Ronald J DeLeeuw

Summary

Affiliation: British Columbia
Country: Canada

Publications

  1. ncbi Whole-genome analysis and HLA genotyping of enteropathy-type T-cell lymphoma reveals 2 distinct lymphoma subtypes
    Ronald J DeLeeuw
    Department of Cancer Genetics, British Columbia Cancer Research Centre, Vancouver, British Columbia, Canada
    Gastroenterology 132:1902-11. 2007
  2. ncbi Comprehensive whole genome array CGH profiling of mantle cell lymphoma model genomes
    Ronald J de Leeuw
    Department of Cancer Genetics, British Columbia Cancer Agency, Vancouver, BC, Canada
    Hum Mol Genet 13:1827-37. 2004
  3. ncbi Sub-megabase resolution tiling (SMRT) array-based comparative genomic hybridization profiling reveals novel gains and losses of chromosomal regions in Hodgkin Lymphoma and Anaplastic Large Cell Lymphoma cell lines
    Faisal M Fadlelmola
    Centre for Translational and Applied Genomics CTAG, Department of Pathology and Laboratory Medicine, British Columbia Cancer Agency, Vancouver Cancer Centre, Vancouver, BC, V5Z 4E6, Canada
    Mol Cancer 7:2. 2008
  4. ncbi MD-SeeGH: a platform for integrative analysis of multi-dimensional genomic data
    Bryan Chi
    Department of Cancer Genetics and Developmental Biology, British Columbia Cancer Research Centre, Vancouver, BC, Canada
    BMC Bioinformatics 9:243. 2008
  5. ncbi SeeGH--a software tool for visualization of whole genome array comparative genomic hybridization data
    Bryan Chi
    British Columbia Cancer Research Centre, British Columbia Cancer Agency, 601 W, 10th Ave, Vancouver, BC, V5Z 1L3 Canada
    BMC Bioinformatics 5:13. 2004
  6. ncbi Cytogenetically balanced translocations are associated with focal copy number alterations
    Spencer K Watson
    Cancer Genetics and Developmental Biology, British Columbia Cancer Research Centre, 675 West 10th Avenue, Vancouver, BC, Canada
    Hum Genet 120:795-805. 2007
  7. ncbi A comprehensive analysis of common copy-number variations in the human genome
    Kendy K Wong
    Department of Cancer Genetics and Developmental Biology, University of British Columbia, Vancouver, BC, Canada
    Am J Hum Genet 80:91-104. 2007
  8. ncbi A tiling resolution DNA microarray with complete coverage of the human genome
    Adrian S Ishkanian
    British Columbia Cancer Research Centre, 601 West 10th Avenue, Vancouver, British Columbia V5Z 1L3, Canada
    Nat Genet 36:299-303. 2004
  9. ncbi Frequent occurrence of deletions in primary mediastinal B-cell lymphoma
    Lindsey R Kimm
    Department of Cancer Genetics and Developmental Biology, British Columbia Cancer Research Centre, Vancouver, BC, Canada
    Genes Chromosomes Cancer 46:1090-7. 2007
  10. ncbi NRG1 gene rearrangements in clinical breast cancer: identification of an adjacent novel amplicon associated with poor prognosis
    Leah M Prentice
    Department of Pathology and Prostate Centre, Genetic Pathology Evaluation Centre, Vancouver General Hospital, Vancouver, BC, Canada V6H 3Z6
    Oncogene 24:7281-9. 2005

