John C Cambier

Summary

Publications

  1. pmc Cellular reactive oxygen species inhibit MPYS induction of IFNβ
    Lei Jin
    Integrated Department of Immunology, University of Colorado Denver School of Medicine and National Jewish Health, Denver, Colorado, United States of America
    PLoS ONE 5:e15142. 2010
  2. pmc Identification and characterization of a loss-of-function human MPYS variant
    L Jin
    Integrated Department of Immunology, University of Colorado Denver School of Medicine and National Jewish Health, Denver, CO 80206 2762, USA
    Genes Immun 12:263-9. 2011
  3. pmc Autoimmunity risk alleles: hotspots in B cell regulatory signaling pathways
    John C Cambier
    Integrated Department of Immunology, University of Colorado School of Medicine and National Jewish Health, Denver, Colorado, USA
    J Clin Invest 123:1928-31. 2013
  4. pmc STING/MPYS mediates host defense against Listeria monocytogenes infection by regulating Ly6C(hi) monocyte migration
    Lei Jin
    Integrated Department of Immunology, University of Colorado Denver School of Medicine and National Jewish Health, Denver, CO 80206, USA
    J Immunol 190:2835-43. 2013
  5. pmc The inositol 5-phosphatase SHIP-1 and adaptors Dok-1 and 2 play central roles in CD4-mediated inhibitory signaling
    Paul M Waterman
    Integrated Department of Immunology, University of Colorado School of Medicine and National Jewish Health, Denver, CO 80206, United States
    Immunol Lett 143:122-30. 2012
  6. pmc MPYS is required for IFN response factor 3 activation and type I IFN production in the response of cultured phagocytes to bacterial second messengers cyclic-di-AMP and cyclic-di-GMP
    Lei Jin
    Integrated Department of Immunology, University of Colorado Denver School of Medicine, Denver, CO 80206, USA
    J Immunol 187:2595-601. 2011
  7. pmc VISA is required for B cell expression of TLR7
    Liang Guo Xu
    Integrated Department of Immunology, University of Colorado School of Medicine, Denver, CO 80206, USA
    J Immunol 188:248-58. 2012
  8. doi B cell maintenance and function in aging
    Igor Kogut
    Integrated Department of Immunology, University of Colorado Denver School of Medicine and National Jewish Health, Denver, CO 80206, USA
    Semin Immunol 24:342-9. 2012
  9. pmc Retention of anergy and inhibition of antibody responses during acute γ herpesvirus 68 infection
    Andrew Getahun
    Integrated Department of Immunology, University of Colorado School of Medicine and National Jewish Health, Denver, CO 80206, USA
    J Immunol 189:2965-74. 2012
  10. pmc Monophosphorylation of CD79a and CD79b ITAM motifs initiates a SHIP-1 phosphatase-mediated inhibitory signaling cascade required for B cell anergy
    Shannon K O'Neill
    Integrated Department of Immunology, University of Colorado School of Medicine and National Jewish Health, Denver, CO 80206, USA
    Immunity 35:746-56. 2011

Collaborators

  • Laurel L Lenz
  • Edwin Liu
  • Linda F van Dyk
  • Lei Jin
  • Anne Laure Perraud
  • Hong Bing Shu
  • Paul M Waterman
  • Shannon K O'Neill
  • Igor Kogut
  • Andrew Getahun
  • Liang Guo Xu
  • Mia J Smith
  • Yuval Yarkoni
  • Kara Lukin
  • Erin Brandl
  • Michael P Cancro
  • Bi Cheng Zhang
  • Susanne Marschner
  • Linda J Akerlund
  • Jean L Scholz
  • Joseph M Dal Porto
  • Desiree Straign
  • Mikael Sigvardsson
  • Scott Fields
  • Robert Mansson
  • Idan Tamir
  • James Hagman
  • Kevin T Merrell
  • Stephen B Gauld
  • Valerie Rodriguez
  • Quan Zhen Li
  • Sasan Zandi
  • Lisa Guerrettaz

