Research Topics
Species | Pierre AyotteSummaryCountry: Canada Publications
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Publications
Relation between methylmercury exposure and plasma paraoxonase activity in inuit adults from NunavikPierre Ayotte
Axe de recherche en santé des populations et environnementale, Centre de Recherche du Centre Hospitalier Universitaire de Québec, Quebec, QC, Canada
Environ Health Perspect 119:1077-83. 2011..Objectives: This study was conducted to determine whether blood mercury levels are linked to decreased plasma PON1 activities in Inuit people who are highly exposed to MeHg through their seafood-based diet...- Assessment of pre- and postnatal exposure to polychlorinated biphenyls: lessons from the Inuit Cohort StudyPierre Ayotte
Department of Social and Preventive Medicine, Laval University and Public Health Research Unit, CHUQ Laval University Medical Centre, Quebec, Quebec, Canada
Environ Health Perspect 111:1253-8. 2003.... 
Prenatal exposure to methylmercury and PCBs affects distinct stages of information processing: an event-related potential study with Inuit childrenOlivier Boucher
Ecole de Psychologie, Universite Laval, Quebec, Canada
Neurotoxicology 31:373-84. 2010..These effects seem to be mitigated in children who are breast-fed for a more extended period...- Response inhibition and error monitoring during a visual go/no-go task in inuit children exposed to lead, polychlorinated biphenyls, and methylmercuryOlivier Boucher
Centre de Recherche du Centre Hospitalier Universitaire de Québec, Quebec, Canada
Environ Health Perspect 120:608-15. 2012..Lead (Pb) and polychlorinated biphenyls (PCBs) are neurotoxic contaminants that have been related to impairment in response inhibition... - Effect of prenatal exposure to polychlorinated biphenyls on incidence of acute respiratory infections in preschool Inuit childrenFrederic Dallaire
Public Health Research Unit, Laval University Medical Center Centre Hospitalier Universitaire de Québec, Quebec City, Quebec, Canada
Environ Health Perspect 114:1301-5. 2006..We set out to assess whether environmental prenatal exposure to polychlorinated biphenyls (PCBs) is associated with incidence of acute respiratory infections in preschool Inuit children... - Acute infections and environmental exposure to organochlorines in Inuit infants from NunavikFrederic Dallaire
Department of Social and Preventive Medicine, Laval University, and Public Health Research Unit, CHUQ Laval University Medical Center, 945 Wolfe Street, Sainte Foy, Quebec G1V 5B3, Canada
Environ Health Perspect 112:1359-65. 2004..05). No association was found when postnatal exposure was considered. These results show a possible association between prenatal exposure to OCs and acute infections early in life in this Inuit population... - Neurophysiologic and neurobehavioral evidence of beneficial effects of prenatal omega-3 fatty acid intake on memory function at school ageOlivier Boucher
Universite Laval, Quebec, Canada
Am J Clin Nutr 93:1025-37. 2011..However, few studies have examined the extent to which these benefits continue to be evident in childhood... - Time trends of persistent organic pollutants and heavy metals in umbilical cord blood of Inuit infants born in Nunavik (Québec, Canada) between 1994 and 2001Frederic Dallaire
Public Health Research Unit, Laval University Medical Center CHUL CHUQ, and Laval University, Quebec City, Quebec, Canada
Environ Health Perspect 111:1660-4. 2003..The decreases observed could be explained by a decrease in food contamination, by changes in dietary habits, or, most likely, by a combination of both... - Thyroid hormone levels of pregnant inuit women and their infants exposed to environmental contaminantsRenee Dallaire
Public Health Research Unit, Centre Hospitalier Universitaire de Québec CHUL, Quebec City, Quebec, Canada
Environ Health Perspect 117:1014-20. 2009..Prenatal exposure to some of them, such as polychlorinated biphenyls (PCBs), has also been associated with adverse neurodevelopmental effects in infants... - Re-evaluation of blood mercury, lead and cadmium concentrations in the Inuit population of Nunavik (Québec): a cross-sectional studyJulie Fontaine
Unite de Recherche en Sante publique, Centre de Recherche du CHUL CHUQ, 2875 boul, Laurier, bureau 600, Québec Québec, G1V 2M2, Canada
Environ Health 7:25. 2008.... 
