Pierre Ayotte

Summary

Country: Canada

Publications

  1. pmc Polyunsaturated fatty acids and calcaneal ultrasound parameters among Inuit women from Nuuk (Greenland): a longitudinal study
    Alexandra Cristina Paunescu
    Axe Santé Publique et Pratiques Optimales en Santé, Centre de Recherche du CHU de Québec, Quebec, Canada
    Int J Circumpolar Health 72:20988. 2013
  2. pmc Plasma concentrations of selected organobromine compounds and polychlorinated biphenyls in postmenopausal women of Québec, Canada
    Torkjel M Sandanger
    Unite de Recherche en Sante publique, Centre Hospitalier Universitaire de Québec and Université Laval, Quebec, Quebec, Canada
    Environ Health Perspect 115:1429-34. 2007
  3. ncbi Levels of circulating polychlorinated biphenyls and mammographic breast density
    Caroline Diorio
    Toxicology Laboratory, Quebec National Public Health Institute, 945, avenue Wolfe, Quebec, QC, G1V 5B3 Canada
    Anticancer Res 33:5483-9. 2013
  4. pmc Assessment of pre- and postnatal exposure to polychlorinated biphenyls: lessons from the Inuit Cohort Study
    Pierre Ayotte
    Department of Social and Preventive Medicine, Laval University and Public Health Research Unit, CHUQ Laval University Medical Centre, Quebec, Quebec, Canada
    Environ Health Perspect 111:1253-8. 2003
  5. pmc Relation between methylmercury exposure and plasma paraoxonase activity in inuit adults from Nunavik
    Pierre Ayotte
    Axe de recherche en santé des populations et environnementale, Centre de Recherche du Centre Hospitalier Universitaire de Québec, Quebec, QC, Canada
    Environ Health Perspect 119:1077-83. 2011
  6. ncbi Prenatal exposure to methylmercury and PCBs affects distinct stages of information processing: an event-related potential study with Inuit children
    Olivier Boucher
    Ecole de Psychologie, Universite Laval, Quebec, Canada
    Neurotoxicology 31:373-84. 2010
  7. pmc Response inhibition and error monitoring during a visual go/no-go task in inuit children exposed to lead, polychlorinated biphenyls, and methylmercury
    Olivier Boucher
    Centre de Recherche du Centre Hospitalier Universitaire de Québec, Quebec, Canada
    Environ Health Perspect 120:608-15. 2012
  8. pmc Plasma organochlorine concentrations and bone ultrasound measurements: a cross-sectional study in peri-and postmenopausal Inuit women from Greenland
    Suzanne Côté
    Unite de Recherche en Sante publique, Centre de Recherche du CHUL CHUQ, Quebec, QC, G1V 5B3, Canada
    Environ Health 5:33. 2006
  9. pmc Prenatal methylmercury, postnatal lead exposure, and evidence of attention deficit/hyperactivity disorder among Inuit children in Arctic Québec
    Olivier Boucher
    Centre de Recherche du Centre Hospitalier Universitaire de Québec, Quebec, Quebec, Canada
    Environ Health Perspect 120:1456-61. 2012
  10. pmc Exposure to organochlorines and mercury through fish and marine mammal consumption: associations with growth and duration of gestation among Inuit newborns
    Renee Dallaire
    School of Psychology, Laval University and CHUQ Research Center, Quebec, Canada
    Environ Int 54:85-91. 2013

Collaborators

Detail Information

Publications69

  1. pmc Polyunsaturated fatty acids and calcaneal ultrasound parameters among Inuit women from Nuuk (Greenland): a longitudinal study
    Alexandra Cristina Paunescu
    Axe Santé Publique et Pratiques Optimales en Santé, Centre de Recherche du CHU de Québec, Quebec, Canada
    Int J Circumpolar Health 72:20988. 2013
    ..Results from in vitro studies, laboratory animal experiments and population studies suggest that omega-3 PUFA intake and a high omega-3/omega-6 ratio exert a positive effect on bone health...
  2. pmc Plasma concentrations of selected organobromine compounds and polychlorinated biphenyls in postmenopausal women of Québec, Canada
    Torkjel M Sandanger
    Unite de Recherche en Sante publique, Centre Hospitalier Universitaire de Québec and Université Laval, Quebec, Quebec, Canada
    Environ Health Perspect 115:1429-34. 2007
    ..Brominated flame retardants, especially polybrominated diphenyl ethers (PBDEs), have been widely used in North America, but little is known about the level of exposure of human populations to these compounds...
