithm for gene fusion discovery in tumor RNA-Seq data
    Andrew McPherson
    Centre for Translational and Applied Genomics, BC Cancer Agency, Vancouver, British Columbia, Canada
    PLoS Comput Biol 7:e1001138. 2011
    ....
  26. doi request reprint Profiling the HeLa S3 transcriptome using randomly primed cDNA and massively parallel short-read sequencing
    Ryan Morin
    Genome Sciences Centre, BC Cancer Agency, Vancouver, British Columbia, Canada
    Biotechniques 45:81-94. 2008
    ..Analysis of these variants, and previously unannotated splicing events in the HeLa S3 cell line, reveals an overrepresentation of gene categories including those previously implicated in cancer...
  27. pmc Feature-based classifiers for somatic mutation detection in tumour-normal paired sequencing data
    Jiarui Ding
    Department of Molecular Oncology, BC Cancer Agency, Vancouver, BC, Canada
    Bioinformatics 28:167-75. 2012
    ..As such, the computational problem of accurately inferring somatic mutations from paired tumour/normal NGS data remains an unsolved challenge...
  28. doi request reprint Use of mutation profiles to refine the classification of endometrial carcinomas
    Melissa K McConechy
    Department of Pathology and Laboratory Medicine, University of British Columbia, BC Cancer Agency, Vancouver, BC, Canada
    J Pathol 228:20-30. 2012
    ..If used in practice, it may lead to improved diagnostic reproducibility and may also serve to stratify patients for targeted therapeutics...
  29. doi request reprint Cell of origin in AML: susceptibility to MN1-induced transformation is regulated by the MEIS1/AbdB-like HOX protein complex
    Michael Heuser
    Terry Fox Laboratory, British Columbia Cancer Agency, Vancouver, British Columbia, Canada
    Cancer Cell 20:39-52. 2011
    ..As MN1 relies on but cannot activate expression of MEIS1/AbdB-like HOX proteins, transcriptional activity of these genes determines cellular susceptibility to MN1-induced transformation and may represent a promising therapeutic target...
  30. pmc Novel expressed sequences identified in a model of androgen independent prostate cancer
    Steven N Quayle
    Genome Sciences Centre, British Columbia Cancer Agency, Vancouver, BC, V5Z 4E6, Canada
    BMC Genomics 8:32. 2007
    ..The molecular changes that occur to allow prostate cells to proliferate in the absence of androgens are not fully understood...
  31. doi request reprint De novo assembly and analysis of RNA-seq data
    Gordon Robertson
    Canada s Michael Smith Genome Sciences Centre, British Columbia Cancer Agency, Vancouver, BC, Canada
    Nat Methods 7:909-12. 2010
    ....
  32. pmc Somatic mutations altering EZH2 (Tyr641) in follicular and diffuse large B-cell lymphomas of germinal-center origin
    Ryan D Morin
    Genome Sciences Centre, BC Cancer Agency, Vancouver, British Columbia, Canada
    Nat Genet 42:181-5. 2010
    ..7% of GCB DLBCLs and 7.2% of FLs and are absent from ABC DLBCLs. Our data are consistent with the notion that EZH2 proteins with mutant Tyr641 have reduced enzymatic activity in vitro...
  33. pmc Retrotransposon-induced heterochromatin spreading in the mouse revealed by insertional polymorphisms
    Rita Rebollo
    Terry Fox Laboratory, British Columbia Cancer Agency, Vancouver, Canada
    PLoS Genet 7:e1002301. 2011
    ..However, the B3galtl gene is subject to transcriptional silencing via IAP-induced heterochromatin. Hence, although rare, IAP-induced local heterochromatin spreading into nearby genes may influence expression and, in turn, host fitness...
  34. ncbi request reprint A clinically validated diagnostic second-generation sequencing assay for detection of hereditary BRCA1 and BRCA2 mutations
    Ian E Bosdet
    Cancer Genetics Laboratory, BC Cancer Agency, Vancouver, British Columbia, Canada Department of Pathology and Laboratory Medicine, University of British Columbia, Vancouver, British Columbia, Canada
    J Mol Diagn 15:796-809. 2013
    ..The results demonstrate that this method is suitable for sensitive, automatable, high-throughput sequence variant detection in the clinical laboratory. ..
