Louis Philippe Boulet

Summary

Country: Canada

Publications

  1. pmc The link between obesity and asthma: a Canadian perspective
    Louis Philippe Boulet
    Unité de Recherche en Pneumologie, Centre de Recherche, Institut Universitaire de Cardiologie et de Pneumologie, Universite Laval, Hopital Laval, Quebec
    Can Respir J 14:217-20. 2007
  2. ncbi request reprint Cough and upper airway disorders in elite athletes: a critical review
    Louis Philippe Boulet
    Department of Pneumology, Institut Universitaire de Cardiologie et de Pneumologie de Quebec, Chemin Ste Foy, Quebec, Quebec, Canada
    Br J Sports Med 46:417-21. 2012
  3. pmc Protocol: influence of budesonide and budesonide/formoterol on asthma control in smoking asthmatic adults
    Louis Philippe Boulet
    Centre de Recherche de Institut Universitaire de Cardiologie et de Pneumologie de Québec, Quebec, Canada
    Open Respir Med J 4:51-7. 2010
  4. ncbi request reprint Influence of cardiac dysfunction and systemic inflammation on pulmonary function and airway responsiveness in obese subjects
    Andrée Anne Gagnon-Audet
    Clin Invest Med 36:E255-63. 2013
  5. pmc Asthma and chronic obstructive pulmonary disease guideline implementation: lessons learned on recruitment of primary care physicians to a knowledge translation study
    Louis Philippe Boulet
    Institut Universitaire de Cardiologie et de Pneumologie de Quebec, Universite Laval, Quebec
    Can Respir J 20:275-80. 2013
  6. pmc Decreased miR-192 expression in peripheral blood of asthmatic individuals undergoing an allergen inhalation challenge
    Masatsugu Yamamoto
    UBC James Hogg Research Centre, St Paul s Hospital, University of British Columbia, Room 166, Burrard Building, 1081 Burrard Street, Vancouver, BC V6Z 1Y6, Canada
    BMC Genomics 13:655. 2012
  7. doi request reprint Asthma and obesity
    L P Boulet
    Institut Universitaire de Cardiologie et de Pneumologie de Quebec, Laval University, Quebec, QC, Canada
    Clin Exp Allergy 43:8-21. 2013
  8. ncbi request reprint Adherence: the goal to control asthma
    Louis Philippe Boulet
    Institut Universitaire de Cardiologie et de Pneumologie de Quebec, Universite Laval, 2725 Chemin Ste Foy, Quebec, QC G1V 4G5, Canada
    Clin Chest Med 33:405-17. 2012
  9. pmc Is there a role for bronchial thermoplasty in the treatment of asthma?
    Louis Philippe Boulet
    Institut Universitaire de Cardiologie et de Pneumologie de Quebec, 2725 Chemin Sainte Foy, Quebec, Québec GIV 4G5, Canada
    Can Respir J 19:191-2. 2012
  10. pmc Global asthma prevalence in adults: findings from the cross-sectional world health survey
    Teresa To
    Child Health Evaluative Sciences, The Hospital for Sick Children, Toronto, Ontario, Canada
    BMC Public Health 12:204. 2012

Detail Information

Publications126 found, 100 shown here

  1. pmc The link between obesity and asthma: a Canadian perspective
    Louis Philippe Boulet
    Unité de Recherche en Pneumologie, Centre de Recherche, Institut Universitaire de Cardiologie et de Pneumologie, Universite Laval, Hopital Laval, Quebec
    Can Respir J 14:217-20. 2007
    ..Smoking did not seem to influence the relationship between asthma and body mass index. Further research should investigate the mechanisms by which obesity may influence the prevalence of asthma or asthma-like symptoms...
  2. ncbi request reprint Cough and upper airway disorders in elite athletes: a critical review
    Louis Philippe Boulet
    Department of Pneumology, Institut Universitaire de Cardiologie et de Pneumologie de Quebec, Chemin Ste Foy, Quebec, Quebec, Canada
    Br J Sports Med 46:417-21. 2012
    ..Furthermore, regulatory agencies' restrictions on the type of drugs allowed for therapeutic use of these conditions in competitive athletes should be checked...
  3. pmc Protocol: influence of budesonide and budesonide/formoterol on asthma control in smoking asthmatic adults
    Louis Philippe Boulet
    Centre de Recherche de Institut Universitaire de Cardiologie et de Pneumologie de Québec, Quebec, Canada
    Open Respir Med J 4:51-7. 2010
    ..A reduced response to inhaled corticosteroids (ICS) has been reported in smoking asthmatic patients but the effects of other medications remain to be evaluated in this population...
  4. ncbi request reprint Influence of cardiac dysfunction and systemic inflammation on pulmonary function and airway responsiveness in obese subjects
    Andrée Anne Gagnon-Audet
    Clin Invest Med 36:E255-63. 2013
    ..This study aimed to determine if AHR is associated with left ventricular diastolic dysfunction and heart rate variability in severely obese subjects...
  5. pmc Asthma and chronic obstructive pulmonary disease guideline implementation: lessons learned on recruitment of primary care physicians to a knowledge translation study
    Louis Philippe Boulet
    Institut Universitaire de Cardiologie et de Pneumologie de Quebec, Universite Laval, Quebec
    Can Respir J 20:275-80. 2013
    ..Implementation of current clinical practice guidelines in asthma and chronic obstructive pulmonary disease (COPD) is suboptimal. New implementation strategies should be developed and evaluated...
  6. pmc Decreased miR-192 expression in peripheral blood of asthmatic individuals undergoing an allergen inhalation challenge
    Masatsugu Yamamoto
    UBC James Hogg Research Centre, St Paul s Hospital, University of British Columbia, Room 166, Burrard Building, 1081 Burrard Street, Vancouver, BC V6Z 1Y6, Canada
    BMC Genomics 13:655. 2012
    ..We aimed to evaluate changes in the microRNA profiles in the peripheral blood of asthmatic subjects undergoing allergen inhalation challenge...
