Jean Martin Beaulieu

Summary

Country: Canada

Publications

  1. pmc Selective deletion of forebrain glycogen synthase kinase 3β reveals a central role in serotonin-sensitive anxiety and social behaviour
    Camille Latapy
    Department of Psychiatry and Neuroscience, Laval University, Quebec City, Quebec, Canada
    Philos Trans R Soc Lond B Biol Sci 367:2460-74. 2012
  2. pmc Beyond cAMP: The Regulation of Akt and GSK3 by Dopamine Receptors
    Jean Martin Beaulieu
    Department of Psychiatry and Neuroscience, Université Laval CRULRG Québec, QC, Canada
    Front Mol Neurosci 4:38. 2011
  3. pmc Inhibition of GSK3 by lithium, from single molecules to signaling networks
    Laure Freland
    Faculty of Medicine, Departments of Psychiatry and Neuroscience, Universite Laval, Quebec QC, Canada
    Front Mol Neurosci 5:14. 2012
  4. pmc A role for Akt and glycogen synthase kinase-3 as integrators of dopamine and serotonin neurotransmission in mental health
    Jean Martin Beaulieu
    Department of Psychiatry and Neuroscience, Faculty of Medicine, Universite Laval, Centre de Recherche Université Laval Robert Giffard CRULRG, Quebec, Canada
    J Psychiatry Neurosci 37:7-16. 2012
  5. doi request reprint Akt/GSK3 signaling in the action of psychotropic drugs
    Jean Martin Beaulieu
    Department of Anatomy and Physiology, Université Laval CRULRG, Quebec, Canada
    Annu Rev Pharmacol Toxicol 49:327-47. 2009
  6. ncbi request reprint Spatial intensity distribution analysis (SpIDA): a new tool for receptor tyrosine kinase activation and transactivation quantification
    Annie Barbeau
    Department of Psychiatry and Neuroscience, Faculty of Medicine, Laval University, Quebec, Canada Institut universitaire en santé mentale de Québec, Quebec, Canada
    Methods Cell Biol 117:1-19. 2013
  7. doi request reprint [Psychotropic drugs and the involvement of the Akt/GSK3 signalling pathway in mental illnesses]
    Thomas Del'Guidice
    Département de psychiatrie et neuroscience, Université Laval CRULRG, chemin de la Canardiere, Bureau F 6500, Beauport, Canada
    Med Sci (Paris) 26:647-51. 2010
  8. pmc Stimulation of 5-HT2C receptors improves cognitive deficits induced by human tryptophan hydroxylase 2 loss of function mutation
    Thomas Del'Guidice
    1 Département de Psychiatrie et de Neurosciences, Faculte de Medecine, Université Laval Pavillon Ferdinand Vandry, Quebec, QC, Canada 2 Institut Universitaire en Santé Mentale de Québec, Quebec, QC, Canada
    Neuropsychopharmacology 39:1125-34. 2014
  9. ncbi request reprint Peripherin-mediated death of motor neurons rescued by overexpression of neurofilament NF-H proteins
    Jean Martin Beaulieu
    Centre for Research in Neurosciences, McGill University, The Research Institute of the McGill University Health Centre, Montreal, Quebec, Canada
    J Neurochem 85:248-56. 2003
  10. doi request reprint Morphine hyperalgesia gated through microglia-mediated disruption of neuronal Cl⁻ homeostasis
    Francesco Ferrini
    Institut universitaire en santé mentale de Québec, Quebec, Canada
    Nat Neurosci 16:183-92. 2013

