Hyperglycemia-induced apoptosis in mouse myocardium: mitochondrial cytochrome C-mediated caspase-3 activation pathwayLu Cai
Department of Medicine, University of Louisville, Louisville, Kentucky, USA
Diabetes 51:1938-48. 2002
..Hyperglycemia-induced myocardial apoptosis is mediated, at least in part, by activation of the cytochrome c-activated caspase-3 pathway, which may be triggered by ROS derived from high levels of glucose...
- Attenuation by metallothionein of early cardiac cell death via suppression of mitochondrial oxidative stress results in a prevention of diabetic cardiomyopathy
Lu Cai
Department of Medicine, The University of Louisville, Louisville, Kentucky, USA
J Am Coll Cardiol 48:1688-97. 2006
..We aimed to test whether attenuation of early-phase cardiac cell death can prevent diabetic cardiomyopathy...
Cardiac metallothionein synthesis in streptozotocin-induced diabetic mice, and its protection against diabetes-induced cardiac injuryYe Song
Department of Medicine, University of Louisville, Louisville, KY, USA
Am J Pathol 167:17-26. 2005
..Overexpressing cardiac MT significantly protects the heart from diabetes-induced injury...
- Cardiac-specific overexpression of HIF-1{alpha} prevents deterioration of glycolytic pathway and cardiac remodeling in streptozotocin-induced diabetic mice
Wanli Xue
Departments of Medicine, University of Louisville School of Medicine, Louisville, Kentucky, USA
Am J Pathol 177:97-105. 2010
..Therefore, elevation of HIF-1alpha provides a cardiac protection from diabetic-induced impairment in glucose metabolism and angiogenesis via up-regulation of HIF-1 target genes...
- Zinc and the diabetic heart
Ye Song
Department of Medicine, University of Louisville, 511 South Floyd Street, MDR 533, KY 40202, USA
Biometals 18:325-32. 2005
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Metallothionein suppresses angiotensin II-induced nicotinamide adenine dinucleotide phosphate oxidase activation, nitrosative stress, apoptosis, and pathological remodeling in the diabetic heartGuihua Zhou
Department of Medicine, University of Louisville School of Medicine, Louisville, Kentucky, USA
J Am Coll Cardiol 52:655-66. 2008
..We evaluated metallothionein (MT)-mediated cardioprotection from angiotensin II (Ang II)-induced pathologic remodeling with and without underlying diabetes...
- Cardiac metallothionein induction plays the major role in the prevention of diabetic cardiomyopathy by zinc supplementation
Jianxun Wang
Department of Medicine, University of Louisville School of Medicine, Louisville, KY 40202, USA
Circulation 113:544-54. 2006
..CONCLUSIONS: These results suggest that the prevention of diabetic cardiomyopathy by zinc supplementation is predominantly mediated by an increase in cardiac MT...
- Interplay between Akt and p38 MAPK pathways in the regulation of renal tubular cell apoptosis associated with diabetic nephropathy
Madhavi J Rane
Department of Medicine, University of Louisville, Louisville, Kentucky 40202, USA
Am J Physiol Renal Physiol 298:F49-61. 2010
..Thus PTEN or Hsp25 could serve as potential therapeutic targets to modulate Akt activation and control p38 MAPK-mediated diabetic complications...
- Essentiality, toxicology and chelation therapy of zinc and copper
Lu Cai
Department of Medicine, The University of Louisville, 511 South Floyd Street, MDR 533, Louisville, KY 40202, USA
Curr Med Chem 12:2753-63. 2005
..In this review, we summarize the toxicity of zinc and copper and the potential treatment for zinc or copper toxicity by zinc- or copper-specific chelators as well as strategy to up-regulate metallothionein...
- Stable overexpression of human metallothionein-IIA in a heart-derived cell line confers oxidative protection
Wanli Xue
Department of Medicine, University of Louisville School of Medicine, Louisville, KY 40202, USA
Toxicol Lett 188:70-6. 2009
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- Metallothionein rescues hypoxia-inducible factor-1 transcriptional activity in cardiomyocytes under diabetic conditions
Wenke Feng
Department of Medicine, University of Louisville School of Medicine, 511 S Floyd Street, MDR532, Louisville, KY 40202, USA
Biochem Biophys Res Commun 360:286-9. 2007
..The addition of MT into the cultures of H9c2 cells relieved the HG suppression of hypoxia-induced luciferase activity. This study indicates that MT can rescue HIF-1 transcriptional activity in cardiomyocytes under diabetic conditions...
- Diabetic cardiomyopathy and its prevention by metallothionein: experimental evidence, possible mechanisms and clinical implications
Lu Cai
Department of Medicine, The University of Louisville, Louisville, KY 40202, USA
Curr Med Chem 14:2193-203. 2007
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- Inhibition of superoxide generation and associated nitrosative damage is involved in metallothionein prevention of diabetic cardiomyopathy
Lu Cai
Department of Medicine, University of Louisville School of Medicine, 511 South Floyd St, MDR 533, Louisville, KY 40202, USA
Diabetes 54:1829-37. 2005
..These results thus suggest that metallothionein prevention of diabetic cardiomyopathy is mediated, at least in part, by suppression of superoxide generation and associated nitrosative damage...