  7. doi request reprint Asthma and obesity
    L P Boulet
    Institut Universitaire de Cardiologie et de Pneumologie de Quebec, Laval University, Quebec, QC, Canada
    Clin Exp Allergy 43:8-21. 2013
    ....
  8. ncbi request reprint Adherence: the goal to control asthma
    Louis Philippe Boulet
    Institut Universitaire de Cardiologie et de Pneumologie de Quebec, Universite Laval, 2725 Chemin Ste Foy, Quebec, QC G1V 4G5, Canada
    Clin Chest Med 33:405-17. 2012
    ..Interventions to improve adherence therefore demand tailoring to the individual by including patient-specific education, addressing patient fears and misconceptions, monitoring adherence, and developing a shared decision process...
  9. pmc Is there a role for bronchial thermoplasty in the treatment of asthma?
    Louis Philippe Boulet
    Institut Universitaire de Cardiologie et de Pneumologie de Quebec, 2725 Chemin Sainte Foy, Quebec, Québec GIV 4G5, Canada
    Can Respir J 19:191-2. 2012
    ..The response to this treatment varies from one patient to another. Consequently, further studies are required to better define the role of this option in the treatment of asthma...
  10. pmc Global asthma prevalence in adults: findings from the cross-sectional world health survey
    Teresa To
    Child Health Evaluative Sciences, The Hospital for Sick Children, Toronto, Ontario, Canada
    BMC Public Health 12:204. 2012
    ..We set out to generate estimates of the global burden of asthma in adults, which may inform the development of strategies to address this common disease...
  11. pmc Seasonal variations of cough reflex sensitivity in elite athletes training in cold air environment
    Julie Turmel
    Centre de Recherche de l Institut Universitaire de Cardiologie et de Pneumologie de Quebec, 2725 Chemin Ste Foy, Quebec, QC G1V 4G5, Canada
    Cough 8:2. 2012
    ..abstract:..
  12. doi request reprint A guide to the translation of the Global Initiative for Asthma (GINA) strategy into improved care
    Louis Philippe Boulet
    Institut Universitaire de Cardiologie et de Pneumologie de Quebec, Quebec, QC, Canada
    Eur Respir J 39:1220-9. 2012
    ..It also provides examples of successful initiatives in various socioeconomic settings...
  13. doi request reprint Effect of bariatric surgery on airway response and lung function in obese subjects with asthma
    Louis Philippe Boulet
    Centre de Recherche de l Institut Universitaire de Cardiologie et de Pneumologie de Quebec, Canada
    Respir Med 106:651-60. 2012
    ..Obesity is a risk factor for self-reported asthma and makes asthma management more difficult. The effects of bariatric surgery on asthma in severely obese subjects remain to be documented...
  14. pmc Airway function, inflammation and regulatory T cell function in subjects in asthma remission
    Louis Philippe Boulet
    Centre de Recherche, Institut universitarie de cardiologie et de pneumologie de Québec, Quebec
    Can Respir J 19:19-25. 2012
    ..Factors associated with asthma remission need to be determined, particularly when remission occurs in adulthood...
  15. pmc Roflumilast attenuates allergen-induced inflammation in mild asthmatic subjects
    Gail M Gauvreau
    Department of Medicine, McMaster University, Hamilton, Ontario, Canada
    Respir Res 12:140. 2011
    ..The objective of this study was to evaluate the effects of roflumilast on bronchoconstriction, airway hyperresponsiveness (AHR), and airway inflammation in mild asthmatic patients undergoing allergen inhalation challenge...
  16. ncbi request reprint Lung hyperinflation, perception of bronchoconstriction and airway hyperresponsiveness
    Louis Philippe Boulet
    Unité de Recherche en Pneumologie, Centre de Recherche, Hopital Laval, Quebec, QC, Canada
    Clin Invest Med 30:2-11. 2007
    ..To compare the influence of underlying airway inflammation and lung hyperinflation on dyspnea during induced bronchoconstriction in subjects with mild asthma (or asymptomatic airway hyperresponsiveness (AAHR)...
  17. ncbi request reprint Influence of obesity on response to fluticasone with or without salmeterol in moderate asthma
    Louis Philippe Boulet
    Hopital Laval, Institut Universitaire de Cardiologie et de Pneumologie, Universite Laval, Quebec, Canada
    Respir Med 101:2240-7. 2007
    ..Obesity may contribute to the development and clinical expression of asthma. However, how obesity can influence response to asthma medications is still uncertain...
  18. pmc Symposium on obesity and asthma - November 2, 2006
    Louis Philippe Boulet
    Centre de Pneumologie, Institut Universitaire de Cardiologie et de Pneumologie de l Universite Laval, Hopital Laval, Quebec
    Can Respir J 14:201-8. 2007
    ....
  19. ncbi request reprint A randomized study comparing ciclesonide and fluticasone propionate in patients with moderate persistent asthma
    Louis Philippe Boulet
    Institut de cardiologie et de pneumologie de l Université Laval, Hopital Laval, 2725 Chemin Sainte Foy, Quebec City, Que, Canada G1V 4G5
    Respir Med 101:1677-86. 2007
    ..To compare the effects of once-daily ciclesonide and twice-daily fluticasone propionate in patients with moderate persistent asthma...
  20. ncbi request reprint Algae-induced occupational asthma in a thalassotherapist
    Louis Philippe Boulet
    Hopital Laval, Centre de Pneumologie, Sainte Foy, Quebec, Canada
    Occup Med (Lond) 56:282-3. 2006
    ..Algae powders have been increasingly used in therapeutic preparations. Their potential as inducers of occupational asthma (OA), however, remains to be demonstrated...
