Christelle Boileau

Summary

Country: Canada

Publications

  1. pmc Diacerein inhibits the synthesis of resorptive enzymes and reduces osteoclastic differentiation/survival in osteoarthritic subchondral bone: a possible mechanism for a protective effect against subchondral bone remodelling
    Christelle Boileau
    Osteoarthritis Research Unit, University of Montreal Hospital Centre, Notre Dame Hospital, 1560 Sherbrooke Street East, Montreal, Quebec, H2L 4M1, Canada
    Arthritis Res Ther 10:R71. 2008
  2. pmc Activation of proteinase-activated receptor 2 in human osteoarthritic cartilage upregulates catabolic and proinflammatory pathways capable of inducing cartilage degradation: a basic science study
    Christelle Boileau
    Osteoarthritis Research Unit, University of Montreal Hospital Centre, Notre Dame Hospital, 1560 Sherbrooke Street East, Montreal, Quebec, H2L 4M1, Canada
    Arthritis Res Ther 9:R121. 2007
  3. pmc Protective effects of total fraction of avocado/soybean unsaponifiables on the structural changes in experimental dog osteoarthritis: inhibition of nitric oxide synthase and matrix metalloproteinase-13
    Christelle Boileau
    Osteoarthritis Research Unit, University of Montreal Hospital Centre, Notre Dame Hospital, Sherbrooke Street East, Montreal, Quebec, Canada
    Arthritis Res Ther 11:R41. 2009
  4. ncbi Magnetic resonance imaging can accurately assess the long-term progression of knee structural changes in experimental dog osteoarthritis
    C Boileau
    Osteoarthritis Research Unit, University of Montreal Hospital Centre, Notre Dame Hospital, 1560 Sherbrooke Street East, Montreal, Quebec, Canada
    Ann Rheum Dis 67:926-32. 2008
  5. pmc The protective effect of licofelone on experimental osteoarthritis is correlated with the downregulation of gene expression and protein synthesis of several major cartilage catabolic factors: MMP-13, cathepsin K and aggrecanases
    Jean Pierre Pelletier
    Osteoarthritis Research Unit, University of Montreal Hospital Centre, Notre Dame Hospital, Montreal, Quebec, Canada
    Arthritis Res Ther 7:R1091-102. 2005
  6. ncbi Licofelone reduces progression of structural changes in a canine model of osteoarthritis under curative conditions: effect on protease expression and activity
    Maxim Moreau
    Osteoarthritis Research Unit, University of Montreal Hospital Centre, Notre Dame Hospital, Quebec, Canada
    J Rheumatol 33:1176-83. 2006
  7. pmc Treatment with ephrin B2 positively impacts the abnormal metabolism of human osteoarthritic chondrocytes
    Steeve Kwan Tat
    Osteoarthritis Research Unit, University of Montreal Hospital Research Centre, Notre Dame Hospital, 1560 Sherbrooke Street East, Montreal, Quebec, Canada
    Arthritis Res Ther 11:R119. 2009
  8. ncbi Regulation of the expression of 5-lipoxygenase-activating protein/5-lipoxygenase and the synthesis of leukotriene B(4) in osteoarthritic chondrocytes: role of transforming growth factor beta and eicosanoids
    Johanne Martel-Pelletier
    Osteoarthritis Research Unit, Centre Hospitalier de l Universite de Montreal, Hopital Notre Dame, Montreal, Quebec, Canada
    Arthritis Rheum 50:3925-33. 2004
  9. doi Proteinase-activated receptor (PAR)-2 activation impacts bone resorptive properties of human osteoarthritic subchondral bone osteoblasts
    Nathalie Amiable
    Osteoarthritis Research Unit, University of Montreal Hospital Centre CRCHUM, Notre Dame Hospital, 1560 Sherbrooke Street East, Montreal, Quebec, Canada
    Bone 44:1143-50. 2009
  10. ncbi Oral treatment with PD-0200347, an alpha2delta ligand, reduces the development of experimental osteoarthritis by inhibiting metalloproteinases and inducible nitric oxide synthase gene expression and synthesis in cartilage chondrocytes
    Christelle Boileau
    Notre Dame Hospital, University of Montreal Hospital Centre, Montreal, Quebec, Canada
    Arthritis Rheum 52:488-500. 2005

Collaborators

Detail Information

Publications31

  1. pmc Diacerein inhibits the synthesis of resorptive enzymes and reduces osteoclastic differentiation/survival in osteoarthritic subchondral bone: a possible mechanism for a protective effect against subchondral bone remodelling
    Christelle Boileau
    Osteoarthritis Research Unit, University of Montreal Hospital Centre, Notre Dame Hospital, 1560 Sherbrooke Street East, Montreal, Quebec, H2L 4M1, Canada
    Arthritis Res Ther 10:R71. 2008
    ..In osteoclasts, we studied MMP-13 and cathepsin K production as well as cell differentiation, proliferation, and survival...
