Robert C Brunham

Summary

Affiliation: British Columbia
Country: Canada

Publications

  1. pmc Novel avian influenza H7N3 strain outbreak, British Columbia
    Martin Hirst
    British Columbia Cancer Agency BCCA Genome Sciences Centre, Vancouver, British Columbia, Canada
    Emerg Infect Dis 10:2192-5. 2004
  2. ncbi request reprint Immunology of Chlamydia infection: implications for a Chlamydia trachomatis vaccine
    Robert C Brunham
    University of British Columbia Centre for Disease Control, Vancouver, British Columbia V5Z 4R4, Canada
    Nat Rev Immunol 5:149-61. 2005
  3. pmc Characterization of murine dendritic cell line JAWS II and primary bone marrow-derived dendritic cells in Chlamydia muridarum antigen presentation and induction of protective immunity
    Xiaozhou Jiang
    University of British Columbia Centre for Disease Control, 655 West 12th Avenue, Vancouver, BC V5Z 4R4, Canada
    Infect Immun 76:2392-401. 2008
  4. doi request reprint Chlamydia trachomatis control requires a vaccine
    Robert C Brunham
    University of British Columbia and the British Columbia Centre for Disease Control, Vancouver, Canada
    Vaccine 31:1892-7. 2013
  5. ncbi request reprint The unexpected impact of a Chlamydia trachomatis infection control program on susceptibility to reinfection
    Robert C Brunham
    University of British Columbia Centre for Disease Control, Vancouver, Canada
    J Infect Dis 192:1836-44. 2005
  6. ncbi request reprint Parran Award Lecture: insights into the epidemiology of sexually transmitted diseases from Ro = betacD
    Robert C Brunham
    UBC Centre for Disease Control, 655 West 12th Avenue, Vancouver, BC V5Z 4R4
    Sex Transm Dis 32:722-4. 2005
  7. pmc A live and inactivated Chlamydia trachomatis mouse pneumonitis strain induces the maturation of dendritic cells that are phenotypically and immunologically distinct
    Jose Rey-Ladino
    University of British Columbia Centre for Disease Control, 655 West 12th Ave, Vancouver, BC V5Z 4R4, Canada
    Infect Immun 73:1568-77. 2005
  8. doi request reprint Considerations on Chlamydia trachomatis disease expression
    Robert C Brunham
    University of British Columbia and British Columbia Centre for Disease Control, Vancouver, BC, Canada
    FEMS Immunol Med Microbiol 55:162-6. 2009
  9. doi request reprint Severe acute respiratory syndrome vaccine efficacy in ferrets: whole killed virus and adenovirus-vectored vaccines
    Raymond H See
    University of British Columbia Centre for Disease Control, Vancouver, BC V5Z 4R4, Canada
    J Gen Virol 89:2136-46. 2008
  10. pmc Novel Chlamydia muridarum T cell antigens induce protective immunity against lung and genital tract infection in murine models
    Hong Yu
    British Columbia Centre for Disease Control, University of British Columbia, Vancouver, British Columbia, Canada
    J Immunol 182:1602-8. 2009

Detail Information

Publications62

  1. pmc Novel avian influenza H7N3 strain outbreak, British Columbia
    Martin Hirst
    British Columbia Cancer Agency BCCA Genome Sciences Centre, Vancouver, British Columbia, Canada
    Emerg Infect Dis 10:2192-5. 2004
    ..This insertion likely occurred by recombination between the hemagglutination and matrix genes in the LPAI virus...
  2. ncbi request reprint Immunology of Chlamydia infection: implications for a Chlamydia trachomatis vaccine
    Robert C Brunham
    University of British Columbia Centre for Disease Control, Vancouver, British Columbia V5Z 4R4, Canada
    Nat Rev Immunol 5:149-61. 2005
    ..In this review, we describe our current understanding of the immune response to infection with Chlamydia spp. and how this information is improving the prospects for development of a vaccine against infection with C. trachomatis...
  3. pmc Characterization of murine dendritic cell line JAWS II and primary bone marrow-derived dendritic cells in Chlamydia muridarum antigen presentation and induction of protective immunity
    Xiaozhou Jiang
    University of British Columbia Centre for Disease Control, 655 West 12th Avenue, Vancouver, BC V5Z 4R4, Canada
    Infect Immun 76:2392-401. 2008
    ..We conclude that the JAWS II cell line can substitute for primary BMDCs in Chlamydia immunobiological studies...