Collaborators

Detail Information

Publications22

  1. pmc Selective deletion of forebrain glycogen synthase kinase 3β reveals a central role in serotonin-sensitive anxiety and social behaviour
    Camille Latapy
    Department of Psychiatry and Neuroscience, Laval University, Quebec City, Quebec, Canada
    Philos Trans R Soc Lond B Biol Sci 367:2460-74. 2012
    ....
  2. pmc Beyond cAMP: The Regulation of Akt and GSK3 by Dopamine Receptors
    Jean Martin Beaulieu
    Department of Psychiatry and Neuroscience, Université Laval CRULRG Québec, QC, Canada
    Front Mol Neurosci 4:38. 2011
    ..Further understanding of the role of Akt/GSK3 signaling in dopamine receptor functions could provide novel targets for pharmacological interventions in dopamine-related disorders...
  3. pmc Inhibition of GSK3 by lithium, from single molecules to signaling networks
    Laure Freland
    Faculty of Medicine, Departments of Psychiatry and Neuroscience, Universite Laval, Quebec QC, Canada
    Front Mol Neurosci 5:14. 2012
    ..A better understanding of these intricate actions of lithium at a systems level may allow the rational development of better mood stabilizer drugs with enhanced selectivity, efficacy, and lesser side effects...
  4. pmc A role for Akt and glycogen synthase kinase-3 as integrators of dopamine and serotonin neurotransmission in mental health
    Jean Martin Beaulieu
    Department of Psychiatry and Neuroscience, Faculty of Medicine, Universite Laval, Centre de Recherche Université Laval Robert Giffard CRULRG, Quebec, Canada
    J Psychiatry Neurosci 37:7-16. 2012
    ..Understanding these interactions may provide a better understanding of mental illnesses, leading to better efficacy of new therapeutic approaches...
  5. doi request reprint Akt/GSK3 signaling in the action of psychotropic drugs
    Jean Martin Beaulieu
    Department of Anatomy and Physiology, Université Laval CRULRG, Quebec, Canada
    Annu Rev Pharmacol Toxicol 49:327-47. 2009
    ..Elucidation of the contribution of multiple signaling pathways to the action of psychotropic drugs may provide a better biological understanding of psychiatric disorders and lead to more efficient therapeutics...
  6. ncbi request reprint Spatial intensity distribution analysis (SpIDA): a new tool for receptor tyrosine kinase activation and transactivation quantification
    Annie Barbeau
    Department of Psychiatry and Neuroscience, Faculty of Medicine, Laval University, Quebec, Canada Institut universitaire en santé mentale de Québec, Quebec, Canada
    Methods Cell Biol 117:1-19. 2013
    ..Therefore, SpIDA enables these biological processes to be monitored directly in their native cellular environment. ..
  7. doi request reprint [Psychotropic drugs and the involvement of the Akt/GSK3 signalling pathway in mental illnesses]
    Thomas Del'Guidice
    Département de psychiatrie et neuroscience, Université Laval CRULRG, chemin de la Canardiere, Bureau F 6500, Beauport, Canada
    Med Sci (Paris) 26:647-51. 2010
    ..Regulation of Akt and GSK3 by monoamine neurotransmitters may provide a better understanding of mental illnesses leading to new therapeutic approaches having better efficacy...
  8. pmc Stimulation of 5-HT2C receptors improves cognitive deficits induced by human tryptophan hydroxylase 2 loss of function mutation
    Thomas Del'Guidice
    1 Département de Psychiatrie et de Neurosciences, Faculte de Medecine, Université Laval Pavillon Ferdinand Vandry, Quebec, QC, Canada 2 Institut Universitaire en Santé Mentale de Québec, Quebec, QC, Canada
    Neuropsychopharmacology 39:1125-34. 2014
    ....
  9. ncbi request reprint Peripherin-mediated death of motor neurons rescued by overexpression of neurofilament NF-H proteins
    Jean Martin Beaulieu
    Centre for Research in Neurosciences, McGill University, The Research Institute of the McGill University Health Centre, Montreal, Quebec, Canada
    J Neurochem 85:248-56. 2003
    ..These findings illustrate the importance of IF protein stoichiometry in formation, localization and toxicity of neuronal inclusion bodies...
  10. doi request reprint Morphine hyperalgesia gated through microglia-mediated disruption of neuronal Cl⁻ homeostasis
    Francesco Ferrini
    Institut universitaire en santé mentale de Québec, Quebec, Canada
    Nat Neurosci 16:183-92. 2013
    ..Our findings dissociate morphine-induced hyperalgesia from tolerance and suggest the microglia-to-neuron P2X4-BDNF-KCC2 pathway as a therapeutic target for preventing hyperalgesia without affecting morphine analgesia...
  11. doi request reprint The electroretinogram as a biomarker of central dopamine and serotonin: potential relevance to psychiatric disorders
    Joëlle Lavoie
    Department of Psychiatry and Neurosciences, Quebec City, Quebec, Canada Department of Ophthalmology and Otorhinolaryngology, Faculty of Medicine, Universite Laval, Quebec City, Quebec, Canada Centre de recherche de l Institut universitaire en santé mentale de Québec, Quebec City, Quebec, Canada
    Biol Psychiatry 75:479-86. 2014
    ..The goal of this study was to evaluate whether ERG anomalies could result from central dopamine or serotonin dysfunctions or from changes in the retinal bioavailability of these neurotransmitters...