  3. ncbi Levels of circulating polychlorinated biphenyls and mammographic breast density
    Caroline Diorio
    Toxicology Laboratory, Quebec National Public Health Institute, 945, avenue Wolfe, Quebec, QC, G1V 5B3 Canada
    Anticancer Res 33:5483-9. 2013
    ....
  4. pmc Assessment of pre- and postnatal exposure to polychlorinated biphenyls: lessons from the Inuit Cohort Study
    Pierre Ayotte
    Department of Social and Preventive Medicine, Laval University and Public Health Research Unit, CHUQ Laval University Medical Centre, Quebec, Quebec, Canada
    Environ Health Perspect 111:1253-8. 2003
    ....
  5. pmc Relation between methylmercury exposure and plasma paraoxonase activity in inuit adults from Nunavik
    Pierre Ayotte
    Axe de recherche en santé des populations et environnementale, Centre de Recherche du Centre Hospitalier Universitaire de Québec, Quebec, QC, Canada
    Environ Health Perspect 119:1077-83. 2011
    ..Objectives: This study was conducted to determine whether blood mercury levels are linked to decreased plasma PON1 activities in Inuit people who are highly exposed to MeHg through their seafood-based diet...
  6. ncbi Prenatal exposure to methylmercury and PCBs affects distinct stages of information processing: an event-related potential study with Inuit children
    Olivier Boucher
    Ecole de Psychologie, Universite Laval, Quebec, Canada
    Neurotoxicology 31:373-84. 2010
    ..These effects seem to be mitigated in children who are breast-fed for a more extended period...
  7. pmc Response inhibition and error monitoring during a visual go/no-go task in inuit children exposed to lead, polychlorinated biphenyls, and methylmercury
    Olivier Boucher
    Centre de Recherche du Centre Hospitalier Universitaire de Québec, Quebec, Canada
    Environ Health Perspect 120:608-15. 2012
    ..Lead (Pb) and polychlorinated biphenyls (PCBs) are neurotoxic contaminants that have been related to impairment in response inhibition...
  8. pmc Plasma organochlorine concentrations and bone ultrasound measurements: a cross-sectional study in peri-and postmenopausal Inuit women from Greenland
    Suzanne Côté
    Unite de Recherche en Sante publique, Centre de Recherche du CHUL CHUQ, Quebec, QC, G1V 5B3, Canada
    Environ Health 5:33. 2006
    ..We hypothesized that this exposure might be related to bone characteristics that are altered in osteoporosis, because hormone deficiency is a known risk factor for the disease...
  9. pmc Prenatal methylmercury, postnatal lead exposure, and evidence of attention deficit/hyperactivity disorder among Inuit children in Arctic Québec
    Olivier Boucher
    Centre de Recherche du Centre Hospitalier Universitaire de Québec, Quebec, Quebec, Canada
    Environ Health Perspect 120:1456-61. 2012
    ..By contrast, lead (Pb) exposure in childhood has been associated with ADHD and disruptive behaviors in several studies...
  10. pmc Exposure to organochlorines and mercury through fish and marine mammal consumption: associations with growth and duration of gestation among Inuit newborns
    Renee Dallaire
    School of Psychology, Laval University and CHUQ Research Center, Quebec, Canada
    Environ Int 54:85-91. 2013
    ....
  11. pmc Effect of prenatal exposure to polychlorinated biphenyls on incidence of acute respiratory infections in preschool Inuit children
    Frederic Dallaire
    Public Health Research Unit, Laval University Medical Center Centre Hospitalier Universitaire de Québec, Quebec City, Quebec, Canada
    Environ Health Perspect 114:1301-5. 2006
    ..We set out to assess whether environmental prenatal exposure to polychlorinated biphenyls (PCBs) is associated with incidence of acute respiratory infections in preschool Inuit children...
  12. pmc Re-evaluation of blood mercury, lead and cadmium concentrations in the Inuit population of Nunavik (Québec): a cross-sectional study
    Julie Fontaine
    Unite de Recherche en Sante publique, Centre de Recherche du CHUL CHUQ, 2875 boul, Laurier, bureau 600, Québec Québec, G1V 2M2, Canada
    Environ Health 7:25. 2008
    ....
