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Genomes and Genes | Christelle BoileauSummaryCountry: Canada Publications
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Activation of proteinase-activated receptor 2 in human osteoarthritic cartilage upregulates catabolic and proinflammatory pathways capable of inducing cartilage degradation: a basic science studyChristelle Boileau
Osteoarthritis Research Unit, University of Montreal Hospital Centre, Notre Dame Hospital, 1560 Sherbrooke Street East, Montreal, Quebec, H2L 4M1, Canada
Arthritis Res Ther 9:R121. 2007..These results suggest PAR-2 as a potential new therapeutic target for the treatment of OA...
Magnetic resonance imaging can accurately assess the long-term progression of knee structural changes in experimental dog osteoarthritisC Boileau
Osteoarthritis Research Unit, University of Montreal Hospital Centre, Notre Dame Hospital, 1560 Sherbrooke Street East, Montreal, Quebec, Canada
Ann Rheum Dis 67:926-32. 2008..In this study, we investigated the reliability of quantitative MRI in assessing knee OA structural changes in the experimental anterior cruciate ligament (ACL) dog model of OA...- Protective effects of total fraction of avocado/soybean unsaponifiables on the structural changes in experimental dog osteoarthritis: inhibition of nitric oxide synthase and matrix metalloproteinase-13Christelle Boileau
Osteoarthritis Research Unit, University of Montreal Hospital Centre, Notre Dame Hospital, Sherbrooke Street East, Montreal, Quebec, Canada
Arthritis Res Ther 11:R41. 2009.... - The protective effect of licofelone on experimental osteoarthritis is correlated with the downregulation of gene expression and protein synthesis of several major cartilage catabolic factors: MMP-13, cathepsin K and aggrecanasesJean Pierre Pelletier
Osteoarthritis Research Unit, University of Montreal Hospital Centre, Notre Dame Hospital, Montreal, Quebec, Canada
Arthritis Res Ther 7:R1091-102. 2005..Moreover, our findings also indicate the possible auto-regulation of 5-LOX gene expression by licofelone in OA cartilage... - Treatment with ephrin B2 positively impacts the abnormal metabolism of human osteoarthritic chondrocytesSteeve Kwan Tat
Osteoarthritis Research Unit, University of Montreal Hospital Research Centre, Notre Dame Hospital, 1560 Sherbrooke Street East, Montreal, Quebec, Canada
Arthritis Res Ther 11:R119. 2009..Hence, we further investigated the possible implication of these ephrin members on the catabolic/anabolic activities of human OA chondrocytes... - Regulation of the expression of 5-lipoxygenase-activating protein/5-lipoxygenase and the synthesis of leukotriene B(4) in osteoarthritic chondrocytes: role of transforming growth factor beta and eicosanoidsJohanne Martel-Pelletier
Osteoarthritis Research Unit, Centre Hospitalier de l Universite de Montreal, Hopital Notre Dame, Montreal, Quebec, Canada
Arthritis Rheum 50:3925-33. 2004.... - Licofelone reduces progression of structural changes in a canine model of osteoarthritis under curative conditions: effect on protease expression and activityMaxim Moreau
Osteoarthritis Research Unit, University of Montreal Hospital Centre, Notre-Dame Hospital, Quebec, Canada
J Rheumatol 33:1176-83. 2006..This beneficial effect is likely mediated through decrease in the synthesis of a number of catabolic factors, including proteolytic enzymes, involved in cartilage breakdown... - Oral treatment with PD-0200347, an alpha2delta ligand, reduces the development of experimental osteoarthritis by inhibiting metalloproteinases and inducible nitric oxide synthase gene expression and synthesis in cartilage chondrocytesChristelle Boileau
Notre-Dame Hospital, University of Montreal Hospital Centre, Montreal, Quebec, Canada
Arthritis Rheum 52:488-500. 2005..It also showed that this effect is linked to the inhibition of the major pathophysiologic mediators responsible for cartilage degradation... 