Detail Information

Publications17

  1. pmc Cellular reactive oxygen species inhibit MPYS induction of IFNβ
    Lei Jin
    Integrated Department of Immunology, University of Colorado Denver School of Medicine and National Jewish Health, Denver, Colorado, United States of America
    PLoS ONE 5:e15142. 2010
    ..Cys-64, -148, -292, -309 and the potential C₈₈xxC₉₁ redox motif in MPYS are indispensable for IFNβ stimulation and IRF3 activation. Thus, our results identify a novel mechanism for ROS regulation of IFNβ stimulation...
  2. pmc Identification and characterization of a loss-of-function human MPYS variant
    L Jin
    Integrated Department of Immunology, University of Colorado Denver School of Medicine and National Jewish Health, Denver, CO 80206 2762, USA
    Genes Immun 12:263-9. 2011
    ..Lastly, we find that the loss of IFNβ activity is due primarily to the R71H and R293Q SNPs in HAQ. We hypothesize that individuals carrying HAQ may exhibit heightened susceptibility to viral infection and respond poorly to DNA vaccines...
  3. pmc Autoimmunity risk alleles: hotspots in B cell regulatory signaling pathways
    John C Cambier
    Integrated Department of Immunology, University of Colorado School of Medicine and National Jewish Health, Denver, Colorado, USA
    J Clin Invest 123:1928-31. 2013
    ....
  4. pmc STING/MPYS mediates host defense against Listeria monocytogenes infection by regulating Ly6C(hi) monocyte migration
    Lei Jin
    Integrated Department of Immunology, University of Colorado Denver School of Medicine and National Jewish Health, Denver, CO 80206, USA
    J Immunol 190:2835-43. 2013
    ..Our findings reveal a novel in vivo function of MPYS that is distinct from its role in activating type I IFN production...
  5. pmc The inositol 5-phosphatase SHIP-1 and adaptors Dok-1 and 2 play central roles in CD4-mediated inhibitory signaling
    Paul M Waterman
    Integrated Department of Immunology, University of Colorado School of Medicine and National Jewish Health, Denver, CO 80206, United States
    Immunol Lett 143:122-30. 2012
    ..Our studies provide evidence for a novel mechanism by which ill-timed CD4-mediated signals activated by ligands such as HIV-1 gp120 lead to disarmament of the immune system...
  6. pmc MPYS is required for IFN response factor 3 activation and type I IFN production in the response of cultured phagocytes to bacterial second messengers cyclic-di-AMP and cyclic-di-GMP
    Lei Jin
    Integrated Department of Immunology, University of Colorado Denver School of Medicine, Denver, CO 80206, USA
    J Immunol 187:2595-601. 2011
    ..Our findings indicate that bifurcating MPYS-dependent and -independent pathways mediate sensing of cytosolic bacterial infections...
  7. pmc VISA is required for B cell expression of TLR7
    Liang Guo Xu
    Integrated Department of Immunology, University of Colorado School of Medicine, Denver, CO 80206, USA
    J Immunol 188:248-58. 2012
    ..Thus, our findings suggest an unexpected link between VISA-mediated cytosolic RLR signaling and autoimmunity...
  8. doi B cell maintenance and function in aging
    Igor Kogut
    Integrated Department of Immunology, University of Colorado Denver School of Medicine and National Jewish Health, Denver, CO 80206, USA
    Semin Immunol 24:342-9. 2012
    ....
  9. pmc Retention of anergy and inhibition of antibody responses during acute γ herpesvirus 68 infection