  21. pmc Implementing practice guidelines: a workshop on guidelines dissemination and implementation with a focus on asthma and COPD
    Louis Philippe Boulet
    Hopital Laval, 2725 Chemin Sainte Foy, Quebec, Canada
    Can Respir J 13:5-47. 2006
    ..It is hoped that this event will be followed by other meetings that focus on how to improve the transfer of key recommendations from evidence-based guidelines into current care, and how to stimulate research to accomplish this...
  22. ncbi request reprint Smoking and asthma: clinical and radiologic features, lung function, and airway inflammation
    Louis Philippe Boulet
    Hopital Laval, 2725 Chemin Sainte Foy, Quebec, QC, Canada, G1V 4G5
    Chest 129:661-8. 2006
    ..In conclusion, compared with nonsmoking asthma patients, smoking asthma patients have features similar to what could be found in early stages of COPD...
  23. ncbi request reprint Future directions in the clinical management of cough: ACCP evidence-based clinical practice guidelines
    Louis Philippe Boulet
    Hôpital Laval 2725, Chemin Sainte Foy, Quebec City, QC, Canada G1V 4G5
    Chest 129:287S-92S. 2006
    ..To impart a call for further research into the identified domains of particular interest in the etiology, management, and treatment of cough...
  24. ncbi request reprint Comparative efficacy of once-daily ciclesonide and budesonide in the treatment of persistent asthma
    L P Boulet
    Institut de cardiologie et de pneumologie de l Université Laval, Hopital Laval, 2725 Chemin Sainte Foy, Quebec City, Que, Canada G1V 4G5
    Respir Med 100:785-94. 2006
    ..The aim of this study was to compare the efficacy and safety of once-daily ciclesonide, a new-generation, on-site-activated, inhaled corticosteroid, with once-daily budesonide in persistent asthma...
  25. ncbi request reprint Deep inspiration avoidance and airway response to methacholine: Influence of body mass index
    Louis Philippe Boulet
    Unité de Recherche en Pneumologie, Institut de cardiologie et de pneumologie de l Université Laval, Hopital Laval, Quebec City
    Can Respir J 12:371-6. 2005
    ....
  26. ncbi request reprint The current state of cough research: the clinician's perspective
    Louis Philippe Boulet
    Hopital Laval, 2725, Chemin Sainte Foy, G1V 4G5, Quebec City, Quebec, Canada
    Lung 186:S17-22. 2008
    ..The effects of the use or nonuse of evidence-based guidelines should be documented. An empiric, integrative approach to management of chronic cough also needs further validation...
  27. ncbi request reprint Airway remodelling: the future
    L P Boulet
    Hopital Laval, 2725, Chemin Sainte Foy, Quebec, QC, Canada
    Eur Respir J 30:831-4. 2007
  28. doi request reprint Asthma-related comorbidities
    Louis Philippe Boulet
    Centre de Recherche de l Institut Universitaire de Cardiologie et de Pneumologie de Quebec, 2725, Chemin Sainte Foy, QC, G1V 4G5, Canada
    Expert Rev Respir Med 5:377-93. 2011
    ..If considered relevant, they should, however, be treated appropriately. Further research is needed on the relationships between these conditions and asthma...
  29. pmc Comparative responses to nasal allergen challenge in allergic rhinitic subjects with or without asthma
    Marie Claire Rousseau
    Centre de Recherche, Institut Universitaire de Cardiologie et de Pneumologie de Quebec, Quebec, QC, Canada
    Allergy Asthma Clin Immunol 7:8. 2011
    ..abstract:..
  30. doi request reprint The Physicians' Practice Assessment Questionnaire on asthma and COPD
    Louis Philippe Boulet
    Institut Universitaire de Cardiologie et de Pneumologie de Quebec, Universite Laval, 2725 Chemin Sainte Foy, Quebec, QC, Canada G1V 4G5
    Respir Med 105:8-14. 2011
    ..6801, p < 0.0001 for COPD). In conclusion, the PPAQ is a new tool to assess implementation of asthma and COPD guidelines; it has the potential to identify care gaps that can be specifically targeted for intervention...
  31. doi request reprint Benefits of low-dose inhaled fluticasone on airway response and inflammation in mild asthma
    Louis Philippe Boulet
    Unité de Recherche en Pneumologie, Institut Universitaire de Cardiologie et de Pneumologie de Quebec, 2725 Chemin Sainte Foy, Québec8, PQ, Canada G1V 4G5
    Respir Med 103:1554-63. 2009
    ..Current guidelines suggest that asthma should be controlled with the lowest dose of maintenance medication required...
  32. doi request reprint Influence of comorbid conditions on asthma
    L P Boulet
    Institut Universitaire de Cardiologie et de Pneumologie, Universite Laval, 2725 Chemin Sainte Foy, Quebec, QC, Canada
    Eur Respir J 33:897-906. 2009
    ..With regard to clinical research, associated conditions may influence the results of trials and should be taken into account in the subjects' inclusion criteria and analysis of data...
  33. ncbi request reprint Safety, pharmacodynamics and pharmacokinetics of TPI 1020 in smokers with asthma
    Louis Philippe Boulet
    Centre de Recherche, Hopital Laval, Institut Universitaire de Cardiologie et de Pneumologie de l Universite Laval, Quebec, QC G1V 4G5, Canada
    Respir Med 103:1159-66. 2009
    ..TPI 1020 is a novel compound with potential for anti-neutrophil effects. TPI 1020 exerts its effects by a dual mechanism of action involving corticosteroid activity and controlled donation of nitric oxide...
  34. ncbi request reprint Irreversible airway obstruction in asthma
    Louis Philippe Boulet
    Centre de Pneumologie, Hopital Laval, Quebec, Quebec, Canada
    Curr Allergy Asthma Rep 9:168-73. 2009
    ....
  35. ncbi request reprint Improving knowledge transfer on chronic respiratory diseases: a Canadian perspective. How to translate recent advances in respiratory diseases into day-to-day care
    L P Boulet
    Institut universitaire de cardiologie et de pneumologie l Université Laval, Hopital Laval, Quebec, Canada
    J Nutr Health Aging 12:758S-763S. 2008
    ....