- Suppression of nitrative damage by metallothionein in diabetic heart contributes to the prevention of cardiomyopathy
Lu Cai
Department of Medicine, University of Louisville, Louisville, KY 40202, USA
Free Radic Biol Med 41:851-61. 2006
..Finally the potential for clinical enhancement of the cardiac MT expression to prevent or delay the occurrence of cardiomyopathy in diabetic patients will also be addressed...
- Diabetes enhances lipopolysaccharide-induced cardiac toxicity in the mouse model
Ye Song
Department of Medicine, University of Louisville School of Medicine, Louisville, KY, USA
Cardiovasc Toxicol 3:363-72. 2003
..These results suggest that diabetes significantly enhances endotoxin-induced cardiac toxicity, possibly through mechanisms that involve inflammatory/acute-phase cytokines...
- Role of iron deficiency and overload in the pathogenesis of diabetes and diabetic complications
Qiuju Liu
Department of Medicine, The University of Louisville, Louisville, KY, USA
Curr Med Chem 16:113-29. 2009
..In the end, the possible therapy using iron chelators for diabetes and diabetic complications will also be discussed...
- Evaluation of insulin-like growth factor-1 in a mouse model of long-term abdominal radiation toxicity
Carsten Nieder
Department of Radiation Oncology, Klinikum rechts der Isar der Technischen Universitat Munchen, Munich, Germany
Anticancer Res 27:183-7. 2007
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- Cell death and diabetic cardiomyopathy
Lu Cai
Department of Medicine, University of Louisville, Louisville, Kentucky 40292, USA
Cardiovasc Toxicol 3:219-28. 2003
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- Prevention by sulforaphane of diabetic cardiomyopathy is associated with up-regulation of Nrf2 expression and transcription activation
Yang Bai
The Cardiovascular Center, The First Hospital of Jilin University, Changchun, China
J Mol Cell Cardiol 57:82-95. 2013
..These results suggest that diabetes-induced cardiomyopathy can be prevented by SFN, which was associated with the up-regulated Nrf2 expression and transcription function...
- Deletion of angiotensin II type 1 receptor gene or scavenge of superoxide prevents chronic alcohol-induced aortic damage and remodelling
Yang Bai
The Cardiovascular Center, The First Hospital of Jilin University, Changchun, China
J Cell Mol Med 16:2530-8. 2012
..Therefore, blocking Ang II/AT1 system or scavenging superoxide may become a potential preventive and/therapeutic approach to alcoholic vascular damage...
- Elevation of serum endothelins and cardiotoxicity induced by particulate matter (PM2.5) in rats with acute myocardial infarction
Y James Kang
Department of Medicine, University of Louisville School of Medicine, KY 40292, USA
Cardiovasc Toxicol 2:253-61. 2002
..This study thus suggests that upregulation of the endothelin system in rats with MI is likely involved in the PM exposure-induced cardiotoxicity...
- Preclinical evaluation of erythropoietin administration in a model of radiation-induced kidney dysfunction
Nicolaus Andratschke
Department of Radiation Oncology, Klinikum rechts der Isar, Technical University of Munich, Munich, Germany
Int J Radiat Oncol Biol Phys 64:1513-8. 2006
..Although insulin-like growth factor-1 has previously been shown to protect the kidney, such an effect could not be demonstrated for EPO. The latter agent even increased the development of nephropathy...
- Rosiglitazone prevents advanced glycation end products-induced renal toxicity likely through suppression of plasminogen activator inhibitor-1
Xiaoyan Yu
Department of Pathology, Institute of Frontier Medical Science, Jilin University, Changchun, China
Toxicol Sci 96:346-56. 2007
..Renal protection of RGZ from AGEs may be associated with the suppression of PAI-1 expression through PPAR-dependent and independent mechanisms...
- Zinc-metallothionein protects from DNA damage induced by radiation better than glutathione and copper- or cadmium-metallothioneins
Lu Cai
Department of Pathology, University of Western Ontario, London, Ont, Canada N6A5C1
Toxicol Lett 136:193-8. 2003
..These results suggest that MT, in particular bound to zinc, is a high-capacity antioxidant to protect radiation-induced DNA damage...
- Endothelin-1-mediated alteration of metallothionein and trace metals in the liver and kidneys of chronically diabetic rats
Lu Cai
Department of Pathology, The University of Western Ontario, London, Ontario, Canada
Int J Exp Diabetes Res 3:193-8. 2002
..No significant effects of bosentan treatment on nondiabetic rats were observed. The data suggest that the possible effects of ET antagonism in diabetes may be mediated via changes in MT and trace metals...
- Zinc- or cadmium-pre-induced metallothionein protects human central nervous system cells and astrocytes from radiation-induced apoptosis
Lu Cai
Department of Pathology, University of Western Ontario London, Canada N6A 5C1
Toxicol Lett 146:217-26. 2004
..These results suggest that MT protected human CNS cells from apoptosis following ionizing radiation, probably through its antioxidant property...
