Lu Cai

Summary

Publications

  1. ncbi request reprint Hyperglycemia-induced apoptosis in mouse myocardium: mitochondrial cytochrome C-mediated caspase-3 activation pathway
    Lu Cai
    Department of Medicine, University of Louisville, Louisville, Kentucky, USA
    Diabetes 51:1938-48. 2002
  2. ncbi request reprint Attenuation by metallothionein of early cardiac cell death via suppression of mitochondrial oxidative stress results in a prevention of diabetic cardiomyopathy
    Lu Cai
    Department of Medicine, The University of Louisville, Louisville, Kentucky, USA
    J Am Coll Cardiol 48:1688-97. 2006
  3. pmc Cardiac metallothionein synthesis in streptozotocin-induced diabetic mice, and its protection against diabetes-induced cardiac injury
    Ye Song
    Department of Medicine, University of Louisville, Louisville, KY, USA
    Am J Pathol 167:17-26. 2005
  4. pmc Cardiac-specific overexpression of HIF-1{alpha} prevents deterioration of glycolytic pathway and cardiac remodeling in streptozotocin-induced diabetic mice
    Wanli Xue
    Departments of Medicine, University of Louisville School of Medicine, Louisville, Kentucky, USA
    Am J Pathol 177:97-105. 2010
  5. ncbi request reprint Zinc and the diabetic heart
    Ye Song
    Department of Medicine, University of Louisville, 511 South Floyd Street, MDR 533, KY 40202, USA
    Biometals 18:325-32. 2005
  6. doi request reprint Metallothionein suppresses angiotensin II-induced nicotinamide adenine dinucleotide phosphate oxidase activation, nitrosative stress, apoptosis, and pathological remodeling in the diabetic heart
    Guihua Zhou
    Department of Medicine, University of Louisville School of Medicine, Louisville, Kentucky, USA
    J Am Coll Cardiol 52:655-66. 2008
  7. ncbi request reprint Cardiac metallothionein induction plays the major role in the prevention of diabetic cardiomyopathy by zinc supplementation
    Jianxun Wang
    Department of Medicine, University of Louisville School of Medicine, Louisville, KY 40202, USA
    Circulation 113:544-54. 2006
  8. pmc Interplay between Akt and p38 MAPK pathways in the regulation of renal tubular cell apoptosis associated with diabetic nephropathy
    Madhavi J Rane
    Department of Medicine, University of Louisville, Louisville, Kentucky 40202, USA
    Am J Physiol Renal Physiol 298:F49-61. 2010
  9. ncbi request reprint Essentiality, toxicology and chelation therapy of zinc and copper
    Lu Cai
    Department of Medicine, The University of Louisville, 511 South Floyd Street, MDR 533, Louisville, KY 40202, USA
    Curr Med Chem 12:2753-63. 2005
  10. pmc Metallothionein rescues hypoxia-inducible factor-1 transcriptional activity in cardiomyocytes under diabetic conditions
    Wenke Feng
    Department of Medicine, University of Louisville School of Medicine, 511 S Floyd Street, MDR532, Louisville, KY 40202, USA
    Biochem Biophys Res Commun 360:286-9. 2007

Collaborators

Detail Information

Publications42

  1. ncbi request reprint Hyperglycemia-induced apoptosis in mouse myocardium: mitochondrial cytochrome C-mediated caspase-3 activation pathway
    Lu Cai
    Department of Medicine, University of Louisville, Louisville, Kentucky, USA
    Diabetes 51:1938-48. 2002
    ..Hyperglycemia-induced myocardial apoptosis is mediated, at least in part, by activation of the cytochrome c-activated caspase-3 pathway, which may be triggered by ROS derived from high levels of glucose...
  2. ncbi request reprint Attenuation by metallothionein of early cardiac cell death via suppression of mitochondrial oxidative stress results in a prevention of diabetic cardiomyopathy
    Lu Cai
    Department of Medicine, The University of Louisville, Louisville, Kentucky, USA
    J Am Coll Cardiol 48:1688-97. 2006
    ..We aimed to test whether attenuation of early-phase cardiac cell death can prevent diabetic cardiomyopathy...