    Andrew Getahun
    Integrated Department of Immunology, University of Colorado School of Medicine and National Jewish Health, Denver, CO 80206, USA
    J Immunol 189:2965-74. 2012
    ..Thus, rather than promoting loss of tolerance, gammaherpesvirus 68 infection induces an immunosuppressed state, reminiscent of compensatory anti-inflammatory response syndrome...
  10. pmc Monophosphorylation of CD79a and CD79b ITAM motifs initiates a SHIP-1 phosphatase-mediated inhibitory signaling cascade required for B cell anergy
    Shannon K O'Neill
    Integrated Department of Immunology, University of Colorado School of Medicine and National Jewish Health, Denver, CO 80206, USA
    Immunity 35:746-56. 2011
    ..Thus, chronic BCR signals maintain anergy in part via ITAM monophosphorylation-directed activation of an inhibitory signaling circuit involving SHIP-1 and Dok-1...
  11. pmc MPYS, a novel membrane tetraspanner, is associated with major histocompatibility complex class II and mediates transduction of apoptotic signals
    Lei Jin
    Integrated Department of Immunology, University of Colorado School of Medicine and National Jewish Medical and Research Center, Denver, CO 80206, USA
    Mol Cell Biol 28:5014-26. 2008
    ..Finally, MHC class II-mediated cell death signaling requires MPYS-dependent activation of the extracellular signal-regulated kinase signaling pathway...
  12. pmc The conundrum of inhibitory signaling by ITAM-containing immunoreceptors: potential molecular mechanisms
    Paul M Waterman
    Integrated Department of Immunology, University of Colorado School of Medicine, Denver CO 80206, USA
    FEBS Lett 584:4878-82. 2010
    ..This new regulatory function of ITAMs has been termed ITAMi (inhibitory ITAM). Here we discuss the potential molecular mechanisms of inhibitory signaling by ITAM-containing receptors...
  13. pmc Differential STIM1 expression in T and B cell subsets suggests a role in determining antigen receptor signal amplitude
    Yuval Yarkoni
    Integrated Department of Immunology, University of Colorado School of Medicine and National Jewish Health, Denver, CO 80206, USA
    Mol Immunol 48:1851-8. 2011
    ....
  14. ncbi SMIP-016 in Action: CD37 as a Death Receptor
    Lei Jin
    Department of Immunology, University of Colorado School of Medicine and National Jewish Health Denver, Denver, CO 80206, USA
    Cancer Cell 21:597-8. 2012
    ..show that CD37 is tyrosine phosphorylated following engagement by a bivalent engineered antibody fragment that binds CD37 and activates both SHP-1-dependent apoptotic signaling and PI3K-AKT-mediated survival signaling...
  15. pmc A dose-dependent role for EBF1 in repressing non-B-cell-specific genes
    Kara Lukin
    Integrated Department of Immunology, National Jewish Health, Denver, CO 80206, USA
    Eur J Immunol 41:1787-93. 2011
    ..Together, our studies suggest that normal levels of EBF1 are critical for maintaining B-cell identity by directing repression of non-B-cell-specific genes...
  16. pmc Change you can B(cell)eive in: recent progress confirms a critical role for B cells in type 1 diabetes
    Shannon K O'Neill
    University of Colorado Denver and National Jewish Health, 1400 Jackson Street, Denver, Colorado 80206, USA
    Curr Opin Endocrinol Diabetes Obes 16:293-8. 2009
    ..Finally, we discuss the use of B cell-targeted therapies for treatment of autoimmunity...

