Pierre Beaulieu

Summary

Country: Canada

Publications

  1. ncbi request reprint Toxic effects of cannabis and cannabinoids: Animal data
    Pierre Beaulieu
    Department of Anesthesiology, CHUM Hotel Dieu, Montreal, Quebec
    Pain Res Manag 10:23A-6A. 2005
  2. ncbi request reprint Effects of nabilone, a synthetic cannabinoid, on postoperative pain
    Pierre Beaulieu
    Department of Anesthesiology, Faculty of Medicine, Universite de Montreal, Quebec, Canada
    Can J Anaesth 53:769-75. 2006
  3. ncbi request reprint The pharmacodynamics of ropivacaine and bupivacaine in combined sciatic and femoral nerve blocks for total knee arthroplasty
    Pierre Beaulieu
    Department of Anesthesiology, CHUM Hotel Dieu, Montreal, Quebec, Canada
    Anesth Analg 103:768-74. 2006
  4. ncbi request reprint Non-opioid strategies for acute pain management
    Pierre Beaulieu
    Department of Anesthesiology, Centre Hospitalier de l Universite de Montreal, Montreal, Quebec, Canada
    Can J Anaesth 54:481-5. 2007
  5. ncbi request reprint [The pharmacology of cannabinoid derivatives: are there applications to treatment of pain?]
    P Beaulieu
    Département d Anesthésiologie, CHUM, Hotel Dieu, 3840 Saint Urbain, Montreal, Quebec, H2W 1T8, Canada
    Ann Fr Anesth Reanim 21:493-508. 2002
  6. ncbi request reprint Reassessment of the role of cannabinoids in the management of pain
    Pierre Beaulieu
    Department of Anesthesiology and Pharmacology, University of Montreal, Montreal, Quebec, Canada
    Curr Opin Anaesthesiol 20:473-7. 2007
  7. ncbi request reprint The local antinociceptive effects of paracetamol in neuropathic pain are mediated by cannabinoid receptors
    Mélina Dani
    Department of Pharmacology, Faculty of Medicine, Université de Montréal CHUM, 3840 rue St Urbain, Montreal, H2W 1T8, Quebec, Canada
    Eur J Pharmacol 573:214-5. 2007
  8. ncbi request reprint Characterization of chronic constriction of the saphenous nerve, a model of neuropathic pain in mice showing rapid molecular and electrophysiological changes
    Jean Sébastien Walczak
    Department of Pharmacology, Universite de Montreal, Montreal, Quebec, Canada
    J Neurosci Res 83:1310-22. 2006
  9. ncbi request reprint Pre-emptive antinociceptive effects of a synthetic cannabinoid in a model of neuropathic pain
    Josee Guindon
    Department of Pharmacology, Faculty of Medicine, Université de Montréal CHUM, 3840 rue St Urbain, Montreal, Quebec, Canada H2W 1T8
    Eur J Pharmacol 568:173-6. 2007
  10. ncbi request reprint Synergistic antinociceptive effects of anandamide, an endocannabinoid, and nonsteroidal anti-inflammatory drugs in peripheral tissue: a role for endogenous fatty-acid ethanolamides?
    Josee Guindon
    Department of Pharmacology, Faculty of Medicine, Universite de Montreal C P 6128, Succ Centre Ville, Montreal, Quebec, Canada H2W 1T8
    Eur J Pharmacol 550:68-77. 2006

