Research Topics

John C Cambier

Summary

Publications

  1. pmc Autoimmunity risk alleles: hotspots in B cell regulatory signaling pathways
    John C Cambier
    Integrated Department of Immunology, University of Colorado School of Medicine and National Jewish Health, Denver, Colorado, USA
    J Clin Invest 123:1928-31. 2013

Research Grants

  1. SIGNAL TRANSDUCTION IN B CELL ACTIVATION
    John Cambier; Fiscal Year: 2005
  2. MOLECULAR BIOLOGY OF B CELL TOLERANCE AND ACTIVATION
    John Cambier; Fiscal Year: 1993
  3. Infectious Agents and B Cell Anergy
    John C Cambier; Fiscal Year: 2011
  4. MOLECULAR BIOLOGY OF B CELL TOLERANCE AND ACTIVATION
    John Cambier; Fiscal Year: 2001
  5. B Cells and Autoimmunity
    John C Cambier; Fiscal Year: 2010
  6. INHIBITORY RECEPTORS AND THEIR MODE OF ACTION
    John Cambier; Fiscal Year: 2004
  7. MOLECULAR BIOLOGY OF B CELL TOLERANCE AND ACTIVATION
    John Cambier; Fiscal Year: 2007
  8. SIGNAL TRANSDUCTION IN B CELL ACTIVATION
    John Cambier; Fiscal Year: 2000
  9. NKIP signaling and functions
    John Cambier; Fiscal Year: 2009
  10. CD45 TYROSINE PHOSPHATASE REGULATION OF SIGNALING
    John Cambier; Fiscal Year: 1993

Detail Information

Publications1

  1. pmc Autoimmunity risk alleles: hotspots in B cell regulatory signaling pathways
    John C Cambier
    Integrated Department of Immunology, University of Colorado School of Medicine and National Jewish Health, Denver, Colorado, USA
    J Clin Invest 123:1928-31. 2013
    ....

Research Grants62

  1. SIGNAL TRANSDUCTION IN B CELL ACTIVATION
    John Cambier; Fiscal Year: 2005
    ..They will involve genetic manipulation and a variety of biochemical and biological assays of signal transduction and cellular responses. These studies may reveal drug discovery targets for autoimmunity and immunodeficiency. ..
  2. MOLECULAR BIOLOGY OF B CELL TOLERANCE AND ACTIVATION
    John Cambier; Fiscal Year: 1993
    ..The studies should provide important insight regarding the basis of T cell-mediated B signaling which is critical for immune defense against many potential pathogens...
  3. Infectious Agents and B Cell Anergy
    John C Cambier; Fiscal Year: 2011
    ..g. EBV in human and gHV68 in mouse, re-awaken anergic B cells thereby leading to autoimmunity. Results of these studies may provide new strategies for prevention, diagnosis and treatment of autoimmunity. ..
  4. MOLECULAR BIOLOGY OF B CELL TOLERANCE AND ACTIVATION
    John Cambier; Fiscal Year: 2001
    ..Results should provide important new insights regarding the molecular basis of immunodeficiency, autoimmunity and aging. ..
  5. B Cells and Autoimmunity
    John C Cambier; Fiscal Year: 2010
    ..Finally, we believe that the studies proposed in retained aim are the most exciting and important scientifically, and thus will make the greatest contribution to the field. ..
  6. INHIBITORY RECEPTORS AND THEIR MODE OF ACTION
    John Cambier; Fiscal Year: 2004
    ..abstract_text> ..
  7. MOLECULAR BIOLOGY OF B CELL TOLERANCE AND ACTIVATION
    John Cambier; Fiscal Year: 2007
    ..In addition they may lead to novel strategies for improved vaccination and immunosuppression. ..
  8. SIGNAL TRANSDUCTION IN B CELL ACTIVATION
    John Cambier; Fiscal Year: 2000
    ..The proposed studies should contribute significantly to our understanding of the molecular basis of B lymphocyte activation, antigen processing and tolerance. ..
  9. NKIP signaling and functions
    John Cambier; Fiscal Year: 2009
    ..Successful completion of these studies will provide important basis for understanding the biochemical and molecular mechanisms of NKIP action in inflammation and innate immunity against viral infection. ..
  10. CD45 TYROSINE PHOSPHATASE REGULATION OF SIGNALING
    John Cambier; Fiscal Year: 1993
    ..The proposed studies should provide important novel insight regarding the role of tyrosine phosphatases in signal transduction...
  11. HIV GP120 DESENSITIZATION OF T CELL RECEPTOR FUNCTION
    John Cambier; Fiscal Year: 2004
    ..The studies may validate SHIP as target for discovery of therapeutic agents for AIDS. ..
  12. IGC REGULATION OF IGE-MEDIATED BASOPHIL DEGRANULATION
    John Cambier; Fiscal Year: 2001
    ..Studies of the ability of phosphopeptides synthesized based on receptor structure to activate PTP1C and inhibit FceRI function may lead to development of new therapeutic approaches in atopic disease. ..
  13. SIGNAL TRANSDUCTION IN B CELL ACTIVATION
    John Cambier; Fiscal Year: 2007
    ..These studies may reveal drug discovery targets for autoimmunity and immunodeficiency. ..
  14. MOLECULAR BIOLOGY OF B CELL TOLERANCE AND ACTIVATION
    John Cambier; Fiscal Year: 1990
    ..Results of these studies should contribute significantly to our understanding of the molecular basis of regulation of lymphocyte growth and differentiation...
  15. Infectious Agents and B Cell Anergy
    John C Cambier; Fiscal Year: 2010
    ..g. EBV in human and gHV68 in mouse, re-awaken anergic B cells thereby leading to autoimmunity. Results of these studies may provide new strategies for prevention, diagnosis and treatment of autoimmunity. ..