Determinants of plasma concentrations of perfluorooctanesulfonate and brominated organic compounds in Nunavik Inuit adults (Canada)Renee Dallaire
Public Health Research Unit, Centre Hospitalier Universitaire de Québec CHUL, Quebec, Quebec, Canada
Environ Sci Technol 43:5130-6. 2009..In conclusion, we found that the remote geographical location and traditional lifestyle of the Nunavik Inuit population do not protect them against exposure to emerging POPs, particularly PFOS...- Effects of prenatal exposure to organochlorines on thyroid hormone status in newborns from two remote coastal regions in Québec, CanadaRenee Dallaire
Public Health Research Unit, Laval University Medical Research Centre Centre Hospitalier, Universitaire de Quebec, Quebec City, Quebec, Canada
Environ Res 108:387-92. 2008..One of the mechanisms by which PCBs might interfere with neurodevelopment is a deficit in thyroid hormone (TH) concentrations... - Effects of perfluorooctanesulfonate exposure on plasma lipid levels in the Inuit population of Nunavik (Northern Quebec)Marie Ludivine Chateau-Degat
Axe santé des populations et environnementale, Research center of the Centre hospitalier universitaire de Québec and Université Laval, Quebec, QC, Canada G1V 2M2
Environ Res 110:710-7. 2010..The Inuit of Nunavik are exposed to environmental contaminants through the consumption of fish and game. This diet is also a source of omega3-polyunsaturated fatty acids (n-3 PUFAs) that are known to lower plasma triacylglycerols... - The relation of lead neurotoxicity to the event-related potential P3b component in Inuit children from arctic QuébecOlivier Boucher
Ecole de Psychologie, Universite Laval, Quebec, Canada
Neurotoxicology 30:1070-7. 2009..This study strengthens the arguments for reducing sources of Pb exposure in Nunavik and for lowering the blood Pb concentrations considered "acceptable" in governmental policies... - Traditional food consumption is associated with higher nutrient intakes in Inuit children attending childcare centres in NunavikDoris Gagné
Groupe d études en nutrition publique, Département des sciences des aliments et de nutrition, Universite Laval, Quebec, Canada
Int J Circumpolar Health 71:18401. 2012..To describe traditional food (TF) consumption and to evaluate its impact on nutrient intakes of preschool Inuit children from Nunavik... - Exposure to toxic metals and persistent organic pollutants in Inuit children attending childcare centers in Nunavik, CanadaHuguette Turgeon O'Brien
Groupe d études en nutrition publique, Département des sciences des aliments et de nutrition, Universite Laval, Quebec, Quebec, Canada
Environ Sci Technol 46:4614-23. 2012..S. cities. PFOS were present in lower concentrations than in Nunavimmiut adults. There is a clear need for continued biomonitoring of blood contaminant levels in this population, particularly for PBDEs and PFASs... - Effect of an environmentally relevant metabolized organochlorine mixture on porcine cumulus-oocyte complexesCéline Campagna
Centre de Recherche en Biologie de la Reproduction, Departement des Sciences Animales, Pavillon Paul Comtois, Universite Laval, Ste Foy, Quebec, Canada
Reprod Toxicol 23:145-52. 2007..This study also indicates that organochlorine metabolites similar in concentrations to levels found in Arctic populations can affect growing cumulus-oocyte complexes without inducing an overt toxicological response... - An environmentally relevant mixture of organochlorines, their metabolites and effects on preimplantation development of porcine embryosCéline Campagna
Centre de Recherche en Biologie de la Reproduction, Departement des Sciences Animales, Pavillon Paul Comtois, Universite Laval, Ste Foy, Quebec, QC, Canada G1V 0A6
Reprod Toxicol 25:361-6. 2008.... - Plasma organochlorine concentrations and bone ultrasound measurements: a cross-sectional study in peri-and postmenopausal Inuit women from GreenlandSuzanne Côté
Unite de Recherche en Sante publique, Centre de Recherche du CHUL CHUQ, Quebec, QC, G1V 5B3, Canada