  36. ncbi request reprint Influence of obesity on the prevalence and clinical features of asthma
    Louis Philippe Boulet
    Centre de Pneumologie, Hopital Laval, Institut Universitaire de Cardiologie et dePneumologie de l Université Laval
    Clin Invest Med 31:E386-90. 2008
    ..Weight loss improves asthma control and reduces medication needs. Research is needed to better define the optimal management of obese asthmatic patients...
  37. pmc Towards Excellence in Asthma Management: final report of an eight-year program aimed at reducing care gaps in asthma management in Quebec
    Louis Philippe Boulet
    Institut de cardiologie et de pneumologie de l Université Laval, Quebec City, Canada
    Can Respir J 15:302-10. 2008
    ..To optimize care, a systematic approach to identifying such shortfalls or 'care gaps', in which all stakeholders of the health care system (including patients) are involved, was proposed...
  38. pmc Playing cards on asthma management: a new interactive method for knowledge transfer to primary care physicians
    Louis Philippe Boulet
    Institut Universitaire de Cardiologie et de Pneumologie, Hopital Laval, Quebec, Canada
    Can Respir J 14:480-4. 2007
    ..To describe an interactive playing card workshop in the communication of asthma guidelines recommendations, and to assess the initial evaluation of this educational tool by family physicians...
  39. ncbi request reprint Comparative improvement of asthma symptoms and expiratory flows after corticosteroid treatment: a method to assess the effect of corticosteroids on large vs. small airways?
    Louis Philippe Boulet
    Institut de cardiologie et de pneumologie de l Hôpital Laval, 2725 Chemin Sainte Foy, Quebec, QC, Canada G1V 4G5
    Respir Med 100:496-502. 2006
    ..This may suggest that this ratio is not useful for evaluating the effect of corticosteroids on small airways, or that extrafine HFA-BDP acts at the level of large- to moderate-caliber airways to produce most of its beneficial effect...
  40. ncbi request reprint Clinical features and airway inflammation in mild asthma versus asymptomatic airway hyperresponsiveness
    Louis Philippe Boulet
    Unité de Recherche en Pneumologie de l Hôpital Laval, Institut Universitaire de Cardiologie et de Pneumologie de l Universite Laval, 2725 Ch Ste Foy, Quebec, Canada
    Respir Med 100:292-9. 2006
    ..We still do not know why some subjects with airway hyperresponsiveness (AHR) experience no respiratory symptoms...
  41. ncbi request reprint Airway inflammation in asthma with incomplete reversibility of airflow obstruction
    L P Boulet
    Hopital Laval, 2725, Chemin Sainte Foy, Sainte Foy, Québec Canada G1V 4G5
    Respir Med 97:739-44. 2003
    ..Non-smoking patients with IRAO had more neutrophils in IS than CRAO...
  42. ncbi request reprint Evaluation of asthma control by physicians and patients: comparison with current guidelines
    Louis Philippe Boulet
    University Institute of Cardiology and Pulmonology, University Laval, Hopital Laval, 2725 Chemin Sainte Foy, Sainte Foy, Quebec G1V 4G5, Canada
    Can Respir J 9:417-23. 2002
    ..It is not known whether physicians are using these criteria to assess treatment needs and how effective such assessments are compared with patient assessment of asthma control...
  43. ncbi request reprint How should we quantify asthma control? A proposal
    Louis Philippe Boulet
    Centre de Recherche de l Hopital Laval, Institut de cardiologie et de pneumologie de l Université Laval, 2725 Chemin Sainte Foy, Sainte Foy, Quebec, Canada
    Chest 122:2217-23. 2002
    ..Current asthma guidelines suggest a series of criteria to assess if asthma is controlled. However, there is a need to develop a simple and practical method to quantify the degree of such control, both in clinical practice and research...
  44. ncbi request reprint Influence of sympatho-vagal balance on airway responsiveness in athletes
    J B Langdeau
    Centre de Recherche de l H pital Laval, Institut Universitaire de Cardiologie et de Pneumologie, Universite Laval, Sainte Foy, Quebec, Canada
    Eur J Appl Physiol 83:370-5. 2000
    ..31, P < 0.05, respectively) This study suggests that the sympatho-vagal balance may contribute to the increased AHR in the population studied but this influence alone cannot explain the higher prevalence of AHR in athletes...
  45. ncbi request reprint Once-daily inhaled corticosteroids for the treatment of asthma
    Louis Philippe Boulet
    Institut de cardiologie et de pneumologie de l Université Laval, Hopital Laval, Quebec City, QC, Canada
    Curr Opin Pulm Med 10:15-21. 2004
    ..Although compliance to this type of medication is often suboptimal and once-daily dosing can help to improve adherence to the treatment, the clinical implications of such a mode of administration should be determined...
  46. ncbi request reprint Effect of salmeterol on allergen-induced airway inflammation in mild allergic asthma
    L P Boulet
    Centre de Recherche de l Hopital Laval, Institut Universitaire de Cardiologie et de Pneumologie de l Universite Laval, 2725, Chemin Sainte Foy, Sainte Foy, Quebec, Canada G1V 4G5
    Clin Exp Allergy 31:430-7. 2001
    ..This is in keeping with the recommendation that salmeterol should only be used with an anti-inflammatory agent, particularly in the context of significant allergen exposure...
  47. ncbi request reprint How to make asthma education happen
    L Boulet
    Centre de pneumologie de l Hôpital Laval 2725, Chemin Sainte Foy, Sainte Foy, Quebec, Canada G1V 4G5
    West Indian Med J 52:10-3. 2003
  48. ncbi request reprint What is new since the last (1999) Canadian Asthma Consensus Guidelines?
    L P Boulet
    Hopital Laval, Sainte Foy, Canada
    Can Respir J 8:5A-27A. 2001
    ..New developments, such as combination therapy, and recent major trials, such as the Children's Asthma Management Project (CAMP) study, are discussed...
