C Bouchard

Summary

Country: Canada

Publications

  1. ncbi Familial resemblance for VO2max in the sedentary state: the HERITAGE family study
    C Bouchard
    Physical Activity Sciences Laboratory, Laval University, Ste Foy, Quebec, Canada
    Med Sci Sports Exerc 30:252-8. 1998
  2. ncbi Linkage between markers in the vicinity of the uncoupling protein 2 gene and resting metabolic rate in humans
    C Bouchard
    Physical Activity Sciences Laboratory, Laval University, Ste Foy, Quebec, Canada
    Hum Mol Genet 6:1887-9. 1997
  3. ncbi Familial aggregation of VO(2max) response to exercise training: results from the HERITAGE Family Study
    C Bouchard
    Physical Activity Sciences Laboratory, Laval University, Ste Foy, Quebec, Canada G1K 7P4
    J Appl Physiol 87:1003-8. 1999
  4. ncbi Familial resemblance of plasma lipids, lipoproteins and postheparin lipoprotein and hepatic lipases in the HERITAGE Family Study
    L Perusse
    Division of Kinesiology, Laval University Medical School, Quebec, Canada
    Arterioscler Thromb Vasc Biol 17:3263-9. 1997
  5. ncbi The Trp64Arg polymorphism of the beta3-adrenergic receptor gene is not associated with training-induced changes in body composition: The HERITAGE Family Study
    C Garenc
    Department of Preventive Medicine, Division of Kinesiology, Laval University, Ste-Foy, , Canada
    Obes Res 9:337-41. 2001
  6. ncbi Genomic scan for genes affecting body composition before and after training in Caucasians from HERITAGE
    Y C Chagnon
    Department of Social and Preventive Medicine and Kinesiology, Laval University, Ste Foy, Quebec, Canada G1K 7P4
    J Appl Physiol 90:1777-87. 2001
  7. ncbi Associations between the leptin receptor gene and adiposity in middle-aged Caucasian males from the HERITAGE family study
    Y C Chagnon
    Physical Activity Sciences Laboratory, Laval University, Ste Foy, Quebec, Canada
    J Clin Endocrinol Metab 85:29-34. 2000
  8. ncbi Race differences in the response of postheparin plasma lipoprotein lipase and hepatic lipase activities to endurance exercise training in men: results from the HERITAGE Family Study
    J Bergeron
    Lipid Research Center, Laval University Medical Research Center, CHUL Pavilion, 2705, boulevard Laurier, RC 412, Quebec, G1V 4G2, Sainte Foy, Canada
    Atherosclerosis 159:399-406. 2001
  9. ncbi Race, visceral adipose tissue, plasma lipids, and lipoprotein lipase activity in men and women: the Health, Risk Factors, Exercise Training, and Genetics (HERITAGE) family study
    J P Despres
    Lipid Research Center, CHUQ Research Center, CHUL Pavilion, Sainte Foy, Quebec, Canada
    Arterioscler Thromb Vasc Biol 20:1932-8. 2000
  10. ncbi Familial aggregation of amount and distribution of subcutaneous fat and their responses to exercise training in the HERITAGE family study
    L Perusse
    Department of Preventive Medicine, Laval University, Quebec, Canada
    Obes Res 8:140-50. 2000

Detail Information

Publications100

  1. ncbi Familial resemblance for VO2max in the sedentary state: the HERITAGE family study
    C Bouchard
    Physical Activity Sciences Laboratory, Laval University, Ste Foy, Quebec, Canada
    Med Sci Sports Exerc 30:252-8. 1998
    ..These results suggest that genetic and nongenetic factors as well as maternal influences contribute to the familial aggregation of VO2max in sedentary individuals...
  2. ncbi Linkage between markers in the vicinity of the uncoupling protein 2 gene and resting metabolic rate in humans
    C Bouchard
    Physical Activity Sciences Laboratory, Laval University, Ste Foy, Quebec, Canada
    Hum Mol Genet 6:1887-9. 1997
    ..The evidence is strong enough to warrant a search for DNA sequence variation in the gene itself...
  3. ncbi Familial aggregation of VO(2max) response to exercise training: results from the HERITAGE Family Study
    C Bouchard
    Physical Activity Sciences Laboratory, Laval University, Ste Foy, Quebec, Canada G1K 7P4
    J Appl Physiol 87:1003-8. 1999
    ..We conclude that the trainability of VO(2max) is highly familial and includes a significant genetic component...
  4. ncbi Familial resemblance of plasma lipids, lipoproteins and postheparin lipoprotein and hepatic lipases in the HERITAGE Family Study
    L Perusse
    Division of Kinesiology, Laval University Medical School, Quebec, Canada
    Arterioscler Thromb Vasc Biol 17:3263-9. 1997
    ....
  5. ncbi The Trp64Arg polymorphism of the beta3-adrenergic receptor gene is not associated with training-induced changes in body composition: The HERITAGE Family Study
    C Garenc
    Department of Preventive Medicine, Division of Kinesiology, Laval University, Ste-Foy, , Canada
    Obes Res 9:337-41. 2001
    ..DISCUSSION: These results suggest that the Trp64Arg polymorphism of the beta3-adrenergic receptor gene is not related to changes in body composition in response to exercise training...
