Richard B Buxton

Summary

Publications

  1. pmc CBF/CMRO2 coupling measured with calibrated BOLD fMRI: sources of bias
    Oleg Leontiev
    Department of Radiology and UCSD Center for Functional Magnetic Resonance Imaging, University of California, San Diego, La Jolla, CA 92093 0677, USA
    Neuroimage 36:1110-22. 2007
  2. ncbi request reprint Modeling the hemodynamic response to brain activation
    Richard B Buxton
    Department of Radiology, 0677, and Center for Functional MRI, University of California San Diego, La Jolla, CA 92093 0677, USA
    Neuroimage 23:S220-33. 2004
  3. pmc The gravitational distribution of ventilation-perfusion ratio is more uniform in prone than supine posture in the normal human lung
    A Cortney Henderson
    Department of Medicine, University of California, San Diego, La Jolla, CA 92093, USA
    J Appl Physiol (1985) 115:313-24. 2013
  4. pmc Caffeine-induced uncoupling of cerebral blood flow and oxygen metabolism: a calibrated BOLD fMRI study
    Joanna E Perthen
    Department of Radiology, Center for Functional Magnetic Resonance Imaging, University of California San Diego, 9500 Gilman Drive, La Jolla, CA 92093 0677, USA
    Neuroimage 40:237-47. 2008
  5. ncbi request reprint Caffeine alters the temporal dynamics of the visual BOLD response
    Thomas T Liu
    Center for Functional Magnetic Resonance Imaging and Department of Radiology, University of California San Diego, La Jolla CA 92093 0677, USA
    Neuroimage 23:1402-13. 2004
  6. pmc Spatial-temporal dynamics of pulmonary blood flow in the healthy human lung in response to altered FI(O2)
    Amran K Asadi
    Department of Medicine, University of California, San Diego, La Jolla, California 92093 0852, USA
    J Appl Physiol (1985) 114:107-18. 2013
  7. pmc Vertical distribution of specific ventilation in normal supine humans measured by oxygen-enhanced proton MRI
    Rui Carlos Sa
    Department of Medicine, University of California, San Diego, 9500 Gilman Dr, La Jolla, CA 92093 0852, USA
    J Appl Physiol (1985) 109:1950-9. 2010
  8. pmc Coupling of cerebral blood flow and oxygen metabolism is conserved for chromatic and luminance stimuli in human visual cortex
    Oleg Leontiev
    Department of Radiology and Center for Functional MRI, University of California, San Diego, CA 92093 0677, USA
    Neuroimage 68:221-8. 2013
  9. pmc Lung volume does not alter the distribution of pulmonary perfusion in dependent lung in supine humans
    Susan R Hopkins
    Department of Medicine, Division of Physiology, University of California, San Diego, La Jolla, CA 92093 0623, USA
    J Physiol 588:4759-68. 2010
  10. pmc Characterizing pulmonary blood flow distribution measured using arterial spin labeling
    A Cortney Henderson
    Department of Medicine, Division of Physiology, University of California, San Diego, La Jolla, CA 92093 0931, USA
    NMR Biomed 22:1025-35. 2009

Detail Information

Publications41

  1. pmc CBF/CMRO2 coupling measured with calibrated BOLD fMRI: sources of bias
    Oleg Leontiev
    Department of Radiology and UCSD Center for Functional Magnetic Resonance Imaging, University of California, San Diego, La Jolla, CA 92093 0677, USA
    Neuroimage 36:1110-22. 2007
    ..These results underscore the importance of a critical evaluation of the methodology, and the adoption of consistent standards for applying the calibrated BOLD approach to the evaluation of CBF/CMRO2 coupling...
  2. ncbi request reprint Modeling the hemodynamic response to brain activation
    Richard B Buxton
    Department of Radiology, 0677, and Center for Functional MRI, University of California San Diego, La Jolla, CA 92093 0677, USA
    Neuroimage 23:S220-33. 2004
    ..This approach has the potential to enhance numerous studies of brain function in development, health, and disease...