  4. doi request reprint Chlamydia trachomatis control requires a vaccine
    Robert C Brunham
    University of British Columbia and the British Columbia Centre for Disease Control, Vancouver, Canada
    Vaccine 31:1892-7. 2013
    ..trachomatis vaccine effort requires coordinated partnership among academic, public health and private sector players together with a commitment to C. trachomatis vaccine control as a global public health priority...
  5. ncbi request reprint The unexpected impact of a Chlamydia trachomatis infection control program on susceptibility to reinfection
    Robert C Brunham
    University of British Columbia Centre for Disease Control, Vancouver, Canada
    J Infect Dis 192:1836-44. 2005
    ..Since 1998, rates have increased, and case counts now exceed those recorded before the intervention...
  6. ncbi request reprint Parran Award Lecture: insights into the epidemiology of sexually transmitted diseases from Ro = betacD
    Robert C Brunham
    UBC Centre for Disease Control, 655 West 12th Avenue, Vancouver, BC V5Z 4R4
    Sex Transm Dis 32:722-4. 2005
  7. pmc A live and inactivated Chlamydia trachomatis mouse pneumonitis strain induces the maturation of dendritic cells that are phenotypically and immunologically distinct
    Jose Rey-Ladino
    University of British Columbia Centre for Disease Control, 655 West 12th Ave, Vancouver, BC V5Z 4R4, Canada
    Infect Immun 73:1568-77. 2005
    ..This result may explain in part the differences in protective immunity induced by natural infection and immunization with whole inactivated organisms and is relevant to rational chlamydia vaccine design strategies...
  8. doi request reprint Considerations on Chlamydia trachomatis disease expression
    Robert C Brunham
    University of British Columbia and British Columbia Centre for Disease Control, Vancouver, BC, Canada
    FEMS Immunol Med Microbiol 55:162-6. 2009
    ..Recent genomic, immunologic, and epidemiologic findings are reviewed. A synthesis is offered which suggests that Chlamydia disease expression results from persistent infection and host immune responses...
  9. doi request reprint Severe acute respiratory syndrome vaccine efficacy in ferrets: whole killed virus and adenovirus-vectored vaccines
    Raymond H See
    University of British Columbia Centre for Disease Control, Vancouver, BC V5Z 4R4, Canada
    J Gen Virol 89:2136-46. 2008
    ....
  10. pmc Novel Chlamydia muridarum T cell antigens induce protective immunity against lung and genital tract infection in murine models
    Hong Yu
    British Columbia Centre for Disease Control, University of British Columbia, Vancouver, British Columbia, Canada
    J Immunol 182:1602-8. 2009
    ....
  11. pmc Survival of Chlamydia muridarum within dendritic cells
    Jose Rey-Ladino
    University of British Columbia Centre for Disease Control, 655 West 12th Avenue, Vancouver, BC, Canada
    Infect Immun 75:3707-14. 2007
    ..Together, these results raise the possibility that Chlamydia-infected DCs may be central to the maintenance of T-cell memory that underlies both immunity and immunopathology...
  12. pmc Chlamydia muridarum T-cell antigens formulated with the adjuvant DDA/TDB induce immunity against infection that correlates with a high frequency of gamma interferon (IFN-gamma)/tumor necrosis factor alpha and IFN-gamma/interleukin-17 double-positive CD4+
    Hong Yu
    British Columbia Centre for Disease Control, Vancouver, BC, Canada
    Infect Immun 78:2272-82. 2010
    ....
  13. pmc Differences in innate immune responses correlate with differences in murine susceptibility to Chlamydia muridarum pulmonary infection
    Xiaozhou Jiang
    British Columbia Centre for Disease Control, University of British Columbia, Vancouver, BC, Canada
    Immunology 129:556-66. 2010
    ..muridarum pulmonary infection are associated with differences in early innate cytokine and cellular responses that are correlated with late differences in T helper type 17 versus type 1 adaptive immune responses...