  6. ncbi Genomic scan for genes affecting body composition before and after training in Caucasians from HERITAGE
    Y C Chagnon
    Department of Social and Preventive Medicine and Kinesiology, Laval University, Ste Foy, Quebec, Canada G1K 7P4
    J Appl Physiol 90:1777-87. 2001
    ..This is the first genomic scan on genes involved in exercise-training-induced changes in body composition that could provide information on the determinants of weight loss...
  7. ncbi Associations between the leptin receptor gene and adiposity in middle-aged Caucasian males from the HERITAGE family study
    Y C Chagnon
    Physical Activity Sciences Laboratory, Laval University, Ste Foy, Quebec, Canada
    J Clin Endocrinol Metab 85:29-34. 2000
    ..0001), SF8 (+30 mm, P = 0.01), FM (+7 kg, P = 0.0004), %FAT (+5%, P = 0.0002), and leptin (+4 ng/mL, P = 0.0006). These results indicate a significant effect of leptin receptor on adiposity in middle-aged Caucasian males...
  8. ncbi Race differences in the response of postheparin plasma lipoprotein lipase and hepatic lipase activities to endurance exercise training in men: results from the HERITAGE Family Study
    J Bergeron
    Lipid Research Center, Laval University Medical Research Center, CHUL Pavilion, 2705, boulevard Laurier, RC 412, Quebec, G1V 4G2, Sainte Foy, Canada
    Atherosclerosis 159:399-406. 2001
    ..However, the generally better metabolic profile of Black individuals may minimize further improvement of lipoprotein-lipid concentrations by exercise training...
  9. ncbi Race, visceral adipose tissue, plasma lipids, and lipoprotein lipase activity in men and women: the Health, Risk Factors, Exercise Training, and Genetics (HERITAGE) family study
    J P Despres
    Lipid Research Center, CHUQ Research Center, CHUL Pavilion, Sainte Foy, Quebec, Canada
    Arterioscler Thromb Vasc Biol 20:1932-8. 2000
    ....
  10. ncbi Familial aggregation of amount and distribution of subcutaneous fat and their responses to exercise training in the HERITAGE family study
    L Perusse
    Department of Preventive Medicine, Laval University, Quebec, Canada
    Obes Res 8:140-50. 2000
    ..Investigate the familial aggregation of amount and distribution of subcutaneous fat and their changes in response to endurance training...
  11. ncbi Association between uncoupling protein 3 gene and obesity-related phenotypes in the Québec Family Study
    C M Lanouette
    Department of Social and Preventive Medicine, Faculty of Medicine, Laval University, Ste Foy, Quebec, Canada
    Mol Med 7:433-41. 2001
    ..Human UCP3 is mainly expressed in skeletal muscle, which plays an important role in energy homeostasis and substrate oxidation. Therefore, UCP3 is a good candidate gene for obesity...
  12. ncbi Evidence of LPL gene-exercise interaction for body fat and LPL activity: the HERITAGE Family Study
    C Garenc
    Division of Kinesiology, Department of Preventive Medicine, Laval University, Ste-Foy, Quebec, Canada G1K 7P4
    J Appl Physiol 91:1334-40. 2001
    ..05) and a greater increase in post-heparin LPL activity (P = 0.02). These results suggest that the LPL S447X polymorphism influences the training-induced changes in body fat and post-heparin LPL activity in women but not in men...
  13. ncbi The hormone-sensitive lipase gene and body composition: the HERITAGE Family Study
    C Garenc
    Division of Kinesiology, Department of Preventive Medicine, Laval University, Ste Foy, Quebec, Canada
    Int J Obes Relat Metab Disord 26:220-7. 2002
    ....
  14. ncbi Acute and chronic effects of exercise on leptin levels in humans
    L Perusse
    Physical Activity Sciences Laboratory, Laval University, Quebec, Canada G1K 7P4
    J Appl Physiol 83:5-10. 1997
    ..We conclude that there are no meaningful acute or chronic effects of exercise, independent of the amount of body fat, on leptin levels in humans...
  15. ncbi Greater than predicted decrease in resting energy expenditure with age: cross-sectional and longitudinal evidence
    G Alfonzo-González
    Division of Kinesiology, Laval University, Sainte Foy, Quebec, Canada
    Eur J Clin Nutr 60:18-24. 2006
    ..To determine whether the age-related decrease in resting energy expenditure (REE) is explained by variations in body composition...
  16. ncbi Cross-trait familial resemblance for body fat and blood lipids: familial correlations in the Quebec Family Study
    L Perusse
    Division of Kinesiology, Laval University School of Medicine, Ste Foy, Quebec, Canada
    Arterioscler Thromb Vasc Biol 17:3270-7. 1997
    ....
  17. ncbi Associations between glucose tolerance, insulin sensitivity and insulin secretion phenotypes and polymorphisms in adiponectin and adiponectin receptor genes in the Quebec Family Study
    S M Ruchat
    Department of Social and Preventive Medicine, Division of Kinesiology, Laval University, Quebec, Canada
    Diabet Med 25:400-6. 2008
    ....