Collaborators

Detail Information

Publications13

  1. ncbi Whole-genome analysis and HLA genotyping of enteropathy-type T-cell lymphoma reveals 2 distinct lymphoma subtypes
    Ronald J DeLeeuw
    Department of Cancer Genetics, British Columbia Cancer Research Centre, Vancouver, British Columbia, Canada
    Gastroenterology 132:1902-11. 2007
    ..Enteropathy-type T-cell lymphoma (ETL) is an aggressive extranodal T-cell non-Hodgkin lymphoma assumed to arise in the setting of celiac disease...
  2. ncbi Comprehensive whole genome array CGH profiling of mantle cell lymphoma model genomes
    Ronald J de Leeuw
    Department of Cancer Genetics, British Columbia Cancer Agency, Vancouver, BC, Canada
    Hum Mol Genet 13:1827-37. 2004
    ..Further characterization of such minimally altered genomic regions identified using whole genome array CGH will define novel dominant oncogenes and tumor suppressor genes that play important roles in the pathogenesis of MCL...
  3. ncbi Sub-megabase resolution tiling (SMRT) array-based comparative genomic hybridization profiling reveals novel gains and losses of chromosomal regions in Hodgkin Lymphoma and Anaplastic Large Cell Lymphoma cell lines
    Faisal M Fadlelmola
    Centre for Translational and Applied Genomics CTAG, Department of Pathology and Laboratory Medicine, British Columbia Cancer Agency, Vancouver Cancer Centre, Vancouver, BC, V5Z 4E6, Canada
    Mol Cancer 7:2. 2008
    ....
  4. ncbi MD-SeeGH: a platform for integrative analysis of multi-dimensional genomic data
    Bryan Chi
    Department of Cancer Genetics and Developmental Biology, British Columbia Cancer Research Centre, Vancouver, BC, Canada
    BMC Bioinformatics 9:243. 2008
    ..Due to the differences in data types it is difficult to conduct parallel analysis of multiple datasets from diverse platforms...
  5. ncbi SeeGH--a software tool for visualization of whole genome array comparative genomic hybridization data
    Bryan Chi
    British Columbia Cancer Research Centre, British Columbia Cancer Agency, 601 W, 10th Ave, Vancouver, BC, V5Z 1L3 Canada
    BMC Bioinformatics 5:13. 2004
    ..Since array CGH provides signal ratio for each DNA segment, visualization would require the reassembly of individual data points into chromosome profiles...
  6. ncbi Cytogenetically balanced translocations are associated with focal copy number alterations
    Spencer K Watson
    Cancer Genetics and Developmental Biology, British Columbia Cancer Research Centre, 675 West 10th Avenue, Vancouver, BC, Canada
    Hum Genet 120:795-805. 2007
    ..Our results reveal that imperfectly balanced translocations in tumor genomes are a phenomenon that occurs at frequencies much higher than previously demonstrated...
  7. ncbi A comprehensive analysis of common copy-number variations in the human genome
    Kendy K Wong
    Department of Cancer Genetics and Developmental Biology, University of British Columbia, Vancouver, BC, Canada
    Am J Hum Genet 80:91-104. 2007
    ..This in-depth survey of CNVs across the human genome provides a valuable baseline for studies involving human genetics...
  8. ncbi A tiling resolution DNA microarray with complete coverage of the human genome
    Adrian S Ishkanian
    British Columbia Cancer Research Centre, 601 West 10th Avenue, Vancouver, British Columbia V5Z 1L3, Canada
    Nat Genet 36:299-303. 2004
    ..Our submegabase resolution tiling set for array CGH (SMRT array) allows comprehensive assessment of genomic integrity and thereby the identification of new genes associated with disease...
  9. ncbi Frequent occurrence of deletions in primary mediastinal B-cell lymphoma
    Lindsey R Kimm
    Department of Cancer Genetics and Developmental Biology, British Columbia Cancer Research Centre, Vancouver, BC, Canada
    Genes Chromosomes Cancer 46:1090-7. 2007
    ..We conclude that consistent losses are present in the PMBCL genome. Given the similar frequency of losses to that of segmental gains of DNA, they are likely to play an important role in the pathogenesis of PMBCL...
  10. ncbi NRG1 gene rearrangements in clinical breast cancer: identification of an adjacent novel amplicon associated with poor prognosis
    Leah M Prentice
    Department of Pathology and Prostate Centre, Genetic Pathology Evaluation Centre, Vancouver General Hospital, Vancouver, BC, Canada V6H 3Z6
    Oncogene 24:7281-9. 2005
    ..Of the two genes in the novel amplicon, expression of SPFH2 correlated most significantly with amplification. This amplicon may emerge as a result of breakpoints and chromosomal rearrangements within the NRG1 locus...
  11. ncbi Identification of novel lung genes in bronchial epithelium by serial analysis of gene expression
    Kim M Lonergan
    Cancer Genetics and Developmental Biology, Department of Cancer Imaging, Canada s Michael Smith Genome Sciences Centre, British Columbia Cancer Research Centre, Vancouver, BC, Canada
    Am J Respir Cell Mol Biol 35:651-61. 2006
    ....
  12. ncbi Methods for high throughput validation of amplified fragment pools of BAC DNA for constructing high resolution CGH arrays
    Spencer K Watson
    Department of Cancer Genetics and Developmental Biology, BC Cancer Agency, 601 W, 10th Ave, Vancouver, BC, V5Z 1L3 Canada
    BMC Genomics 5:6. 2004
    ..The AFP sequencing technique described in this study is a novel method designed to verify the identity of array spotting solution in a high throughput manner...
  13. ncbi CD20 mutations involving the rituximab epitope are rare in diffuse large B-cell lymphomas and are not a significant cause of R-CHOP failure
    Nathalie A Johnson
    Clinical Professor of Pathology, Department of Pathology, British Columbia Cancer Agency, 600 W 10 Avenue, Vancouver, BC, V5Z 4E6, Canada
    Haematologica 94:423-7. 2009
    ..CD20 protein-negative relapses occur after R-CHOP therapy but their clinical relevance is unknown...