  3. pmc Cardiac metallothionein synthesis in streptozotocin-induced diabetic mice, and its protection against diabetes-induced cardiac injury
    Ye Song
    Department of Medicine, University of Louisville, Louisville, KY, USA
    Am J Pathol 167:17-26. 2005
    ..Overexpressing cardiac MT significantly protects the heart from diabetes-induced injury...
  4. pmc Cardiac-specific overexpression of HIF-1{alpha} prevents deterioration of glycolytic pathway and cardiac remodeling in streptozotocin-induced diabetic mice
    Wanli Xue
    Departments of Medicine, University of Louisville School of Medicine, Louisville, Kentucky, USA
    Am J Pathol 177:97-105. 2010
    ..Therefore, elevation of HIF-1alpha provides a cardiac protection from diabetic-induced impairment in glucose metabolism and angiogenesis via up-regulation of HIF-1 target genes...
  5. ncbi request reprint Zinc and the diabetic heart
    Ye Song
    Department of Medicine, University of Louisville, 511 South Floyd Street, MDR 533, KY 40202, USA
    Biometals 18:325-32. 2005
    ....
  6. doi request reprint Metallothionein suppresses angiotensin II-induced nicotinamide adenine dinucleotide phosphate oxidase activation, nitrosative stress, apoptosis, and pathological remodeling in the diabetic heart
    Guihua Zhou
    Department of Medicine, University of Louisville School of Medicine, Louisville, Kentucky, USA
    J Am Coll Cardiol 52:655-66. 2008
    ..We evaluated metallothionein (MT)-mediated cardioprotection from angiotensin II (Ang II)-induced pathologic remodeling with and without underlying diabetes...
  7. ncbi request reprint Cardiac metallothionein induction plays the major role in the prevention of diabetic cardiomyopathy by zinc supplementation
    Jianxun Wang
    Department of Medicine, University of Louisville School of Medicine, Louisville, KY 40202, USA
    Circulation 113:544-54. 2006
    ..The present study therefore explored whether zinc supplementation can protect against diabetic cardiomyopathy through cardiac MT induction...
  8. pmc Interplay between Akt and p38 MAPK pathways in the regulation of renal tubular cell apoptosis associated with diabetic nephropathy
    Madhavi J Rane
    Department of Medicine, University of Louisville, Louisville, Kentucky 40202, USA
    Am J Physiol Renal Physiol 298:F49-61. 2010
    ..Thus PTEN or Hsp25 could serve as potential therapeutic targets to modulate Akt activation and control p38 MAPK-mediated diabetic complications...
  9. ncbi request reprint Essentiality, toxicology and chelation therapy of zinc and copper
    Lu Cai
    Department of Medicine, The University of Louisville, 511 South Floyd Street, MDR 533, Louisville, KY 40202, USA
    Curr Med Chem 12:2753-63. 2005
    ..In this review, we summarize the toxicity of zinc and copper and the potential treatment for zinc or copper toxicity by zinc- or copper-specific chelators as well as strategy to up-regulate metallothionein...
  10. pmc Metallothionein rescues hypoxia-inducible factor-1 transcriptional activity in cardiomyocytes under diabetic conditions
    Wenke Feng
    Department of Medicine, University of Louisville School of Medicine, 511 S Floyd Street, MDR532, Louisville, KY 40202, USA
    Biochem Biophys Res Commun 360:286-9. 2007
    ..The addition of MT into the cultures of H9c2 cells relieved the HG suppression of hypoxia-induced luciferase activity. This study indicates that MT can rescue HIF-1 transcriptional activity in cardiomyocytes under diabetic conditions...
  11. doi request reprint Stable overexpression of human metallothionein-IIA in a heart-derived cell line confers oxidative protection
    Wanli Xue
    Department of Medicine, University of Louisville School of Medicine, Louisville, KY 40202, USA
    Toxicol Lett 188:70-6. 2009
    ....
  12. ncbi request reprint Diabetic cardiomyopathy and its prevention by metallothionein: experimental evidence, possible mechanisms and clinical implications
    Lu Cai
    Department of Medicine, The University of Louisville, Louisville, KY 40202, USA
    Curr Med Chem 14:2193-203. 2007
    ....