  18. ncbi Evidence for interaction between PPARG Pro12Ala and PPARGC1A Gly482Ser polymorphisms in determining type 2 diabetes intermediate phenotypes in overweight subjects
    S M Ruchat
    Department of Preventive Medicine, Laval University, Quebec, Canada
    Exp Clin Endocrinol Diabetes 117:455-9. 2009
    ..We hypothesized that independent and interactive effects of the PPARG Pro12Ala and PPARGC1A Gly482Ser polymorphisms influence T2DM intermediate phenotypes...
  19. ncbi Familial aggregation of submaximal aerobic performance in the HERITAGE Family study
    L Perusse
    Division of Kinesiology, School of Medicine, Laval University, Quebec, Canada
    Med Sci Sports Exerc 33:597-604. 2001
    ..This study examines the contribution of genetic factors to submaximal aerobic performance phenotypes measured before and after 20 wk of endurance training...
  20. ncbi Decreased fasting and oral glucose stimulated C-peptide in nondiabetic subjects with sequence variants in the sulfonylurea receptor 1 gene
    S J Weisnagel
    Physical Activity Sciences Laboratory, Laval University, Ste Foy, Quebec, Canada
    Diabetes 50:697-702. 2001
    ....
  21. ncbi A genome-wide scan for abdominal fat assessed by computed tomography in the Québec Family Study
    L Perusse
    Department of Preventive Medicine, Laval University, Ste Foy, Quebec, Canada
    Diabetes 50:614-21. 2001
    ....
  22. ncbi Plasma post-heparin lipase activities in the HERITAGE Family Study: the reproducibility, gender differences, and associations with lipoprotein levels. HEalth, RIsk factors, exercise Training and GEnetics
    J P Despres
    Physical Activity Sciences Laboratory, Laval University, Ste Foy, Quebec, Canada
    Clin Biochem 32:157-65. 1999
    ..Examine the reproducibility of plasma lipid and lipoprotein measurements in the HERITAGE Family Study...
  23. ncbi Haplotypes in the phospholipid transfer protein gene are associated with obesity-related phenotypes: the Québec Family Study
    Y Bosse
    Lipid Research Center, CHUL Research Center, Laval University, Quebec, Canada
    Int J Obes (Lond) 29:1338-45. 2005
    ..The phospholipid transfer protein (PLTP) may play a role in body fat regulation...
  24. ncbi Human resistin gene polymorphism is associated with visceral obesity and fasting and oral glucose stimulated C-peptide in the Québec Family Study
    L Bouchard
    Division of Kinesiology, Department of Social and Preventive Medicine, Faculty of Medicine, Laval University, Ste Foy, Quebec
    J Endocrinol Invest 27:1003-9. 2004
    ..These results suggest that in men, the human resistin gene is associated with reduced amount of visceral obesity and lower insulin secretory responses to a glucose load...
  25. ncbi Associations between USF1 gene variants and cardiovascular risk factors in the Quebec Family Study
    A C Choquette
    Lipid Research Center, CHUQ, CHUL, Quebec, Canada
    Clin Genet 71:245-53. 2007
    ..561-100 A/A and c.*187 T/T genotypes had more favorable adiposity indices (<0.04). In summary, significant associations between relatively common USF1 genetic variants and CVD risk factors were observed in French Canadians...
  26. ncbi Evidence for the existence of adaptive thermogenesis during weight loss
    E Doucet
    Division of Kinesiology, Laval University, Ste-Foy, , Canada
    Br J Nutr 85:715-23. 2001
    ....
  27. ncbi Post-heparin lipolytic enzyme activities, sex hormones and sex hormone-binding globulin (SHBG) in men and women: The HERITAGE Family Study
    A Desmeules
    Molecular Endocrinology and Oncology Research Center, Laval University, Quebec, Que, Canada
    Atherosclerosis 171:343-50. 2003
    ..These associations appear to be independent from concomitant variation in total adiposity or body fat distribution...
  28. ncbi Fat balance and ageing: results from the Québec Family Study
    A Tremblay
    Physical Activity Sciences Laboratory, Laval University, Ste Foy, Quebec, Canada
    Br J Nutr 79:413-8. 1998
    ..This observation suggests that there is a strong effect of age-related factors on fat balance...
  29. ncbi Muscle adiposity and body fat distribution in type 1 and type 2 diabetes: varying relationships according to diabetes type
    M C Dubé
    Faculty of Medicine, Department of Physiology and Endocrinology, Laval University, QC, Canada
    Int J Obes (Lond) 30:1721-8. 2006
    ....
  30. ncbi Investigation of LRP8 gene in 1p31 QTL linked to LDL peak particle diameter in the Quebec family study
    G Dolley
    Department of Food Science and Nutrition, Laval University, Quebec City, Canada
    Mol Genet Metab 102:448-52. 2011
    ..005, p=0.004 and p=0.01, respectively) but not with LDL size-related variables. These results suggest that LRP8 gene polymorphisms influence plasma cholesterol levels as well as size and composition of LDL particles...
  31. ncbi Spousal resemblance and risk of 7-year increases in obesity and central adiposity in the Canadian population
    P T Katzmarzyk
    Physical Activity Sciences Laboratory, Laval University Ste Foy, Quebec, Canada
    Obes Res 7:545-51. 1999
    ....
  32. ncbi Impact of high-intensity exercise on energy expenditure, lipid oxidation and body fatness
    M Yoshioka
    Division of Kinesiology, Laval University, Ste-Foy, , Canada
    Int J Obes Relat Metab Disord 25:332-9. 2001
    ..CONCLUSION: These results suggest that high-intensity exercise favors a lesser body fat deposition which might be related to an increase in post-exercise energy metabolism that is mediated by beta-adrenergic stimulation...