Research Grants62

  1. MOLECULAR BIOLOGY OF B CELL TOLERANCE AND ACTIVATION
    John Cambier; Fiscal Year: 2004
    ..In addition they may lead to novel strategies for improved vaccination and immunosuppression. ..
  2. INHIBITORY RECEPTORS AND THEIR MODE OF ACTION
    John Cambier; Fiscal Year: 2004
    ..abstract_text> ..
  3. HIV GP120 DESENSITIZATION OF T CELL RECEPTOR FUNCTION
    John Cambier; Fiscal Year: 2003
    ..The studies may validate SHIP as target for discovery of therapeutic agents for AIDS. ..
  4. MOLECULAR BIOLOGY OF B CELL TOLERANCE AND ACTIVATION
    John Cambier; Fiscal Year: 1993
    ..The studies should provide important insight regarding the basis of T cell-mediated B signaling which is critical for immune defense against many potential pathogens...
  5. MOLECULAR BIOLOGY OF B CELL TOLERANCE AND ACTIVATION
    John Cambier; Fiscal Year: 2003
    ..In addition they may lead to novel strategies for improved vaccination and immunosuppression. ..
  6. INHIBITORY RECEPTORS AND THEIR MODE OF ACTION
    John Cambier; Fiscal Year: 2000
    ..abstract_text> ..
  7. IGC REGULATION OF IGE-MEDIATED BASOPHIL DEGRANULATION
    John Cambier; Fiscal Year: 2000
    ..Studies of the ability of phosphopeptides synthesized based on receptor structure to activate PTP1C and inhibit FceRI function may lead to development of new therapeutic approaches in atopic disease. ..
  8. INHIBITORY RECEPTORS AND THEIR MODE OF ACTION
    John Cambier; Fiscal Year: 2003
    ..abstract_text> ..
  9. INHIBITORY RECEPTORS AND THEIR MODE OF ACTION
    John Cambier; Fiscal Year: 2002
    ..abstract_text> ..
  10. MOLECULAR BIOLOGY OF B CELL TOLERANCE AND ACTIVATION
    John Cambier; Fiscal Year: 1991
    ..The studies should provide important insight regarding the basis of T cell-mediated B signaling which is critical for immune defense against many potential pathogens...
  11. MOLECULAR BIOLOGY OF B CELL TOLERANCE AND ACTIVATION
    John Cambier; Fiscal Year: 2001
    ..Results should provide important new insights regarding the molecular basis of immunodeficiency, autoimmunity and aging. ..
  12. HIV GP120 DESENSITIZATION OF T CELL RECEPTOR FUNCTION
    John Cambier; Fiscal Year: 2002
    ..The studies may validate SHIP as target for discovery of therapeutic agents for AIDS. ..
  13. B Cells and Autoimmunity
    John Cambier; Fiscal Year: 2009
    ..Finally, we believe that the studies proposed in retained aim are the most exciting and important scientifically, and thus will make the greatest contribution to the field. ..
  14. B Cells and Autoimmunity
    John C Cambier; Fiscal Year: 2010
    ..Finally, we believe that the studies proposed in retained aim are the most exciting and important scientifically, and thus will make the greatest contribution to the field. ..
  15. NKIP signaling and functions
    John Cambier; Fiscal Year: 2009
    ..Successful completion of these studies will provide important basis for understanding the biochemical and molecular mechanisms of NKIP action in inflammation and innate immunity against viral infection. ..
  16. MOLECULAR BIOLOGY OF B CELL TOLERANCE AND ACTIVATION
    John Cambier; Fiscal Year: 2006
    ..In addition they may lead to novel strategies for improved vaccination and immunosuppression. ..
  17. SIGNAL TRANSDUCTION IN B CELL ACTIVATION
    John Cambier; Fiscal Year: 2005
    ..They will involve genetic manipulation and a variety of biochemical and biological assays of signal transduction and cellular responses. These studies may reveal drug discovery targets for autoimmunity and immunodeficiency. ..
  18. SIGNAL TRANSDUCTION IN B CELL ACTIVATION
    John Cambier; Fiscal Year: 2000
    ..The proposed studies should contribute significantly to our understanding of the molecular basis of B lymphocyte activation, antigen processing and tolerance. ..
  19. NKIP signaling and functions
    John Cambier; Fiscal Year: 2009
    ..Successful completion of these studies will provide important basis for understanding the biochemical and molecular mechanisms of NKIP action in inflammation and innate immunity against viral infection. ..
  20. Infectious Agents and B Cell Anergy
    John C Cambier; Fiscal Year: 2011
    ..g. EBV in human and gHV68 in mouse, re-awaken anergic B cells thereby leading to autoimmunity. Results of these studies may provide new strategies for prevention, diagnosis and treatment of autoimmunity. ..
  21. SIGNAL TRANSDUCTION IN B CELL ACTIVATION
    John Cambier; Fiscal Year: 2002
    ..They will involve genetic manipulation and a variety of biochemical and biological assays of signal transduction and cellular responses. These studies may reveal drug discovery targets for autoimmunity and immunodeficiency. ..