  13. ncbi request reprint Inhibition of superoxide generation and associated nitrosative damage is involved in metallothionein prevention of diabetic cardiomyopathy
    Lu Cai
    Department of Medicine, University of Louisville School of Medicine, 511 South Floyd St, MDR 533, Louisville, KY 40202, USA
    Diabetes 54:1829-37. 2005
    ..These results thus suggest that metallothionein prevention of diabetic cardiomyopathy is mediated, at least in part, by suppression of superoxide generation and associated nitrosative damage...
  14. ncbi request reprint Suppression of nitrative damage by metallothionein in diabetic heart contributes to the prevention of cardiomyopathy
    Lu Cai
    Department of Medicine, University of Louisville, Louisville, KY 40202, USA
    Free Radic Biol Med 41:851-61. 2006
    ..Finally the potential for clinical enhancement of the cardiac MT expression to prevent or delay the occurrence of cardiomyopathy in diabetic patients will also be addressed...
  15. ncbi request reprint Role of iron deficiency and overload in the pathogenesis of diabetes and diabetic complications
    Qiuju Liu
    Department of Medicine, The University of Louisville, Louisville, KY, USA
    Curr Med Chem 16:113-29. 2009
    ..In the end, the possible therapy using iron chelators for diabetes and diabetic complications will also be discussed...
  16. ncbi request reprint Diabetes enhances lipopolysaccharide-induced cardiac toxicity in the mouse model
    Ye Song
    Department of Medicine, University of Louisville School of Medicine, Louisville, KY, USA
    Cardiovasc Toxicol 3:363-72. 2003
    ..These results suggest that diabetes significantly enhances endotoxin-induced cardiac toxicity, possibly through mechanisms that involve inflammatory/acute-phase cytokines...
  17. ncbi request reprint Evaluation of insulin-like growth factor-1 in a mouse model of long-term abdominal radiation toxicity
    Carsten Nieder
    Department of Radiation Oncology, Klinikum rechts der Isar der Technischen Universitat Munchen, Munich, Germany
    Anticancer Res 27:183-7. 2007
    ....
  18. doi request reprint Roles of microRNAs in pressure overload- and ischemia-related myocardial remodeling
    Shanshan Zhou
    The Cardiovascular Center, The First Hospital of Jilin University, Changchun, China Kosair Children s Hospital Research Institute, Department of Pediatrics, University of Louisville, Louisville, KY, USA
    Life Sci 93:855-62. 2013
    ..This review provides an overview of several miRNAs' impacts in pressure-overload and ischemia-induced cardiac remodeling and HF. ..
  19. pmc Associations between structural and functional changes to the kidney in diabetic humans and mice
    David W Powell
    Department of Medicine, University of Louisville, Louisville, KY, USA
    Life Sci 93:257-64. 2013
    ..This article also looks at the value of these mouse models to understanding human DN as well as potential pitfalls in translating the mouse results to humans. ..
  20. ncbi request reprint Cell death and diabetic cardiomyopathy
    Lu Cai
    Department of Medicine, University of Louisville, Louisville, Kentucky 40292, USA
    Cardiovasc Toxicol 3:219-28. 2003
    ....
  21. pmc Magnolia extract (BL153) ameliorates kidney damage in a high fat diet-induced obesity mouse model
    Wenpeng Cui
    The Second Hospital of Jilin University, Changchun 130041, China The Kosair Children s Hospital Research Institute, Department of Pediatrics of the University of Louisville, Louisville, KY 20202, USA
    Oxid Med Cell Longev 2013:367040. 2013
    ..The present study indicates that BL153 administration may be a novel approach for renoprotection in obese individuals by antiinflammation and anti-oxidative stress most likely via upregulation of PGC-1 α and HK II signal in the kidney. ..
  22. doi request reprint Prevention by sulforaphane of diabetic cardiomyopathy is associated with up-regulation of Nrf2 expression and transcription activation
    Yang Bai
    The Cardiovascular Center, The First Hospital of Jilin University, Changchun, China
    J Mol Cell Cardiol 57:82-95. 2013
    ..These results suggest that diabetes-induced cardiomyopathy can be prevented by SFN, which was associated with the up-regulated Nrf2 expression and transcription function...
  23. doi request reprint Deletion of angiotensin II type 1 receptor gene or scavenge of superoxide prevents chronic alcohol-induced aortic damage and remodelling
    Yang Bai
    The Cardiovascular Center, The First Hospital of Jilin University, Changchun, China
    J Cell Mol Med 16:2530-8. 2012
    ..Therefore, blocking Ang II/AT1 system or scavenging superoxide may become a potential preventive and/therapeutic approach to alcoholic vascular damage...