  33. ncbi Contribution of several candidate gene polymorphisms in the determination of adiposity changes: results from the Québec Family Study
    L Bouchard
    Division of Kinesiology, Department of Social and Preventive Medicine, Faculty of Medicine, Laval University, Ste Foy, Quebec, Canada
    Int J Obes (Lond) 31:891-9. 2007
    ..Several candidate genes have been associated with obesity, but very few studies have tested more than one gene simultaneously...
  34. ncbi Association of sleep duration with type 2 diabetes and impaired glucose tolerance
    J P Chaput
    Division of Kinesiology, Department of Social and Preventive Medicine, Faculty of Medicine, Laval University, Quebec City, Quebec, Canada
    Diabetologia 50:2298-304. 2007
    ..The aim of this study was to assess the relationship between sleep duration and type 2 diabetes or impaired glucose tolerance (IGT)...
  35. ncbi A +2138InsCAGACC polymorphism of the melanocortin receptor 3 gene is associated in human with fat level and partitioning in interaction with body corpulence
    N Boucher
    Laval Hospital Research Center and Kinesiology, Department of Social and Preventive Medicine, Faculty of Medicine, Laval University, Ste Foy, Quebec, Canada
    Mol Med 8:158-65. 2002
    ....
  36. ncbi Interactions between dietary fat intake and FASN genetic variation influence LDL peak particle diameter
    G Dolley
    Institute of Nutraceuticals and Functional Foods INAF, Laval University, Quebec, Canada
    J Nutrigenet Nutrigenomics 4:137-45. 2011
    ..FASN may play a role in the regulation of feeding and may be a potential therapeutic target for obesity and insulin resistance...
  37. ncbi Linkage and association of the sodium potassium-adenosine triphosphatase alpha2 and beta1 genes with respiratory quotient and resting metabolic rate in the Québec Family Study
    P T Katzmarzyk
    Physical Activity Sciences Laboratory, Laval University, Ste Foy, Quebec, Canada
    J Clin Endocrinol Metab 84:2093-7. 1999
    ..1% and 0.3% of the variance in RQ in younger and older adults, respectively. The results suggest that the sodium potassium adenosine triphosphatase alpha2 gene may play a role in fuel oxidation, particularly in younger individuals...
  38. ncbi The Three-Factor Eating Questionnaire and BMI in adolescents: results from the Québec family study
    A R Gallant
    Division of Kinesiology, Department of Preventive Medicine, Universite Laval, Quebec, QC, Canada
    Br J Nutr 104:1074-9. 2010
    ..These results show that the eating behaviour traits of disinhibition and rigid control are independently related to BMI z-scores in this group of adolescents...
  39. ncbi Influences of the phosphatidylcholine transfer protein gene variants on the LDL peak particle size
    G Dolley
    CRML, CHUL Research Centre, 2705 Boul Laurier, Ste Foy, Canada
    Atherosclerosis 195:297-302. 2007
    ..In the liver, phosphatidylcholine transfer protein binds specifically phosphatidylcholine suggesting a role for this protein in the formation of HDL and possibly VLDL phospholipid membranes...
  40. ncbi Linkage and association studies between the melanocortin receptors 4 and 5 genes and obesity-related phenotypes in the Québec Family Study
    Y C Chagnon
    Physical Activity Sciences Laboratory, Laval University, Ste Foy, Quebec, Canada
    Mol Med 3:663-73. 1997
    ....
  41. ncbi Genome-wide linkage scan reveals multiple susceptibility loci influencing lipid and lipoprotein levels in the Quebec Family Study
    Y Bosse
    Lipid Research Center, Laval University Medical Research Center, and Department of Food Science and Nutrition, Laval University, Quebec, Canada
    J Lipid Res 45:419-26. 2004
    ..In conclusion, this genome scan provides evidence for several QTLs influencing lipid and lipoprotein levels. Promising candidate genes were located in the vicinity of the genomic regions showing evidence of linkage...
  42. ncbi Estimation of daily energy needs with the FAO/WHO/UNU 1985 procedures in adults: comparison to whole-body indirect calorimetry measurements
    G Alfonzo-González
    Division of Kinesiology, Laval University, Sainte Foy, Quebec, Canada
    Eur J Clin Nutr 58:1125-31. 2004
    ..To compare estimated daily energy needs with their measured values...
  43. ncbi The human obesity gene map: the 2000 update
    L Perusse
    Department of Social and Preventive Medicine, Faculty of Medicine, Laval University, Sainte Foy, Quebec, Canada
    Obes Res 9:135-69. 2001
    ..Likewise, the number of negative studies, which are only partially reviewed here, is also on the rise...
  44. ncbi A polymorphism in the alpha2a-adrenoceptor gene and endurance athlete status
    B Wolfarth
    Physical Activity Sciences Laboratory, Faculty of Medicine, Laval University, Ste Foy, Quebec, Canada
    Med Sci Sports Exerc 32:1709-12. 2000
    ....