  3. pmc The gravitational distribution of ventilation-perfusion ratio is more uniform in prone than supine posture in the normal human lung
    A Cortney Henderson
    Department of Medicine, University of California, San Diego, La Jolla, CA 92093, USA
    J Appl Physiol (1985) 115:313-24. 2013
    ....
  4. pmc Caffeine-induced uncoupling of cerebral blood flow and oxygen metabolism: a calibrated BOLD fMRI study
    Joanna E Perthen
    Department of Radiology, Center for Functional Magnetic Resonance Imaging, University of California San Diego, 9500 Gilman Drive, La Jolla, CA 92093 0677, USA
    Neuroimage 40:237-47. 2008
    ..A calibrated BOLD methodology using R(2) * is a promising approach for evaluating CBF and CMRO(2) changes in response to pharmacological interventions...
  5. ncbi request reprint Caffeine alters the temporal dynamics of the visual BOLD response
    Thomas T Liu
    Center for Functional Magnetic Resonance Imaging and Department of Radiology, University of California San Diego, La Jolla CA 92093 0677, USA
    Neuroimage 23:1402-13. 2004
    ..The reproducibility of the results was verified in one subject who was scanned on 3 different days. The dynamic changes are similar to those previously reported for baseline CBF reductions induced by hypocapnia and hyperoxia...
  6. pmc Spatial-temporal dynamics of pulmonary blood flow in the healthy human lung in response to altered FI(O2)
    Amran K Asadi
    Department of Medicine, University of California, San Diego, La Jolla, California 92093 0852, USA
    J Appl Physiol (1985) 114:107-18. 2013
    ..These results clearly demonstrate a temporal change in the sampled distribution of pulmonary blood flow in response to hypoxia, which is not observed when considering only the relative dispersion of the spatial distribution...
  7. pmc Vertical distribution of specific ventilation in normal supine humans measured by oxygen-enhanced proton MRI
    Rui Carlos Sa
    Department of Medicine, University of California, San Diego, 9500 Gilman Dr, La Jolla, CA 92093 0852, USA
    J Appl Physiol (1985) 109:1950-9. 2010
    ..This SV imaging technique can be used to quantify regional SV in the lung with proton MRI...
  8. pmc Coupling of cerebral blood flow and oxygen metabolism is conserved for chromatic and luminance stimuli in human visual cortex
    Oleg Leontiev
    Department of Radiology and Center for Functional MRI, University of California, San Diego, CA 92093 0677, USA
    Neuroimage 68:221-8. 2013
    ..We conclude that CBF-CMRO(2) coupling is conserved for the chromatic and luminance stimuli used, suggesting a consistent coupling for blob and inter-blob neuronal populations despite the difference in CO concentration...
  9. pmc Lung volume does not alter the distribution of pulmonary perfusion in dependent lung in supine humans
    Susan R Hopkins
    Department of Medicine, Division of Physiology, University of California, San Diego, La Jolla, CA 92093 0623, USA
    J Physiol 588:4759-68. 2010
    ..In supine posture, the gravitational influence on perfusion is remarkably similar over most of the lung, irrespective of lung volume...
  10. pmc Characterizing pulmonary blood flow distribution measured using arterial spin labeling
    A Cortney Henderson
    Department of Medicine, Division of Physiology, University of California, San Diego, La Jolla, CA 92093 0931, USA
    NMR Biomed 22:1025-35. 2009
    ..This suggests that the GSD is a useful measure of pulmonary blood flow heterogeneity with the advantage of being less affected by the ASL signal from tagged blood in larger vessels...
  11. pmc Regional differences in the coupling of cerebral blood flow and oxygen metabolism changes in response to activation: implications for BOLD-fMRI
    Beau M Ances
    Department of Neurosciences, University of California, San Diego, CA 92093 0677, USA
    Neuroimage 39:1510-21. 2008
    ..Because of this strong sensitivity to n, BOLD response amplitudes cannot be interpreted as a quantitative reflection of underlying metabolic changes, particularly when comparing cortical and subcortical regions...
