Robert Bissonnette

Summary

Country: Canada

Publications

  1. ncbi request reprint Photodynamic therapy with methylaminolevulinate 80 mg/g without occlusion improves acne vulgaris
    Robert Bissonnette
    Innovaderm Research Inc, Montreal, Quebec, Canada
    J Drugs Dermatol 9:1347-52. 2010
  2. doi request reprint Efficacy and safety of topical WBI-1001 in patients with mild to moderate psoriasis: results from a randomized double-blind placebo-controlled, phase II trial
    R Bissonnette
    Innovaderm Research Inc, Montreal, QC, Canada
    J Eur Acad Dermatol Venereol 26:1516-21. 2012
  3. doi request reprint Effects of the tumor necrosis factor-α antagonist adalimumab on arterial inflammation assessed by positron emission tomography in patients with psoriasis: results of a randomized controlled trial
    Robert Bissonnette
    Department of Dermatology, Innovaderm Research Inc, Montreal, Quebec, Canada
    Circ Cardiovasc Imaging 6:83-90. 2013
  4. doi request reprint Influence of the quantity of sunscreen applied on the ability to protect against ultraviolet-induced polymorphous light eruption
    Robert Bissonnette
    Innovaderm Research Inc, Montreal, QC, Canada
    Photodermatol Photoimmunol Photomed 28:240-3. 2012
  5. doi request reprint Efficacy and safety of topical WBI-1001 in patients with mild to severe atopic dermatitis: results from a 12-week, multicentre, randomized, placebo-controlled double-blind trial
    R Bissonnette
    Innovaderm Research Inc, Montreal, QC H2K 4L5, Canada
    Br J Dermatol 166:853-60. 2012
  6. doi request reprint Treatment of palmoplantar psoriasis with infliximab: a randomized, double-blind placebo-controlled study
    R Bissonnette
    Innovaderm Research Inc, Sherbrooke Est, Montreal, QC, Canada
    J Eur Acad Dermatol Venereol 25:1402-8. 2011
  7. ncbi request reprint Efficacy and tolerability of topical tacrolimus ointment for the treatment of male genital psoriasis
    Robert Bissonnette
    Innovaderm Research Inc, Montreal QC
    J Cutan Med Surg 12:230-4. 2008
  8. ncbi request reprint Randomized study comparing the efficacy and tolerance of a lipophillic hydroxy acid derivative of salicylic acid and 5% benzoyl peroxide in the treatment of facial acne vulgaris
    R Bissonnette
    Innovaderm Research, Montreal, Canada
    J Cosmet Dermatol 8:19-23. 2009
  9. ncbi request reprint Safety of conventional systemic agents and biologic agents in the treatment of psoriasis
    Robert Bissonnette
    Innovaderm Research, Montreal, QC
    J Cutan Med Surg 13:S67-76. 2009
  10. doi request reprint Successful retreatment with alitretinoin in patients with relapsed chronic hand eczema
    R Bissonnette
    Innovaderm Research Inc, 1851 Rue Sherbrooke E, Suite 502, Montreal, QC H2K 4L5, Canada
    Br J Dermatol 162:420-6. 2010

Detail Information

Publications38

  1. ncbi request reprint Photodynamic therapy with methylaminolevulinate 80 mg/g without occlusion improves acne vulgaris
    Robert Bissonnette
    Innovaderm Research Inc, Montreal, Quebec, Canada
    J Drugs Dermatol 9:1347-52. 2010
    ..Photodynamic therapy (PDT) with methylaminolevulinate (MAL) under occlusion is effective for the treatment of acne vulgaris but is associated with significant phototoxic side effects...
  2. doi request reprint Efficacy and safety of topical WBI-1001 in patients with mild to moderate psoriasis: results from a randomized double-blind placebo-controlled, phase II trial
    R Bissonnette
    Innovaderm Research Inc, Montreal, QC, Canada
    J Eur Acad Dermatol Venereol 26:1516-21. 2012
    ..There is a need for the development of novel non-steroidal topical drugs for the treatment of psoriasis...