  2. pmc Activation of proteinase-activated receptor 2 in human osteoarthritic cartilage upregulates catabolic and proinflammatory pathways capable of inducing cartilage degradation: a basic science study
    Christelle Boileau
    Osteoarthritis Research Unit, University of Montreal Hospital Centre, Notre Dame Hospital, 1560 Sherbrooke Street East, Montreal, Quebec, H2L 4M1, Canada
    Arthritis Res Ther 9:R121. 2007
    ..These results suggest PAR-2 as a potential new therapeutic target for the treatment of OA...
  3. pmc Protective effects of total fraction of avocado/soybean unsaponifiables on the structural changes in experimental dog osteoarthritis: inhibition of nitric oxide synthase and matrix metalloproteinase-13
    Christelle Boileau
    Osteoarthritis Research Unit, University of Montreal Hospital Centre, Notre Dame Hospital, Sherbrooke Street East, Montreal, Quebec, Canada
    Arthritis Res Ther 11:R41. 2009
    ....
  4. ncbi Magnetic resonance imaging can accurately assess the long-term progression of knee structural changes in experimental dog osteoarthritis
    C Boileau
    Osteoarthritis Research Unit, University of Montreal Hospital Centre, Notre Dame Hospital, 1560 Sherbrooke Street East, Montreal, Quebec, Canada
    Ann Rheum Dis 67:926-32. 2008
    ..In this study, we investigated the reliability of quantitative MRI in assessing knee OA structural changes in the experimental anterior cruciate ligament (ACL) dog model of OA...
  5. pmc The protective effect of licofelone on experimental osteoarthritis is correlated with the downregulation of gene expression and protein synthesis of several major cartilage catabolic factors: MMP-13, cathepsin K and aggrecanases
    Jean Pierre Pelletier
    Osteoarthritis Research Unit, University of Montreal Hospital Centre, Notre Dame Hospital, Montreal, Quebec, Canada
    Arthritis Res Ther 7:R1091-102. 2005
    ..Moreover, our findings also indicate the possible auto-regulation of 5-LOX gene expression by licofelone in OA cartilage...
  6. ncbi Licofelone reduces progression of structural changes in a canine model of osteoarthritis under curative conditions: effect on protease expression and activity
    Maxim Moreau
    Osteoarthritis Research Unit, University of Montreal Hospital Centre, Notre Dame Hospital, Quebec, Canada
    J Rheumatol 33:1176-83. 2006
    ..The effect of drug treatment on the expression and activity of metalloproteases in the OA cartilage was also studied...
  7. pmc Treatment with ephrin B2 positively impacts the abnormal metabolism of human osteoarthritic chondrocytes
    Steeve Kwan Tat
    Osteoarthritis Research Unit, University of Montreal Hospital Research Centre, Notre Dame Hospital, 1560 Sherbrooke Street East, Montreal, Quebec, Canada
    Arthritis Res Ther 11:R119. 2009
    ..Hence, we further investigated the possible implication of these ephrin members on the catabolic/anabolic activities of human OA chondrocytes...