  35. pmc Global analysis of in vivo Foxa2-binding sites in mouse adult liver using massively parallel sequencing
    Elizabeth D Wederell
    Terry Fox Laboratory, BC Cancer Agency, Vancouver, Canada
    Nucleic Acids Res 36:4549-64. 2008
    ..Our comprehensive results for in vivo Foxa2-binding sites in the mouse liver will contribute to resolving transcriptional regulatory networks that are important for adult liver function...
  36. pmc DNA methylation and SETDB1/H3K9me3 regulate predominantly distinct sets of genes, retroelements, and chimeric transcripts in mESCs
    Mohammad M Karimi
    Department of Medical Genetics, Life Sciences Institute, The University of British Columbia, Vancouver, British Columbia, V6T 1Z3, Canada
    Cell Stem Cell 8:676-87. 2011
    ..Thus, SETDB1 plays a previously unappreciated yet critical role in inhibiting aberrant gene transcription by suppressing the expression of proximal ERVs...
  37. doi request reprint Applications of new sequencing technologies for transcriptome analysis
    Olena Morozova
    BC Cancer Agency, Genome Sciences Center, Vancouver, BC V5Z 4S6, Canada
    Annu Rev Genomics Hum Genet 10:135-51. 2009
    ....
  38. pmc Concurrent CIC mutations, IDH mutations, and 1p/19q loss distinguish oligodendrogliomas from other cancers
    Stephen Yip
    Department of Pathology and Laboratory Medicine, BC Cancer Agency, BC, Canada
    J Pathol 226:7-16. 2012
    ..Our detailed study of genetic aberrations in oligodendroglioma suggests a functional interaction between CIC mutation, IDH1/2 mutation, and 1p/19q co-deletion...
  39. pmc Analysis of the prostate cancer cell line LNCaP transcriptome using a sequencing-by-synthesis approach
    Matthew N Bainbridge
    British Columbia Cancer Agency BCCA Genome Sciences Centre, Vancouver, British Columbia, Canada
    BMC Genomics 7:246. 2006
    ..Although the sequence reads are short, they can readily be used for re-sequencing. By re-sequencing the mRNA products of a cell, one may rapidly discover polymorphisms and splice variants particular to that cell...
  40. doi request reprint Genome-wide identification of human microRNAs located in leukemia-associated genomic alterations
    Daniel T Starczynowski
    British Columbia Cancer Agency Research Centre, Vancouver, BC, Canada
    Blood 117:595-607. 2011
    ..This detailed genomic and small RNA analysis points to a subset of miRNAs that may play a role in myeloid malignancies...
  41. ncbi request reprint Genome-wide profiles of STAT1 DNA association using chromatin immunoprecipitation and massively parallel sequencing
    Gordon Robertson
    British Columbia Cancer Agency Genome Sciences Centre, 675 West 10th Avenue, Vancouver, British Columbia V5Z 4S6, Canada
    Nat Methods 4:651-7. 2007
    ..ChIP-seq targets were enriched in sequences similar to known STAT1 binding motifs. Comparisons with two ChIP-PCR data sets suggested that ChIP-seq sensitivity was between 70% and 92% and specificity was at least 95%...
  42. pmc De novo genome sequence assembly of a filamentous fungus using Sanger, 454 and Illumina sequence data
    Scott DiGuistini
    Department of Wood Science, University of British Columbia, Vancouver, BC, V6T 1Z4, Canada
    Genome Biol 10:R94. 2009
    ..Our results demonstrate that eukaryotic genome sequences can be accurately assembled by combining Illumina, 454 and Sanger sequence data...