  13. pmc Neurophysiologic and neurobehavioral evidence of beneficial effects of prenatal omega-3 fatty acid intake on memory function at school age
    Olivier Boucher
    Universite Laval, Quebec, Canada
    Am J Clin Nutr 93:1025-37. 2011
    ..However, few studies have examined the extent to which these benefits continue to be evident in childhood...
  14. pmc In vitro activation of cord blood mononuclear cells and cytokine production in a remote coastal population exposed to organochlorines and methyl mercury
    Houda Bilrha
    Rheumatology Immunology Research Unit, CHUQ Laval University Medical Center, Quebec City, Quebec, Canada
    Environ Health Perspect 111:1952-7. 2003
    ....
  15. pmc Acute infections and environmental exposure to organochlorines in Inuit infants from Nunavik
    Frederic Dallaire
    Department of Social and Preventive Medicine, Laval University, and Public Health Research Unit, CHUQ Laval University Medical Center, 945 Wolfe Street, Sainte Foy, Quebec G1V 5B3, Canada
    Environ Health Perspect 112:1359-65. 2004
    ..05). No association was found when postnatal exposure was considered. These results show a possible association between prenatal exposure to OCs and acute infections early in life in this Inuit population...
  16. pmc Thyroid hormone levels of pregnant inuit women and their infants exposed to environmental contaminants
    Renee Dallaire
    Public Health Research Unit, Centre Hospitalier Universitaire de Québec CHUL, Quebec City, Quebec, Canada
    Environ Health Perspect 117:1014-20. 2009
    ..Prenatal exposure to some of them, such as polychlorinated biphenyls (PCBs), has also been associated with adverse neurodevelopmental effects in infants...
  17. doi Associations between plasma persistent organic pollutant levels and blood pressure in Inuit adults from Nunavik
    Beatriz Valera
    Axe Santé Publique et Pratiques Optimales en Santé, Centre de Recherche du CHU de Québec, Canada
    Environ Int 59:282-9. 2013
    ..High POP levels have been detected in Arctic populations and the exposure is related to high consumption of fish and marine mammals, which represent the traditional diet of these populations...
  18. pmc Time trends of persistent organic pollutants and heavy metals in umbilical cord blood of Inuit infants born in Nunavik (Québec, Canada) between 1994 and 2001
    Frederic Dallaire
    Public Health Research Unit, Laval University Medical Center CHUL CHUQ, and Laval University, Quebec City, Quebec, Canada
    Environ Health Perspect 111:1660-4. 2003
    ..The decreases observed could be explained by a decrease in food contamination, by changes in dietary habits, or, most likely, by a combination of both...
  19. pmc Temporal trends of organochlorine concentrations in umbilical cord blood of newborns from the lower north shore of the St. Lawrence river (Québec, Canada)
    Frederic Dallaire
    Public Health Research Unit, Laval University Medical Center, and Laval University, Quebec, Canada
    Environ Health Perspect 110:835-8. 2002
    ..These results show that prenatal exposure to persistent OCs has declined significantly between 1993 and 2000 in this population...
  20. pmc Biomarker measurements in a coastal fish-eating population environmentally exposed to organochlorines
    Pierre Ayotte
    Unite de Recherche en Sante publique, Centre Hospitalier Universitaire de Quebec, Universite Laval, Quebec, Canada
    Environ Health Perspect 113:1318-24. 2005
    ..Our data are consistent with smoking-induced liver CYP1A2 activity altering heme metabolism and increasing the biotransformation of mono-ortho PCB congeners...
  21. pmc Environmental exposure to polychlorinated biphenyls and placental CYP1A1 activity in Inuit women from northern Québec
    Daria Pereg
    Département de Biologie médicale, Faculte de Medecine, Université Laval et Unité de recherche en santé et environnement, Ste Foy, Quebec, Canada
    Environ Health Perspect 110:607-12. 2002
    ..We conclude that dietary exposure to PCBs in Inuit women from Nunavik does not significantly influence EROD activity in the placenta, implicating tobacco smoking as the major modulating factor...
  22. doi Effects of perfluorooctanesulfonate exposure on plasma lipid levels in the Inuit population of Nunavik (Northern Quebec)
    Marie Ludivine Chateau-Degat
    Axe santé des populations et environnementale, Research center of the Centre hospitalier universitaire de Québec and Université Laval, Quebec, QC, Canada G1V 2M2
    Environ Res 110:710-7. 2010
    ..The Inuit of Nunavik are exposed to environmental contaminants through the consumption of fish and game. This diet is also a source of omega3-polyunsaturated fatty acids (n-3 PUFAs) that are known to lower plasma triacylglycerols...
