Philip Awadalla

Summary

Country: Canada

Publications

  1. ncbi High recombination rates and hotspots in a Plasmodium falciparum genetic cross
    Hongying Jiang
    Laboratory of Malaria and Vector Research, National Institute of Allergy and Infectious Diseases, National Institutes of Health, 9000 Rockville Pike, Bethesda, MD 20892, USA
    Genome Biol 12:R33. 2011
  2. ncbi Selection shapes malaria genomes and drives divergence between pathogens infecting hominids versus rodents
    Franck Prugnolle
    Laboratoire GEMI, UMR 2724 CNRS IRD, 911 Avenue Agropolis, BP 64501, 34394 Montpellier Cedex 5, France
    BMC Evol Biol 8:223. 2008
  3. ncbi Direct measure of the de novo mutation rate in autism and schizophrenia cohorts
    Philip Awadalla
    Department of Pediatrics, Universite de Montreal, Quebec, Canada
    Am J Hum Genet 87:316-24. 2010
  4. ncbi A population genetic approach to mapping neurological disorder genes using deep resequencing
    Rachel A Myers
    Department of Pediatrics, University of Montreal, Montreal, Canada
    PLoS Genet 7:e1001318. 2011
  5. ncbi De novo mutations in the gene encoding the synaptic scaffolding protein SHANK3 in patients ascertained for schizophrenia
    Julie Gauthier
    Department of Medicine, Centre of Excellence in Neuromics of Université de Montréal, Centre Hospitalier de L Universite de Montreal Research Center, Universite de Montreal, Montreal, QC H2L 2W5, Canada
    Proc Natl Acad Sci U S A 107:7863-8. 2010
  6. ncbi Next-generation sequencing approaches for genetic mapping of complex diseases
    Ferran Casals
    Centre de Recherche du Centre Hospitalier Universitaire Sainte Justine, Universite de Montreal, Montreal, Quebec, Canada
    J Neuroimmunol 248:10-22. 2012

Collaborators

Detail Information

Publications6

  1. ncbi High recombination rates and hotspots in a Plasmodium falciparum genetic cross
    Hongying Jiang
    Laboratory of Malaria and Vector Research, National Institute of Allergy and Infectious Diseases, National Institutes of Health, 9000 Rockville Pike, Bethesda, MD 20892, USA
    Genome Biol 12:R33. 2011
    ..A better understanding of these mechanisms may provide important information for studying parasite evolution, immune evasion and drug resistance...
  2. ncbi Selection shapes malaria genomes and drives divergence between pathogens infecting hominids versus rodents
    Franck Prugnolle
    Laboratoire GEMI, UMR 2724 CNRS IRD, 911 Avenue Agropolis, BP 64501, 34394 Montpellier Cedex 5, France
    BMC Evol Biol 8:223. 2008
    ..reichenowi) versus parasites infecting rodent hosts (P. yoelii yoelii, P. berghei, and P. chabaudi). Adaptation by the parasite to its host is likely highly critical to the evolution of these species...
  3. ncbi Direct measure of the de novo mutation rate in autism and schizophrenia cohorts
    Philip Awadalla
    Department of Pediatrics, Universite de Montreal, Quebec, Canada
    Am J Hum Genet 87:316-24. 2010
    ..Our results emphasize the importance of DNMs as genetic mechanisms in ASD and SCZ and the limitations of using DNA from archived cell lines to identify functional variants...
  4. ncbi A population genetic approach to mapping neurological disorder genes using deep resequencing
    Rachel A Myers
    Department of Pediatrics, University of Montreal, Montreal, Canada
    PLoS Genet 7:e1001318. 2011
    ..Additionally, our findings support the hypothesis that rare mutations account for a proportion of the phenotypic variance of these complex disorders...
  5. ncbi De novo mutations in the gene encoding the synaptic scaffolding protein SHANK3 in patients ascertained for schizophrenia
    Julie Gauthier
    Department of Medicine, Centre of Excellence in Neuromics of Université de Montréal, Centre Hospitalier de L Universite de Montreal Research Center, Universite de Montreal, Montreal, QC H2L 2W5, Canada
    Proc Natl Acad Sci U S A 107:7863-8. 2010
    ..As mutations in SHANK3 were previously reported in autism, the occurrence of SHANK3 mutations in subjects with a schizophrenia phenotype suggests a molecular genetic link between these two neurodevelopmental disorders...
  6. ncbi Next-generation sequencing approaches for genetic mapping of complex diseases
    Ferran Casals
    Centre de Recherche du Centre Hospitalier Universitaire Sainte Justine, Universite de Montreal, Montreal, Quebec, Canada
    J Neuroimmunol 248:10-22. 2012
    ..In this review we present the main next-generation sequencing technologies, with their major contributions and possible applications to the study of the genetic etiology of complex diseases...