  43. doi request reprint System-level analysis of neuroblastoma tumor-initiating cells implicates AURKB as a novel drug target for neuroblastoma
    Olena Morozova
    Genome Sciences Centre, BC Cancer Agency, University of British Columbia, Vancouver, British Columbia, Canada
    Clin Cancer Res 16:4572-82. 2010
    ..NB tumor-initiating cells (TICs), isolated from metastases and primary tumors, may escape treatment and contribute to tumor relapse. New therapies that target the TICs may therefore prevent or treat tumor recurrences...
  44. doi request reprint Identification of miR-145 and miR-146a as mediators of the 5q- syndrome phenotype
    Daniel T Starczynowski
    British Columbia Cancer Agency Research Centre, Vancouver, British Columbia, Canada
    Nat Med 16:49-58. 2010
    ..Thus, inappropriate activation of innate immune signals in HSPCs phenocopies several clinical features of 5q- syndrome...
  45. ncbi request reprint Clonal Analysis via Barcoding Reveals Diverse Growth and Differentiation of Transplanted Mouse and Human Mammary Stem Cells
    Long V Nguyen
    Terry Fox Laboratory, BC Cancer Agency, 675 West 10 th Avenue, Vancouver, BC V5Z 1L3, Canada
    Cell Stem Cell 14:253-63. 2014
    ....
  46. pmc Human illness from avian influenza H7N3, British Columbia
    S Aleina Tweed
    British Columbia Centre for Disease Control, Vancouver, British Columbia, Canada
    Emerg Infect Dis 10:2196-9. 2004
    ..Surveillance identified two persons with confirmed avian influenza infection. Symptoms included conjunctivitis and mild influenzalike illness...
  47. doi request reprint Epigenetics and human disease
    Martin Hirst
    Genome Sciences Centre, British Columbia Cancer Agency, Vancouver, British Columbia, Canada, V5Z 1L3
    Int J Biochem Cell Biol 41:136-46. 2009
    ..In this review we provide an overview of recent advances in our understanding of the roles that DNA and histone modification play in the onset and progression of human disease...
  48. pmc Evolution of an adenocarcinoma in response to selection by targeted kinase inhibitors
    Steven Jm Jones
    Genome Sciences Centre, British Columbia Cancer Agency, 570 West 7th Avenue, Vancouver, BC, V5Z 4S6, Canada
    Genome Biol 11:R82. 2010
    ..We investigated the utility of massively parallel sequencing to characterize an adenocarcinoma of the tongue, before and after treatment...
  49. doi request reprint Using next-generation sequencing for the diagnosis of rare disorders: a family with retinitis pigmentosa and skeletal abnormalities
    Kasmintan A Schrader
    Department of Pathology and Laboratory Medicine, University of British Columbia, Vancouver, BC, Canada
    J Pathol 225:12-8. 2011
    ..The diagnosis was confirmed by biochemical studies and both broadens the mucolipidosis type III phenotype and demonstrates the clinical utility of next-generation sequencing to diagnose rare genetic diseases...
  50. pmc Analysis of the clonal growth and differentiation dynamics of primitive barcoded human cord blood cells in NSG mice
    Alice M S Cheung
    Terry Fox Laboratory, BC Cancer Agency, Vancouver, BC, Canada
    Blood 122:3129-37. 2013
    ..These findings highlight the caveats and utility of this model to analyze human hematopoietic stem cell control in vivo...
  51. ncbi request reprint A transgenic mouse model demonstrating the oncogenic role of mutations in the polycomb-group gene EZH2 in lymphomagenesis
    Tobias Berg
    Terry Fox Laboratory, British Columbia Cancer Agency, Vancouver, BC, Canada Department of Medicine, Hematology and Oncology, University of Frankfurt, Frankfurt Main, Germany German Cancer Consortium DKTK, Heidelberg, Germany German Cancer Research Center dkfz, Heidelberg, Germany
    Blood 123:3914-24. 2014
    ..This murine lymphoma model provides a new tool to study global changes in the epigenome caused by this frequent mutation and a promising model system for testing novel treatments. ..
  52. pmc Novel avian influenza H7N3 strain outbreak, British Columbia
    Martin Hirst
    British Columbia Cancer Agency BCCA Genome Sciences Centre, Vancouver, British Columbia, Canada
    Emerg Infect Dis 10:2192-5. 2004
    ..This insertion likely occurred by recombination between the hemagglutination and matrix genes in the LPAI virus...