  14. pmc Immunization with live and dead Chlamydia muridarum induces different levels of protective immunity in a murine genital tract model: correlation with MHC class II peptide presentation and multifunctional Th1 cells
    Hong Yu
    British Columbia Centre for Disease Control, University of British Columbia, Vancouver, British Columbia V5Z 4R4, Canada
    J Immunol 186:3615-21. 2011
    ..muridarum. These insights should prove useful for improving vaccine design for Chlamydia trachomatis...
  15. ncbi request reprint Immunoproteomic discovery of novel T cell antigens from the obligate intracellular pathogen Chlamydia
    Karuna P Karunakaran
    British Columbia Centre for Disease Control, 655 West 12th Avenue, Vancouver, BC, Canada
    J Immunol 180:2459-65. 2008
    ..The results provide evidence for lead vaccine candidates for a T cell-based subunit molecular vaccine against Chlamydia infection suitable for human study...
  16. pmc Genetic profiling of dendritic cells exposed to live- or ultraviolet-irradiated Chlamydia muridarum reveals marked differences in CXC chemokine profiles
    Michelle L Zaharik
    University of British Columbia Centre for Disease Control, Vancouver, BC, Canada
    Immunology 120:160-72. 2007
    ..This has implications as to why early inactivated chlamydial vaccines were ineffective and suggests that new vaccine design efforts may benefit from in vitro DC screening for ELR chemokine expression profiles...
  17. pmc Protective measures and human antibody response during an avian influenza H7N3 outbreak in poultry in British Columbia, Canada
    Danuta M Skowronski
    BC Centre for Disease Control, Vancouver, BC
    CMAJ 176:47-53. 2007
    ..In 2004 an outbreak of avian influenza of the H7N3 subtype occurred among poultry in British Columbia, Canada. We report compliance with recommended protective measures and associated human infections during this outbreak...
  18. ncbi request reprint Comparative evaluation of two severe acute respiratory syndrome (SARS) vaccine candidates in mice challenged with SARS coronavirus
    Raymond H See
    University of British Columbia Centre for Disease Control, Vancouver, BC V5Z 4R4, Canada
    J Gen Virol 87:641-50. 2006
    ..Finally, the sera of vaccinated mice contained antibodies to S, further suggesting a role for this protein in conferring protective immunity against SARS-CoV infection...
  19. pmc Chlamydia muridarum T cell antigens and adjuvants that induce protective immunity in mice
    Hong Yu
    British Columbia Centre for Disease Control, University of British Columbia, Vancouver, British Columbia, Canada
    Infect Immun 80:1510-8. 2012
    ..The T cell antigens and adjuvants discovered in this study are of further interest in the development of a molecularly defined Chlamydia vaccine...
  20. pmc Modeling control strategies of respiratory pathogens
    Babak Pourbohloul
    Division of Mathematical Modeling, University of British Columbia Centre for Disease Control, Vancouver, British Columbia, Canada
    Emerg Infect Dis 11:1249-56. 2005
    ..Contact network epidemiology can provide valuable quantitative input to public health decisionmaking, even before a pathogen is well characterized...
  21. pmc Longitudinal analysis of genotype distribution of influenza A virus from 2003 to 2005
    Annie Mak
    BC Centre for Disease Control, 655 W12th Ave, Vancouver, BC V5Z 4R4, Canada
    J Clin Microbiol 44:3583-8. 2006
    ..Our findings indicate that genotype determination promises to be a rapid approach for detecting new strains of influenza A viruses in a population...
  22. doi request reprint Chlamydia public health programs and the epidemiology of pelvic inflammatory disease and ectopic pregnancy
    Michael L Rekart
    School of Population and Public Health, University of British Columbia, Vancouver, Canada
    J Infect Dis 207:30-8. 2013
    ....
  23. pmc Development of a Chlamydia trachomatis T cell Vaccine
    Karuna P Karunakaran
    British Columbia Centre for Disease Control, Vancouver, B C, Canada
    Hum Vaccin 6:676-80. 2010
    ..This review mainly focuses on an immunoproteomic approach used in our laboratory to identify Chlamydia T cell antigens and how these T cell antigens can be developed into a future human Chlamydia vaccine...
  24. ncbi request reprint GM-CSF transgene-based adjuvant allows the establishment of protective mucosal immunity following vaccination with inactivated Chlamydia trachomatis
    Hang Lu
    British Columbia Center for Disease Control and Department of Medicine, University of British Columbia, Vancouver, Canada
    J Immunol 169:6324-31. 2002
    ..In aggregate, the findings demonstrate that the local cytokine environment is critical to the induction of protective immunity following chlamydial vaccination and that GM-CSF may be a useful adjuvant for a chlamydial vaccine...