Proteinase-activated receptor (PAR)-2 activation impacts bone resorptive properties of human osteoarthritic subchondral bone osteoblastsNathalie Amiable
Osteoarthritis Research Unit, University of Montreal Hospital Centre CRCHUM, Notre Dame Hospital, 1560 Sherbrooke Street East, Montreal, Quebec, Canada
Bone 44:1143-50. 2009..In this study, we investigated the expression, production, modulation, and role of PAR-2 in human OA subchondral bone osteoblasts...- Oral treatment with a Brachystemma calycinum D don plant extract reduces disease symptoms and the development of cartilage lesions in experimental dog osteoarthritis: inhibition of protease-activated receptor 2Christelle Boileau
Osteoarthritis Research Unit, University of Montreal Hospital Research Centre, CR CHUM, Notre Dame Hospital, 1560 Sherbrooke Street East, JA de Sève Pavilion, 2nd Floor, Montreal, Quebec H2L 4M1, Canada
Ann Rheum Dis 69:1179-84. 2010.... - Modulation of OPG, RANK and RANKL by human chondrocytes and their implication during osteoarthritisSteeve Kwan Tat
Osteoarthritis Research Unit, University of Montreal Hospital Research Centre, Notre Dame Hospital, Montreal, Quebec, Canada
Rheumatology (Oxford) 48:1482-90. 2009..Furthermore, the role of OPG and RANKL on the production of catabolic/anabolic factors was assessed... - The in situ up-regulation of chondrocyte interleukin-1-converting enzyme and interleukin-18 levels in experimental osteoarthritis is mediated by nitric oxideChristelle Boileau
Osteoarthritis Research Unit, , , 1560 Rue Sherbrooke East, Montreal, Quebec H2L 4M1, Canada
Arthritis Rheum 46:2637-47. 2002..Interestingly, it appears that ICE synthesis is not regulated by the endogenous production of NO. These data highlight the role played by iNOS in regulating the synthesis of major catabolic factors involved in OA cartilage degradation... - Identification in human osteoarthritic chondrocytes of proteins binding to the novel regulatory site AGRE in the human matrix metalloprotease 13 proximal promoterZhiyong Fan
, , Montreal, Quebec, Canada
Arthritis Rheum 54:2471-80. 2006..CONCLUSION: These data suggest that the binding of p130(cas) and NMP-4 to the AGRE site regulates MMP-13 expression and may trigger the change in human chondrocytes from the L-OA state to the H-OA state... - The peroxisome proliferator-activated receptor gamma agonist pioglitazone reduces the development of cartilage lesions in an experimental dog model of osteoarthritis: in vivo protective effects mediated through the inhibition of key signaling and cataboliChristelle Boileau
University of Montreal Hospital Centre, Notre Dame Hospital, Montreal, Quebec, Canada
Arthritis Rheum 56:2288-98. 2007.... - Activation of the receptor EphB4 by its specific ligand ephrin B2 in human osteoarthritic subchondral bone osteoblastsSteeve Kwan Tat
University of Montreal Hospital Centre, Notre Dame Hospital, Montreal, Quebec, Canada
Arthritis Rheum 58:3820-30. 2008..The purpose of this study was to investigate the importance of the ephrin system in OA subchondral bone osteoblasts... - Extracellular localization of galectin-3 has a deleterious role in joint tissuesAudrée Janelle-Montcalm
Unité de recherche en arthrose, Centre de Recherche de l Université de Montréal CRCHUM, Montreal, Quebec, Canada
Arthritis Res Ther 9:R20. 2007..These findings indicate that high levels of extracellular gal-3, which could be encountered locally during the inflammatory process, have deleterious effects in both cartilage and subchondral bone tissues... - The inhibition of subchondral bone resorption in the early phase of experimental dog osteoarthritis by licofelone is associated with a reduction in the synthesis of MMP-13 and cathepsin KJean Pierre Pelletier
Osteoarthritis Research Unit, Centre Hospitalier de l Universite de Montreal, Hopital Notre Dame, Montreal, Quebec, Canada H2L 4M1
Bone 34:527-38. 2004.... - Diacerein inhibits the synthesis of resorptive enzymes and reduces osteoclastic differentiation/survival in osteoarthritic subchondral bone: a possible mechanism for a protective effect against subchondral bone remodellingChristelle Boileau
Osteoarthritis Research Unit, University of Montreal Hospital Centre, Notre Dame Hospital, 1560 Sherbrooke Street East, Montreal, Quebec, H2L 4M1, Canada
Arthritis Res Ther 10:R71. 2008..In osteoclasts, we studied MMP-13 and cathepsin K production as well as cell differentiation, proliferation, and survival... - Treatment with tiludronic acid helps reduce the development of experimental osteoarthritis lesions in dogs with anterior cruciate ligament transection followed by reconstructive surgery: a 1-year study with quantitative magnetic resonance imagingJean Pierre Pelletier
Osteoarthritis Research Unit, University of Montreal Hospital Research Centre CRCHUM Notre Dame Hospital, 1560 Sherbrooke Street East, Montreal, QC H2L 4M1, Canada
J Rheumatol 38:118-28. 2011.... - Licofelone (ML-3000), a dual inhibitor of 5-lipoxygenase and cyclooxygenase, reduces the level of cartilage chondrocyte death in vivo in experimental dog osteoarthritis: inhibition of pro-apoptotic factorsChristelle Boileau
Osteoarthritis Research Unit, Hĵpital Notre Dame, , , Canada