  49. ncbi request reprint Physiopathology of airway hyperresponsiveness
    Louis Philippe Boulet
    Hopital Laval, 2725, Chemin Sainte Foy, Sainte Foy, Quebec, G1V 4G5, Canada
    Curr Allergy Asthma Rep 3:166-71. 2003
    ..Other factors, such as neurohumoral influences and "geometric factors" (eg, airway caliber), can modulate the degree of AHR...
  50. ncbi request reprint Airway hyperresponsiveness, inflammation, and subepithelial collagen deposition in recently diagnosed versus long-standing mild asthma. Influence of inhaled corticosteroids
    L P Boulet
    Institut de cardiologie et de pneumologie de l Université Laval, H opital Laval, Sainte Foy, Quebec, Canada
    Am J Respir Crit Care Med 162:1308-13. 2000
    ..It also indicates that once asthma becomes symptomatic, airway responsiveness cannot normalize in most subjects over such a time period, even with a high dose of ICS...
  51. ncbi request reprint Airway inflammation and structural changes in airway hyper-responsiveness and asthma: an overview
    L P Boulet
    Unite de Recherche, Centre de Pneumologie de l Hôpital Laval, Réseau canadien des Centres d exellence en santé respiratoire, Sainte Foy, Canada
    Can Respir J 5:16-21. 1998
    ..This paper reviews some of the main components of airway inflammation and structural changes in asthma, and discusses how these processes may interact to modify airway function and induce respiratory symptoms...
  52. ncbi request reprint The ozone layer and metered dose inhalers
    L P Boulet
    Institut de cardiologie et de pneumologie de l Université Laval, Sainte Foy, Canada
    Can Respir J 5:176-9. 1998
    ..It also requires a harmonization of actions taken by industry, government, licencing bodies and patients or health professional associations to ensure adequate information and education to the public and respiratory care providers...
  53. ncbi request reprint Asthma education: what has been its impact?
    L P Boulet
    Centre de Pneumologie de l Hôpital Laval, Sainte Foy, Quebec, Canada
    Can Respir J 5:91A-6A. 1998
    ..Hopefully, such initiatives will be supported and implemented to provide cost effective educational interventions that will improve quality of life of asthma sufferers and reduce health care costs...
  54. ncbi request reprint Comparison of once- with twice-daily dosing of fluticasone propionate in mild and moderate asthma
    L P Boulet
    Centre de Pneumologie de l Hôpital Laval, Universite Laval, Sainte Foy, Quebec
    Can Respir J 7:239-47. 2000
    ....
  55. ncbi request reprint Lower airway inflammatory responses to high-intensity training in athletes
    Louis Philippe Boulet
    Centre de Recherche, Institut de cardiologie et de pneumologie de l Université Laval, Hopital Laval, Quebec City, Canada
    Clin Invest Med 28:15-22. 2005
    ..High intensity exercise may induce airway inflammation and subsequent remodelling in these subjects. Our aim was to evaluate the effects of high-intensity training on induced-sputum cell populations in elite athletes...
  56. ncbi request reprint Asymptomatic airway hyperresponsiveness: a curiosity or an opportunity to prevent asthma?
    Louis Philippe Boulet
    Institut Universitaire de Cardiologie et de Pneumologie de l Universite Laval, Hopital Laval, Sainte Foy, Quebec, Canada
    Am J Respir Crit Care Med 167:371-8. 2003
  57. ncbi request reprint Physicians' assessment of asthma control in low vs. high asthma-related morbidity regions
    Louis Philippe Boulet
    Institut de cardiologie et de pneumologie de l Université Laval, Hopital Laval, Quebec QC, Canada
    J Asthma 41:813-24. 2004
    ..low asthma-related morbidity region (LMR), as determined by a large-scale populational survey (asthma cartography)...
  58. ncbi request reprint Safety and efficacy of HFA-134a beclomethasone dipropionate extra-fine aerosol over six months
    Louis Philippe Boulet
    Institut Universitaire de Cardiologie et de Pneumologie, l Université Laval, Hopital Laval, Sainte Foy, Quebec
    Can Respir J 11:123-30. 2004
    ..To compare the systemic safety and efficacy of hydrofluoroalkane beclomethasone dipropionate (HFA-BDP) extra-fine aerosol 800 microg/day with chlorofluorocarbon (CFC)-BDP 1500 microg/day...
  59. ncbi request reprint Airway remodeling and inflammation in competitive swimmers training in indoor chlorinated swimming pools
    Valerie Bougault
    Centre de Recherche de l Institut Universitaire de Cardiologie et de Pneumologie de Quebec, Quebec City, Quebec, Canada
    J Allergy Clin Immunol 129:351-8, 358.e1. 2012
    ..Airway disorders are common in regular chlorinated swimming pool attendees, particularly competitive athletes, but the impact of intense swimming training on airway function and structure remains unclear...
  60. ncbi request reprint Is there an association between coronary atherosclerosis and airway responsiveness?
    Julie Turmel
    Laval Hospital Quebec Heart Lung Institute, Quebec City, Montreal, Canada
    Acta Cardiol 63:347-53. 2008
    ..Our objective was to assess the potential relationship between AHR and coronary atherosclerosis plaque volume as assessed by 3-dimensional intravascular ultrasound (IVUS)...
  61. ncbi request reprint Asthma and sleep apnea in patients with morbid obesity: outcome after bariatric surgery
    Barbara Simard
    Pulmonary Research Unit, Cardiology and Respiratory Institute, Laval University, Laval Hospital, Quebec, QC, Canada
    Obes Surg 14:1381-8. 2004
    ..The authors determined the prevalence of asthma and SAS in morbidly obese patients and the effect of biliopancreatic diversion with duodenal switch (BPD-DS) on these conditions...