  8. ncbi Regulation of the expression of 5-lipoxygenase-activating protein/5-lipoxygenase and the synthesis of leukotriene B(4) in osteoarthritic chondrocytes: role of transforming growth factor beta and eicosanoids
    Johanne Martel-Pelletier
    Osteoarthritis Research Unit, Centre Hospitalier de l Universite de Montreal, Hopital Notre Dame, Montreal, Quebec, Canada
    Arthritis Rheum 50:3925-33. 2004
    ....
  9. doi Proteinase-activated receptor (PAR)-2 activation impacts bone resorptive properties of human osteoarthritic subchondral bone osteoblasts
    Nathalie Amiable
    Osteoarthritis Research Unit, University of Montreal Hospital Centre CRCHUM, Notre Dame Hospital, 1560 Sherbrooke Street East, Montreal, Quebec, Canada
    Bone 44:1143-50. 2009
    ..In this study, we investigated the expression, production, modulation, and role of PAR-2 in human OA subchondral bone osteoblasts...
  10. ncbi Oral treatment with PD-0200347, an alpha2delta ligand, reduces the development of experimental osteoarthritis by inhibiting metalloproteinases and inducible nitric oxide synthase gene expression and synthesis in cartilage chondrocytes
    Christelle Boileau
    Notre Dame Hospital, University of Montreal Hospital Centre, Montreal, Quebec, Canada
    Arthritis Rheum 52:488-500. 2005
    ..The effects of PD-0200347 on the major pathways involved in OA cartilage degradation, including matrix metalloproteinases (MMPs) and the inducible form of nitric oxide synthase (iNOS), were also studied...
  11. doi Oral treatment with a Brachystemma calycinum D don plant extract reduces disease symptoms and the development of cartilage lesions in experimental dog osteoarthritis: inhibition of protease-activated receptor 2
    Christelle Boileau
    Osteoarthritis Research Unit, University of Montreal Hospital Research Centre, CR CHUM, Notre Dame Hospital, 1560 Sherbrooke Street East, JA de Sève Pavilion, 2nd Floor, Montreal, Quebec H2L 4M1, Canada
    Ann Rheum Dis 69:1179-84. 2010
    ....
  12. doi Modulation of OPG, RANK and RANKL by human chondrocytes and their implication during osteoarthritis
    Steeve Kwan Tat
    Osteoarthritis Research Unit, University of Montreal Hospital Research Centre, Notre Dame Hospital, Montreal, Quebec, Canada
    Rheumatology (Oxford) 48:1482-90. 2009
    ..Furthermore, the role of OPG and RANKL on the production of catabolic/anabolic factors was assessed...
  13. ncbi The in situ up-regulation of chondrocyte interleukin-1-converting enzyme and interleukin-18 levels in experimental osteoarthritis is mediated by nitric oxide
    Christelle Boileau
    Osteoarthritis Research Unit, Hopital Notre Dame, Centre Hospitalier de l Universite de Montreal, 1560 Rue Sherbrooke East, Montreal, Quebec H2L 4M1, Canada
    Arthritis Rheum 46:2637-47. 2002
    ..Interleukin-18 (IL-18) was also studied and served as reference for the effects of ICE...
  14. ncbi Identification in human osteoarthritic chondrocytes of proteins binding to the novel regulatory site AGRE in the human matrix metalloprotease 13 proximal promoter
    Zhiyong Fan
    Centre Hospitalier de l Universite de Montreal, Hopital Notre Dame, Montreal, Quebec, Canada
    Arthritis Rheum 54:2471-80. 2006
    ..In this study, we sought to determine the importance of individual AGRE bases in promoter activity and to identify AGRE binding proteins from L-OA and H-OA chondrocyte complexes...
  15. ncbi The peroxisome proliferator-activated receptor gamma agonist pioglitazone reduces the development of cartilage lesions in an experimental dog model of osteoarthritis: in vivo protective effects mediated through the inhibition of key signaling and cataboli
    Christelle Boileau
    University of Montreal Hospital Centre, Notre Dame Hospital, Montreal, Quebec, Canada
    Arthritis Rheum 56:2288-98. 2007
    ....