  12. doi request reprint β-Arrestins in the central nervous system
    Camille Latapy
    Département de Psychiatrie et de Neurosciences, Faculte de Medecine, Universite Laval, Pavillon Ferdinand Vandry, Quebec City, Quebec, Canada
    Prog Mol Biol Transl Sci 118:267-95. 2013
    ..Development of such approaches may lead to new drugs having better clinical efficacy and lesser side effects...
  13. doi request reprint Glycogen synthase kinase-3β haploinsufficiency lengthens the circadian locomotor activity period in mice
    Joëlle Lavoie
    Centre de Recherche de l Institut Universitaire en Santé Mentale de Québec, Behavioral Platform, Quebec City, Quebec, Canada
    Behav Brain Res 253:262-5. 2013
    ....
  14. pmc D1 dopamine receptor coupling to PLCβ regulates forward locomotion in mice
    Ivan O Medvedev
    Department of Cell Biology, Duke University Medical Center, Durham, North Carolina 27710, Department of Pharmacology and Toxicology, Faculty of Medicine, University of Toronto, Toronto, Ontario M5S 1A8, Canada, Department of Neuroscience and Brain Technologies, Istituto Italiano di Tecnologia, 16163 Genova, Italy, Skolkovo Institute of Science and Technology, Skolkovo, Moscow Region, 143025, Russia, Faculty of Biology and Soil Science, St Petersburg State University, St Petersburg 199034, Russia, and Department of Psychiatry and Neuroscience, Faculty of Medicine, Laval University and Institut universitaire en santé mentale de Québec, Quebec City, Quebec G1J 2G3, Canada
    J Neurosci 33:18125-33. 2013
    ....
  15. doi request reprint Looking at lithium: molecular moods and complex behaviour
    Jean Martin Beaulieu
    Department of Anatomy and Physiology, Université Laval CRULRG, Quebec, Canada G1J 2G3
    Mol Interv 8:230-41. 2008
    ....
  16. pmc Role of Beta-arrestin 2 downstream of dopamine receptors in the Basal Ganglia
    Thomas Del'Guidice
    Department of Psychiatry and Neuroscience, Faculty of Medicine, Centre de Recherche Université Laval Robert Giffard Québec, QC, Canada
    Front Neuroanat 5:58. 2011
    ..Understanding these mechanisms may lead to a better comprehension of the several roles played by these structures in the regulation of mood and to the development of new psychoactive drugs having better therapeutic efficacy...
  17. ncbi request reprint Glycogen synthase kinase-3 overexpression replicates electroretinogram anomalies of offspring at high genetic risk for schizophrenia and bipolar disorder
    Joëlle Lavoie
    Centre de Recherche de l Institut Universitaire en Santé Mentale de Québec, Quebec City, Canada Departments of Psychiatry and Neuroscience and Ophthalmology, Otorhinolaryngology, Quebec City, Canada Cervico Facial Surgery, Faculty of Medicine, Universite Laval, Quebec City, Canada
    Biol Psychiatry 76:93-100. 2014
    ..Several genetic variants associated with enhanced risk for SZ and/or BD can activate glycogen synthase kinase-3 isozymes (GSK3α and β). Here we examined the potential contribution of GSK3α and β in the modulation of the ERG...
  18. doi request reprint Dissociations between cognitive and motor effects of psychostimulants and atomoxetine in hyperactive DAT-KO mice
    Thomas Del'Guidice
    Département de Psychiatrie et de Neurosciences, Faculte de Medecine, Universite Laval, Pavillon Ferdinand Vandry, 1050, avenue de la Medecine, Quebec City, QC, Canada
    Psychopharmacology (Berl) 231:109-22. 2014
    ..However, the mechanism of action of these drugs and their impact on cognition in the absence of DAT remain poorly understood...
  19. doi request reprint Quantification of receptor tyrosine kinase activation and transactivation by G-protein-coupled receptors using spatial intensity distribution analysis (SpIDA)
    Annie Barbeau
    Department of Psychiatry and Neuroscience, Faculty of Medicine, Laval University, Quebec, QC, Canada
    Methods Enzymol 522:109-31. 2013
    ..Therefore, SpIDA enables these biological processes to be monitored directly in their native cellular environment...
  20. doi request reprint Galectin-3 is required for resident microglia activation and proliferation in response to ischemic injury
    Mélanie Lalancette-Hébert
    Centre de Recherche du Centre Hospitalier de l Universite Laval, Quebec City, Quebec G1V 4G2, Canada
    J Neurosci 32:10383-95. 2012
    ..Together, our findings suggest that galectin-3 is required for resident microglia activation and proliferation in response to ischemic injury...
  21. ncbi request reprint Up-regulation of peripherin is associated with alterations in synaptic plasticity in CA1 and CA3 regions of hippocampus
    Jasna Kriz
    Centre Hospitalier de l Universite Laval Research Center, Quebec City, Quebec, Canada
    Neurobiol Dis 18:409-20. 2005
    ..4.0%). In the hippocampus of Per mice, the levels of MAP2 were decreased, though synaptophysin and PSD95 remained unchanged. These intriguing findings suggest a role of peripherin in the alteration of hippocampal synaptic plasticity...
  22. doi request reprint The physiology, signaling, and pharmacology of dopamine receptors
    Jean Martin Beaulieu
    Department of Psychiatry and Neuroscience, Faculty of Medicine, Université Laval Centre de Recherche de l Université Laval Robert Giffard, Quebec City, Quebec, Canada
    Pharmacol Rev 63:182-217. 2011
    ....