  62. ncbi request reprint Are questionnaires on respiratory symptoms reliable predictors of airway hyperresponsiveness in athletes and sedentary subjects?
    Helene Turcotte
    Centre de Recherche de l Hopital Laval, Institut Universitaire de Cardiologie et de Pneumologie, Universite Laval, Sainte Foy, Quebec, Canada
    J Asthma 40:71-80. 2003
    ....
  63. doi request reprint Gender differences in the prevalence of airway hyperresponsiveness and asthma in athletes
    Jean Bruno Langdeau
    Centre de Recherche de l Hopital Laval, Institut Universitaire de Cardiologie et de Pneumologie, Universite Laval, Quebec, QC, Canada
    Respir Med 103:401-6. 2009
    ..We looked at the comparative prevalence of AHR, physician-diagnosed asthma and respiratory symptoms during exercise in female (F) and male (M) athletes...
  64. doi request reprint Fibroblast growth factor-2 is a sputum remodeling biomarker of severe asthma
    Elyse Y Bissonnette
    Centre de Recherche de l Institut Universitaire de Cardiologie et de Pneumologie de Quebec, Universite Laval, Quebec City, QC, Canada
    J Asthma 51:119-26. 2014
    ..Given the large phenotypic diversity of asthma, our aim was to characterize molecular profiles related to asthma severity using selected remodeling biomarkers in induced sputum...
  65. ncbi request reprint Prevalence of respiratory symptoms in an athlete population
    Helene Turcotte
    Centre de Recherche de l Hopital Laval, Institut Universitaire de Cardiologie et de Pneumologie, Universite Laval, 2725, Chemin Sainte Foy, Sainte Foy, Quebec, Canada G1V 4G5
    Respir Med 97:955-63. 2003
    ....
  66. ncbi request reprint Airway inflammatory responses following exposure to occupational agents
    Philippe Prince
    Centre de Recherche de l Institut Universitaire de Cardiologie et de Pneumologie de Quebec, Quebec City, Canada
    Chest 141:1522-7. 2012
    ..We assessed the changes in airway inflammatory cells following SIC in sensitized workers, and looked at the influence of various factors on the pattern of inflammatory responses to SIC...
  67. ncbi request reprint Bronchial challenges and respiratory symptoms in elite swimmers and winter sport athletes: Airway hyperresponsiveness in asthma: its measurement and clinical significance
    Valerie Bougault
    Centre de Recherche de l Institut Universitaire de Cardiologie et de Pneumologie de Quebec, Quebec, QC, Canada
    Chest 138:31S-37S. 2010
    ..Furthermore, the choice of methods for assessing methacholine challenge and EVH responses influences the prevalences of AHR and EIB...
  68. doi request reprint Comparative clinical and airway inflammatory features of asthmatics with or without polyps
    Lara Bilodeau
    Centre de recherche de l Institute universitaire de cardiologie et de pneumologie de Québec, Quebec, Canada
    Rhinology 48:420-5. 2010
    ..Nasal polyposis (NP) is associated with a more severe and steroid-resistant asthma...
  69. doi request reprint The respiratory health of swimmers
    Valerie Bougault
    Centre de Recherche de l Institut Universitaire de Cardiologie et de Pneumologie de Quebec, Quebec, Canada
    Sports Med 39:295-312. 2009
    ....
  70. doi request reprint Expiratory flows and airway inflammation in elderly asthmatic patients
    Marie Eve Ducharme
    Centre de Recherche de l Institut Universitaire de Cardiologie et de Pneumologie de Quebec, 2725, Chemin Ste Foy, Québec Québec, Canada
    Respir Med 105:1284-9. 2011
    ..Asthma in the elderly is associated with a more marked airway obstruction and sputum neutrophilia. Both age and the dose of corticosteroids need to be considered in the interpretation of the clinical relevance of sputum neutrophil count...
  71. doi request reprint Frequency of work-related respiratory symptoms in workers without asthma
    Samah Chiry
    Hopital du Sacre Coeur de Montreal, Quebec, Canada
    Am J Ind Med 52:447-54. 2009
    ....
  72. ncbi request reprint Effects of protease inhibitors on mediator preservation in the supernatant of induced sputum
    Julie St-Laurent
    Centre de Recherche, Hopital Laval, Institut Universitaire de Cardiologie et de Pneumologie de l Universite Laval, 2725 Chemin Ste Foy, Quebec, Que, Canada
    J Immunoassay Immunochem 28:385-94. 2007
    ..Concentrations of IL-6 and fibronectin were higher when using, respectively, the commercial cocktail, and aprotinin. Protease inhibitors, if added, should be carefully chosen at the beginning of each study, to optimize the results...
  73. ncbi request reprint Clinical management of chronic obstructive pulmonary disease and asthma in an obese patient
    Andréa Lessard
    Universite Laval, Hopital Laval, Institut Universitaire de Cardiologie et de Pneumologie de l Universite Laval, 2725 Chemin Sainte Foy, G1V 4G5 Quebec, Canada
    Expert Opin Pharmacother 9:83-93. 2008
    ..The influence of weight loss, response to present therapies as well as new targets for the treatment of COPD and asthma in obese subjects are also discussed, in addition to future directions for research...
  74. ncbi request reprint Obesity and asthma: a specific phenotype?
    Andréa Lessard
    Hopital Laval, 2725 Chemin Sainte Foy, Quebec, QC Canada, G1V 4G5
    Chest 134:317-23. 2008
    ..Obesity is associated with an increased prevalence of asthma, especially in women, and appears to be more severe in the obese. This study aimed to determine if obese subjects have a specific asthma phenotype...
  75. doi request reprint Alveolar macrophage subpopulations in bronchoalveolar lavage and induced sputum of asthmatic and control subjects
    Julie St-Laurent
    Centre de Recherche de l Hopital Laval, Institut Universitaire de Cardiologie et de Pneumologie de l Universite Laval, Quebec, Canada
    J Asthma 46:1-8. 2009
    ..Alveolar macrophages (AM) are the most numerous immune cells in the airways and are involved in the immunological homeostasis of the lung. Intriguingly, their role in asthma remains unclear probably, in part, because of their heterogeneity...
