Genomes and Genes
- Twenty years of biliopancreatic diversion: what is the goal of the surgery?Simon Biron
Department of Surgery, Laval University, Quebec, Canada
Obes Surg 14:160-4. 2004..We explored the pertinence of defining success: a residual BMI <40 or <35 kg/m(2), and the need for reporting results with stratification by initial obesity and length of follow-up...
- LINE-1 methylation in visceral adipose tissue of severely obese individuals is associated with metabolic syndrome status and related phenotypesValérie Turcot
Institute of Nutraceuticals and Functional Foods, 2440 Hochelaga Blvd, Quebec City, G1V 0A6, Canada
Clin Epigenetics 4:10. 2012..abstract:..
- Duodenal switch improved standard biliopancreatic diversion: a retrospective studyPicard Marceau
Department of Surgery, Laval University, Laval Hospital, Quebec, Quebec, Canada
Surg Obes Relat Dis 5:43-7. 2009..This was a retrospective study, performed 10 years after surgery, to compare the results between biliopancreatic diversion (BPD) with distal gastrectomy (DG) versus BPD with duodenal switch (DS)...
- Changes in predicted cardiovascular disease risk after biliopancreatic diversion surgery in severely obese patientsMarie Eve Piché
Quebec Heart and Lung Institute Laval University, Quebec, Canada
Metabolism 63:79-86. 2014..To determine the impact of biliopancreatic diversion with duodenal switch (BPD-DS) surgery on cardiovascular risk profile and predicted cardiovascular risk in severely obese patients...
- Perioperative complications in a consecutive series of 1000 duodenal switchesLaurent Biertho
Department of Surgery, Institut Universitaire de Cardiologie et de Pneumologie de Quebec, Quebec, Quebec, Canada
Surg Obes Relat Dis 9:63-8. 2013....
- Is biliopancreatic diversion with duodenal switch indicated for patients with body mass index <50 kg/m2?Laurent Biertho
Department of Surgery, Division of Bariatric and General Surgery, Institut Universitaire de Cardiologie et de Pneumologie de Quebec, Quebec, Canada
Surg Obes Relat Dis 6:508-14. 2010..The aim of the present study was to present our long-term results with the DS in patients with an initial BMI of <50 kg/m(2)...
- Association of LIPA gene polymorphisms with obesity-related metabolic complications among severely obese patientsFrederic Guenard
Nutraceuticals and Functional Foods Institute, Laval University, Quebec City, Quebec, Canada
Obesity (Silver Spring) 20:2075-82. 2012..04). These results thus suggest that LIPA polymorphisms contribute to the interindividual variability observed in obesity-related metabolic complications...
- Waist circumference is useless to assess the prevalence of metabolic abnormalities in severely obese womenVicky Drapeau
Division of Kinesiology, Department of Social and Preventive Medicine, Laval University, Quebec, Canada
Obes Surg 17:905-9. 2007....
- DPP4 gene DNA methylation in the omentum is associated with its gene expression and plasma lipid profile in severe obesityValérie Turcot
Nutraceuticals and Functional Foods Institute, Quebec, Quebec, Canada
Obesity (Silver Spring) 19:388-95. 2011....
- Long-term experience with duodenal switch in adolescentsPicard Marceau
Department of Bariatric Surgery, Laval Hospital, Laval University, Chemin Ste Foy, Quebec, Canada
Obes Surg 20:1609-16. 2010..Severe or extreme obesity in children and adolescents is a progressive damaging disease, increasingly requiring surgical treatment. Timing and choice of operation are controversial...
- Association of OSBPL11 gene polymorphisms with cardiovascular disease risk factors in obesityLuigi Bouchard
Montreal University Community Genomics Medicine Center, Chicoutimi Hospital, Universite de Montreal, Chicoutimi, Quebec, Canada
Obesity (Silver Spring) 17:1466-72. 2009..63; P < 0.001), hyperglycemia/diabetes (OR = 1.48; P < 0.004) as well as with MetS per se (OR = 1.56; P < 0.01). These results suggest that the OSBPL11 gene is involved in cholesterol and glucose metabolism in obese individuals...
- Duodenal switch: long-term resultsPicard Marceau
Department of Surgery, Laval University, Laval Hospital, Quebec, Canada
Obes Surg 17:1421-30. 2007..This report summarizes our 15-year experience with duodenal switch (DS) as a primary procedure on 1,423 patients from 1992 to 2005...
- Accelerated satiation after duodenal switchPicard Marceau
Department of Surgery, Laval University, Quebec, Canada
Surg Obes Relat Dis 1:408-12. 2005..It is a test that is well known by physiologists but has never been used clinically. It is based on the observation that repeated pleasant gustatory stimuli turn into unpleasantness in the process of satiation...
- Gene expression variability in subcutaneous and omental adipose tissue of obese menYonghua Zhang
Molecular Endocrinology and Oncology Research Center, Laval University Medical Research Center, Quebec, Canada
Gene Expr 14:35-46. 2007....