  45. ncbi Do 6-y changes in eating behaviors predict changes in body weight? Results from the Québec Family Study
    V Drapeau
    Division of Kinesiology, Laval University, Quebec, Canada
    Int J Obes Relat Metab Disord 27:808-14. 2003
    ....
  46. ncbi DNA polymorphism in the uncoupling protein (UCP) gene and human body fat
    J M Oppert
    Physical Activity Sciences Laboratory, Laval University, Quebec, Canada
    Int J Obes Relat Metab Disord 18:526-31. 1994
    ..3-kb allele was found in individuals who gained more body fat over time...
  47. ncbi The human obesity gene map: the 1999 update
    Y C Chagnon
    Department of Social and Preventive Medicine, Faculty of Medicine, Laval University, Sainte Foy, Quebec, Canada
    Obes Res 8:89-117. 2000
    ..The number of genes, markers, and chromosomal regions that have been associated or linked with human obesity phenotypes continues to increase and is now well above 200...
  48. ncbi Monitoring high-intensity endurance exercise with heart rate and thresholds
    M R Boulay
    Physical Activity Sciences Laboratory, Laval University, Ste Foy, Quebec, Canada
    Med Sci Sports Exerc 29:125-32. 1997
    ..However, heart rate and VO2 at the ventilatory threshold seem to be more suitable markers for that purpose...
  49. ncbi Insulin resistance and abdominal adiposity in young men with documented malnutrition during the first year of life
    N G Boulé
    Division of Kinesiology, Laval University, Ste Foy, Quebec, Canada
    Int J Obes Relat Metab Disord 27:598-604. 2003
    ..It was hypothesised that participants with early life malnutrition would display a more pronounced deterioration of insulin sensitivity in association with a gain in abdominal fat...
  50. ncbi A new gene related to human obesity identified by suppression subtractive hybridization
    M Larose
    Kinesiology, Physical Activity Sciences Laboratory, Laval University, Sainte-Foy, , Canada G1K 7P4
    Int J Obes Relat Metab Disord 25:770-6. 2001
    ..CONCLUSION: Using the SSH technique, we have identified a new gene, called Adipogene, which is overexpressed in the adipose tissue of the obese individuals and could be involved in obesity...
  51. ncbi Relationship between perceptions of physical activity and health-related fitness
    R J Shephard
    Physical Activity Sciences Laboratory, Laval University, Ste Foy, Quebec, Canada
    J Sports Med Phys Fitness 35:149-58. 1995
    ..To assess perceptions of fitness, intensity and frequency of habitual physical activity as predictors of cardiovascular function, metabolic health and obesity...
  52. ncbi The genetics of obesity: from genetic epidemiology to molecular markers
    C Bouchard
    Physical Activity Sciences Laboratory, Laval University, Ste Foy, Quebec, Canada
    Mol Med Today 1:45-50. 1995
    ..It appears likely that the susceptibility to obesity depends, to a large extent, on several autosomal genes...
  53. ncbi Role of genetic factors in childhood obesity and in susceptibility to dietary variations
    L Perusse
    Department of Social and Preventive Medicine, Laval University, Ste Foy, Que, Canada
    Ann Med 31:19-25. 1999
    ..Finally, there is increasing evidence that responsiveness to dietary intervention is genetically determined...
  54. ncbi Human papillomaviruses and vulvar vestibulitis
    C Morin
    Department of Pathology and Cytology, Quebec City, Canada
    Obstet Gynecol 95:683-7. 2000
    ..To assess the relationship between human papillomavirus (HPV) infection and vulvar vestibulitis syndrome...
  55. ncbi Evaluation of a modified sanitary napkin as a sample self-collection device for the detection of genital chlamydial infection in women
    M Alary
    Direction Régionale de la Santé Publique de Québec, Centre de Recherche, Hôpital du St Sacrement du Centre Hospitalier Affilié Universitaire de Québec, Quebec, Canada
    J Clin Microbiol 39:2508-12. 2001
    ..6% (451 of 462) for urine samples. These results suggest that a modified sanitary napkin represents an effective noninvasive device for self-collection of specimens to detect urogenital C. trachomatis infection...
  56. ncbi Gene-diet interactions in obesity
    L Perusse
    Division of Kinesiology, the Department of Social and Preventive Medicine, The Faculty of Medicine, Laval University, Ste Foy, Canada
    Am J Clin Nutr 72:1285S-1290S. 2000
    ..In addition, gene-diet interactions in children need to be investigated to determine whether the genes involved are the same as those found in adults...
  57. ncbi Managing atypical squamous cells of undetermined significance in Papanicolaou smears
    C Morin
    Departments of Pathology, Social and Preventive Medicine, and of Gynecology and Obstetrics, Laval University, Quebec, Canada
    J Reprod Med 46:799-805. 2001
    ....
  58. ncbi Genetics of obesity: advances from rodent studies
    Y C Chagnon
    Physical Activity Sciences Laboratory, Laval University, Ste-Foy, , Canada
    Trends Genet 12:441-4. 1996
  59. ncbi Effects of endurance exercise training on plasma HDL cholesterol levels depend on levels of triglycerides: evidence from men of the Health, Risk Factors, Exercise Training and Genetics (HERITAGE) Family Study
    C Couillard
    Lipid Research Center, Laval University Medical Research Center, CHUL Pavilion, Sainte-Foy, , Canada
    Arterioscler Thromb Vasc Biol 21:1226-32. 2001
    ..Results of the present study suggest that regular endurance exercise training may be particularly helpful in men with low HDL cholesterol, elevated TGs, and abdominal obesity...