  16. ncbi The inhibition of subchondral bone resorption in the early phase of experimental dog osteoarthritis by licofelone is associated with a reduction in the synthesis of MMP-13 and cathepsin K
    Jean Pierre Pelletier
    Osteoarthritis Research Unit, Centre Hospitalier de l Universite de Montreal, Hopital Notre Dame, Montreal, Quebec, Canada H2L 4M1
    Bone 34:527-38. 2004
    ....
  17. doi Activation of the receptor EphB4 by its specific ligand ephrin B2 in human osteoarthritic subchondral bone osteoblasts
    Steeve Kwan Tat
    University of Montreal Hospital Centre, Notre Dame Hospital, Montreal, Quebec, Canada
    Arthritis Rheum 58:3820-30. 2008
    ..The purpose of this study was to investigate the importance of the ephrin system in OA subchondral bone osteoblasts...
  18. doi Cartilage in normal and osteoarthritis conditions
    Johanne Martel-Pelletier
    Osteoarthritis Research Unit, University of Montreal Hospital Centre, Montreal, Canada
    Best Pract Res Clin Rheumatol 22:351-84. 2008
    ..The alterations in osteoarthritic cartilage are numerous and involve morphologic and metabolic changes in chondrocytes, as well as biochemical and structural alterations in the extracellular matrix macromolecules...
  19. pmc Extracellular localization of galectin-3 has a deleterious role in joint tissues
    Audrée Janelle-Montcalm
    Unité de recherche en arthrose, Centre de Recherche de l Université de Montréal CRCHUM, Montreal, Quebec, Canada
    Arthritis Res Ther 9:R20. 2007
    ..These findings indicate that high levels of extracellular gal-3, which could be encountered locally during the inflammatory process, have deleterious effects in both cartilage and subchondral bone tissues...
  20. doi Treatment with tiludronic acid helps reduce the development of experimental osteoarthritis lesions in dogs with anterior cruciate ligament transection followed by reconstructive surgery: a 1-year study with quantitative magnetic resonance imaging
    Jean Pierre Pelletier
    Osteoarthritis Research Unit, University of Montreal Hospital Research Centre CRCHUM Notre Dame Hospital, 1560 Sherbrooke Street East, Montreal, QC H2L 4M1, Canada
    J Rheumatol 38:118-28. 2011
    ....
  21. ncbi Licofelone (ML-3000), a dual inhibitor of 5-lipoxygenase and cyclooxygenase, reduces the level of cartilage chondrocyte death in vivo in experimental dog osteoarthritis: inhibition of pro-apoptotic factors
    Christelle Boileau
    Osteoarthritis Research Unit, Hĵpital Notre Dame, Centre Hospitalier de l Universite de Montreal, Quebec, Canada
    J Rheumatol 29:1446-53. 2002
    ..e., caspase-3, COX-2, and inducible nitric oxide synthase (iNOS)...
  22. doi Proteinase-activated receptor-2 gene disruption limits the effect of osteoarthritis on cartilage in mice: a novel target in joint degradation
    Nathalie Amiable
    Osteoarthritis Research Unit, University of Montreal Hospital Research Centre, Notre Dame Hospital, 1560 Sherbrooke Street East, Montreal, Quebec, Canada
    J Rheumatol 38:911-20. 2011
    ..Evidence indicates that proteinase-activated receptor (PAR)-2 participates in the degradative processes of human osteoarthritis (OA). We evaluated the in vivo effect of PAR-2 on articular lesions in a PAR-2-knockout (KO) mouse model of OA...
  23. ncbi Differential gene expression and regulation of the bone morphogenetic protein antagonists follistatin and gremlin in normal and osteoarthritic human chondrocytes and synovial fibroblasts
    Ginette Tardif
    Osteoarthritis Research Unit, Hopital Notre Dame, Montreal, Quebec, Canada
    Arthritis Rheum 50:2521-30. 2004
    ....