Environ Health 5:33. 2006..We hypothesized that this exposure might be related to bone characteristics that are altered in osteoporosis, because hormone deficiency is a known risk factor for the disease... - Portrait of outpatient visits and hospitalizations for acute infections in Nunavik preschool childrenFrederic Dallaire
Department of Social and Preventive Medicine, Laval University, and Public Health Research Unit, CHUQ Laval University Medical Center, Quebec, Canada
Can J Public Health 97:362-8. 2006..Inuit children from around the world are burdened by a high rate of infectious diseases. The objective of this study was to evaluate the incidence rate of infections in Inuit preschool children from Nunavik (Northern Québec)... - Determinants of AhR-mediated transcriptional activity induced by plasma extracts from Nunavik Inuit adultsThierry C M Medehouenou
Axe de recherche en santé des populations et environnementale, Centre de recherche du Centre hospitalier universitaire de Québec and Université Laval, 2875 boulevard Laurier, Quebec, QC, Canada
Chemosphere 80:75-82. 2010..AhR-mediated transcriptional activity measures may prove useful in investigating possible associations between exposure to AhR agonists and adverse health effects in this indigenous population... - Temporal trends of organochlorine concentrations in umbilical cord blood of newborns from the lower north shore of the St. Lawrence river (Québec, Canada)Frederic Dallaire
Public Health Research Unit, Laval University Medical Center, and Laval University, Quebec, Canada
Environ Health Perspect 110:835-8. 2002..These results show that prenatal exposure to persistent OCs has declined significantly between 1993 and 2000 in this population... - Polychlorinated biphenyls and organochlorine pesticides in plasma of older CanadiansThierry Comlan Marc Medehouenou
Faculte de Pharmacie, Universite Laval, Quebec, Canada
Environ Res 111:1313-20. 2011..These plasma concentrations from a large population based study can be considered as baseline data for body burdens of older Canadians... - Exposure to organochlorines and mercury through fish and marine mammal consumption: associations with growth and duration of gestation among Inuit newbornsRenee Dallaire
School of Psychology, Laval University and CHUQ Research Center, Quebec, Canada
Environ Int 54:85-91. 2013.... - A physiologically based pharmacokinetic model for the assessment of infant exposure to persistent organic pollutants in epidemiologic studiesMarc André Verner
Departement des Sciences Biologiques, Centre TOXEN, Universite du Quebec a Montreal, and Centre de recherche du Hospitalier Universitaire de Québec, Montreal, Quebec, Canada
Environ Health Perspect 117:481-7. 2009..Epidemiologic studies to date have relied on the analysis of biological samples drawn pre- or post-natally for exposure assessment, an approach that might not capture some key events in the toxicokinetics of POPs... - Vitamin D receptor polymorphisms (FokI, BsmI) and breast cancer risk: association replication in two case-control studies within French Canadian populationMarc Sinotte
Unité de recherche en santé des populations, Centre Hospitalier Affilie Universitaire De Quebec, 1050 Chemin Sainte Foy, Quebec, Quebec, Canada G1S 4L8
Endocr Relat Cancer 15:975-83. 2008..They also suggest that variability in observed associations between VDR FokI and breast cancer from different studies may partly be explained by the proportion of study subjects with a family history of breast cancer... - Long-term effects of prenatal omega-3 fatty acid intake on visual function in school-age childrenCaroline Jacques
Sainte Justine University Hospital Research Center, Montreal, Quebec, Canada
J Pediatr 158:83-90, 90.e1. 2011..To assess the long-term effect on visual development of omega-3 polyunsaturated fatty acid (n-3 PUFA) intake during gestation... - Environmental exposure to polychlorinated biphenyls and placental CYP1A1 activity in Inuit women from northern QuébecDaria Pereg
, , , Ste-Foy, , Canada