  25. ncbi request reprint International health: five reasons why Canadians should get involved
    Michael L Rekart
    University of British Columbia Centre for Disease Control, 655 West 12th Avenue, Vancouver, BC V5Z 4R4
    Can J Public Health 94:258-9. 2003
  26. ncbi request reprint Needs, gaps and opportunities for infectious disease research in British Columbia: a perspective from population and public health
    David M Patrick
    University of British Columbia, British Columbia Centre for Disease Control, Vancouver, BC
    Can J Public Health 97:S24-32, S27-36. 2006
    ..A review of infectious disease research activity and capacity was performed in British Columbia and linked to a process for identifying needs, gaps and opportunities from a public health perspective...
  27. doi request reprint Whole-genome sequencing and social-network analysis of a tuberculosis outbreak
    Jennifer L Gardy
    British Columbia Centre for Disease Control, Vancouver, BC, Canada
    N Engl J Med 364:730-9. 2011
    ..Traditional contact tracing did not identify a source. We used whole-genome sequencing and social-network analysis in an effort to describe the outbreak dynamics at a higher resolution...
  28. pmc Immuno-epidemiologic correlates of pandemic H1N1 surveillance observations: higher antibody and lower cell-mediated immune responses with advanced age
    Danuta M Skowronski
    British Columbia Centre for Disease Control, Vancouver, BC, V5Z 4R4, Canada
    J Infect Dis 203:158-67. 2011
    ..Pandemic H1N1 (pH1N1) surveillance data showed lower attack rates but higher risk of severe outcomes with advanced age. We explored immuno-epidemiologic correlates of surveillance findings including humoral and cell-mediated immunity (CMI)...
  29. ncbi request reprint Levels of antibodies against cytomegalovirus and Chlamydophila pneumoniae are increased in early onset pre-eclampsia
    Peter von Dadelszen
    Department of Obstetrics and Gynaecology, Children s and Women s Health Centre of British Columbia, University of British Columbia, 2H30 4500 Oak Street, Vancouver, BC, Canada V6H 3N1
    BJOG 110:725-30. 2003
    ..Could reactivated chronic infection be both a trigger for these differential maternal responses to the same underlying pathology and a link between pre-eclampsia and its attendant lifelong risks of atherosclerosis?..
  30. ncbi request reprint Impact of mass treatment on syphilis transmission: a mathematical modeling approach
    Babak Pourbohloul
    University of British Columbia Centre for Disease Control, Vancouver, Canada
    Sex Transm Dis 30:297-305. 2003
    ..By 1 year postintervention, syphilis cases had rebounded significantly. We investigate the cause of this postintervention rebound...
  31. ncbi request reprint Rapid response research to emerging infectious diseases: lessons from SARS
    B Brett Finlay
    Biotechnology Laboratory and Department of Biochemistry and Molecular Biology, University of British Columbia, Vancouver, British Columbia V6T 1Z3, Canada
    Nat Rev Microbiol 2:602-7. 2004
  32. pmc Molecular analysis of the multiple GroEL proteins of Chlamydiae
    Karuna P Karunakaran
    University of British Columbia Centre for Disease Control Genome Sequence Centre, British Columbia Cancer Agency, Vancouver, British Columbia, Canada
    J Bacteriol 185:1958-66. 2003
    ..coli groEL mutant. Complementation did not occur with groEL2 or groEL3 alone or together with groES. The role for each of the three GroELs in the chlamydial developmental cycle and in disease pathogenesis requires further study...
  33. pmc Vaccination against 2009 pandemic H1N1 in a population dynamical model of Vancouver, Canada: timing is everything
    Jessica M Conway
    Division of Mathematical Modeling, University of British Columbia Centre for Disease Control, 655 West 12th Avenue, V5Z 4R4 Vancouver, British Columbia, Canada
    BMC Public Health 11:932. 2011
    ..We adapted a city-level contact network model to study different campaigns on influenza morbidity and mortality...
