Tiffany W Chow
Affiliation: Baycrest Centre for Geriatric Care
- Incorporating new diagnostic schemas, genetics, and proteinopathy into the evaluation of frontotemporal degenerationTiffany W Chow
Baycrest Rotman Research Institute, 3560 Bathurst Street, 8th Floor Brain Health Complex, Toronto, ON M6A 2E1, Canada
Continuum (Minneap Minn) 19:438-56. 2013..Neurologists, neuropsychologists, and speech pathologists are particularly involved in the diagnosis and recognition of etiologies for patients with deficits in frontal lobe function and language...
- Overlap in frontotemporal atrophy between normal aging and patients with frontotemporal dementiasTiffany W Chow
Division of Neurology, Department of Medicine, University of Toronto, Toronto, Canada
Alzheimer Dis Assoc Disord 22:327-35. 2008..While volumetry identified left-sided atrophy as useful for identifying FTD cases, future studies should determine whether clinicians could make these distinctions on viewing routine diagnostic magnetic resonance imaging scans...
- A case of apathy due to frontotemporal dementia responsive to memantineKira A Links
Baycrest, Rotman Research Institute, Toronto, ON, Canada
Neurocase 19:256-61. 2013..To study the effect of memantine on apathy, a common symptom of behavioral variant frontotemporal dementia (bvFTD)...
- Abnormal network connectivity in frontotemporal dementia: evidence for prefrontal isolationNorman A S Farb
Rotman Research Institute, Baycrest Centre, Toronto, Ontario, Canada
Cortex 49:1856-73. 2013..Recent neuroimaging research also associates FTD with alterations in the brain's intrinsic connectivity networks. The present study explored the relationship between neural network connectivity and specific behavioral symptoms in FTD...
- Trajectories of behavioral disturbance in dementiaTiffany W Chow
Rotman Research Institute of Baycrest, Toronto, ON, Canada
J Alzheimers Dis 31:143-9. 2012..These results support a crescendo-decrescendo trajectory of behavioral symptoms in bvFTD but do not suggest that there is a similar pattern in AD, and further longitudinal data collection is necessary...
- Apathy symptom profile and behavioral associations in frontotemporal dementia vs dementia of Alzheimer typeTiffany W Chow
Baycrest Rotman Research Institute, University of Toronto, Toronto, Ontario M6A 2E1, Canada
Arch Neurol 66:888-93. 2009..Apathy is a common and significant problem in patients with dementia, regardless of its cause. Observations about frontosubcortical circuit syndromes indicate that apathy may have affective, behavioral, or cognitive manifestations...
- Cholinergic pathways and cognition in patients with schizophrenia: a pilot studyTarek K Rajji
Geriatric Mental Health Program, Centre for Addiction and Mental Health, Toronto, Canada
Schizophr Res 139:46-52. 2012..The objective of this study was to evaluate the impact of compromised cholinergic pathways on executive versus non-executive cognitive functions of patients with schizophrenia...
- Fluorodeoxyglucose positron emission tomography in semantic dementia after 6 months of memantine: an open-label pilot studyTiffany W Chow
Division of Neurology, Baycrest, Toronto, Canada
Int J Geriatr Psychiatry 28:319-25. 2013..To follow up on the increases we reported in normalized metabolic activity in salience network hubs from a 2-month open-label study of memantine in frontotemporal dementia (FTD)...
- Whole-brain white matter disruption in semantic and nonfluent variants of primary progressive aphasiaGraeme C Schwindt
Institute of Medical Science, University of Toronto, Toronto, Ontario, Canada
Hum Brain Mapp 34:973-84. 2013..Further, they suggest that differences in the relative sensitivity of diffusion metrics may reflect differences in the nature of underlying white matter pathology in these two subtypes...
- Verb production in the nonfluent and semantic variants of primary progressive aphasia: the influence of lexical and semantic factorsKarine Marcotte
a Toronto Rehabilitation Institute, Toronto, Canada
Cogn Neuropsychol 31:565-83. 2014..The present findings suggest that lexicosemantic attributes affect verb production in the semantic variant, whereas both lexicosemantic and syntactic attributes affect verb production in the nonfluent variant. ..