Environ Health Perspect 110:607-12. 2002..We conclude that dietary exposure to PCBs in Inuit women from Nunavik does not significantly influence EROD activity in the placenta, implicating tobacco smoking as the major modulating factor... - Prenatal methylmercury, postnatal lead exposure, and evidence of attention deficit/hyperactivity disorder among Inuit children in Arctic QuébecOlivier Boucher
Centre de Recherche du Centre Hospitalier Universitaire de Québec, Quebec, Quebec, Canada
Environ Health Perspect 120:1456-61. 2012..By contrast, lead (Pb) exposure in childhood has been associated with ADHD and disruptive behaviors in several studies... - Effects of an environmentally relevant organochlorine mixture and a metabolized extract of this mixture on porcine sperm parameters in vitroCéline Campagna
Centre de Recherche en Biologie de la Reproduction, Departement des Sciences Animales, Pavillon Paul Comtois, Universite Laval, Quebec City, Quebec, Canada
J Androl 30:317-24. 2009..In contrast, short and physiologically relevant exposure to the metabolized extract of this mixture induced only limited adverse effects on sperm motility... - Thyroid function and plasma concentrations of polyhalogenated compounds in Inuit adultsRenee Dallaire
Public Health Research Unit, Centre Hospitalier Universitaire de Québec CHUL, 2875 boulevard Laurier Edifice Delta, Quebec, Canada
Environ Health Perspect 117:1380-6. 2009..So far, epidemiologic studies have focused on the potential effect of a small number of them, namely, polychlorinated biphenyls (PCBs) and some organochlorines (OCs), without paying attention to other important PHCs... - Differential effects of a complex organochlorine mixture on the proliferation of breast cancer cell linesMichel Aubé
Axe de recherche en santé des populations et environnementale, Centre de recherche du Centre hospitalier universitaire de Québec and Université Laval, 2875 boulevard Laurier, Edifice Delta 2, bureau 600, Quebec, QC, Canada
Environ Res 111:337-47. 2011..Other mixtures of contaminants that include emerging compounds of interest such as brominated flame retardants and perfluoroalkyl compounds should be tested for their capacity to induce breast cancer cell proliferation... - Plasma concentrations of selected organobromine compounds and polychlorinated biphenyls in postmenopausal women of Québec, CanadaTorkjel M Sandanger
Unite de Recherche en Sante publique, Centre Hospitalier Universitaire de Québec and Université Laval, Quebec, Quebec, Canada
Environ Health Perspect 115:1429-34. 2007..Brominated flame retardants, especially polybrominated diphenyl ethers (PBDEs), have been widely used in North America, but little is known about the level of exposure of human populations to these compounds... - Omega-3 fatty acids and risk of dementia: the Canadian Study of Health and AgingEdeltraut Kröger
Centre d Excellence sur le Vieillissement de Quebec, Unite de Recherche sur le Vieillissement, Centre de recherche FRSQ du Centre hospitalier affilié universitaire de Québec, Quebec, Canada
Am J Clin Nutr 90:184-92. 2009..Fish is the main dietary source of n-3 PUFAs and is sometimes contaminated with mercury. This neurotoxicant may modify the association with dementia... - Exposure to carbon monoxide during indoor kartingBenoît Lévesque
Institut National de Sante Publique du Quebec, Canada
Int J Environ Health Res 15:41-4. 2005..CO concentrations were monitored thereafter. The guideline of 25 ppm for 60 min was always respected... - In vitro activation of cord blood mononuclear cells and cytokine production in a remote coastal population exposed to organochlorines and methyl mercuryHouda Bilrha
Rheumatology-Immunology Research Unit, CHUQ-Laval University Medical Center, , , Canada
Environ Health Perspect 111:1952-7. 2003.... - 1,1-dichloro-2,2-bis(p-chlorophenyl)ethylene (p,p'-DDE) disrupts the estrogen-androgen balance regulating the growth of hormone-dependent breast cancer cellsMichel Aubé
Unite de Recherche en Sante publique, Centre de Recherche du Centre Hospitalier Universitaire de Québec CHUL, 2875 boulevard Laurier, Quebec, QC G1V 2M2, Canada