  23. doi Effects of prenatal exposure to organochlorines on thyroid hormone status in newborns from two remote coastal regions in Québec, Canada
    Renee Dallaire
    Public Health Research Unit, Laval University Medical Research Centre Centre Hospitalier, Universitaire de Quebec, Quebec City, Quebec, Canada
    Environ Res 108:387-92. 2008
    ..One of the mechanisms by which PCBs might interfere with neurodevelopment is a deficit in thyroid hormone (TH) concentrations...
  24. ncbi Determinants of plasma concentrations of perfluorooctanesulfonate and brominated organic compounds in Nunavik Inuit adults (Canada)
    Renee Dallaire
    Public Health Research Unit, Centre Hospitalier Universitaire de Québec CHUL, Quebec, Quebec, Canada
    Environ Sci Technol 43:5130-6. 2009
    ..In conclusion, we found that the remote geographical location and traditional lifestyle of the Nunavik Inuit population do not protect them against exposure to emerging POPs, particularly PFOS...
  25. pmc The relation of lead neurotoxicity to the event-related potential P3b component in Inuit children from arctic Québec
    Olivier Boucher
    Ecole de Psychologie, Universite Laval, Quebec, Canada
    Neurotoxicology 30:1070-7. 2009
    ..This study strengthens the arguments for reducing sources of Pb exposure in Nunavik and for lowering the blood Pb concentrations considered "acceptable" in governmental policies...
  26. ncbi Plasma polychlorinated biphenyl and organochlorine pesticide concentrations in dementia: The Canadian Study of Health and Aging
    Thierry Comlan Marc Medehouenou
    Faculte de Pharmacie, Universite Laval, Quebec City, Quebec, Canada Centre d excellence sur le vieillissement de Québec, Santé des populations et pratiques optimales en santé, Centre de Recherche du CHU de Québec, Quebec City, Quebec, Canada
    Environ Int 69:141-7. 2014
    ..Here, we assess associations of plasma PCB and OC pesticide concentrations with all-cause dementia and Alzheimer's disease (AD)...
  27. pmc Vitamin D receptor polymorphisms (FokI, BsmI) and breast cancer risk: association replication in two case-control studies within French Canadian population
    Marc Sinotte
    Unité de recherche en santé des populations, Centre Hospitalier Affilie Universitaire De Quebec, 1050 Chemin Sainte Foy, Quebec, Quebec, Canada G1S 4L8
    Endocr Relat Cancer 15:975-83. 2008
    ..They also suggest that variability in observed associations between VDR FokI and breast cancer from different studies may partly be explained by the proportion of study subjects with a family history of breast cancer...
  28. doi Determinants of AhR-mediated transcriptional activity induced by plasma extracts from Nunavik Inuit adults
    Thierry C M Medehouenou
    Axe de recherche en santé des populations et environnementale, Centre de recherche du Centre hospitalier universitaire de Québec and Université Laval, 2875 boulevard Laurier, Quebec, QC, Canada
    Chemosphere 80:75-82. 2010
    ..AhR-mediated transcriptional activity measures may prove useful in investigating possible associations between exposure to AhR agonists and adverse health effects in this indigenous population...
  29. doi Exposure to toxic metals and persistent organic pollutants in Inuit children attending childcare centers in Nunavik, Canada
    Huguette Turgeon O'Brien
    Groupe d études en nutrition publique, Département des sciences des aliments et de nutrition, Universite Laval, Quebec, Quebec, Canada
    Environ Sci Technol 46:4614-23. 2012
    ..S. cities. PFOS were present in lower concentrations than in Nunavimmiut adults. There is a clear need for continued biomonitoring of blood contaminant levels in this population, particularly for PBDEs and PFASs...
  30. pmc Traditional food consumption is associated with higher nutrient intakes in Inuit children attending childcare centres in Nunavik
    Doris Gagné
    Groupe d études en nutrition publique, Département des sciences des aliments et de nutrition, Universite Laval, Quebec, Canada
    Int J Circumpolar Health 71:18401. 2012
    ..To describe traditional food (TF) consumption and to evaluate its impact on nutrient intakes of preschool Inuit children from Nunavik...