  60. ncbi Net environmental benefit: introducing a new LCA approach on wastewater treatment systems
    D Godin
    Département de génie civil et de génie des eaux, Universite Laval, 1065 avenue de la medecine, Quebec, G1V 0A6, Canada
    Water Sci Technol 65:1624-31. 2012
    ....
  61. ncbi A methodology for identifying vulnerable locations to taste and odour problems in a drinking water system
    F Proulx
    Division des laboratoires du Service de l environnement de la Ville de Quebec, 210, St Sacrement, Quebec, G1N 3X6, Canada
    Water Sci Technol 55:177-83. 2007
    ....
  62. ncbi Identification of an obesity quantitative trait locus on mouse chromosome 2 and evidence of linkage to body fat and insulin on the human homologous region 20q
    A V Lembertas
    Department of Medicine, Molecular Biology Institute, University of California, Los Angeles, California 90095 1679, USA
    J Clin Invest 100:1240-7. 1997
    ..These data provide evidence that a locus on human chromosome 20q contributes to body fat and insulin in a human population, and demonstrate the utility of using interspecies syntenic relationships to find relevant disease loci in humans...
  63. ncbi The agouti-related protein and body fatness in humans
    G Argyropoulos
    Pennington Biomedical Research Center, Louisiana State University, Baton Rouge 70808, USA
    Int J Obes Relat Metab Disord 27:276-80. 2003
    ....
  64. ncbi Genome-wide linkage scans for prediabetes phenotypes in response to 20 weeks of endurance exercise training in non-diabetic whites and blacks: the HERITAGE Family Study
    P An
    Division of Biostatistics, Washington University School of Medicine, Campus Box 8067, 660 South Euclid Avenue, St Louis, MO, 63110, USA
    Diabetologia 48:1142-9. 2005
    ....
  65. ncbi Pooling analysis of genetic data: the association of leptin receptor (LEPR) polymorphisms with variables related to human adiposity
    M Heo
    New York Obesity Research Center, Columbia University College of Physicians and Surgeons, New York, New York 10025, USA
    Genetics 159:1163-78. 2001
    ..Although certain genotypic effects could be population specific, there was no statistically compelling evidence that any of the three LEPR alleles is associated with BMI or waist circumference in the general population...
  66. ncbi Polymorphisms in the leptin receptor gene, body composition and fat distribution in overweight and obese women
    M Wauters
    Department of Endocrinology, Metabolism and Clinical Nutrition, University Hospital Antwerp, Antwerp, Belgium
    Int J Obes Relat Metab Disord 25:714-20. 2001
    ....
  67. ncbi Generalized abdominal visceral fat prediction models for black and white adults aged 17-65 y: the HERITAGE Family Study
    P R Stanforth
    Department of Kinesiology and Health Education, The University of Texas, Austin, TX 78712, USA
    Int J Obes Relat Metab Disord 28:925-32. 2004
    ....
  68. ncbi Clustering of metabolic abnormalities in obese individuals: the role of genetic factors
    O Ukkola
    Pennington Biomedical Research Center, Louisiana State University, Baton Rouge 70808-4124, USA
    Ann Med 33:79-90. 2001
    ..The reduction of excess body fat, the most common clinical feature among the cluster of metabolic abnormalities, should be the focus of the prevention and treatment of the metabolic syndrome...
  69. ncbi Tsp509I polymorphism in exon 2 of the glucocorticoid receptor gene in relation to obesity and cortisol secretion: cohort study
    R Rosmond
    Pennington Biomedical Research Center, Louisiana State University, Baton Rouge, LA 70808, USA
    BMJ 322:652-3. 2001
  70. ncbi Polymorphisms in the leptin and leptin receptor genes in relation to resting metabolic rate and respiratory quotient in the Québec Family Study
    R J F Loos
    Human Genomics Laboratory, Pennington Biomedical Research Center, Baton Rouge, LA 70808, USA
    Int J Obes (Lond) 30:183-90. 2006
    ..Leptin (LEP) is an endocrine hormone that participates in many metabolic pathways, including those associated with the central regulation of energy homeostasis...
  71. ncbi BMI, fat mass, abdominal adiposity and visceral fat: where is the 'beef'?
    C Bouchard
    Pennington Biomedical Research Center, Baton Rouge, LA, USA
    Int J Obes (Lond) 31:1552-3. 2007
  72. ncbi Genome-wide scan to identify quantitative trait loci for baseline resting heart rate and its response to endurance exercise training: the HERITAGE Family Study
    P An
    Division of Biostatistics, Washington University School of Medicine, St Louis, Missouri, USA
    Int J Sports Med 27:31-6. 2006
    ..In conclusion, among QTLs on 1 q, 2 p, 3 p, 4 q, and 11 p that replicated across subsamples and studies, 11 p is most promising for dense mapping and association studies in HERITAGE and other cohorts...
  73. ncbi FTO: the first gene contributing to common forms of human obesity
    R J F Loos
    MRC Epidemiology Unit, Institute of Metabolic Science, Cambridge, UK
    Obes Rev 9:246-50. 2008
    ..The expectations are high but many challenges remain. Among the latter, translating new advances into useful guidelines for prevention and treatment of obesity will be the most demanding...