  76. pmc Quality of bronchial biopsies for morphology study and cell sampling: a comparison of asthmatic and healthy subjects
    Isabelle Labonté
    Centre de Pneumologie, Hopital Laval, Quebec City, Canada
    Can Respir J 15:431-5. 2008
    ..Bronchial biopsies are widely used for histopathological, primary cell culture and genetic studies, but very few reports have evaluated their quality...
  77. ncbi request reprint TGF-beta suppresses EGF-induced MAPK signaling and proliferation in asthmatic epithelial cells
    Abdelhabib Semlali
    Centre de Recherche, Hopital Laval, 2725 Chemin Sainte Foy, Sainte Foy, PQ, G1V 4G5 Canada
    Am J Respir Cell Mol Biol 38:202-8. 2008
    ..Our results suggest that TGF-beta restrains EGFR phosphorylation and downstream signaling in bronchial epithelial cells...
  78. ncbi request reprint Comparison of two in vitro models of cigarette smoke exposure
    Julie St-Laurent
    Centre de Recherche, Hopital Laval, Institut Universitaire de Cardiologie et de Pneumologie de l Universite Laval, Quebec City, Quebec, Canada
    Inhal Toxicol 21:1148-53. 2009
    ..CSE and the smoking chamber differently modulate bronchial epithelial cell mediator production, demonstrating that the model of cigarette smoke exposure used can influence the data obtained...
  79. ncbi request reprint Influence of cigarette smoke on the arginine pathway in asthmatic airways: increased expression of arginase I
    Celine Bergeron
    Meakins Christie Laboratories, McGill University, Montreal, Quebec, Canada
    J Allergy Clin Immunol 119:391-7. 2007
    ..We have shown that arginase I and iNOS are upregulated in asthma. Smoking asthmatic subjects are reported to have low exhaled nitric oxide levels. The effect of cigarette smoking on the expression of arginase I in asthma is unknown...
  80. doi request reprint Leptin and adiponectin in obese and non-obese subjects with asthma
    Andréa Lessard
    Centre de Recherche Clinique, l Institut Universitaire de Cardiologie et de Pneumologie de Québec, QC, Canada
    Biomarkers 16:271-3. 2011
    ..To understand the role of leptin and adiponectin in obese asthmatics...
  81. ncbi request reprint Characteristics and medical resource use of asthmatic subjects with and without work-related asthma
    Catherine Lemiere
    Hôpital du Sacré Coeur de Montréal Québec, Montreal, Quebec, Canada
    J Allergy Clin Immunol 120:1354-9. 2007
    ..Asthma is work related when there is an association between symptoms and work. Occupational asthma (OA) is induced by the workplace, whereas work-exacerbated asthma (WEA) is triggered by the workplace but not induced by it...
  82. ncbi request reprint CysLT1-R expression following allergen provocation in asthma and allergic rhinitis
    Marie Eve Boulay
    Unité de Recherche en Pneumologie, Centre de Recherche, de l Institut universitaire de cardiologie et de pneumologie de Québec, Quebec, QC G1V 4G5, Canada
    Prostaglandins Leukot Essent Fatty Acids 83:15-22. 2010
    ..No difference was observed between groups, suggesting that changes in CysLT(1)-R expression occur whether or not the subject has concurrent asthma...
  83. ncbi request reprint Influence of natural exposure to pollens and domestic animals on airway responsiveness and inflammation in sensitized non-asthmatic subjects
    Marie Eve Boulay
    Centre de Recherche, Hopital Laval, Institut Universitaire de Cardiologie et de Pneumologie de l Universite Laval, Sainte Foy, Quebec, Canada
    Int Arch Allergy Immunol 128:336-43. 2002
    ..Lower airway inflammation may be present in non-asthmatic subjects during natural exposure to relevant allergens and may eventually lead to the development of asthma...
  84. pmc Influence of current or former smoking on asthma management and control
    Louis Philippe Boulet
    Unité de Recherche en Pneumologie, Centre de Recherche de l Hopital Laval, Institut Universitaire de Cardiologie et de Pneumologie de l Universite Laval, Quebec City, Quebec
    Can Respir J 15:275-9. 2008
    ..In patients with asthma, smoking has been associated with accelerated decline in pulmonary function, poor disease control and reduced responsiveness to corticosteroids...
  85. ncbi request reprint AP-1 overexpression impairs corticosteroid inhibition of collagen production by fibroblasts isolated from asthmatic subjects
    Eric Jacques
    Centre de Recherche, Institut Universitaire de Cardiologie et de Pneumologie, Sainte Foy, Quebec, Canada
    Am J Physiol Lung Cell Mol Physiol 299:L281-7. 2010
    ..These results show that Dex failed to reduce collagen production in fibroblasts from asthmatic subjects. This impaired response may be related to AP-1 overexpression in these cells...
  86. ncbi request reprint New insights into occupational asthma
    Louis Philippe Boulet
    Unité de Recherche en Pneumologie, Institut de cardiologie et de pneumologie de l Université Laval, Hopital Laval, Quebec, Canada
    Curr Opin Allergy Clin Immunol 7:96-101. 2007
    ..To examine recent publications on the types of agents involved in occupational asthma, the mechanisms by which they induce asthma, and how best to evaluate and treat workers suspected of this respiratory condition...
  87. ncbi request reprint Comparative prevalence of asthma in different groups of athletes: a survey
    Jean Bruno Langdeau
    Centre de Recherche de l Hopital Laval, Institut Universitaire de Cardiologie et de Pneumologie, Universite Laval, Quebec City
    Can Respir J 11:402-6. 2004
    ..The type of air predominantly inhaled during training seems to play an important role in the development of airway hyperresponsiveness in athletes; however, this factor has not been evaluated for asthma...