  31. ncbi Effect of an environmentally relevant metabolized organochlorine mixture on porcine cumulus-oocyte complexes
    Céline Campagna
    Centre de Recherche en Biologie de la Reproduction, Departement des Sciences Animales, Pavillon Paul Comtois, Universite Laval, Ste Foy, Quebec, Canada
    Reprod Toxicol 23:145-52. 2007
    ..This study also indicates that organochlorine metabolites similar in concentrations to levels found in Arctic populations can affect growing cumulus-oocyte complexes without inducing an overt toxicological response...
  32. doi An environmentally relevant mixture of organochlorines, their metabolites and effects on preimplantation development of porcine embryos
    Céline Campagna
    Centre de Recherche en Biologie de la Reproduction, Departement des Sciences Animales, Pavillon Paul Comtois, Universite Laval, Ste Foy, Quebec, QC, Canada G1V 0A6
    Reprod Toxicol 25:361-6. 2008
    ....
  33. ncbi Effects of gestational and lactational exposure to organochlorine compounds on cellular, humoral, and innate immunity in swine
    Houda Bilrha
    Unité de recherche en Rhumatologie et Immunologie, Centre de Recherche du CHUL CHUQ, Quebec, QC, Canada G1V 4G2
    Toxicol Sci 77:41-50. 2004
    ..Furthermore, the high dose decreased the antibody response to Mycoplasma hyopneumoniae. Our results indicate that developmental exposure to an environmentally relevant OC mixture alters the immune function in swine...
  34. doi Polychlorinated biphenyls and organochlorine pesticides in plasma of older Canadians
    Thierry Comlan Marc Medehouenou
    Faculte de Pharmacie, Universite Laval, Quebec, Canada
    Environ Res 111:1313-20. 2011
    ..These plasma concentrations from a large population based study can be considered as baseline data for body burdens of older Canadians...
  35. ncbi Effect of dietary calcium intake on lead exposure in Inuit children attending childcare centres in Nunavik
    Huguette Turgeon O'Brien
    a Département des sciences des aliments et de nutrition, Universite Laval, Quebec, Canada
    Int J Environ Health Res 24:482-95. 2014
    ..015 and p = 0.024, respectively). Consuming traditional foods rich in calcium as well as milk and alternatives may protect against lead exposure. ..
  36. doi Relation between dietary acrylamide exposure and biomarkers of internal dose in Canadian teenagers
    Benjamin Brisson
    1 Institut national de santé publique du Québec, Quebec, Canada 2 Université Laval, Quebec, Canada
    J Expo Sci Environ Epidemiol 24:215-21. 2014
    ..05) were associated with adduct levels. Levels of hemoglobin adducts were above biomonitoring equivalent values corresponding to a 1 × 10(-4) excess cancer risk, which may indicate the need to reduce AA exposure in the population. ..
  37. pmc Associations between prenatal cigarette smoke exposure and externalized behaviors at school age among Inuit children exposed to environmental contaminants
    Caroline Desrosiers
    Universite Laval, Quebec City, Quebec, Canada Centre de recherche du Centre Hospitalier Universitaire de Québec, Quebec City, Quebec, Canada
    Neurotoxicol Teratol 39:84-90. 2013
    ..Interactions with lead (Pb) and mercury (Hg), two contaminants associated with behavioral problems, were also explored...
  38. ncbi Portrait of outpatient visits and hospitalizations for acute infections in Nunavik preschool children
    Frederic Dallaire
    Department of Social and Preventive Medicine, Laval University, and Public Health Research Unit, CHUQ Laval University Medical Center, Quebec, Canada
    Can J Public Health 97:362-8. 2006
    ..Inuit children from around the world are burdened by a high rate of infectious diseases. The objective of this study was to evaluate the incidence rate of infections in Inuit preschool children from Nunavik (Northern Québec)...
  39. pmc A physiologically based pharmacokinetic model for the assessment of infant exposure to persistent organic pollutants in epidemiologic studies
    Marc André Verner
    Departement des Sciences Biologiques, Centre TOXEN, Universite du Quebec a Montreal, and Centre de recherche du Hospitalier Universitaire de Québec, Montreal, Quebec, Canada
    Environ Health Perspect 117:481-7. 2009
    ..Epidemiologic studies to date have relied on the analysis of biological samples drawn pre- or post-natally for exposure assessment, an approach that might not capture some key events in the toxicokinetics of POPs...
  40. pmc Long-term effects of prenatal omega-3 fatty acid intake on visual function in school-age children
    Caroline Jacques
    Sainte Justine University Hospital Research Center, Montreal, Quebec, Canada
    J Pediatr 158:83-90, 90.e1. 2011
    ..To assess the long-term effect on visual development of omega-3 polyunsaturated fatty acid (n-3 PUFA) intake during gestation...