  34. doi request reprint Mapping the protein interaction network in methicillin-resistant Staphylococcus aureus
    Artem Cherkasov
    Division of Infectious Diseases, Department of Medicine, University of British Columbia, Vancouver, British Columbia, Canada
    J Proteome Res 10:1139-50. 2011
    ..Thus, this empirical MRSA-252 PIN provides a rich source for identifying critical proteins essential for network stability, many of which can be considered as prospective antimicrobial drug targets...
  35. pmc Coordinated response to SARS, Vancouver, Canada
    Danuta M Skowronski
    British Columbia Centre for Disease Control, Vancouver, British Columbia, Canada
    Emerg Infect Dis 12:155-8. 2006
    ..Baseline preparedness for pandemic threats may account for the absence of sustained transmission and fewer cases of SARS in Vancouver...
  36. ncbi request reprint Severe acute respiratory syndrome (SARS): a year in review
    Danuta M Skowronski
    University of British Columbia Center for Disease Control, Vancouver, British Columbia, Canada V5Z 4R4
    Annu Rev Med 56:357-81. 2005
    ..This review synthesizes lessons learned from this remarkable achievement. These lessons can be applied to re-emergence of SARS or to the next pandemic threat to arise...
  37. ncbi request reprint Time evolution of epidemic disease on finite and infinite networks
    Pierre André Noël
    University of British Columbia Centre for Disease Control, Vancouver, British Columbia, Canada V5Z 4R4
    Phys Rev E Stat Nonlin Soft Matter Phys 79:026101. 2009
    ..This formalism can be equally applied to similar percolation phenomena on networks in other areas of science and technology...
  38. ncbi request reprint Potential cost-effectiveness of annual influenza immunization for infants and toddlers: experience from Canada
    Danuta M Skowronski
    University of British Columbia Centre for Disease Control, 655 West 12th Avenue, Vancouver, BC, Canada V5Z 4R4
    Vaccine 24:4222-32. 2006
    ..We assess cost-effectiveness of this program in Canada...
  39. pmc Structural characterization of genomes by large scale sequence-structure threading: application of reliability analysis in structural genomics
    Artem Cherkasov
    Division of Infectious Diseases, Faculty of Medicine, University of British Columbia, Vancouver, British Columbia, Canada
    BMC Bioinformatics 5:101. 2004
    ..For instance, Weibull distributions are widely used in reliability, maintainability and safety work to model time-to-failure of mechanical devices, mechanisms, building constructions and equipment...
  40. pmc Initial human transmission dynamics of the pandemic (H1N1) 2009 virus in North America
    Babak Pourbohloul
    Division of Mathematical Modeling, British Columbia Centre for Disease Control, Vancouver, British Columbia, Canada
    Influenza Other Respir Viruses 3:215-22. 2009
    ..We determined the reproduction number of pandemic (H1N1) 2009 by analyzing the dynamics of the complete case series in Mexico City during this early period...
  41. pmc Association between the 2008-09 seasonal influenza vaccine and pandemic H1N1 illness during Spring-Summer 2009: four observational studies from Canada
    Danuta M Skowronski
    British Columbia Centre for Disease Control BCCDC, Vancouver, British Columbia, Canada
    PLoS Med 7:e1000258. 2010
    ..Several epidemiologic investigations were conducted through the summer to assess this putative association...
  42. ncbi request reprint Targeted mass treatment for syphilis with oral azithromycin
    Michael L Rekart
    University of British Columbia Centre for Disease Control, Canada
    Lancet 361:313-4. 2003
    ..0001<p<0.0044). This rate rebound and the absence of a sustained effect suggest that targeted mass treatment for syphilis, even though feasible, should not be done routinely...
  43. pmc Identification of pyruvate kinase in methicillin-resistant Staphylococcus aureus as a novel antimicrobial drug target
    Roya Zoraghi
    Department of Medicine, Centre for High Throughput Biology, University of British Columbia, Vancouver, British Columbia, Canada
    Antimicrob Agents Chemother 55:2042-53. 2011
    ....
  44. ncbi request reprint Does antigen-specific cytokine response correlate with the experience of oculorespiratory syndrome after influenza vaccine?
    Danuta M Skowronski
    University of British Columbia Centre for Disease Control, Epidemiology Services, Vancouver, British Columbia, Canada
    J Infect Dis 187:495-9. 2003
    ..Although vaccinated ORS-affected individuals had less of a type 1 basis than did vaccinated unaffected individuals, this difference was not statistically significant...