Collaborators

Detail Information

Publications29

  1. ncbi request reprint Toxic effects of cannabis and cannabinoids: Animal data
    Pierre Beaulieu
    Department of Anesthesiology, CHUM Hotel Dieu, Montreal, Quebec
    Pain Res Manag 10:23A-6A. 2005
    ..Animal toxicity data, however, are difficult to extrapolate to humans...
  2. ncbi request reprint Effects of nabilone, a synthetic cannabinoid, on postoperative pain
    Pierre Beaulieu
    Department of Anesthesiology, Faculty of Medicine, Universite de Montreal, Quebec, Canada
    Can J Anaesth 53:769-75. 2006
    ..It was hypothesized that nabilone, an oral cannabinoid synthetic tetrahydrocannabinol analogue, decreases morphine consumption, pain scores, nausea and vomiting following major surgery...
  3. ncbi request reprint The pharmacodynamics of ropivacaine and bupivacaine in combined sciatic and femoral nerve blocks for total knee arthroplasty
    Pierre Beaulieu
    Department of Anesthesiology, CHUM Hotel Dieu, Montreal, Quebec, Canada
    Anesth Analg 103:768-74. 2006
    ..A new systematic method to assess sciatic and femoral nerve blockade is proposed...
  4. ncbi request reprint Non-opioid strategies for acute pain management
    Pierre Beaulieu
    Department of Anesthesiology, Centre Hospitalier de l Universite de Montreal, Montreal, Quebec, Canada
    Can J Anaesth 54:481-5. 2007
    ..Obtaining CME credits for this module is not based upon attaining a specific score: the goal of participating is to define potential areas for improvement...
  5. ncbi request reprint [The pharmacology of cannabinoid derivatives: are there applications to treatment of pain?]
    P Beaulieu
    Département d Anesthésiologie, CHUM, Hotel Dieu, 3840 Saint Urbain, Montreal, Quebec, H2W 1T8, Canada
    Ann Fr Anesth Reanim 21:493-508. 2002
    ..To present the cannabinoid system together with recent findings on the pharmacology of these compounds in the treatment of pain...
  6. ncbi request reprint Reassessment of the role of cannabinoids in the management of pain
    Pierre Beaulieu
    Department of Anesthesiology and Pharmacology, University of Montreal, Montreal, Quebec, Canada
    Curr Opin Anaesthesiol 20:473-7. 2007
    ..The aim of this article is to assess the role of cannabinoids in the treatment of acute and chronic pain in humans...
  7. ncbi request reprint The local antinociceptive effects of paracetamol in neuropathic pain are mediated by cannabinoid receptors
    Mélina Dani
    Department of Pharmacology, Faculty of Medicine, Université de Montréal CHUM, 3840 rue St Urbain, Montreal, H2W 1T8, Quebec, Canada
    Eur J Pharmacol 573:214-5. 2007
    ..These effects were inhibited by the administration of cannabinoid CB(1) (AM251) and CB(2) (AM630) receptor antagonists. The participation of the peripheral cannabinoid system in paracetamol analgesia is suggested...
  8. ncbi request reprint Characterization of chronic constriction of the saphenous nerve, a model of neuropathic pain in mice showing rapid molecular and electrophysiological changes
    Jean Sébastien Walczak
    Department of Pharmacology, Universite de Montreal, Montreal, Quebec, Canada
    J Neurosci Res 83:1310-22. 2006
    ..This model takes advantage of the possible use in the future of genetically modified mice and of an exclusively sensory nerve for a comprehensive study of peripheral mechanisms of neuropathic pain...
  9. ncbi request reprint Pre-emptive antinociceptive effects of a synthetic cannabinoid in a model of neuropathic pain
    Josee Guindon
    Department of Pharmacology, Faculty of Medicine, Université de Montréal CHUM, 3840 rue St Urbain, Montreal, Quebec, Canada H2W 1T8
    Eur J Pharmacol 568:173-6. 2007
    ..In conclusion, pre-emptive use of cannabinoids produced greater antinociceptive effects in a model of neuropathic pain and this effect is mediated by cannabinoid CB(1) and CB(2) receptors...
  10. ncbi request reprint Synergistic antinociceptive effects of anandamide, an endocannabinoid, and nonsteroidal anti-inflammatory drugs in peripheral tissue: a role for endogenous fatty-acid ethanolamides?
    Josee Guindon