- Occupation attributes relate to location of atrophy in frontotemporal lobar degenerationR Nathan Spreng
Rotman Research Institute, Baycrest Centre, Toronto, ON, Canada
Neuropsychologia 48:3634-41. 2010..Alternatively, long-term engagement of activities associated with these occupations contributed to left-lateralized reserve, right-lateralized dysfunction, or both...
- What are the different initial presentations of frontotemporal dementia?Tiffany W Chow
Department of Medicine, Division of Neurology, University of Toronto, Rotman Research Institute, 3560 Bathurst St, Toronto, ON, M6A 2E1, Canada
J Mol Neurosci 45:710-2. 2011....
- Recollection and familiarity for public events in neurologically intact older adults and two brain-damaged patientsRaluca Petrican
Department of Psychology, University of Toronto, 100 St George Street, Toronto, Ontario M5S 3G3, Canada
Neuropsychologia 48:945-60. 2010..We discuss the present results in the context of neuroanatomical and process-oriented theories of how memories age...
- 100 years after Alzheimer: contemporary neurology practice assessment of referrals for dementiaTiffany W Chow
Department of Medicine, Division of Neurology, University of Toronto, Toronto, Ontario, Canada
Am J Alzheimers Dis Other Demen 23:516-27. 2008..The prevalence of dementia is placing an increased burden on specialists...
- Magnetic resonance imaging in frontotemporal dementia shows subcortical atrophyTiffany W Chow
Department of Medicine, Division of Neurology, University of Toronto, Toronto, Ont, Canada
Dement Geriatr Cogn Disord 26:79-88. 2008..We explored the extent to which subcortical atrophy on structural magnetic resonance imaging may indicate a subcortical contribution to the progression of FTD...
- Lifetime History of Depression Predicts Increased Amyloid-β Accumulation in Patients with Mild Cognitive ImpairmentJun Ku Chung
Institute of Medical Science, Faculty of Medicine, University of Toronto, Toronto, Canada Multimodal Imaging Group Research Imaging Centre, Centre for Addiction and Mental Health, Toronto, Canada
J Alzheimers Dis 45:907-19. 2015..Increased Aβ in the bilateral frontal lobes may be a biomarker of depressive symptomology in aMCI patients. Further studies should test whether higher Aβ predicts future conversion into AD in this population. ..
- Grey matter atrophy in mild cognitive impairment / early Alzheimer disease associated with delusions: a voxel-based morphometry studyWindsor Kwan Chun Ting
Keenan Research Centre for Biomedical Science, The Li Ka Shing Knowledge Institute, St Michael s Hospital, 209 Victoria Street, Toronto, ON, Canada, M5B 1T8
Curr Alzheimer Res 12:165-72. 2015....
- Alzheimer's disease neuropathologic changes in semantic dementiaTiffany W Chow
Rotman Research Institute and Division of Neurology, Baycrest, Toronto, ON, Canada
Neurocase 16:15-22. 2010..This case series examines retrospectively which clinical parameters might have pointed to the neuropathological diagnosis of AD...
- An international needs assessment of caregivers for frontotemporal dementiaTiffany W Chow
Rotman Research Institute, Baycrest, 3560 Bathurst Street, 8th Floor Brain Health Complex, Toronto, Ontario, M6A 2E1, Canada
Can J Neurol Sci 38:753-7. 2011..To guide development of public awareness and caregiver support resources for frontotemporal dementia (FTD) syndromes...
- Development of supportive services for frontotemporal dementias through community engagementAdriana Shnall
Baycrest Health Sciences, Toronto, Ontario, Canada
Int Rev Psychiatry 25:246-52. 2013..The strength of these interventions is that services were developed with involvement of stakeholders in FTD care from the start, to deal with gaps in services in a sustainable way...
- Effects of aging on 5-HT(2A) R binding: a HRRT PET study with and without partial volume correctionsHiroyuki Uchida
Centre for Addiction and Mental Health, Toronto, Ontario, Canada
Int J Geriatr Psychiatry 26:1300-8. 2011....
- MMSE scores decline at a greater rate in frontotemporal degeneration than in ADTiffany W Chow
Rotman Research Institute of Baycrest, University of Toronto Department of Medicine, Division of Neurology, Toronto, Canada
Dement Geriatr Cogn Disord 22:194-9. 2006..018). Changes in MMSE subscores paralleled the clinical diagnostic criteria for FTD. The more rapid progression on the language subscore was observed in both language and behavioral variants of FTD...