- Fluvastatin prevents nephropathy likely through suppression of connective tissue growth factor-mediated extracellular matrix accumulation
Ye Song
Department of Pathology, Institute of Frontier Medical Science, Jilin University, Changchun, PR China
Exp Mol Pathol 76:66-75. 2004
..Therefore, fluvastatin may be a potential candidate for developing a pharmaceutical approach to the prevention of diabetic nephropathy due to its both lipid-lowering and direct anti-renal ECM accumulation actions...
- Alcoholic cardiomyopathy: acetaldehyde, insulin insensitization and ER stress
Lu Cai
J Mol Cell Cardiol 44:979-82. 2008
- Diabetes-induced alteration of F4/80+ macrophages: a study in mice with streptozotocin-induced diabetes for a long term
Haixia Ma
Transplantation Biology Research Division, State Key Laboratory of Biomembrane and Membrane Biotechnology, Institute of Zoology, Chinese Academy of Sciences, Datun Road, Chaoyang, Beijing 100101, China
J Mol Med (Berl) 86:391-400. 2008
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- Acceleration of diabetic wound healing with chitosan-crosslinked collagen sponge containing recombinant human acidic fibroblast growth factor in healing-impaired STZ diabetic rats
Wei Wang
The Chinese American Research Institute for Diabetic Complications, School of Pharmaceutical Sciences, Wenzhou Medical College, China
Life Sci 82:190-204. 2008
..All these results suggest that CCCS/FGF is an ideal wound-dressing to improve the recovery of healing-impaired wound such as diabetic skin wound, which provides a great potential use in clinics for diabetic patients in the future...
- High level glucose increases mutagenesis in human lymphoblastoid cells
Ying Zhang
Department of Environmental, Radiological Health Science, Colorado State University, Fort Collins, Colorado 80521, USA
Int J Biol Sci 3:375-9. 2007
..This study is the first to indicate that HG is able to induce gene mutation which may be one of the important mechanisms of diabetes-associated carcinogenesis...
- Low-dose radiation (LDR) induces hematopoietic hormesis: LDR-induced mobilization of hematopoietic progenitor cells into peripheral blood circulation
Wei Li
Department of Hematology and Oncology, First University Hospital, PR China
Exp Hematol 32:1088-96. 2004
..CONCLUSION: These results suggest that LDR induces hematopoietic hormesis, as demonstrated by HPC proliferation and peripheral mobilization, providing a potential approach to clinical application for HPC peripheral mobilization...
- Apoptotic cell death induced by low-dose radiation in male germ cells: hormesis and adaptation
Guangwei Liu
Ministry of Health Radiobiology Research Unit, School of Public Health, Jilin University, Changchun, China
Crit Rev Toxicol 37:587-605. 2007
..This review also discusses the possible effects of LDR-induced apoptotic hormesis and adaptive response on the modulation of inheritable genomic damage caused by subsequent radiation exposure to male germ cells...
- Advanced glycation end-products induce connective tissue growth factor-mediated renal fibrosis predominantly through transforming growth factor beta-independent pathway
Guihua Zhou
Department of Pathology, Jilin University, Changchun, People's Republic of China
Am J Pathol 165:2033-43. 2004
..These results suggest that AGE-induced CTGF expression, predominantly through a TGF-beta 1-independent pathway, plays a critical role in renal ECM accumulation leading to diabetic nephropathy...
- Enhanced protection of modified human acidic fibroblast growth factor with polyethylene glycol against ischemia/reperfusion-induced retinal damage in rats
Zhifeng Huang
Chinese American Research Institute for Diabetic Complications, School of Pharmaceutical Science, Wenzhou Medical College, China
Toxicol Lett 170:146-56. 2007
..The protection is probably mediated by antioxidant protective mechanisms...
- [Changes of cycle and apoptosis of spermatogenic cells and antioxidant capacity in male rats with diabetes mellitus]
Hong-Guang Zhao
MH Radiobiology Research Unit, School of Public Health, Jilin University, Changchun, Jilin 130021, China
Zhonghua Nan Ke Xue 11:735-9. 2005
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- High level expression of human endostatin in Pichia pastoris using a synthetic gene construct
Zhijian Su
School of Pharmaceutical Science, Wenzhou Medical College, Wenzhou, 325035, China
Appl Microbiol Biotechnol 73:1355-62. 2007
..pastoris using artificial synthetic gene of preference in P. pastoris was able to inhibit the acidic fibroblast growth factor-induced proliferation of endothelial cells in vitro...
- Effect of low-level radiation on the death of male germ cells
Guangwei Liu
Ministry of Health Radiobiology Research Unit, School of Public Health, Jilin University, Changchun, China 130021
Radiat Res 165:379-89. 2006
..These results suggest that low-level radiation induces increased apoptosis in male germ cells but also induces a significant adaptive response that decreases cell death after a subsequent high-dose irradiation...
- Flux through the hexosamine pathway is a determinant of nuclear factor kappaB- dependent promoter activation
Leighton R James
Department of Medicine, University of Toronto, Toronto, Ontario, Canada
Diabetes 51:1146-56. 2002
..These results suggest that increased flux through the hexosamine pathway leads to NF-kappaB-dependent promoter activation in MCs...