    Department of Pharmacology, Faculty of Medicine, Universite de Montreal C P 6128, Succ Centre Ville, Montreal, Quebec, Canada H2W 1T8
    Eur J Pharmacol 550:68-77. 2006
    ..Finally, locally injected anandamide with either NSAID (ibuprofen or rofecoxib) generates higher amount of fatty-acid ethanolamides. The exact comprehension of the mechanisms involved needs further investigation...
  11. ncbi request reprint Recent advances in the pharmacological management of pain
    Josee Guindon
    Department of Pharmacology, Faculty of Medicine, Universite de Montreal, Montreal, Quebec, Canada
    Drugs 67:2121-33. 2007
    ..Broadening of our knowledge is needed to improve basic and clinical research in this field in order to better alleviate pain in millions of people...
  12. ncbi request reprint Local interactions between anandamide, an endocannabinoid, and ibuprofen, a nonsteroidal anti-inflammatory drug, in acute and inflammatory pain
    Josee Guindon
    Department of Pharmacology, Faculty of Medicine, Universite de Montreal, C P 6128, Succ Centre Ville, Montreal, Que, Canada H3C 3J7
    Pain 121:85-93. 2006
    ..The combination of anandamide with ibuprofen produced synergistic antinociceptive effects involving both cannabinoid CB1 and CB2 receptors. Comprehension of the mechanisms involved needs further investigation...
  13. ncbi request reprint Opioids and cannabinoids interactions: involvement in pain management
    Julie Desroches
    Department of Pharmacology, Faculty of Medicine, Université de Montréal CHUM, 3840 rue St Urbain, Montreal, H2W 1T8, Quebec, Canada
    Curr Drug Targets 11:462-73. 2010
    ..Thus, the present review is focused on bidirectional interactions between opioids and cannabinoids and their potent repercussions on pain modulation...
  14. ncbi request reprint The antinociceptive effects of local injections of propofol in rats are mediated in part by cannabinoid CB1 and CB2 receptors
    Josee Guindon
    Department of Pharmacology, Faculty of Medicine, Université de Montréal CHUM, Montreal, Quebec, Canada
    Anesth Analg 104:1563-9, table of contents. 2007
    ....
  15. ncbi request reprint [The cannabinoid system and pain: a new therapeutic avenue?]
    Julie Desroches
    Departement de Pharmacologie, Faculte de Medecine, Universite de Montreal, Montreal, Canada
    Rev Med Suisse 4:1505-6, 1508-10, 1512-3. 2008
    ..Targeting preferentially peripheral cannabinoid receptors to avoid unwanted psychotropic effects is a new interesting avenue requiring further investigation...
  16. ncbi request reprint Cannabinoids for the treatment of pain: an update on recent clinical trials
    Mark Ware
    McGill University, Montreal, Quebec
    Pain Res Manag 10:27A-30A. 2005
    ..Clinicians working in pain management should be aware of the options becoming available from the cannabinoid class of medications...
  17. ncbi request reprint Comparison of three models of neuropathic pain in mice using a new method to assess cold allodynia: the double plate technique
    Jean Sébastien Walczak
    Department of Pharmacology, Universite de Montreal, Canada
    Neurosci Lett 399:240-4. 2006
    ..In conclusion, the double plate technique provides a new, relevant method for assessing cold allodynia in mice. The advantages and drawbacks with the other techniques are discussed...
  18. ncbi request reprint Neuromuscular blockade does not change the incidence or severity of pharyngolaryngeal discomfort after LMA anesthesia
    Thomas M Hemmerling
    Department of Anesthesiology, Universite de Montreal, Hotel Dieu, 3840 St Urbain, Montreal, Quebec H2W 1T8, Canada
    Can J Anaesth 51:728-32. 2004
    ..This study examined the influence of neuromuscular blockade on the incidence and severity of pharyngolaryngeal discomfort after positive pressure ventilation using a LMA...
  19. ncbi request reprint Antihyperalgesic effects of local injections of anandamide, ibuprofen, rofecoxib and their combinations in a model of neuropathic pain
    Josee Guindon
    Department of Pharmacology, Faculty of Medicine, Université de Montréal CHUM, 3840 rue St Urbain, Montreal, H2W 1T8 Québec, Canada