Breast Cancer Res 10:R16. 2008.... - Cancer risk associated with household exposure to chloroformBenoît Lévesque
Unite de Recherche en Sante publique, Centre Hospitalier Universitaire de Quebec, Beauport, Canada
J Toxicol Environ Health A 65:489-502. 2002..Data indicate that for this range of exposure the safety margin appears therefore considerable with respect to the potential carcinogenic effect of household exposure to CHCl3... - Biomarker measurements in a coastal fish-eating population environmentally exposed to organochlorinesPierre Ayotte
, , , , Canada
Environ Health Perspect 113:1318-24. 2005..Our data are consistent with smoking-induced liver CYP1A2 activity altering heme metabolism and increasing the biotransformation of mono-ortho PCB congeners... - An environmentally-relevant mixture of organochlorines and its vehicle control, dimethylsulfoxide, induce ultrastructural alterations in porcine oocytesCéline Campagna
Centre de Recherche en Biologie de la Reproduction, Departement des Sciences Animales, Universite Laval, Quebec, Canada
Mol Reprod Dev 73:83-91. 2006..This study is the first to demonstrate the effect of environmental contaminants on mammalian oocyte ultrastructure... - Profiling of endogenous estrogens, their precursors, and metabolites in endometrial cancer patients: association with risk and relationship to clinical characteristicsEtienne Audet-Walsh
Centre Hospitalier Universitaire de Quebec Research Center, Laval Universiy, Quebec, Canada
J Clin Endocrinol Metab 96:E330-9. 2011..Endometrial cancer (EC) predominantly occurs after menopause and is strongly related to steroid hormones, particularly estrogens. However, the relationship between these hormones and clinical characteristics remains unaddressed... - Reduced seminal parameters associated with environmental DDT exposure and p,p'-DDE concentrations in men in Chiapas, Mexico: a cross-sectional studyChristiaan De Jager
Centre de Recherche en Biologie de la Reproduction, , , , , Canada
J Androl 27:16-27. 2006..J Androl. 1998;19:5). This is the first epidemiological study demonstrating effects after nonoccupational exposures to DDT. Based on these findings, the effect of DDT on male reproductive health should not be ignored... - Pentachlorophenol and hydroxylated polychlorinated biphenyl metabolites in umbilical cord plasma of neonates from coastal populations in QuébecCourtney D Sandau
Centre for Analytical and Environmental Chemistry, Department of Chemistry, Carleton University, Ottawa, Ontario, Canada
Environ Health Perspect 110:411-7. 2002..Further studies are needed to examine the effects of chlorinated phenolic compounds on thyroid hormone status in newborns... - Comparison of polychlorinated biphenyl levels across studies of human neurodevelopmentMatthew P Longnecker
Epidemiology Branch, National Institute of Environmental Health Sciences, Research Triangle Park, North Carolina 27709, USA
Environ Health Perspect 111:65-70. 2003..S. studies or recent Dutch, German, and northern Québec studies. Our results will facilitate a direct comparison of the findings on PCBs and neurodevelopment when they are published for all 10 studies... - Cord blood lymphocyte functions in newborns from a remote maritime population exposed to organochlorines and methylmercuryMarthe Belles-Isles
, Centre hospitalier universitaire de Quebec-CHUL, Ste-Foy, Canada
J Toxicol Environ Health A 65:165-82. 2002..Epidemiological studies are needed to determine the relevance of these alterations in predicting detrimental health effects in the developing child... - Exposure of a Cree population living near mine tailings in northern Quebec (Canada) to metals and metalloidsDominique Bussières
Institut National de Sante Publique du Quebec, Canada
Arch Environ Health 59:732-41. 2004..43). Blood cadmium increased with age and smoking (R2 = 0.61). No influence of mine residues was observed among residents of Oujé-Bougoumou, but lifestyle exposure associations were noted for both communities... - Beneficial effects of a polyunsaturated fatty acid on infant development: evidence from the inuit of arctic QuebecJoseph L Jacobson