  3. doi request reprint Effects of the tumor necrosis factor-α antagonist adalimumab on arterial inflammation assessed by positron emission tomography in patients with psoriasis: results of a randomized controlled trial
    Robert Bissonnette
    Department of Dermatology, Innovaderm Research Inc, Montreal, Quebec, Canada
    Circ Cardiovasc Imaging 6:83-90. 2013
    ..Systemic treatments for moderate to severe psoriasis can reduce skin and joint inflammation; however, their effects on vascular inflammation are unknown...
  4. doi request reprint Influence of the quantity of sunscreen applied on the ability to protect against ultraviolet-induced polymorphous light eruption
    Robert Bissonnette
    Innovaderm Research Inc, Montreal, QC, Canada
    Photodermatol Photoimmunol Photomed 28:240-3. 2012
    ..The aim of this study was to compare the ability of sunscreens to protect against UV-induced polymorphous light eruption (PLE) when applied at 2 mg/cm(2) and 1 mg/cm(2) ...
  5. doi request reprint Efficacy and safety of topical WBI-1001 in patients with mild to severe atopic dermatitis: results from a 12-week, multicentre, randomized, placebo-controlled double-blind trial
    R Bissonnette
    Innovaderm Research Inc, Montreal, QC H2K 4L5, Canada
    Br J Dermatol 166:853-60. 2012
    ..There is a need for the development of novel nonsteroidal topical drugs for the treatment of atopic dermatitis (AD)...
  6. doi request reprint Treatment of palmoplantar psoriasis with infliximab: a randomized, double-blind placebo-controlled study
    R Bissonnette
    Innovaderm Research Inc, Sherbrooke Est, Montreal, QC, Canada
    J Eur Acad Dermatol Venereol 25:1402-8. 2011
    ..Palmoplantar psoriasis is a difficult to treat variant of plaque psoriasis...
  7. ncbi request reprint Efficacy and tolerability of topical tacrolimus ointment for the treatment of male genital psoriasis
    Robert Bissonnette
    Innovaderm Research Inc, Montreal QC
    J Cutan Med Surg 12:230-4. 2008
    ..Genital psoriasis is difficult to treat and has a significant psychological impact on affected patients...
  8. ncbi request reprint Randomized study comparing the efficacy and tolerance of a lipophillic hydroxy acid derivative of salicylic acid and 5% benzoyl peroxide in the treatment of facial acne vulgaris
    R Bissonnette
    Innovaderm Research, Montreal, Canada
    J Cosmet Dermatol 8:19-23. 2009
    ..New topical treatments for acne vulgaris are needed for patients who have tolerance problems with current treatments...
  9. ncbi request reprint Safety of conventional systemic agents and biologic agents in the treatment of psoriasis
    Robert Bissonnette
    Innovaderm Research, Montreal, QC
    J Cutan Med Surg 13:S67-76. 2009
    ..This article reviews the safety profiles of both classes of treatments...
  10. doi request reprint Successful retreatment with alitretinoin in patients with relapsed chronic hand eczema
    R Bissonnette
    Innovaderm Research Inc, 1851 Rue Sherbrooke E, Suite 502, Montreal, QC H2K 4L5, Canada
    Br J Dermatol 162:420-6. 2010
    ..Patients with severe chronic hand eczema (CHE) often respond to therapy with oral alitretinoin (9-cis retinoic acid). However, the efficacy of alitretinoin after disease relapse has not been demonstrated...
  11. ncbi request reprint The AWARE study: methodology and baseline characteristics
    Robert Bissonnette
    Innovaderm Research Inc, Montreal, QC
    J Cutan Med Surg 13:S113-21. 2009
    ..Alefacept was the first biologic therapy approved by Health Canada for the treatment of moderate to severe chronic plaque psoriasis and is used either alone or as part of combination therapy...
  12. doi request reprint A double-blind study of tolerance and efficacy of a new urea-containing moisturizer in patients with atopic dermatitis
    Robert Bissonnette
    Innovaderm Research Inc, Montreal, Quebec, Canada
    J Cosmet Dermatol 9:16-21. 2010
    ..However, the safety and efficacy of moisturizers are rarely studied in this patient population. Aims To evaluate the efficacy and tolerability of urea-containing moisturizers in subjects with atopic dermatitis...