    Neuropharmacology 50:814-23. 2006
    ..Local use of endocannabinoids to treat neuropathic pain may be an interesting way to treat this condition without having the deleterious central effects of systemic cannabinoids...
  20. doi request reprint Estimation of pain intensity in emergency medicine: a validation study
    Raoul Daoust
    Department of Emergency Medicine, Faculty of Medicine, Universite de Montreal, Research Center, Sacré Coeur Hospital of Montréal, 5400 Gouin Ouest, Montreal, Que H4J1C5, Canada
    Pain 138:565-70. 2008
    ..It is probably a valid tool to estimate acute pain in the ED. However, the VNRS is less valid in that context because of its wide limits of agreement and variable bias (mainly in lower scores)...
  21. doi request reprint Endocannabinoids decrease neuropathic pain-related behavior in mice through the activation of one or both peripheral CB1 and CB2 receptors
    Julie Desroches
    Department of Pharmacology, Universite de Montreal, Montreal, Quebec, Canada
    Neuropharmacology 77:441-52. 2014
    ..The antinociceptive properties of AEA and URB597 were mediated only by CB1 receptors. ..
  22. ncbi request reprint An NS3 protease inhibitor with antiviral effects in humans infected with hepatitis C virus
    Daniel Lamarre
    Department of Biological Sciences Boehringer Ingelheim Canada Ltd, Laval, Quebec, H7S 2G5, Canada
    Nature 426:186-9. 2003
    ..Our results further illustrate the potential of the viral-enzyme-targeted drug discovery approach for the development of new HCV therapeutics...
  23. ncbi request reprint Behavioral, pharmacological and molecular characterization of the saphenous nerve partial ligation: a new model of neuropathic pain
    J S Walczak
    Department of Pharmacology, Universite de Montreal, Department of Nephrology, Quebec, Canada
    Neuroscience 132:1093-102. 2005
    ..In conclusion, we have shown that the SPL is an adequate model that will provide a new tool for clarifying peripheral mechanisms of neuropathic pain in an exclusive sensory nerve...
  24. pmc Modulation of the anti-nociceptive effects of 2-arachidonoyl glycerol by peripherally administered FAAH and MGL inhibitors in a neuropathic pain model
    J Desroches
    Department of Pharmacology, Université de Montréal CHUM, Montreal, Quebec, Canada
    Br J Pharmacol 155:913-24. 2008
    ..This was performed in the presence or absence of cannabinoid CB(1) (AM251) and CB(2) (AM630) receptor antagonists...
  25. pmc The antinociceptive effects of intraplantar injections of 2-arachidonoyl glycerol are mediated by cannabinoid CB2 receptors
    J Guindon
    Department of Pharmacology, Faculty of Medicine, Universite de Montreal, Quebec, Canada
    Br J Pharmacol 150:693-701. 2007
    ..The peripheral antinociceptive effects of 2-AG and URB602 in an inflammatory model of pain are not yet determined. We have evaluated these effects with and without the cannabinoid CB(1) (AM251) and CB(2) (AM630) receptor antagonists...
  26. ncbi request reprint Antinociceptive effects of tetrodotoxin (TTX) in rodents
    J Marcil
    Department of Anesthesiology, Faculty of Medicine, Universite de Montreal, Montreal, Quebec, Canada
    Br J Anaesth 96:761-8. 2006
    ..Tetrodotoxin (TTX) is a powerful sodium channel blocker extracted from the puffer fish. The analgesic effects of TTX were investigated in different animal pain models...
  27. ncbi request reprint The role of the endogenous cannabinoid system in peripheral analgesia
    Josee Guindon
    Neuroscience and Behavior Program, Department of Psychology, University of Georgia, Athens, GA, USA
    Curr Mol Pharmacol 2:134-9. 2009
    ....
  28. ncbi request reprint Cannabinoids for postoperative pain
    Pierre Beaulieu
    Anesthesiology 106:397; author reply 397-8. 2007
  29. ncbi request reprint Cannabimimetic eicosanoids in cancer and inflammation: an update
    Dominique Melck
    Endocannabinoid Research Group, Istituto per la Chimica di Molecule di Interesse Biologico, Consiglio Nazionale delle Ricerche, Via Toiano 6, 80072 Arco Felice, NA, Italy
    Adv Exp Med Biol 507:381-6. 2002