  24. doi The BMP antagonists follistatin and gremlin in normal and early osteoarthritic cartilage: an immunohistochemical study
    G Tardif
    Osteoarthritis Research Unit, University of Montreal Hospital Centre, Notre Dame Hospital, Montreal, Quebec, Canada
    Osteoarthritis Cartilage 17:263-70. 2009
    ..Using the OA dog model, we determined if these BMP antagonists were produced at different stages during the disease process by comparing their in situ temporal and spatial distribution...
  25. ncbi Diacerein reduces the level of cartilage chondrocyte DNA fragmentation and death in experimental dog osteoarthritic cartilage at the same time that it inhibits caspase-3 and inducible nitric oxide synthase
    J P Pelletier
    Osteoarthritis Research Unit, Hopital Notre Dame, Centre Hospitalier de l Universite de Montreal, Montreal, Quebec, Canada
    Clin Exp Rheumatol 21:171-7. 2003
    ..The study also aimed to explore the effect of the drug on the level of important factors involved in this phenomenon, i.e., caspase-3 and inducible nitric oxide synthase (iNOS)...
  26. pmc PD-0200347, an alpha2delta ligand of the voltage gated calcium channel, inhibits in vivo activation of the Erk1/2 pathway in osteoarthritic chondrocytes: a PKCalpha dependent effect
    C Boileau
    Osteoarthritis Research Unit, Notre Dame Hospital, University of Montreal Hospital Centre, Montreal, Quebec, Canada H2L 4M1
    Ann Rheum Dis 65:573-80. 2006
    ....
  27. doi Histone deacetylase inhibitors suppress interleukin-1beta-induced nitric oxide and prostaglandin E2 production in human chondrocytes
    N Chabane
    Osteoarthritis Research Unit, Centre Hospitalier de l Universite de Montreal, Notre Dame Hospital, Department of Medicine, University of Montreal, 1560 Sherbrooke Street East, Montreal, Quebec, Canada H2L 4M1
    Osteoarthritis Cartilage 16:1267-74. 2008
    ....
  28. pmc The regulation of human MMP-13 by licofelone, an inhibitor of cyclo-oxygenases and 5-lipoxygenase, in human osteoarthritic chondrocytes is mediated by the inhibition of the p38 MAP kinase signalling pathway
    C Boileau
    Osteoarthritis Research Unit, University of Montreal Hospital Centre, Notre Dame Hospital, 1560 Sherbrooke St East, Montreal, Quebec, Canada H2L 4M1
    Ann Rheum Dis 64:891-8. 2005
    ..Licofelone, a novel dual inhibitor of cyclo-oxygenases (COX) and 5-lipoxygenase (5-LOX), can modulate MMP-13 production in human osteoarthritis chondrocytes...
  29. pmc Differential regulation of the bone morphogenic protein antagonist chordin in human normal and osteoarthritic chondrocytes
    G Tardif
    Osteoarthritis Research Unit, Hopital Notre Dame, Centre Hospitalier de l Universite de Montreal, 1560 Sherbrooke Street East, Montreal, Quebec, Canada H2L 4M1
    Ann Rheum Dis 65:261-4. 2006
    ....
  30. ncbi Interleukin 17, a nitric oxide-producing cytokine with a peroxynitrite-independent inhibitory effect on proteoglycan synthesis
    Sandrine Pacquelet
    Faculte de Medecine, Vandoeuvre les Nancy, France
    J Rheumatol 29:2602-10. 2002
    ..To compare the potency of 2 cytokines, interleukin 17 (IL-17) and IL-1beta, on rat cartilage proteoglycan synthesis with special attention to nitric oxide (NO) and peroxynitrite formation...
  31. ncbi Nitric oxide (NO) and cartilage metabolism: NO effects are modulated by superoxide in response to IL-1
    Jean Yves Jouzeau
    Laboratoire de Pharmacologie et UMR 7561 CNRS UHP, Faculte de Medecine, Vandoeuvre les Nancy, France
    Biorheology 39:201-14. 2002
    ..We conclude that superoxide is a key modulator of NO-mediated effects in chondrocyte stimulated with IL-1 and that a combined therapy with NO synthase inhibitors and antioxidants may be promising for a full cartilage protection...