  41. doi Omega-3 fatty acids and risk of dementia: the Canadian Study of Health and Aging
    Edeltraut Kröger
    Centre d Excellence sur le Vieillissement de Quebec, Unite de Recherche sur le Vieillissement, Centre de recherche FRSQ du Centre hospitalier affilié universitaire de Québec, Quebec, Canada
    Am J Clin Nutr 90:184-92. 2009
    ..Fish is the main dietary source of n-3 PUFAs and is sometimes contaminated with mercury. This neurotoxicant may modify the association with dementia...
  42. pmc Domain-specific effects of prenatal exposure to PCBs, mercury, and lead on infant cognition: results from the Environmental Contaminants and Child Development Study in Nunavik
    Olivier Boucher
    Centre de Recherche du Centre Hospitalier Universitaire de Québec, Quebec City, Quebec, Canada
    Environ Health Perspect 122:310-6. 2014
    ..Polychlorinated biphenyls (PCBs), methylmercury (MeHg), and lead (Pb) are environmental contaminants known for their adverse effects on cognitive development...
  43. doi Differential effects of a complex organochlorine mixture on the proliferation of breast cancer cell lines
    Michel Aubé
    Axe de recherche en santé des populations et environnementale, Centre de recherche du Centre hospitalier universitaire de Québec and Université Laval, 2875 boulevard Laurier, Edifice Delta 2, bureau 600, Quebec, QC, Canada
    Environ Res 111:337-47. 2011
    ..Other mixtures of contaminants that include emerging compounds of interest such as brominated flame retardants and perfluoroalkyl compounds should be tested for their capacity to induce breast cancer cell proliferation...
  44. doi Effects of an environmentally relevant organochlorine mixture and a metabolized extract of this mixture on porcine sperm parameters in vitro
    Céline Campagna
    Centre de Recherche en Biologie de la Reproduction, Departement des Sciences Animales, Pavillon Paul Comtois, Universite Laval, Quebec City, Quebec, Canada
    J Androl 30:317-24. 2009
    ..In contrast, short and physiologically relevant exposure to the metabolized extract of this mixture induced only limited adverse effects on sperm motility...
  45. pmc Thyroid function and plasma concentrations of polyhalogenated compounds in Inuit adults
    Renee Dallaire
    Public Health Research Unit, Centre Hospitalier Universitaire de Québec CHUL, 2875 boulevard Laurier Edifice Delta, Quebec, Canada
    Environ Health Perspect 117:1380-6. 2009
    ..So far, epidemiologic studies have focused on the potential effect of a small number of them, namely, polychlorinated biphenyls (PCBs) and some organochlorines (OCs), without paying attention to other important PHCs...
  46. doi Biomarkers of arsenic exposure and effects in a Canadian rural population exposed through groundwater consumption
    Louise Normandin
    1 Institut national de santé publique du Québec INSPQ, Montreal, Quebec, Canada 2 Department of Environmental and Occupational Health, Chair of Toxicological Risk Assessment and Management and Institut de recherche en santé publique, University of Montreal, Main Station, Montreal, Quebec, Canada
    J Expo Sci Environ Epidemiol 24:127-34. 2014
    ..However, this increased internal As dose was not associated with higher oxidative damage to DNA as reflected by urinary 8-OHdG levels. ..
  47. doi Evaluation of pyrethroid exposures in pregnant women from 10 Caribbean countries
    Eric Dewailly
    Laval University CHUQ Research Center, Quebec, Canada Institut national de santé publique du Québec, Canada
    Environ Int 63:201-6. 2014
    ....
  48. pmc 1,1-dichloro-2,2-bis(p-chlorophenyl)ethylene (p,p'-DDE) disrupts the estrogen-androgen balance regulating the growth of hormone-dependent breast cancer cells
    Michel Aubé
    Unite de Recherche en Sante publique, Centre de Recherche du Centre Hospitalier Universitaire de Québec CHUL, 2875 boulevard Laurier, Quebec, QC G1V 2M2, Canada
    Breast Cancer Res 10:R16. 2008
    ....
  49. ncbi Reduced seminal parameters associated with environmental DDT exposure and p,p'-DDE concentrations in men in Chiapas, Mexico: a cross-sectional study
    Christiaan De Jager
    Centre de Recherche en Biologie de la Reproduction, Departement des Sciences Animales, Universite Laval, Quebec City, Quebec, Canada
    J Androl 27:16-27. 2006
    ..J Androl. 1998;19:5). This is the first epidemiological study demonstrating effects after nonoccupational exposures to DDT. Based on these findings, the effect of DDT on male reproductive health should not be ignored...