J Rheumatol 29:1446-53. 2002..These findings may explain some of the mechanisms by which licofelone reduces the progression of experimental OA... - Cartilage in normal and osteoarthritis conditionsJohanne Martel-Pelletier
Osteoarthritis Research Unit, University of Montreal Hospital Centre, Montreal, Canada
Best Pract Res Clin Rheumatol 22:351-84. 2008..The alterations in osteoarthritic cartilage are numerous and involve morphologic and metabolic changes in chondrocytes, as well as biochemical and structural alterations in the extracellular matrix macromolecules... - Proteinase-activated receptor-2 gene disruption limits the effect of osteoarthritis on cartilage in mice: a novel target in joint degradationNathalie Amiable
Osteoarthritis Research Unit, University of Montreal Hospital Research Centre, Notre Dame Hospital, 1560 Sherbrooke Street East, Montreal, Quebec, Canada
J Rheumatol 38:911-20. 2011..Evidence indicates that proteinase-activated receptor (PAR)-2 participates in the degradative processes of human osteoarthritis (OA). We evaluated the in vivo effect of PAR-2 on articular lesions in a PAR-2-knockout (KO) mouse model of OA... - Differential gene expression and regulation of the bone morphogenetic protein antagonists follistatin and gremlin in normal and osteoarthritic human chondrocytes and synovial fibroblastsGinette Tardif
Osteoarthritis Research Unit, , Montreal, Quebec, Canada
Arthritis Rheum 50:2521-30. 2004..The data suggest that follistatin and gremlin might appear at different stages during the OA process, making them interesting targets for the treatment of this disease... - The BMP antagonists follistatin and gremlin in normal and early osteoarthritic cartilage: an immunohistochemical studyG Tardif
Osteoarthritis Research Unit, University of Montreal Hospital Centre, Notre Dame Hospital, Montreal, Quebec, Canada
Osteoarthritis Cartilage 17:263-70. 2009..Using the OA dog model, we determined if these BMP antagonists were produced at different stages during the disease process by comparing their in situ temporal and spatial distribution... - Diacerein reduces the level of cartilage chondrocyte DNA fragmentation and death in experimental dog osteoarthritic cartilage at the same time that it inhibits caspase-3 and inducible nitric oxide synthaseJ P Pelletier
Osteoarthritis Research Unit, Hopital Notre Dame, Centre Hospitalier de l Universite de Montreal, Montreal, Quebec, Canada
Clin Exp Rheumatol 21:171-7. 2003..The study also aimed to explore the effect of the drug on the level of important factors involved in this phenomenon, i.e., caspase-3 and inducible nitric oxide synthase (iNOS)... - PD-0200347, an alpha2delta ligand of the voltage gated calcium channel, inhibits in vivo activation of the Erk1/2 pathway in osteoarthritic chondrocytes: a PKCalpha dependent effectC Boileau
Osteoarthritis Research Unit, Notre-Dame Hospital, University of Montreal Hospital Centre, Montreal, Quebec, Canada H2L 4M1
Ann Rheum Dis 65:573-80. 2006..This effect is associated with reduction of the activation of transcription factors such as Elk-1, which leads to the inhibition of the induction of the major catabolic factors involved in the degradation process of OA cartilage... - Histone deacetylase inhibitors suppress interleukin-1beta-induced nitric oxide and prostaglandin E2 production in human chondrocytesN Chabane
Osteoarthritis Research Unit, Centre Hospitalier de l Universite de Montreal, Notre Dame Hospital, Department of Medicine, University of Montreal, 1560 Sherbrooke Street East, Montreal, Quebec, Canada H2L 4M1
Osteoarthritis Cartilage 16:1267-74. 2008.... - The regulation of human MMP-13 by licofelone, an inhibitor of cyclo-oxygenases and 5-lipoxygenase, in human osteoarthritic chondrocytes is mediated by the inhibition of the p38 MAP kinase signalling pathwayC Boileau
Osteoarthritis Research Unit, University of Montreal Hospital Centre, Notre-Dame Hospital, 1560 Sherbrooke St East, Montreal, Quebec, Canada H2L 4M1
Ann Rheum Dis 64:891-8. 2005..This may explain some of the mechanisms whereby licofelone exerts its positive effect on osteoarthritic changes... - Differential regulation of the bone morphogenic protein antagonist chordin in human normal and osteoarthritic chondrocytesG Tardif
Osteoarthritis Research Unit, , , 1560 Sherbrooke Street East, Montreal, Quebec, Canada H2L 4M1
Ann Rheum Dis 65:261-4. 2006..CONCLUSIONS: The differential distribution and regulation of chordin in normal and osteoarthritic cartilage and chondrocytes suggests an involvement of this antagonist in the osteoarthritic process... - Interleukin 17, a nitric oxide-producing cytokine with a peroxynitrite-independent inhibitory effect on proteoglycan synthesisSandrine Pacquelet
, , France
J Rheumatol 29:2602-10. 2002.... - Nitric oxide (NO) and cartilage metabolism: NO effects are modulated by superoxide in response to IL-1Jean Yves Jouzeau
Laboratoire de Pharmacologie et UMR 7561 CNRS UHP, Faculte de Medecine, Vandoeuvre les Nancy, France
Biorheology 39:201-14. 2002..We conclude that superoxide is a key modulator of NO-mediated effects in chondrocyte stimulated with IL-1 and that a combined therapy with NO synthase inhibitors and antioxidants may be promising for a full cartilage protection...