  22. Infectious Agents and B Cell Anergy
    John C Cambier; Fiscal Year: 2010
    ..g. EBV in human and gHV68 in mouse, re-awaken anergic B cells thereby leading to autoimmunity. Results of these studies may provide new strategies for prevention, diagnosis and treatment of autoimmunity. ..
  23. SIGNAL TRANSDUCTION IN B CELL ACTIVATION
    John Cambier; Fiscal Year: 2003
    ..They will involve genetic manipulation and a variety of biochemical and biological assays of signal transduction and cellular responses. These studies may reveal drug discovery targets for autoimmunity and immunodeficiency. ..
  24. SIGNAL TRANSDUCTION IN B CELL ACTIVATION
    John Cambier; Fiscal Year: 2007
    ..These studies may reveal drug discovery targets for autoimmunity and immunodeficiency. ..
  25. NKIP signaling and functions
    John Cambier; Fiscal Year: 2007
    ..Successful completion of these studies will provide important basis for understanding the biochemical and molecular mechanisms of NKIP action in inflammation and innate immunity against viral infection. ..
  26. HIV GP120 DESENSITIZATION OF T CELL RECEPTOR FUNCTION
    John Cambier; Fiscal Year: 2004
    ..The studies may validate SHIP as target for discovery of therapeutic agents for AIDS. ..
  27. MOLECULAR BIOLOGY OF B CELL TOLERANCE AND ACTIVATION
    John Cambier; Fiscal Year: 2007
    ..In addition they may lead to novel strategies for improved vaccination and immunosuppression. ..
  28. SIGNAL TRANSDUCTION IN B CELL ACTIVATION
    John Cambier; Fiscal Year: 2004
    ..They will involve genetic manipulation and a variety of biochemical and biological assays of signal transduction and cellular responses. These studies may reveal drug discovery targets for autoimmunity and immunodeficiency. ..
  29. MOLECULAR BIOLOGY OF B CELL TOLERANCE AND ACTIVATION
    John Cambier; Fiscal Year: 2005
    ..In addition they may lead to novel strategies for improved vaccination and immunosuppression. ..
  30. MOLECULAR BIOLOGY OF B CELL TOLERANCE AND ACTIVATION
    John Cambier; Fiscal Year: 1999
    ..Results should provide important new insights regarding the molecular basis of immunodeficiency, autoimmunity and aging. ..
  31. MOLECULAR BIOLOGY OF B CELL TOLERANCE AND ACTIVATION
    John Cambier; Fiscal Year: 1990
    ..Results of these studies should contribute significantly to our understanding of the molecular basis of regulation of lymphocyte growth and differentiation...
  32. MOLECULAR BIOLOGY OF B CELL TOLERANCE AND ACTIVATION
    John Cambier; Fiscal Year: 1992
    ..The studies should provide important insight regarding the basis of T cell-mediated B signaling which is critical for immune defense against many potential pathogens...
  33. SIGNAL TRANSDUCTION IN B CELL ACTIVATION
    John Cambier; Fiscal Year: 1999
    ..The proposed studies should contribute significantly to our understanding of the molecular basis of B lymphocyte activation, antigen processing and tolerance. ..
  34. MOLECULAR BIOLOGY OF B CELL TOLERANCE AND ACTIVATION
    John Cambier; Fiscal Year: 2000
    ..Results should provide important new insights regarding the molecular basis of immunodeficiency, autoimmunity and aging. ..
  35. IGC REGULATION OF IGE-MEDIATED BASOPHIL DEGRANULATION
    John Cambier; Fiscal Year: 2001
    ..Studies of the ability of phosphopeptides synthesized based on receptor structure to activate PTP1C and inhibit FceRI function may lead to development of new therapeutic approaches in atopic disease. ..
  36. NKIP signaling and functions
    John Cambier; Fiscal Year: 2009
    ..Successful completion of these studies will provide important basis for understanding the biochemical and molecular mechanisms of NKIP action in inflammation and innate immunity against viral infection. ..
  37. IGC REGULATION OF IGE-MEDIATED BASOPHIL DEGRANULATION
    John Cambier; Fiscal Year: 1999
    ..Studies of the ability of phosphopeptides synthesized based on receptor structure to activate PTP1C and inhibit FceRI function may lead to development of new therapeutic approaches in atopic disease. ..
  38. CD45 TYROSINE PHOSPHATASE REGULATION OF SIGNALING
    John Cambier; Fiscal Year: 1993
    ..The proposed studies should provide important novel insight regarding the role of tyrosine phosphatases in signal transduction...
  39. INHIBITORY RECEPTORS AND THEIR MODE OF ACTION
    John Cambier; Fiscal Year: 2001
    ..abstract_text> ..
  40. SIGNAL TRANSDUCTION IN B CELL ACTIVATION
    John Cambier; Fiscal Year: 2001
    ..They will involve genetic manipulation and a variety of biochemical and biological assays of signal transduction and cellular responses. These studies may reveal drug discovery targets for autoimmunity and immunodeficiency. ..