- Waist girth does not predict metabolic complications in severely obese menIsabelle Lemieux
Division of Kinesiology, Laval Hospital Research Center, Laval University, Quebec, Canada G1K 7P4
Diabetes Care 29:1417-9. 2006
- Health-related quality of life in morbid obesityKarine Duval
Centre de Recherche, Hopital Laval, Institut Universitaire de Cardiologie et de Pneumologie de l Universite Laval, Quebec, Canada
Obes Surg 16:574-9. 2006..In order to evaluate the impact of severe obesity and its treatment on quality of life (QoL), it would be important to first identify the areas of QoL most likely to be affected by the disease...
- Asthma and sleep apnea in patients with morbid obesity: outcome after bariatric surgeryBarbara Simard
Pulmonary Research Unit, Cardiology and Respiratory Institute, Laval University, Laval Hospital, Quebec, QC, Canada
Obes Surg 14:1381-8. 2004..The authors determined the prevalence of asthma and SAS in morbidly obese patients and the effect of biliopancreatic diversion with duodenal switch (BPD-DS) on these conditions...
- Androgen inactivation and steroid-converting enzyme expression in abdominal adipose tissue in menKarine Blouin
Molecular Endocrinology and Oncology Research Center, Laval University Medical Research Center, Laval University, 2705 Laurier Boulevard T3 67, Quebec, Quebec, Canada G1V 4G2
J Endocrinol 191:637-49. 2006..Further studies are required to elucidate whether local androgen inactivation in abdominal adipose tissue is involved in the modulation of adipocyte metabolism and regional fat distribution in men...
- ZFP36: a promising candidate gene for obesity-related metabolic complications identified by converging genomicsLuigi Bouchard
Lipid Research Center, Laval University, Quebec, Canada
Obes Surg 17:372-82. 2007..The aim of this study was to compare the adipose tissue gene expression profiles of obese men with and without the MS and to apply an integrative genomic approach to propose new candidate genes...
- Comparison between arterial and venous sampling of circulating hormones, substrates and peptides in severe obesityJulie Martin
Institut Universitaire de Cardiologie et de Pneumologie de Quebec, 2725 Chemin Ste Foy, Quebec, QC, Canada
Clin Invest Med 34:E82-7. 2011..The comparability of a given sample site (arterial vs. venous) with regards to blood parameters is yet to be established...
- Outcome of pregnancies after biliopancreatic diversionPicard Marceau
Department of Surgery, Laval University, 2725 Chemin Sainte Foy, Quebec G1V 4G5, Canada
Obes Surg 14:318-24. 2004..This is a follow-up report of our initial findings regarding pregnancy and neonatal outcomes in biliopancreatic diversion (BPD) patients, with addition of a new cohort of children born to mothers after BPD...
- The laval questionnaire: a new instrument to measure quality of life in morbid obesityFanny Therrien
Centre de Recherche, Institut universitaire de cardiologie et de pneumologie de Québec affilié à l Université Laval, 2725 Chemin Ste Foy, Quebec, Quebec G1V 4G5, Canada
Health Qual Life Outcomes 9:66. 2011..Our objective was to validate a new self-administered questionnaire specific to morbid obesity to be used in clinical trials. The study was carried out at the bariatric surgery clinic of Laval Hospital, Quebec City, Canada...
- Does bone change after biliopancreatic diversion?Picard Marceau
Department of Surgery, Laval Hospital, Quebec City, Quebec, Canada
J Gastrointest Surg 6:690-8. 2002..Provided that there is close surveillance for metabolic disturbances, the use of appropriate supplements, and the avoidance of malnutrition, the beneficial effects of surgery far outweigh the risk of postoperative bone disease...
- Biliopancreatic diversion with duodenal switch improves insulin sensitivity and secretion through caloric restrictionCharles Étienne Plourde
Department of Medicine, Division of Endocrinology, Centre de Recherche Clinique Etienne Le Bel, Universite de Sherbrooke, Quebec, Canada Centre de recherche de l Institut universitaire de cardiologie et de pneumologie de Québec, Universite Laval, Quebec, Canada
Obesity (Silver Spring) 22:1838-46. 2014..To assess the rapid improvement of insulin sensitivity and β-cell function following biliopancreatic diversion with duodenal switch (BPD-DS) and determine the role played by caloric restriction in these changes...
- Omental and subcutaneous adipose tissue steroid levels in obese menChantal Bélanger
Molecular Endocrinology and Oncology Research Center, Laval University, Canada
Steroids 71:674-82. 2006..Androgen concentration differences in omental versus subcutaneous adipose tissue suggest a depot-specific impact of these hormones on adipocyte function and metabolism...
- Metabolic profile in severely obese women is less deteriorated than expected when compared to moderately obese womenVicky Drapeau
Division of Kinesiology, Department of Social and Preventive Medicine, Laval University, Sainte Foy, Quebec, Canada G1K 7P4
Obes Surg 16:501-9. 2006..This study aimed to compare the metabolic profile of pre- and postmenopausal severely obese women with moderately obese women...
- Impact of bariatric surgery on cardiac structure, function and clinical manifestations in morbid obesityPaul Poirier
Department of Cardiology, Institut Universitaire de Cardiologie et de Pneumologie, Laval Hospital, 2725 Chemin Sainte Foy, Sainte Foy, Quebec, G1V 4G5, Canada
Expert Rev Cardiovasc Ther 2:193-201. 2004..Nevertheless, numerous different techniques are still in use today. Weight loss has beneficial impacts on functional and structural cardiac status and will be reviewed in this report...