  45. ncbi request reprint Effect of immune response on transmission dynamics for sexually transmitted infections
    Suvendrini Lena
    University of British Columbia Centre for Disease Control, Vancouver, British Columbia, Canada
    J Infect Dis 191:S78-84. 2005
    ..Elucidation of the immunobiological and behavioral factors that shape STI transmission should inform better STI prevention and control programs...
  46. pmc Molecular detection and seroepidemiology of the Chlamydia pneumoniae bacteriophage (PhiCpn1)
    Karuna P Karunakaran
    University of British Columbia Centre for Disease Control, Vancouver, Canada
    J Clin Microbiol 40:4010-4. 2002
    ..9; 95% confidence interval, 1.1 to 175). Our studies indicate that phage-containing strains of C. pneumoniae are uncommonly found by isolation but may commonly infect individuals with vascular disease...
  47. ncbi request reprint Neisseria meningitidis carriage during an outbreak of serogroup C disease
    David M Patrick
    Communicable Disease Epidemiology, University of British Columbia Centre for Disease Control, Vancouver, British Columbia, Canada
    Clin Infect Dis 37:1183-8. 2003
    ....
  48. ncbi request reprint The Genome sequence of the SARS-associated coronavirus
    Marco A Marra
    British Columbia Cancer Agency BCCA Genome Sciences Centre, 600 West 10th Avenue, Vancouver, British Columbia V5Z 4E6, Canada
    Science 300:1399-404. 2003
    ....
  49. doi request reprint Protecting the next generation: what is the role of the duration of human papillomavirus vaccine-related immunity?
    Oliver P Günther
    University of British Columbia Centre for Disease Control, Vancouver, British Columbia
    J Infect Dis 197:1653-61. 2008
    ..There is strong evidence that human papillomavirus (HPV) is necessary for the development of cervical cancer. A prophylactic HPV vaccine with high reported efficacy was approved in North America in 2006...
  50. ncbi request reprint Immunoepidemiologic profile of Chlamydia trachomatis infection: importance of heat-shock protein 60 and interferon- gamma
    Craig R Cohen
    Department of Obstetrics, Gynecology, and Reproductive Science, University of California, San Francisco, San Francisco, California 94105, USA
    J Infect Dis 192:591-9. 2005
    ..This investigation supports a direct role for C. trachomatis-specific immune responses in altering the risk of infection and suggests immune correlates of protection that are potentially useful in vaccine development...
  51. ncbi request reprint Immunogenetic correlates for Chlamydia trachomatis-associated tubal infertility
    Craig R Cohen
    Departments of Obstetrics and Gynecology, University of Washington, Box 356460, Seattle, WA 98195, USA
    Obstet Gynecol 101:438-44. 2003
    ..To understand immunogenetic mechanisms of Chlamydia trachomatis infection and tubal scarring...
  52. ncbi request reprint Identification of severe acute respiratory syndrome in Canada
    Susan M Poutanen
    Toronto Medical Laboratories and Mount Sinai Hospital Department of Microbiology, Toronto, Canada
    N Engl J Med 348:1995-2005. 2003
    ..This report summarizes the initial epidemiologic findings, clinical description, and diagnostic findings that followed the identification of SARS in Canada...
  53. ncbi request reprint Associations among human leukocyte antigen (HLA) class II DQ variants, bacterial sexually transmitted diseases, endometritis, and fertility among women with clinical pelvic inflammatory disease
    Roberta B Ness
    Graduate School of Public Health and Pittsburgh Cancer Institute, University of Pittsburgh, Pittsburgh, Pennsylvania, USA
    Sex Transm Dis 31:301-4. 2004
    ..We investigated associations between HLA class II DQ alleles, chlamydial and gonococcal cervicitis, endometritis, and infertility among women with pelvic inflammatory disease (PID)...
  54. ncbi request reprint The arrested immunity hypothesis and the epidemiology of chlamydia control
    Robert C Brunham
    Sex Transm Dis 35:53-4. 2008
  55. ncbi request reprint Aggregate content influences the Th1/Th2 immune response to influenza vaccine: evidence from a mouse model
    Shawn Babiuk
    Vaccine and Infectious Disease Organization, Saskatoon, SK, Canada
    J Med Virol 72:138-42. 2004
    ..We confirm that vaccine aggregates deviate the immune response to a greater Th2 cytokine pattern with potential implications for vaccine screening, safety, and efficacy...