  50. ncbi An environmentally-relevant mixture of organochlorines and its vehicle control, dimethylsulfoxide, induce ultrastructural alterations in porcine oocytes
    Céline Campagna
    Centre de Recherche en Biologie de la Reproduction, Departement des Sciences Animales, Universite Laval, Quebec, Canada
    Mol Reprod Dev 73:83-91. 2006
    ..This study is the first to demonstrate the effect of environmental contaminants on mammalian oocyte ultrastructure...
  51. ncbi Exposure to carbon monoxide during indoor karting
    Benoît Lévesque
    Institut National de Sante Publique du Quebec, Canada
    Int J Environ Health Res 15:41-4. 2005
    ..CO concentrations were monitored thereafter. The guideline of 25 ppm for 60 min was always respected...
  52. ncbi Determination of bisphenol A, triclosan and their metabolites in human urine using isotope-dilution liquid chromatography-tandem mass spectrometry
    Gilles Provencher
    Centre de Toxicologie du Quebec, Institut national de santé publique du Québec INSPQ, 945 Wolfe, Quebec, QC, Canada G1V 5B3
    J Chromatogr A 1348:97-104. 2014
    ..To our knowledge, we are the first to report levels of free, sulfated and glucuronidated TCS levels in human urine. ..
  53. doi Dietary exposure to acrylamide in adolescents from a Canadian urban center
    Louise Normandin
    Institut National de Sante Publique du Quebec, Quebec, Quebec, Canada
    Food Chem Toxicol 57:75-83. 2013
    ..Margins of exposure based on genotoxic benchmark dose limits were estimated to be low (≈<100) in high-consumer adolescents, indicating the need to continue efforts to reduce dietary acrylamide exposure...
  54. doi Profiling of endogenous estrogens, their precursors, and metabolites in endometrial cancer patients: association with risk and relationship to clinical characteristics
    Etienne Audet-Walsh
    Centre Hospitalier Universitaire de Quebec Research Center, Laval Universiy, Quebec, Canada
    J Clin Endocrinol Metab 96:E330-9. 2011
    ..Endometrial cancer (EC) predominantly occurs after menopause and is strongly related to steroid hormones, particularly estrogens. However, the relationship between these hormones and clinical characteristics remains unaddressed...
  55. ncbi Cancer risk associated with household exposure to chloroform
    Benoît Lévesque
    Unite de Recherche en Sante publique, Centre Hospitalier Universitaire de Quebec, Beauport, Canada
    J Toxicol Environ Health A 65:489-502. 2002
    ..Data indicate that for this range of exposure the safety margin appears therefore considerable with respect to the potential carcinogenic effect of household exposure to CHCl3...
  56. pmc Comparison of polychlorinated biphenyl levels across studies of human neurodevelopment
    Matthew P Longnecker
    Epidemiology Branch, National Institute of Environmental Health Sciences, Research Triangle Park, North Carolina 27709, USA
    Environ Health Perspect 111:65-70. 2003
    ..S. studies or recent Dutch, German, and northern Québec studies. Our results will facilitate a direct comparison of the findings on PCBs and neurodevelopment when they are published for all 10 studies...
  57. pmc Pentachlorophenol and hydroxylated polychlorinated biphenyl metabolites in umbilical cord plasma of neonates from coastal populations in Québec
    Courtney D Sandau
    Centre for Analytical and Environmental Chemistry, Department of Chemistry, Carleton University, Ottawa, Ontario, Canada
    Environ Health Perspect 110:411-7. 2002
    ..Further studies are needed to examine the effects of chlorinated phenolic compounds on thyroid hormone status in newborns...
  58. ncbi Exposure of a Cree population living near mine tailings in northern Quebec (Canada) to metals and metalloids
    Dominique Bussières
    Institut National de Sante Publique du Quebec, Canada
    Arch Environ Health 59:732-41. 2004
    ..43). Blood cadmium increased with age and smoking (R2 = 0.61). No influence of mine residues was observed among residents of Oujé-Bougoumou, but lifestyle exposure associations were noted for both communities...