  12. pmc Quantitative MRI measurement of lung density must account for the change in T(2) (*) with lung inflation
    Rebecca J Theilmann
    Department of Radiology, University of California, San Diego, La Jolla, California, USA
    J Magn Reson Imaging 30:527-34. 2009
    ..To evaluate lung water density at three different levels of lung inflation in normal lungs using a fast gradient echo sequence developed for rapid imaging...
  13. pmc Luminance contrast of a visual stimulus modulates the BOLD response more than the cerebral blood flow response in the human brain
    Christine L Liang
    Department of Radiology, University of California, San Diego, CA 92093 0677, USA
    Neuroimage 64:104-11. 2013
    ..3 at the highest contrast level. The implication of these results for fMRI studies is that the magnitude of the BOLD response does not accurately reflect the magnitude of underlying physiological processes...
  14. ncbi request reprint Effects of age on pulmonary perfusion heterogeneity measured by magnetic resonance imaging
    David L Levin
    Department of Radiology, University of California, San Diego, La Jolla, CA 92093 0623, USA
    J Appl Physiol (1985) 102:2064-70. 2007
    ....
  15. pmc Vertical gradients in regional lung density and perfusion in the supine human lung: the Slinky effect
    Susan R Hopkins
    Department of Medicine, University of California, San Diego, La Jolla, California 92093, USA
    J Appl Physiol (1985) 103:240-8. 2007
    ..This implies that measurements of perfusion in vivo will be influenced by density distributions and will differ from excised lungs where density gradients are reduced by processing...
  16. ncbi request reprint A primer on functional magnetic resonance imaging
    Gregory G Brown
    Psychology Service MC 116B, VA San Diego Healthcare System, 3350 La Jolla Village Drive, La Jolla, California 92161, USA
    Neuropsychol Rev 17:107-25. 2007
    ..In the fourth section, calibrated fMRI, which uses BOLD and ASL to infer alterations of oxygen utilization during behavioral activation, is reviewed. The discussion concludes with challenges confronting studies of individual cases...
  17. ncbi request reprint Imaging periodic currents using alternating balanced steady-state free precession
    Giedrius T Buracas
    Department of Radiology, UCSD Center for Functional MRI, La Jolla, California 92037, USA
    Magn Reson Med 59:140-8. 2008
    ..Current phantom experiments employing ABSS imaging resulted in detection of magnetic field variations as small as 0.15nT in scans lasting for 36 sec, which is more sensitive than using gradient-recalled echo imaging...
  18. ncbi request reprint Vascular space occupancy weighted imaging with control of residual blood signal and higher contrast-to-noise ratio
    Wen Chau Wu
    Department of Radiology, University of California at San Diego, La Jolla, CA 92093, USA
    IEEE Trans Med Imaging 26:1319-27. 2007
    ..Results also demonstrated its advantages of 1.6-fold higher CNR and insensitivity to variant tissue/blood T1 as well as inversion efficiency...
  19. pmc Pulmonary perfusion in the prone and supine postures in the normal human lung
    G Kim Prisk
    Department of Medicine, University of California, San Diego, La Jolla, California 92093 0931, USA
    J Appl Physiol (1985) 103:883-94. 2007
    ....
  20. pmc Early brain swelling in acute hypoxia
    David J Dubowitz
    UCSD Centre for Functional MRI, 9500 Gilman Dr, MC 0677, La Jolla, CA 92093 0677, USA
    J Appl Physiol (1985) 107:244-52. 2009
    ..These acute-phase changes are present in all individuals, irrespective of susceptibility to AMS...
  21. ncbi request reprint Coupling of cerebral blood flow and oxygen consumption during physiological activation and deactivation measured with fMRI
    Kamil Uludag
    0677 Center for Functional MRI, Department of Radiology, University of California, San Diego, La Jolla, CA 92093 0677, USA
    Neuroimage 23:148-55. 2004
    ....
  22. pmc On multiple alternating steady states induced by periodic spin phase perturbation waveforms
    Giedrius T Buracas
    Center for Functional MRI, Department of Radiology, University of California, San Diego, La Jolla, California 92037, USA
    Magn Reson Med 67:1412-8. 2012
    ..Thus, multiple alternating steady state technique is potentially applicable to MR imaging of the waveforms of periodic neuronal activity...