  56. ncbi request reprint Chlamydia antibodies, chlamydia heat shock protein, and adverse sequelae after pelvic inflammatory disease: the PID Evaluation and Clinical Health (PEACH) Study
    Roberta B Ness
    Department of Epidemiology, University of Pittsburgh, PA 15261, USA
    Sex Transm Dis 35:129-35. 2008
    ..Among women with pelvic inflammatory disease (PID), we assessed the associations among antibodies to Chlamydia trachomatis elementary bodies (EB), antibodies to chlamydia heat shock protein (Chsp60), rates of pregnancy, and PID recurrence...
  57. ncbi request reprint Network theory and SARS: predicting outbreak diversity
    Lauren Ancel Meyers
    Section of Integrative Biology and Institute for Cellular and Molecular Biology, University of Texas at Austin, 1 University Station C0930, Austin, TX 78712, USA
    J Theor Biol 232:71-81. 2005
    ..We offer quantitative insight into the heterogeneity of SARS outbreaks worldwide, and illustrate the utility of this approach for assessing public health strategies...
  58. ncbi request reprint Serum antibody response to the heat shock protein 60 of Chlamydia trachomatis in women with developing cervical cancer
    Jorma Paavonen
    Department of Obstetrics and Gynecology, University of Helsinki, Haartmaninkatu 2, 00290 Helsinki, Finland
    Am J Obstet Gynecol 189:1287-92. 2003
    ..The purpose of this study was to determine whether serum antibody response to the three versions of chlamydial heat shock protein 60 is associated with an increased risk for cervical cancer...
  59. ncbi request reprint Serologic evidence of past infection with Chlamydia trachomatis, in relation to ovarian cancer
    Roberta B Ness
    Graduate School of Public Health and Pittsburgh Cancer Institute, University of Pittsburgh, 130 DeSoto Street, 517 Parran Hall, Pittsburgh, PA 15261, USA
    J Infect Dis 187:1147-52. 2003
    ..09) in ovarian cancer risk associated with CHSP60-1 but not with CHSP60-2, CHSP60-3, or CHSP10. These data suggest that past or chronic persistent infection with chlamydia may be a risk factor for ovarian cancer...
  60. ncbi request reprint Immunogenicity of a receptor-binding domain of SARS coronavirus spike protein in mice: implications for a subunit vaccine
    Alexander N Zakhartchouk
    Vaccine and Infectious Disease Organization VIDO, University of Saskatchewan, 120 Veterinary Road, Saskatoon, Sask, Canada S7N 5E3
    Vaccine 25:136-43. 2007
    ..This finding suggests that carbohydrate is important for the immunogenicity of the S318-510 protein fragment and provide useful information for designing an effective and safe SARS subunit vaccine...
  61. pmc Evidence that plant-like genes in Chlamydia species reflect an ancestral relationship between Chlamydiaceae, cyanobacteria, and the chloroplast
    Fiona S L Brinkman
    Department of Molecular Biology and Biochemistry, Simon Fraser University, Burnaby, British Columbia, Canada, V5A 1S6
    Genome Res 12:1159-67. 2002
    ....
  62. ncbi request reprint Sexually transmitted disease thresholds in Manitoba, Canada
    Ann M Jolly
    University of Manitoba, Winnipeg, Manitoba
    Ann Epidemiol 15:781-8. 2005
    ..We hypothesized that people with repeated bacterial STI's and their sex partners include the theoretical core group and that they differ from singly infected noncore individuals...

Research Grants3

  1. Development of a Chlamydia T Cell Vaccine Based on Dendritic Cell Immunoprotemics
    Robert Brunham; Fiscal Year: 2009
    ..In this proposal a novel immunoproteomic approach is described based on identifying Chlamydia peptides capable of producing protective cellular immunity that shows great promise towards the development of a Chlamydia vaccine. ..
  2. Development of a Chlamydia T Cell Vaccine Based on Dendritic Cell Immunoprotemics
    Leonard J Foster; Fiscal Year: 2010
    ..In this proposal a novel immunoproteomic approach is described based on identifying Chlamydia peptides capable of producing protective cellular immunity that shows great promise towards the development of a Chlamydia vaccine. ..