  59. doi Beneficial effects of a polyunsaturated fatty acid on infant development: evidence from the inuit of arctic Quebec
    Joseph L Jacobson
    Department of Psychiatry and Behavioral Neurosciences, Wayne State University School of Medicine, Detroit, Michigan, USA
    J Pediatr 152:356-64. 2008
    ....
  60. ncbi Cord blood lymphocyte functions in newborns from a remote maritime population exposed to organochlorines and methylmercury
    Marthe Belles-Isles
    Unité de recherche en rhumatologie immunologie, Centre Hospitalier Universitaire de Québec CHUL, Ste Foy, Canada
    J Toxicol Environ Health A 65:165-82. 2002
    ..Epidemiological studies are needed to determine the relevance of these alterations in predicting detrimental health effects in the developing child...
  61. ncbi Nonoccupational determinants of plasma DDT and p,p'-DDE in men from Chiapas, Mexico
    Albino Barraza-Villarreal
    Center for Population Health Research, National Institute of Public Health, Cuernavaca, Morelos, Mexico
    Arch Environ Health 59:42-9. 2004
    ..High levels of chlorinated pesticides were found despite being banned in Mexico for agricultural and public health use. Findings demonstrate the role of antimalarial campaigns as a major contributing factor for high DDT plasma levels...
  62. ncbi Alterations of visual evoked potentials in preschool Inuit children exposed to methylmercury and polychlorinated biphenyls from a marine diet
    Dave Saint-Amour
    Departement d Ophtalmologie, CHU Sainte Justine, 3175, Cote Sainte Catherine, Montreal, Que, Canada H3T 1C5
    Neurotoxicology 27:567-78. 2006
    ..e. at the preschool age. Our findings suggest that VEP can be used as a valuable tool to assess the developmental neurotoxicity of environmental contaminants in fish-eating populations...
  63. ncbi Plasma concentrations of polychlorinated biphenyls and the risk of breast cancer: a congener-specific analysis
    Alain Demers
    Department of Preventive Oncology and Epidemiology, CancerCare Manitoba, Winnipeg, Manitoba, Canada
    Am J Epidemiol 155:629-35. 2002
    ..Alternatively, the results may be explained by differences between cases and controls regarding metabolic pathways involved in the biotransformation of both mono-ortho PCBs and estrogens...
  64. ncbi Gestational age and birth weight in relation to n-3 fatty acids among Inuit (Canada)
    Michel Lucas
    Public Health Research Unit, Laval University Medical Research Centre, Centre Hospitalier Universitaire de Quebec, Quebec G1V 5B3, Canada
    Lipids 39:617-26. 2004
    ..In this seafood-eating population, an increase in the proportion of n-3 HUFA (of the total HUFA), measured in umbilical cord plasma phospholipids, was associated with a significantly longer GA...
  65. ncbi Vitamin A concentration in umbilical cord blood of infants from three separate regions of the province of Québec (Canada)
    Frederic Dallaire
    Public Health Research Unit, Laval University Medical Center CHUL CHUQ, and Laval University, Sainte Foy, Quebec
    Can J Public Health 94:386-90. 2003
    ..This study was conducted to evaluate the prevalence of blood vitamin A deficiency in newborns from 3 distinct populations of the province of Québec...
  66. ncbi Neuromotor functions in Inuit preschool children exposed to Pb, PCBs, and Hg
    Christine Després
    Cognitive Neuroscience Center, University of Quebec at Montreal, Montreal, Quebec, C P 8888 Succ Centre Ville, Canada H3C 3P8
    Neurotoxicol Teratol 27:245-57. 2005
    ..Tremor amplitude was related to blood Hg concentrations at testing time, which corroborate an effect already reported among adults...
  67. ncbi Neonatal vitamin A deficiency and its impact on acute respiratory infections among preschool Inuit children
    Cynthia Cameron
    Public Health Research Unit, Laval University Medical Center CHUL, Quebec City, Quebec
    Can J Public Health 99:102-6. 2008
    ..To assess if vitamin A concentration in umbilical cord blood is associated with incidence and severity of respiratory infections in preschool Inuit children from Nunavik (Québec, Canada)...
  68. ncbi An environmentally relevant organochlorine mixture impairs sperm function and embryo development in the porcine model
    Céline Campagna
    Centre de Recherche en Biologie de la Reproduction, Departement de sciences animales, Departement de Medecine sociale et preventive, Pavilion Paul Comtois, Universite Laval, Sainte Foy, Quebec, Canada G1K 7P4
    Biol Reprod 67:80-7. 2002
    ....