  74. ncbi Adiponectin concentration and insulin indicators following overfeeding in identical twins
    O Ukkola
    Department of Internal Medicine and Biocenter Oulu, University of Oulu, Oulu, Finland
    J Endocrinol Invest 31:132-7. 2008
    ..Low adiponectin levels have been associated with high body mass index, low insulin sensitivity, and diabetes...
  75. ncbi The biological predisposition to obesity: beyond the thrifty genotype scenario
    C Bouchard
    Human Genomics Laboratory, Pennington Biomedical Research Center, Baton Rouge, LA, USA
    Int J Obes (Lond) 31:1337-9. 2007
  76. ncbi Functional dimorphism of two hAgRP promoter SNPs in linkage disequilibrium
    F Bai
    Pennington Biomedical Research Center, Baton Rouge, LA 70808, USA
    J Med Genet 41:350-3. 2004
    ..The region encompassing the -38C>T SNP had approximately 1000-fold higher activity than the region encompassing the -3019G>A SNP, potentially determining the net functional effect between these two SNPs...
  77. ncbi The human gene map for performance and health-related fitness phenotypes
    T Rankinen
    Pennington Biomedical Research Center, Human Genomics Laboratory, Baton Rouge, LA 70808-4124, USA
    Med Sci Sports Exerc 33:855-67. 2001
    ..A yearly update of this human gene map will be published...
  78. ncbi A 12-year follow-up study of treated obese children in Japan
    K Togashi
    Human Genomics Laboratory, Pennington Biomedical Research Center, Baton Rouge, Louisiana, USA
    Int J Obes Relat Metab Disord 26:770-7. 2002
    ....
  79. ncbi A meta-analytic investigation of linkage and association of common leptin receptor (LEPR) polymorphisms with body mass index and waist circumference
    M Heo
    New York Obesity Research Center, St Luke s Roosevelt Hospital, Columbia University College of Physicians and Surgeons, New York, NY, USA
    Int J Obes Relat Metab Disord 26:640-6. 2002
    ....
  80. ncbi A C-1291G polymorphism in the alpha2A-adrenergic receptor gene (ADRA2A) promoter is associated with cortisol escape from dexamethasone and elevated glucose levels
    R Rosmond
    Department of Clinical Chemistry, Sahlgrenska University Hospital, Goteborg, Sweden
    J Intern Med 251:252-7. 2002
    ....
  81. ncbi Spousal resemblance in the Canadian population: implications for the obesity epidemic
    P T Katzmarzyk
    School of Kinesiology and Health Science, York University, Toronto, Ontario, Canada
    Int J Obes Relat Metab Disord 26:241-6. 2002
    ..To determine the extent of the spousal resemblance for adiposity and leanness in the Canadian population...
  82. ncbi Is adiposity at normal body weight relevant for cardiovascular disease risk?
    S Tanaka
    Human Genomics Laboratory, Pennington Biomedical Research Center, Baton Rouge, Louisiana 70808 4124, USA
    Int J Obes Relat Metab Disord 26:176-83. 2002
    ..To examine the relation between adiposity and risk factors for cardiovascular disease (CVD) in normal weight (NW) individuals...
  83. ncbi Beta-2 adrenergic receptor variants are associated with subcutaneous fat accumulation in response to long-term overfeeding
    O Ukkola
    Pennington Biomedical Research Center, Baton Rouge, Louisiana 70808-4124, USA
    Int J Obes Relat Metab Disord 25:1604-8. 2001
    ..Genetic variation at the ADRB2 locus could thus be one of the factors responsible for the large inter-individual differences observed in the response to long-term alterations in energy balance and should be further investigated...
  84. ncbi Mutations in the preproghrelin/ghrelin gene associated with obesity in humans
    O Ukkola
    Pennington Biomedical Research Center, Baton Rouge, Louisiana, USA
    J Clin Endocrinol Metab 86:3996-9. 2001
    ..In conclusion, the data provide evidence that a low frequency sequence variation in the ghrelin gene could play a role in the etiology of obesity...
  85. ncbi A polymorphism in the regulatory region of the corticotropin-releasing hormone gene in relation to cortisol secretion, obesity, and gene-gene interaction
    R Rosmond
    Department of Heart and Lung Diseases, Goteborg University, Goteborg, Sweden
    Metabolism 50:1059-62. 2001
    ..From these results, we conclude that an abnormal production rate of the CRH gene product in the presence of an inadequate glucocorticoid receptor density might lead to elevated cortisol levels...
  86. ncbi A missense mutation in the human melanocortin-4 receptor gene in relation to abdominal obesity and salivary cortisol
    R Rosmond
    Research Centre for Endocrinology and Metabolism, Department of Internal Medicine, Sahlgrenska University Hospital, Goteborg, Sweden
    Diabetologia 44:1335-8. 2001
    ....
  87. ncbi Interactions among the glucocorticoid receptor, lipoprotein lipase and adrenergic receptor genes and abdominal fat in the Québec Family Study
    O Ukkola
    Pennington Biomedical Research Center, Baton Rouge, Louisiana 70808 4124, USA
    Int J Obes Relat Metab Disord 25:1332-9. 2001
    ....