  53. pmc Whole-genome profiling of mutagenesis in Caenorhabditis elegans
    Stephane Flibotte
    Department of Zoology, University of British Columbia, Vancouver, British Columbia V6T 1Z4, Canada
    Genetics 185:431-41. 2010
    ..We also present evidence of genetic drift among laboratory wild-type strains derived from the Bristol N2 strain. We make several suggestions for best practice using massively parallel short read sequencing to ensure mutation detection...
  54. pmc DNA template strand sequencing of single-cells maps genomic rearrangements at high resolution
    Ester Falconer
    Terry Fox Laboratory, BC Cancer Agency, Vancouver, British Columbia, Canada
    Nat Methods 9:1107-12. 2012
    ..The ability to map SCE events at high resolution and fine-tune reference genomes by Strand-seq dramatically expands the scope of single-cell sequencing...
  55. pmc Spark: a navigational paradigm for genomic data exploration
    Cydney B Nielsen
    Canada s Michael Smith Genome Sciences Centre, BC Cancer Agency, Vancouver, British Columbia, V5Z 4S6, Canada
    Genome Res 22:2262-9. 2012
    ....
  56. pmc Genome and transcriptome analyses of the mountain pine beetle-fungal symbiont Grosmannia clavigera, a lodgepole pine pathogen
    Scott DiGuistini
    Department of Wood Science, University of British Columbia, Vancouver, BC, Canada V6T 1Z4
    Proc Natl Acad Sci U S A 108:2504-9. 2011
    ..This work is a major step toward understanding the biological interactions between the tripartite MPB/fungus/forest system...
  57. pmc A mouse atlas of gene expression: large-scale digital gene-expression profiles from precisely defined developing C57BL/6J mouse tissues and cells
    Asim S Siddiqui
    Canada s Michael Smith Genome Sciences Centre, British Columbia Cancer Research Centre, British Columbia Cancer Agency, Vancouver, BC, Canada V5Z 4S6
    Proc Natl Acad Sci U S A 102:18485-90. 2005
    ..The visual cortex, pancreas, mammary gland, preimplantation embryo, and placenta contain the largest number of differentially expressed transcripts, 25% of which are previously undescribed loci...
  58. ncbi request reprint Mutation of FOXL2 in granulosa-cell tumors of the ovary
    Sohrab P Shah
    Centre for Translational and Applied Genomics, British Columbia Cancer Agency, Vancouver, Canada
    N Engl J Med 360:2719-29. 2009
    ..The pathogenesis of these tumors is unknown. Moreover, their histopathological diagnosis can be challenging, and there is no curative treatment beyond surgery...
  59. pmc Large-scale production of SAGE libraries from microdissected tissues, flow-sorted cells, and cell lines
    Jaswinder Khattra
    Canada s Michael Smith Genome Sciences Centre, BC Cancer Research Centre, BC Cancer Agency, Vancouver, British Columbia V5Z 4S6, Canada
    Genome Res 17:108-16. 2007
    ....
  60. pmc Next generation sequencing of prostate cancer from a patient identifies a deficiency of methylthioadenosine phosphorylase, an exploitable tumor target
    Colin C Collins
    Vancouver Prostate Centre, University of British Columbia, Vancouver, British Columbia, Canada
    Mol Cancer Ther 11:775-83. 2012
    ..The combination of genome sequencing and patient-derived xenografts can identify candidate therapeutic agents and evaluate them for personalized oncology...
  61. pmc Isolation and identification of L-dopa decarboxylase as a protein that binds to and enhances transcriptional activity of the androgen receptor using the repressed transactivator yeast two-hybrid system
    Latif A Wafa
    Department of Pathology and Laboratory Medicine, University of British Columbia, Vancouver, BC, V6T 2B5, Canada
    Biochem J 375:373-83. 2003
    ..Together, our data demonstrate that DDC interacts with AR to enhance steroid receptor transactivation, which may have important implications in prostate cancer progression...