Sharon M Gorski
Affiliation: British Columbia
Bosc D, Vezenkov L, Bortnik S, An J, Xu J, Choutka C, et al
. A new quinoline-based chemical probe inhibits the autophagy-related cysteine protease ATG4B. Sci Rep. 2018;8:11653 pubmed publisher
..These findings suggest that LV-320 will serve as a relevant chemical tool to study the various roles of ATG4B in cancer and other contexts. ..
Xu J, Camfield R, Gorski S. The interplay between exosomes and autophagy - partners in crime. J Cell Sci. 2018;131: pubmed publisher
..Finally, we discuss the implications of exosome and autophagy interplay in the context of neurodegeneration and cancer. ..
Yang K, Sathiyaseelan P, Ho C, Gorski S. Evolution of tools and methods for monitoring autophagic flux in mammalian cells. Biochem Soc Trans. 2018;46:97-110 pubmed publisher
..We also discuss the potential limitations of these approaches and recommend using a combination of strategies and multiple different autophagy markers to reliably evaluate autophagic flux in mammalian cells. ..
Devorkin L, Go N, Hou Y, Moradian A, Morin G, Gorski S. The Drosophila effector caspase Dcp-1 regulates mitochondrial dynamics and autophagic flux via SesB. J Cell Biol. 2014;205:477-92 pubmed publisher
..These data reveal a new mitochondrial-associated molecular link between nonapoptotic caspase function and autophagy regulation in vivo. ..
Chittaranjan S, Xu J, Kuzyk M, Dullat H, Wilton J, Devorkin L, et al
. The Drosophila TIPE family member Sigmar interacts with the Ste20-like kinase Misshapen and modulates JNK signaling, cytoskeletal remodeling and autophagy. Biol Open. 2015;4:672-84 pubmed publisher
..Together, these findings link Sigmar to the JNK pathway, cytoskeletal remodeling and autophagy activity during salivary gland development, and provide new insights into TIPE family member function. ..
Bortnik S, Gorski S. Clinical Applications of Autophagy Proteins in Cancer: From Potential Targets to Biomarkers. Int J Mol Sci. 2017;18: pubmed publisher
..In this review, we address the recent trends, challenges and advances in the assessment of the biomarker potential of clinically relevant autophagy proteins in human cancers. ..
Copeland J, Bosdet I, Freeman J, Guo M, Gorski S, Hay B. echinus, required for interommatidial cell sorting and cell death in the Drosophila pupal retina, encodes a protein with homology to ubiquitin-specific proteases. BMC Dev Biol. 2007;7:82 pubmed
..Characterization of likely echinus null alleles and genetic interactions suggests that echinus acts at a novel point(s) to regulate interommatidial cell sorting and/or cell death in the fly eye. ..