  88. ncbi request reprint Deep inspiration avoidance and methacholine response in normal subjects and patients with asthma
    Barbara Simard
    Institut de cardiologie et de pneumologie de l Université Laval, Hopital Laval, Quebec City, QC, Canada
    Chest 127:135-42. 2005
    ..Deep inspiration (DI) avoidance and time intervals between inhalation and measurement of FEV1 may influence methacholine challenges...
  89. ncbi request reprint Towards excellence in asthma management (TEAM): a populational disease-management model
    Louis Philippe Boulet
    Institut de cardiologie et de pneumologie de l Université Laval, Hopital Laval, Quebec City, Quebec, Canada
    J Asthma 39:341-50. 2002
    ..We hope that this model of disease management will progressively reduce the burden associated with asthma, and potentially other chronic diseases, and will result in the more effective use of health services...
  90. pmc Asthma counselling targeted to removal of domestic animals
    L Hagan
    Universite Laval, Laval, Canada
    Can Respir J 15:33-8. 2008
    ....
  91. ncbi request reprint Airway response to low-dose allergen exposure in allergic nonasthmatic and asthmatic subjects: eosinophils, fibronectin, and vascular endothelial growth factor
    Marie Eve Boulay
    Centre de Recherche, Hopital Laval, Institut Universitaire de Cardiologie et de Pneumologie de l Universite Laval, Ste Foy, Quebec, Canada
    Chest 123:430S. 2003
  92. ncbi request reprint Safety and effectiveness of long-acting inhaled beta-agonist bronchodilators when taken with inhaled corticosteroids
    Pierre Ernst
    McGill University, Montreal, Quebec, Canada
    Ann Intern Med 145:692-4. 2006
    ....
  93. ncbi request reprint Cigarette smoke differently alters normal and ovalbumin-sensitized bronchial epithelial cells from rat
    Julie St-Laurent
    Centre de Recherche, Institut Universitaire de Cardiologie et de Pneumologie de Quebec, QC, Canada
    J Asthma 46:577-81. 2009
    ..These cells produce a wide range of mediators involved in inflammation and remodeling processes. However, the effects of chronic smoke exposure on the release and production of these mediators remain unclear...
  94. ncbi request reprint Airway remodeling-associated mediators in moderate to severe asthma: effect of steroids on TGF-beta, IL-11, IL-17, and type I and type III collagen expression
    Jamila Chakir
    Centre de Recherche, Hopital Laval, Institut Universitaire de Cardiologie et de Pneumologie, Laval, Quebec, Canada
    J Allergy Clin Immunol 111:1293-8. 2003
    ..TGF-beta, IL-11, and IL-17 are profibrotic cytokines involved in the formation of subepithelial fibrosis and are increased in patients with asthma, particularly in those with severe disease...
  95. ncbi request reprint Metalloproteinase-9 in induced sputum correlates with the severity of the late allergen-induced asthmatic response
    Marie Eve Boulay
    Centre de Recherche de l Hopital Laval, Institut Universitaire de Cardiologie et de Pneumologie, Universite Laval, Sainte Foy, Que, Canada
    Respiration 71:216-24. 2004
    ..Allergen exposure activates the inflammatory/repair process in sensitized subjects. Induced-sputum analysis is a non-invasive method that allows the assessment of changes in inflammatory and remodeling mediators implicated in asthma...
  96. doi request reprint Polymorphisms in the interleukin-22 receptor alpha-1 gene are associated with severe chronic rhinosinusitis
    Leandra Mfuna Endam
    Department of Otolaryngology, Hotel Dieu Hospital, Montreal University, Montreal, PQ, Canada
    Otolaryngol Head Neck Surg 140:741-7. 2009
    ..Stimulation of interleukin-22 receptor alpha-1 (IL22RA1) was reported to increase the innate immune responses in inflammatory diseases. Moreover, a reduced level of IL22RA1 was found in patients with recalcitrant CRS with nasal polyps...
  97. ncbi request reprint A fast, simple, and inexpensive method to collect exhaled breath condensate for pH determination
    Philippe Prince
    Unité de Recherche en Pneumologie, Centre de Recherche de l Hopital Laval, Institut Universitaire de Cardiologie et de Pneumologie de l Universite Laval, Quebec, Quebec, Canada
    Ann Allergy Asthma Immunol 97:622-7. 2006
    ..Exhaled breath condensate (EBC) analysis is a noninvasive method for assessing lower airway inflammation. Various methods of collecting EBC have been described. However, they are often time-consuming or involve expensive equipment...
  98. ncbi request reprint Effects of a selective ET(A)-receptor antagonist, atrasentan (ABT-627), in murine models of allergic asthma: demonstration of mouse strain specificity
    Mélanie Gosselin
    Laval Hospital Research Center, Quebec Heart and Lung Institute, 2725 Chemin Ste Foy, Ste Foy, QC G1V 4G5, Canada
    Clin Sci (Lond) 103:367S-370S. 2002
    ....
  99. ncbi request reprint The determinants of prevalence of health complaints among young competitive swimmers
    Benoît Lévesque
    Institut National de Sante Publique du Quebec, 945 Ave Wolfe, G1V 5B3, Sainte Foy, Quebec, Canada
    Int Arch Occup Environ Health 80:32-9. 2006
    ..The objective of this study was to compare the prevalence of health complaints of young swimmers and young indoor soccer players and to evaluate the relationship between chloramine concentrations and the athletes' health complaints...
  100. ncbi request reprint Tissue-engineered human asthmatic bronchial equivalents
    Jean Sébastien Paquette
    Laboratoire de Génie Tissulaire LOEX, Hôpital de l Enfant Jésus du CHA, Quebec, Canada
    Eur Cell Mater 7:1-11; discussion 1-11. 2004
    ..These BE appear to be very good models to study the mechanisms involved in asthma in vitro...