  23. pmc A novel method of combining blood oxygenation and blood flow sensitive magnetic resonance imaging techniques to measure the cerebral blood flow and oxygen metabolism responses to an unknown neural stimulus
    Aaron B Simon
    Department of Bioengineering and Medical Scientist Training Program, University of California San Diego, La Jolla, California, USA
    PLoS ONE 8:e54816. 2013
    ....
  24. doi request reprint An analysis of the use of hyperoxia for measuring venous cerebral blood volume: comparison of the existing method with a new analysis approach
    Nicholas P Blockley
    Center for Functional Magnetic Resonance Imaging, Department of Radiology, University of California San Diego, La Jolla, CA, USA
    Neuroimage 72:33-40. 2013
    ..Both methods were tested experimentally, with the new method producing results that are consistent with the limited literature in this area...
  25. pmc Reproducibility of BOLD, perfusion, and CMRO2 measurements with calibrated-BOLD fMRI
    Oleg Leontiev
    Department of Radiology and Center for Functional MRI, University of California, San Diego, CA 92093 0677, USA
    Neuroimage 35:175-84. 2007
    ..We conclude that the calibrated BOLD approach provides a highly reproducible measurement of n that can serve as a useful quantitative probe of the coupling of blood flow and energy metabolism in the brain...
  26. pmc Regional cerebral blood flow during acute hypoxia in individuals susceptible to acute mountain sickness
    Edward A W Dyer
    Department of Medicine, Division of Physiology, University of California San Diego, USA
    Respir Physiol Neurobiol 160:267-76. 2008
    ..1+/-7.7 ml/(100 g min) (10+/-11%), AMS-R = 8.3+/-5.7 ml/(100 g min) (17+/-11%), p = 0.57; WM: AMS-S = 4.3+/-5.1 ml/(100 g min) (12+/-15%), AMS-R = 4.8+/-2.9 ml/(100 g min) (16+/-9%), p = 0.82)...
  27. ncbi request reprint Functional MRI of global and local processing in children
    Pamela Moses
    Department of Cognitive Science, University of California of San Diego, La Jolla, California 92093, USA
    Neuroimage 16:415-24. 2002
    ..Importantly these patterns of functional activation mirror the profiles of RT performance. Together they demonstrate a shift from undifferentiated, bilateral processing toward hemispheric lateralization...
  28. ncbi request reprint Discrepancies between BOLD and flow dynamics in primary and supplementary motor areas: application of the balloon model to the interpretation of BOLD transients
    Takayuki Obata
    Department of Radiology, University of California at San Diego, 92039 0677, La Jolla, CA, USA
    Neuroimage 21:144-53. 2004
    ..This study illustrates the utility and the limitations of using theoretical models combined with ASL techniques to understand the dynamics of the BOLD response...
  29. pmc A review of calibrated blood oxygenation level-dependent (BOLD) methods for the measurement of task-induced changes in brain oxygen metabolism
    Nicholas P Blockley
    Center for Functional Magnetic Resonance Imaging, Department of Radiology, University of California San Diego, La Jolla, CA, USA
    NMR Biomed 26:987-1003. 2013
    ..Important aspects of practical implementation are reviewed and reported applications of this methodology are presented...
  30. pmc Cortical depth-specific microvascular dilation underlies laminar differences in blood oxygenation level-dependent functional MRI signal
    Peifang Tian
    Department of Neurosciences, University of California at San Diego, La Jolla, CA 92093, USA
    Proc Natl Acad Sci U S A 107:15246-51. 2010
    ....
  31. ncbi request reprint Quantifying CBF with arterial spin labeling
    Richard B Buxton
    Center for Functional MRI, University of California, San Diego, La Jolla, California CA 92093 0677, USA
    J Magn Reson Imaging 22:723-6. 2005
    ..The ASL approach has the potential to provide a robust estimation of CBF, although the timing of water exchange into tissue and the effects of pulsatile flow require further investigation...
