Maria Jose Campagnole Santos
Kangussu L, Guimarães P, Nadu A, Melo M, Santos R, Campagnole Santos M. Activation of angiotensin-(1-7)/Mas axis in the brain lowers blood pressure and attenuates cardiac remodeling in hypertensive transgenic (mRen2)27 rats. Neuropharmacology. 2015;97:58-66 pubmed publisher
Almeida Santos A, Kangussu L, Moreira F, Santos R, Aguiar D, Campagnole Santos M. Anxiolytic- and antidepressant-like effects of angiotensin-(1-7) in hypertensive transgenic (mRen2)27 rats. Clin Sci (Lond). 2016;130:1247-55 pubmed publisher
..Again, Ang-(1-7) reversed this phenotype. Thus, our data showed that Ang-(1-7) can modulate anxiety- and depression-like behaviours in TGRs and warrant further investigation as a new therapy for certain psychiatric disorders. ..
Magalhães G, Rodrigues Machado M, Motta Santos D, Alenina N, Bader M, Santos R, et al
. Chronic allergic pulmonary inflammation is aggravated in angiotensin-(1-7) Mas receptor knockout mice. Am J Physiol Lung Cell Mol Physiol. 2016;311:L1141-L1148 pubmed publisher
..Our data indicate that impairment of the ANG-(1-7)/Mas receptor pathway may lead to worsening of the pathophysiological changes of asthma. ..
Kangussu L, Almeida Santos A, Moreira F, Fontes M, Santos R, Aguiar D, et al
. Reduced anxiety-like behavior in transgenic rats with chronically overproduction of angiotensin-(1-7): Role of the Mas receptor. Behav Brain Res. 2017;331:193-198 pubmed publisher
..Therefore, facilitation of the Ang-(1-7)/Mas receptor signaling may be further investigated as an additional strategy for the treatment of anxiety-related disorders. ..