  88. ncbi Genetic factors as predictors of weight gain in young adult Dutch men and women
    C T M van Rossum
    Department of Chronic Diseases Epidemiology, National Institute of Public Health and the Environment, Bilthoven, The Netherlands
    Int J Obes Relat Metab Disord 26:517-28. 2002
    ..Polymorphisms in these genes may contribute to weight gain through effects on energy intake, energy expenditure or adipogenesis...
  89. ncbi Allelic variants in the GABA(A)alpha6 receptor subunit gene (GABRA6) is associated with abdominal obesity and cortisol secretion
    R Rosmond
    Department of Clinical Chemistry, Sahlgrenska University Hospital, Goteborg, Sweden
    Int J Obes Relat Metab Disord 26:938-41. 2002
    ..At the level of the brain, cortisol secretion is partly controlled by gamma-aminobutyric acid (GABA), which is the major inhibitory neurotransmitter in the vertebrate brain, and acts by binding to GABA(A) receptors...
  90. ncbi Two variants in the resistin gene and the response to long-term overfeeding
    O Ukkola
    Department of Internal Medicine and Biocenter Oulu, University of Oulu, Oulu, Finland
    Eur J Clin Nutr 58:654-9. 2004
    ..The results suggest that sequence variation in the resistin gene is involved in the adaptation to chronic positive energy balance...
  91. ncbi Role of candidate genes in the responses to long-term overfeeding: review of findings
    O Ukkola
    Pennington Biomedical Research Center, Louisiana State University, Baton Rouge, LA 70808-4124, USA
    Obes Rev 5:3-12. 2004
    ..Further research with larger sample sizes should make it possible to identify the specific contributions of DNA sequence variations at multiple candidate gene loci in the complex response to chronic positive energy balance...
  92. ncbi Sex differences in the relationships of abdominal fat to cardiovascular disease risk among normal-weight white subjects
    S Tanaka
    Division of Human Nutrition, National Institute of Health and Nutrition, Shinjuku-ku, Tokyo, Japan
    Int J Obes Relat Metab Disord 28:320-3. 2004
    ..Thus, only NW female adults with more AVF tended to have a more adverse CVD risk factor profile...
  93. ncbi Obesity--is it a genetic disorder?
    R J F Loos
    Human Genomics Laboratory, Pennington Biomedical Research Center, Baton Rouge, LA 70808, USA
    J Intern Med 254:401-25. 2003
    ..This growing body of research may help in the development of anti-obesity agents and perhaps genetic tests to predict the risk for obesity...
  94. ncbi Genetic variation at the adipsin locus and response to long-term overfeeding
    O Ukkola
    Department of Internal Medicine and Biocenter Oulu, University of Oulu, Oulu, Finland
    Eur J Clin Nutr 57:1073-8. 2003
    ..These findings provide new information on the role of adipsin on individual differences in response to chronically elevated food intake...
  95. ncbi Leptin receptor gene polymorphisms are associated with insulin in obese women with impaired glucose tolerance
    M Wauters
    Department of Endocrinology, Metabolism, and Clinical Nutrition, University Hospital Antwerp, Belgium
    J Clin Endocrinol Metab 86:3227-32. 2001
    ..In conclusion, these data indicate that LEPR polymorphisms are associated with insulin and glucose metabolism in women with impaired glucose homeostasis...
  96. ncbi The genetics of human obesity: recent progress
    C Bouchard
    , USA
    Bull Mem Acad R Med Belg 156:455-62; discussion 463-4. 2001
    ..One approach is to scan the genome with a high number of polymorphic markers to identify chromosomal regions harboring genes implicated in the development of obesity. Such studies can be helpful in defining new targets to explore...
  97. ncbi Stability of adiposity phenotypes from childhood and adolescence into young adulthood with contribution of parental measures
    P T Campbell
    School of Kinesiology and Health Science, York University, Toronto, Ontario, Canada
    Obes Res 9:394-400. 2001
    ..Overall, parental measures offer less predictive value than do measures of childhood and adolescent body composition and adipose tissue distribution...
  98. ncbi Adiposity, adipose tissue distribution and mortality rates in the Canada Fitness Survey follow-up study
    P T Katzmarzyk
    School of Kinesiology and Health Science, York University, Toronto, Ontario, Canada
    Int J Obes Relat Metab Disord 26:1054-9. 2002
    ..To compare mortality rates across indicators of adiposity and relative adipose tissue distribution in the Canadian population...
  99. ncbi Genetics and blood pressure response to exercise, and its interactions with adiposity
    T Rankinen
    Pennington Biomedical Research Center, Human Genomics Laboratory, Baton Rouge, LA 70808-4124, USA
    Prev Cardiol 5:138-44. 2002
    ..The current knowledge regarding the role of genetic factors in the modification of blood pressure responses to endurance training will be summarized and discussed...
  100. ncbi Genetic variation at the uncoupling protein 1, 2 and 3 loci and the response to long-term overfeeding
    O Ukkola
    Pennington Biomedical Research Center, 6400 Perkins Road, Baton Rouge, LA 70808-4124, USA
    Eur J Clin Nutr 55:1008-15. 2001
    ..A longer period of exposure to chronic positive energy balance conditions may be necessary before sequence variation in UCP2 and UCP3 makes an impact on thyroid metabolism to influence body mass and composition changes...