  13. doi request reprint Efficacy and safety of adalimumab in patients with plaque psoriasis who have shown an unsatisfactory response to etanercept
    Robert Bissonnette
    Innovaderm Research Inc, Montreal, Quebec, Canada
    J Am Acad Dermatol 63:228-34. 2010
    ..The safety and efficacy of adalimumab in patients who have shown an unsatisfactory response to etanercept are unknown...
  14. ncbi request reprint Treatment of acne with photodynamic therapy
    R Bissonnette
    Innovaderm Research Inc, Montreal, Quebec, Canada
    G Ital Dermatol Venereol 146:445-56. 2011
    ..However more research is needed to determine the optimal treatment parameters and to design strategies to improve treatment tolerability...
  15. doi request reprint Protection afforded by sunscreens containing inorganic sunscreening agents against blue light sensitivity induced by aminolevulinic acid
    Robert Bissonnette
    Innovaderm Research Inc, Montreal, QC, Canada
    Dermatol Surg 34:1469-76. 2008
    ..Application of aminolevulinic acid (ALA) for photodynamic therapy induces significant sensitivity to visible light...
  16. ncbi request reprint Irradiance and light dose influence histological localization of photodamage induced by photodynamic therapy with aminolaevulinic acid
    R Bissonnette
    Notre Dame Hospital CHUM, Dermatology, 1560 Sherbrooke East, Montreal, Quebec, Canada
    Br J Dermatol 151:653-5. 2004
    ..Photodynamic therapy (PDT) with aminolaevulinic acid (ALA) is used in many countries for the treatment of actinic keratoses...
  17. ncbi request reprint Chemopreventative thoughts for photodynamic therapy
    Robert Bissonnette
    Innovaderm Research, 1851 Sherbrooke Street East, Suite 502, Montreal, QC H2K 4L5, Canada
    Dermatol Clin 25:95-100. 2007
    ..Recent clinical studies also suggest that large surface photodynamic therapy can prevent the development of actinic keratoses and possibly skin cancer...
  18. ncbi request reprint A randomized, multicenter, double-blind, placebo-controlled phase 2 trial of ISA247 in patients with chronic plaque psoriasis
    Robert Bissonnette
    Innovaderm Research, Montreal, Canada
    J Am Acad Dermatol 54:472-8. 2006
    ..Use of current oral calcineurin inhibitors for the treatment of psoriasis is limited by toxicity...
  19. doi request reprint Clobetasol propionate shampoo 0.05% is efficacious and safe for long-term control of moderate scalp psoriasis
    Yves Poulin
    Centre de Recherche Dermatologique du Québec Metropolitain, Quebec City, Quebec, Canada
    J Dermatolog Treat 21:185-92. 2010
    ..The alternate treatment regimen with CP shampoo is efficacious and safe for long-term management of moderate scalp psoriasis...
  20. ncbi request reprint Integrating biologic agents into management of moderate-to-severe psoriasis: a consensus of the Canadian Psoriasis Expert Panel. February 27, 2004
    Lyn Guenther
    Department of Dermatology, University of Western Ontario, London, Ontario, Canada
    J Cutan Med Surg 8:321-37. 2004
    ..5..
  21. ncbi request reprint Weekly topical application of methyl aminolevulinate followed by light exposure delays the appearance of UV-induced skin tumours in mice
    Soraya Sharfaei
    Division of Dermatology, Montreal University Hospital Center, Notre Dame Hospital, 1560 Sherbrooke East, Montreal, Quebec, Canada H2L 4M1
    Arch Dermatol Res 294:237-42. 2002
    ..In conclusion, topical MAL followed by light under suberythematous conditions delayed the appearance of UV-induced skin tumours without increasing mortality or morbidity, and thus acted in a prophylactic manner...