Department of Psychiatry and Behavioral Neurosciences, Wayne State University School of Medicine, Detroit, Michigan, USA
J Pediatr 152:356-64. 2008.... - Neuromotor functions in Inuit preschool children exposed to Pb, PCBs, and HgChristine Després
Cognitive Neuroscience Center, University of Quebec at Montreal, Montreal, Quebec, C P 8888 Succ Centre Ville, Canada H3C 3P8
Neurotoxicol Teratol 27:245-57. 2005..Tremor amplitude was related to blood Hg concentrations at testing time, which corroborate an effect already reported among adults... - Plasma concentrations of polychlorinated biphenyls and the risk of breast cancer: a congener-specific analysisAlain Demers
Department of Preventive Oncology and Epidemiology, CancerCare Manitoba, Winnipeg, Manitoba, Canada
Am J Epidemiol 155:629-35. 2002..Alternatively, the results may be explained by differences between cases and controls regarding metabolic pathways involved in the biotransformation of both mono-ortho PCBs and estrogens... - Neonatal vitamin A deficiency and its impact on acute respiratory infections among preschool Inuit childrenCynthia Cameron
Public Health Research Unit, Laval University Medical Center CHUL, Quebec City, Quebec
Can J Public Health 99:102-6. 2008..To assess if vitamin A concentration in umbilical cord blood is associated with incidence and severity of respiratory infections in preschool Inuit children from Nunavik (Québec, Canada)... - An environmentally relevant organochlorine mixture impairs sperm function and embryo development in the porcine modelCéline Campagna
Centre de Recherche en Biologie de la Reproduction, Departement de sciences animales, Departement de Medecine sociale et preventive, Pavilion Paul Comtois, Universite Laval, Sainte Foy, Quebec, Canada G1K 7P4
Biol Reprod 67:80-7. 2002.... - Vitamin A concentration in umbilical cord blood of infants from three separate regions of the province of Québec (Canada)Frederic Dallaire
Public Health Research Unit, Laval University Medical Center CHUL CHUQ, and Laval University, Sainte Foy, Quebec
Can J Public Health 94:386-90. 2003..This study was conducted to evaluate the prevalence of blood vitamin A deficiency in newborns from 3 distinct populations of the province of Québec... - Effects of gestational and lactational exposure to organochlorine compounds on cellular, humoral, and innate immunity in swineHouda Bilrha
, Centre de Recherche du CHUL-CHUQ, , QC, Canada G1V 4G2
Toxicol Sci 77:41-50. 2004..Furthermore, the high dose decreased the antibody response to Mycoplasma hyopneumoniae. Our results indicate that developmental exposure to an environmentally relevant OC mixture alters the immune function in swine... - Gestational age and birth weight in relation to n-3 fatty acids among Inuit (Canada)Michel Lucas
Public Health Research Unit, Laval University Medical Research Centre, , , Canada
Lipids 39:617-26. 2004..In this seafood-eating population, an increase in the proportion of n-3 HUFA (of the total HUFA), measured in umbilical cord plasma phospholipids, was associated with a significantly longer GA... - Nonoccupational determinants of plasma DDT and p,p'-DDE in men from Chiapas, MexicoAlbino Barraza-Villarreal
Center for Population Health Research, National Institute of Public Health, Cuernavaca, Morelos, Mexico
Arch Environ Health 59:42-9. 2004..High levels of chlorinated pesticides were found despite being banned in Mexico for agricultural and public health use. Findings demonstrate the role of antimalarial campaigns as a major contributing factor for high DDT plasma levels... - Alterations of visual evoked potentials in preschool Inuit children exposed to methylmercury and polychlorinated biphenyls from a marine dietDave Saint-Amour
, CHU Sainte-Justine, 3175, , , Que, Canada H3T 1C5
Neurotoxicology 27:567-78. 2006..e. at the preschool age. Our findings suggest that VEP can be used as a valuable tool to assess the developmental neurotoxicity of environmental contaminants in fish-eating populations...