  24. ncbi request reprint Elevation of serum endothelins and cardiotoxicity induced by particulate matter (PM2.5) in rats with acute myocardial infarction
    Y James Kang
    Department of Medicine, University of Louisville School of Medicine, KY 40292, USA
    Cardiovasc Toxicol 2:253-61. 2002
    ..This study thus suggests that upregulation of the endothelin system in rats with MI is likely involved in the PM exposure-induced cardiotoxicity...
  25. ncbi request reprint Preclinical evaluation of erythropoietin administration in a model of radiation-induced kidney dysfunction
    Nicolaus Andratschke
    Department of Radiation Oncology, Klinikum rechts der Isar, Technical University of Munich, Munich, Germany
    Int J Radiat Oncol Biol Phys 64:1513-8. 2006
    ..To test whether the clinically available growth factor erythropoietin (EPO) influences radiation-induced normal-tissue damage in a model of kidney dysfunction...
  26. ncbi request reprint Rosiglitazone prevents advanced glycation end products-induced renal toxicity likely through suppression of plasminogen activator inhibitor-1
    Xiaoyan Yu
    Department of Pathology, Institute of Frontier Medical Science, Jilin University, Changchun, China
    Toxicol Sci 96:346-56. 2007
    ..Renal protection of RGZ from AGEs may be associated with the suppression of PAI-1 expression through PPAR-dependent and independent mechanisms...
  27. ncbi request reprint Flux through the hexosamine pathway is a determinant of nuclear factor kappaB- dependent promoter activation
    Leighton R James
    Department of Medicine, University of Toronto, Toronto, Ontario, Canada
    Diabetes 51:1146-56. 2002
    ..These results suggest that increased flux through the hexosamine pathway leads to NF-kappaB-dependent promoter activation in MCs...
  28. doi request reprint Alcoholic cardiomyopathy: acetaldehyde, insulin insensitization and ER stress
    Lu Cai
    J Mol Cell Cardiol 44:979-82. 2008
  29. doi request reprint Diabetes-induced alteration of F4/80+ macrophages: a study in mice with streptozotocin-induced diabetes for a long term
    Haixia Ma
    Transplantation Biology Research Division, State Key Laboratory of Biomembrane and Membrane Biotechnology, Institute of Zoology, Chinese Academy of Sciences, Datun Road, Chaoyang, Beijing 100101, China
    J Mol Med (Berl) 86:391-400. 2008
    ....
  30. doi request reprint Acceleration of diabetic wound healing with chitosan-crosslinked collagen sponge containing recombinant human acidic fibroblast growth factor in healing-impaired STZ diabetic rats
    Wei Wang
    The Chinese American Research Institute for Diabetic Complications, School of Pharmaceutical Sciences, Wenzhou Medical College, China
    Life Sci 82:190-204. 2008
    ..All these results suggest that CCCS/FGF is an ideal wound-dressing to improve the recovery of healing-impaired wound such as diabetic skin wound, which provides a great potential use in clinics for diabetic patients in the future...
  31. pmc High level glucose increases mutagenesis in human lymphoblastoid cells
    Ying Zhang
    Department of Environmental, Radiological Health Science, Colorado State University, Fort Collins, Colorado 80521, USA
    Int J Biol Sci 3:375-9. 2007
    ..This study is the first to indicate that HG is able to induce gene mutation which may be one of the important mechanisms of diabetes-associated carcinogenesis...
  32. ncbi request reprint Zinc-metallothionein protects from DNA damage induced by radiation better than glutathione and copper- or cadmium-metallothioneins
    Lu Cai
    Department of Pathology, University of Western Ontario, London, Ont, Canada N6A5C1
    Toxicol Lett 136:193-8. 2003
    ..These results suggest that MT, in particular bound to zinc, is a high-capacity antioxidant to protect radiation-induced DNA damage...
  33. ncbi request reprint Zinc- or cadmium-pre-induced metallothionein protects human central nervous system cells and astrocytes from radiation-induced apoptosis
    Lu Cai
    Department of Pathology, University of Western Ontario London, Canada N6A 5C1
    Toxicol Lett 146:217-26. 2004
    ..These results suggest that MT protected human CNS cells from apoptosis following ionizing radiation, probably through its antioxidant property...