  22. ncbi request reprint Systemic photodynamic therapy with aminolevulinic acid induces apoptosis in lesional T lymphocytes of psoriatic plaques
    Robert Bissonnette
    Division of Dermatology, University of Montreal Hospital Center, Notre Dame Hospital, 1560 Sherbrooke Street East, Rm K 5201, Montreal, Quebec, Canada H2L 4M1
    J Invest Dermatol 119:77-83. 2002
    ..It has been suggested that induction of apoptosis in lesional T lymphocytes may be indicative of longer remission time following treatment of psoriasis...
  23. ncbi request reprint Multiple large-surface photodynamic therapy sessions with topical or systemic aminolevulinic acid and blue light in UV-exposed hairless mice
    Younan Liu
    Division of Dermatology, University of Montreal Hospital Centre, Montreal, Quebec, Canada
    J Cutan Med Surg 8:131-9. 2004
    ..The use of photodynamic therapy (PDT) with topical aminolevulinic acid (ALA) on large skin surfaces has recently been reported for patients with multiple actinic keratoses...
  24. ncbi request reprint Clobetasol propionate shampoo 0.05% is efficacious and safe for long-term control of scalp psoriasis
    Yves Poulin
    Centre de Recherche Dermatologique du Québec Metropolitain, Quebec City, Quebec, Canada
    Cutis 85:43-50. 2010
    ..Clobetasol propionate shampoo is efficacious and safe for acute management and long-term maintenance of moderate to severe scalp psoriasis...
  25. doi request reprint Humanized anti-CD2 monoclonal antibody treatment of plaque psoriasis: efficacy and pharmacodynamic results of two randomized, double-blind, placebo-controlled studies of intravenous and subcutaneous siplizumab
    Robert Bissonnette
    Innovaderm Research Inc, 1851 Sherbrooke Street East, Suite 502, Montreal, QC H2K 4L5, Canada
    Arch Dermatol Res 301:429-42. 2009
    ..Higher doses of siplizumab may be required to detect significant improvements in psoriasis; however, further development of this agent was not planned...
  26. ncbi request reprint Protoporphyrin IX fluorescence kinetics in UV-induced tumours and normal skin of hairless mice after topical application of 5-aminolevulinic acid methyl ester
    Petras Juzenas
    Division of Dermatology, Notre Dame Hospital, Montreal University Hospital Center, 1560 Sherbrooke Street East, Rm K 5201, Quebec, H2L 4M1, Montreal, Canada
    J Photochem Photobiol B 67:11-7. 2002
    ..In conclusion, the highest tumour to normal skin PpIX ratio was observed 3 h after application of 8% ALA-Me, suggesting that light exposure should be performed at this time in order to achieve an optimal PDT effect in this tumour model...
  27. doi request reprint A randomized, double-blind, placebo-controlled, phase I study of MEDI-545, an anti-interferon-alfa monoclonal antibody, in subjects with chronic psoriasis
    Robert Bissonnette
    Innovaderm Research, Inc, Montreal, Quebec, Canada
    J Am Acad Dermatol 62:427-36. 2010
    ..Interferon-alfa (IFN-alpha) has been implicated in the pathogenesis of psoriasis...
  28. doi request reprint Randomized trial comparing a chemical peel containing a lipophilic hydroxy acid derivative of salicylic acid with a salicylic acid peel in subjects with comedonal acne
    Annie Levesque
    Innovaderm Research Inc, 1851 Sherbrooke Street East, Suite 502, Montreal, Quebec, Canada H2K 4L5
    J Cosmet Dermatol 10:174-8. 2011
    ..Lipohydroxyacid is a lipophilic derivative of salicylic acid with comedolytic properties...
  29. ncbi request reprint XP-828L in the treatment of mild to moderate psoriasis: randomized, double-blind, placebo-controlled study
    Yves Poulin
    Department of Medicine, Laval University, Quebec City, Quebec, Canada
    Altern Med Rev 12:352-9. 2007
    ..XP-828L, a protein extract obtained from sweet whey, has demonstrated potential benefit for the treatment of mild to moderate psoriasis in an open-label study...
