Affiliation: British Columbia
- Clinical utility of testing human immunodeficiency virus for drug resistanceP R Harrigan
British Columbia Centre for Excellence in HIV AIDS, Vancouver, BC, V6Z 1Y6, Canada
Clin Infect Dis 30:S117-22. 2000..HIV drug-resistance testing is also useful as a tool for new antiretroviral drug design and development, as well as for monitoring the spread of primary HIV drug resistance...
- A mutation in the 3' region of the human immunodeficiency virus type 1 reverse transcriptase (Y318F) associated with nonnucleoside reverse transcriptase inhibitor resistanceP Richard Harrigan
BC Centre for Excellence in HIV AIDS, 603 1081 Burrard Street, Vancouver, British Columbia V6Z 1Y6, Canada
J Virol 76:6836-40. 2002..3-, and 84-fold, respectively, as well as >100- and >60-fold decreases in delavirdine and nevirapine susceptibility, respectively. These results indicate the importance of the Y318F substitution in HIV-1 drug resistance...
- Antiretroviral concentrations in untimed plasma samples predict therapy outcome in a population with advanced diseaseChristopher S Alexander
British Columbia Centre for Excellence in HIV AIDS, University of British Columbia, Vancouver, British Columbia, Canada
J Infect Dis 188:541-8. 2003..01). These results may reflect incomplete adherence, since a strong association (P<.001) was found between low drug levels and an imperfect prescription-refill record (<95%)...
- Modest decreases in NNRTI susceptibility do not influence virological outcome in patients receiving initial NNRTI-containing triple therapyP Richard Harrigan
BC Centre for Excellence in HIV AIDS, Vancouver, BC, Canada
Antivir Ther 8:395-402. 2003....
- Predictors of HIV drug-resistance mutations in a large antiretroviral-naive cohort initiating triple antiretroviral therapyP Richard Harrigan
British Columbia Centre for Excellence in HIV AIDS, and Department of Medicine, University of British Columbia, Vancouver, Canada
J Infect Dis 191:339-47. 2005....
- HIV-1 drug resistance: degree of underestimation by a cross-sectional versus a longitudinal testing approachP Richard Harrigan
British Columbia Centre for Excellence in HIV AIDS, St Paul s Hospital, University of British Columbia, Vancouver, British Columbia, Canada
J Infect Dis 191:1325-30. 2005..Our results suggest that analysis of a combined historical genotype rather than of a cross-sectional genotype may lead to more accurate estimates of antiretroviral drug resistance in individual patients and in patient populations...
- Simple rapid method for quantification of antiretrovirals by liquid chromatography-tandem mass-spectrometryAndrew Volosov
Children s National Medical Center, Washington, DC, USA
Clin Biochem 35:99-103. 2002....