  34. ncbi request reprint Fluvastatin prevents nephropathy likely through suppression of connective tissue growth factor-mediated extracellular matrix accumulation
    Ye Song
    Department of Pathology, Institute of Frontier Medical Science, Jilin University, Changchun, PR China
    Exp Mol Pathol 76:66-75. 2004
    ..Therefore, fluvastatin may be a potential candidate for developing a pharmaceutical approach to the prevention of diabetic nephropathy due to its both lipid-lowering and direct anti-renal ECM accumulation actions...
  35. ncbi request reprint Low-dose radiation (LDR) induces hematopoietic hormesis: LDR-induced mobilization of hematopoietic progenitor cells into peripheral blood circulation
    Wei Li
    Department of Hematology and Oncology, First University Hospital, PR China
    Exp Hematol 32:1088-96. 2004
    ..The aim of this study was to investigate the stimulating effect of low-dose radiation (LDR) on bone marrow hematopoietic progenitor cell (HPC) proliferation and peripheral blood mobilization...
  36. pmc Advanced glycation end-products induce connective tissue growth factor-mediated renal fibrosis predominantly through transforming growth factor beta-independent pathway
    Guihua Zhou
    Department of Pathology, Jilin University, Changchun, People s Republic of China
    Am J Pathol 165:2033-43. 2004
    ..These results suggest that AGE-induced CTGF expression, predominantly through a TGF-beta 1-independent pathway, plays a critical role in renal ECM accumulation leading to diabetic nephropathy...
  37. ncbi request reprint [Changes of cycle and apoptosis of spermatogenic cells and antioxidant capacity in male rats with diabetes mellitus]
    Hong Guang Zhao
    MH Radiobiology Research Unit, School of Public Health, Jilin University, Changchun, Jilin 130021, China
    Zhonghua Nan Ke Xue 11:735-9. 2005
    ..To explore the changes of cycle and apoptosis of spermatogenic cells and antioxidant capacity of the serum and testis in male rats with diabetes mellitus...
  38. ncbi request reprint Effect of low-level radiation on the death of male germ cells
    Guangwei Liu
    Ministry of Health Radiobiology Research Unit, School of Public Health, Jilin University, Changchun, China 130021
    Radiat Res 165:379-89. 2006
    ..These results suggest that low-level radiation induces increased apoptosis in male germ cells but also induces a significant adaptive response that decreases cell death after a subsequent high-dose irradiation...
  39. ncbi request reprint High level expression of human endostatin in Pichia pastoris using a synthetic gene construct
    Zhijian Su
    School of Pharmaceutical Science, Wenzhou Medical College, Wenzhou, 325035, China
    Appl Microbiol Biotechnol 73:1355-62. 2007
    ..pastoris using artificial synthetic gene of preference in P. pastoris was able to inhibit the acidic fibroblast growth factor-induced proliferation of endothelial cells in vitro...
  40. ncbi request reprint Enhanced protection of modified human acidic fibroblast growth factor with polyethylene glycol against ischemia/reperfusion-induced retinal damage in rats
    Zhifeng Huang
    Chinese American Research Institute for Diabetic Complications, School of Pharmaceutical Science, Wenzhou Medical College, China
    Toxicol Lett 170:146-56. 2007
    ..The protection is probably mediated by antioxidant protective mechanisms...
  41. ncbi request reprint Apoptotic cell death induced by low-dose radiation in male germ cells: hormesis and adaptation
    Guangwei Liu
    Ministry of Health Radiobiology Research Unit, School of Public Health, Jilin University, Changchun, China
    Crit Rev Toxicol 37:587-605. 2007
    ..This review also discusses the possible effects of LDR-induced apoptotic hormesis and adaptive response on the modulation of inheritable genomic damage caused by subsequent radiation exposure to male germ cells...
  42. pmc Endothelin-1-mediated alteration of metallothionein and trace metals in the liver and kidneys of chronically diabetic rats
    Lu Cai
    Department of Pathology, The University of Western Ontario, London, Ontario, Canada
    Int J Exp Diabetes Res 3:193-8. 2002
    ..No significant effects of bosentan treatment on nondiabetic rats were observed. The data suggest that the possible effects of ET antagonism in diabetes may be mediated via changes in MT and trace metals...