  30. doi request reprint Effect of adalimumab on sleep parameters in patients with psoriasis and obstructive sleep apnea: a randomized controlled trial
    Catherine Maari
    Innovaderm Research, Montreal, QC, Canada
    J Dermatolog Treat 25:57-60. 2014
    ..Obstructive sleep apnea (OSA) is frequently seen in patients with psoriasis vulgaris. The effect of adalimumab, a TNF-α antagonist, on OSA is unknown...
  31. ncbi request reprint Repeated exposure to blue light does not improve psoriasis
    Catherine Maari
    Division of Dermatology, University of Montreal Hospital Centre, Quebec, Canada
    J Am Acad Dermatol 49:55-8. 2003
    ..Activation of PpIX with blue light after exogenous topical application of its precursor, aminolevulinic acid, can improve psoriasis. Light activation of endogenous PpIX for the treatment of psoriasis has never been studied...
  32. ncbi request reprint Photodynamic therapy with toluidine blue in Jurkat cells: cytotoxicity, subcellular localization and apoptosis induction
    Jean Francois Tremblay
    University of Montreal Hospital Centre, 1560 Sherbrooke East, Montreal, Canada
    Photochem Photobiol Sci 1:852-6. 2002
    ..At the time of light exposure TBO was present in the endoplasmic reticulum and Golgi regions. In conclusion, TBO-based photodynamic therapy has a potent phototoxic effect and induces apoptosis in Jurkat cells...
  33. ncbi request reprint Topical agents for the treatment of psoriasis, past, present and future
    Jean Francois Tremblay
    Division of Dermatology, University of Montreal Hospital Centre, Notre Dame Hospital, Montreal, Quebec, Canada
    J Cutan Med Surg 6:8-11. 2002
  34. ncbi request reprint Photodynamic therapy of multiple nonmelanoma skin cancers with verteporfin and red light-emitting diodes: two-year results evaluating tumor response and cosmetic outcomes
    Harvey Lui
    Division of Dermatology, University of British Columbia and Vancouver General Hospital, Vancouver, Canada
    Arch Dermatol 140:26-32. 2004
    ..Efficient treatment of patients with multiple synchronous nonmelanoma skin cancers represents a therapeutic challenge...
  35. ncbi request reprint Guidelines on the use of photodynamic therapy for nonmelanoma skin cancer: an international consensus. International Society for Photodynamic Therapy in Dermatology, 2005
    Lasse R Braathen
    Dermatological University Clinic, Bern, Switzerland
    J Am Acad Dermatol 56:125-43. 2007
    ..PDT may also be a means of preventing certain nonmelanoma skin cancers in immunosuppressed patients...
  36. ncbi request reprint XP-828l in the treatment of mild to moderate psoriasis: randomized, double-blind, placebo-controlled study
    Yves Poulin
    Centre de Recherche Dermatologique du Québec Métropolitain Québec, Canada
    J Cutan Med Surg 10:241-8. 2006
    ..XP-828L, a protein extract obtained from sweet whey, has demonstrated potential benefit for the treatment of mild to moderate psoriasis in an open-label study...
  37. doi request reprint Does hormone therapy improve age-related skin changes in postmenopausal women? A randomized, double-blind, double-dummy, placebo-controlled multicenter study assessing the effects of norethindrone acetate and ethinyl estradiol in the improvement of mild t
    Tania J Phillips
    Boston University School of Medicine, Boston, Massachusetts 02118, USA
    J Am Acad Dermatol 59:397-404.e3. 2008
    ..In postmenopausal women, declining estrogen levels are associated with a variety of skin changes, many of which are reportedly improved by estrogen supplementation...
  38. ncbi request reprint Open-label study to assess the safety and efficacy of imiquimod 5% cream applied once daily three times per week in cycles for treatment of actinic keratoses on the head
    Jason K Rivers
    Department of Dermatology and Skin Science, University of British Columbia, Vancouver, British Columbia, Canada
    J Cutan Med Surg 12:97-101. 2008
    ..Local skin reactions are common during imiquimod treatment of actinic keratosis (AK). Cyclical application of imiquimod may improve tolerability while maintaining efficacy...