  32. ncbi request reprint Analysis and design of perfusion-based event-related fMRI experiments
    Thomas T Liu
    Department of Radiology, University of California at San Diego, La Jolla, California, 92093, USA
    Neuroimage 16:269-82. 2002
    ..Numerical simulations and results from ASL experiments are used to support the theoretical findings...
  33. pmc Dynamic models of BOLD contrast
    Richard B Buxton
    Department of Radiology, Center for Functional MRI, and Kavli Institute for Brain and Mind, University of California, San Diego, La Jolla, California, CA 92093 0677, USA
    Neuroimage 62:953-61. 2012
    ....
  34. pmc A general analysis of calibrated BOLD methodology for measuring CMRO2 responses: comparison of a new approach with existing methods
    Nicholas P Blockley
    Center for Functional Magnetic Resonance Imaging, Department of Radiology, University of California San Diego, La Jolla, CA 92093 0677, USA
    Neuroimage 60:279-89. 2012
    ....
  35. pmc The challenge of connecting the dots in the B.R.A.I.N
    Anna Devor
    Department of Neurosciences, University of California San Diego, La Jolla, CA 92093, USA Department of Radiology, University of California San Diego, La Jolla, CA 92093, USA Martinos Center for Biomedical Imaging, Massachusetts General Hospital, Harvard Medical School, Charlestown, MA 02129, USA Electronic address
    Neuron 80:270-4. 2013
    ..Here, we outline our collective vision for what we can achieve within a decade with properly targeted efforts and discuss likely technological deliverables and neuroscience progress. ..
  36. pmc Adaptation of cerebral oxygen metabolism and blood flow and modulation of neurovascular coupling with prolonged stimulation in human visual cortex
    Farshad Moradi
    Department of Radiology, University of California, San Diego, CA 92103 8756, USA
    Neuroimage 82:182-9. 2013
    ..However BOLD modulations may not accurately represent the underlying metabolic nonlinearity due to modulation of the coupling of blood flow and oxygen metabolism changes. ..
  37. ncbi request reprint Gadolinium-DTPA-dextran: a macromolecular MR blood pool contrast agent
    Claude B Sirlin
    Department of Radiology, University of California, San Diego, 200 West Arbor Drive, San Diego, CA, USA
    Acad Radiol 11:1361-9. 2004
    ..The purpose of this study was to test gadolinium-diethylenetriaminepentaacetate-dextran ([Gd]DTPA-dextran) as a new water soluble macromolecular blood pool agent for MR imaging...
  38. pmc Steep head-down tilt has persisting effects on the distribution of pulmonary blood flow
    A Cortney Henderson
    Univ of California, San Diego, Dept of Medicine, 9500 Gilman Dr, 0931, La Jolla, CA 92093 0931, USA
    J Appl Physiol (1985) 101:583-9. 2006
    ..05). We speculate that the mechanism most likely responsible for our findings is that increased pulmonary capillary pressures and fluid efflux in the lung resulting from head-down tilt alters regional blood flow distribution...
  39. ncbi request reprint Measuring the effects of indomethacin on changes in cerebral oxidative metabolism and cerebral blood flow during sensorimotor activation
    Kamil Uludag
    Magn Reson Med 51:1088-9; author reply 1090. 2004
  40. ncbi request reprint BOLD and perfusion response to finger-thumb apposition after acetazolamide administration: differential relationship to global perfusion
    Gregory G Brown
    VA San Diego Healthcare System, San Diego, California 92161, USA
    J Cereb Blood Flow Metab 23:829-37. 2003
    ....
  41. ncbi request reprint Alternative brain organization after prenatal cerebral injury: convergent fMRI and cognitive data
    Joan Stiles
    Department of Cognitive Science, University of California, San Diego 92093 0515, USA
    J Int Neuropsychol Soc 9:604-22. 2003
    ..In addition, the coupling of the activation with the behavioral data allows us to go beyond the simple mapping of functional sites, to ask questions about how those sites may have come to mediate the spatial functions...