Genomes and Genes


Maria Jose Campagnole Santos



  1. Kangussu L, Guimarães P, Nadu A, Melo M, Santos R, Campagnole Santos M. Activation of angiotensin-(1-7)/Mas axis in the brain lowers blood pressure and attenuates cardiac remodeling in hypertensive transgenic (mRen2)27 rats. Neuropharmacology. 2015;97:58-66 pubmed publisher
  2. Almeida Santos A, Kangussu L, Moreira F, Santos R, Aguiar D, Campagnole Santos M. Anxiolytic- and antidepressant-like effects of angiotensin-(1-7) in hypertensive transgenic (mRen2)27 rats. Clin Sci (Lond). 2016;130:1247-55 pubmed publisher
    ..Again, Ang-(1-7) reversed this phenotype. Thus, our data showed that Ang-(1-7) can modulate anxiety- and depression-like behaviours in TGRs and warrant further investigation as a new therapy for certain psychiatric disorders. ..
  3. Magalhães G, Rodrigues Machado M, Motta Santos D, Alenina N, Bader M, Santos R, et al. Chronic allergic pulmonary inflammation is aggravated in angiotensin-(1-7) Mas receptor knockout mice. Am J Physiol Lung Cell Mol Physiol. 2016;311:L1141-L1148 pubmed publisher
    ..Our data indicate that impairment of the ANG-(1-7)/Mas receptor pathway may lead to worsening of the pathophysiological changes of asthma. ..
  4. Kangussu L, Almeida Santos A, Moreira F, Fontes M, Santos R, Aguiar D, et al. Reduced anxiety-like behavior in transgenic rats with chronically overproduction of angiotensin-(1-7): Role of the Mas receptor. Behav Brain Res. 2017;331:193-198 pubmed publisher
    ..Therefore, facilitation of the Ang-(1-7)/Mas receptor signaling may be further investigated as an additional strategy for the treatment of anxiety-related disorders. ..