Igor A Butovich

Summary

Publications

  1. ncbi The Meibomian puzzle: combining pieces together
    Igor A Butovich
    Department of Ophthalmology and Graduate School of Biomedical Sciences, University of Texas Southwestern Medical Center, 5323 Harry Hines Blvd, Dallas, TX 75390 9057, USA
    Prog Retin Eye Res 28:483-98. 2009
  2. ncbi Lipidomics of human Meibomian gland secretions: Chemistry, biophysics, and physiological role of Meibomian lipids
    Igor A Butovich
    Department of Ophthalmology and the Graduate School of Biomedical Sciences, University of Texas Southwestern Medical Center, 5323 Harry Hines Blvd, Dallas, TX 75390 9057, USA
    Prog Lipid Res 50:278-301. 2011
  3. ncbi Toward an animal model of the human tear film: biochemical comparison of the mouse, canine, rabbit, and human meibomian lipidomes
    Igor A Butovich
    Department of Ophthalmology, University of Texas Southwestern Medical Center, Dallas, TX 75390, USA
    Invest Ophthalmol Vis Sci 53:6881-96. 2012
  4. ncbi Increased evaporative rates in laboratory testing conditions simulating airplane cabin relative humidity: an important factor for dry eye syndrome
    Eduardo Uchiyama
    Department of Ophthalmology, The University of Texas Southwestern Medical Center at Dallas, Dallas, TX 75390 9057, USA
    Eye Contact Lens 33:174-6. 2007
  5. ncbi Pattern of vital staining and its correlation with aqueous tear deficiency and meibomian gland dropout
    Eduardo Uchiyama
    Department of Ophthalmology, The University of Texas Southwestern Medical Center at Dallas, Dallas, TX 75390 9057, USA
    Eye Contact Lens 33:177-9. 2007
  6. ncbi Evaluation and quantitation of intact wax esters of human meibum by gas-liquid chromatography-ion trap mass spectrometry
    Igor A Butovich
    Department of Ophthalmology, University of Texas Southwestern Medical Center, Dallas, Texas 75390 9057, USA
    Invest Ophthalmol Vis Sci 53:3766-81. 2012
  7. ncbi Effects of free fatty acids on meibomian lipid films
    Juan C Arciniega
    Department of Ophthalmology, University of Texas Southwestern Medical Center at Dallas, TX 75390 9057, USA
    Exp Eye Res 93:452-9. 2011
  8. ncbi Human tear film and meibum. Very long chain wax esters and (O-acyl)-omega-hydroxy fatty acids of meibum
    Igor A Butovich
    Department of Ophthalmology, University of Texas Southwestern Medical Center, Dallas, TX 75390, USA
    J Lipid Res 50:2471-85. 2009
  9. ncbi Understanding and analyzing meibomian lipids--a review
    Igor A Butovich
    Department of Ophthalmology and Graduate School of Biomedical Sciences, University of Texas Southwestern Medical Center, Dallas, Texas, USA
    Curr Eye Res 33:405-20. 2008
  10. ncbi On the lipid composition of human meibum and tears: comparative analysis of nonpolar lipids
    Igor A Butovich
    Department of Ophthalmology and Graduate School of Biomedical Sciences, University of Texas Southwestern Medical Center, Dallas, Texas, USA
    Invest Ophthalmol Vis Sci 49:3779-89. 2008

Collaborators

Detail Information

Publications22

  1. ncbi The Meibomian puzzle: combining pieces together
    Igor A Butovich
    Department of Ophthalmology and Graduate School of Biomedical Sciences, University of Texas Southwestern Medical Center, 5323 Harry Hines Blvd, Dallas, TX 75390 9057, USA
    Prog Retin Eye Res 28:483-98. 2009
    ..Thus, these compounds may become an important target in biochemistry and (patho)physiology of ocular surface and dry eye research...
  2. ncbi Lipidomics of human Meibomian gland secretions: Chemistry, biophysics, and physiological role of Meibomian lipids
    Igor A Butovich
    Department of Ophthalmology and the Graduate School of Biomedical Sciences, University of Texas Southwestern Medical Center, 5323 Harry Hines Blvd, Dallas, TX 75390 9057, USA
    Prog Lipid Res 50:278-301. 2011
    ..It is concluded that despite a substantial progress in the area of Meibomian glands lipidomics, there are large areas of uncertainty that need to be addressed in future experiments...
  3. ncbi Toward an animal model of the human tear film: biochemical comparison of the mouse, canine, rabbit, and human meibomian lipidomes
    Igor A Butovich
    Department of Ophthalmology, University of Texas Southwestern Medical Center, Dallas, TX 75390, USA
    Invest Ophthalmol Vis Sci 53:6881-96. 2012
    ....
  4. ncbi Increased evaporative rates in laboratory testing conditions simulating airplane cabin relative humidity: an important factor for dry eye syndrome
    Eduardo Uchiyama
    Department of Ophthalmology, The University of Texas Southwestern Medical Center at Dallas, Dallas, TX 75390 9057, USA
    Eye Contact Lens 33:174-6. 2007
    ....
  5. ncbi Pattern of vital staining and its correlation with aqueous tear deficiency and meibomian gland dropout
    Eduardo Uchiyama
    Department of Ophthalmology, The University of Texas Southwestern Medical Center at Dallas, Dallas, TX 75390 9057, USA
    Eye Contact Lens 33:177-9. 2007
    ....
  6. ncbi Evaluation and quantitation of intact wax esters of human meibum by gas-liquid chromatography-ion trap mass spectrometry
    Igor A Butovich
    Department of Ophthalmology, University of Texas Southwestern Medical Center, Dallas, Texas 75390 9057, USA
    Invest Ophthalmol Vis Sci 53:3766-81. 2012
    ..Their complete characterization on the level of individual intact lipid species has not been completed yet. We obtained detailed structural information on previously uncharacterized meibomian WE...
  7. ncbi Effects of free fatty acids on meibomian lipid films
    Juan C Arciniega
    Department of Ophthalmology, University of Texas Southwestern Medical Center at Dallas, TX 75390 9057, USA
    Exp Eye Res 93:452-9. 2011
    ....
  8. ncbi Human tear film and meibum. Very long chain wax esters and (O-acyl)-omega-hydroxy fatty acids of meibum
    Igor A Butovich
    Department of Ophthalmology, University of Texas Southwestern Medical Center, Dallas, TX 75390, USA
    J Lipid Res 50:2471-85. 2009
    ..and the aqueous subphase beneath it, a role previously attributed to phospholipids...
  9. ncbi Understanding and analyzing meibomian lipids--a review
    Igor A Butovich
    Department of Ophthalmology and Graduate School of Biomedical Sciences, University of Texas Southwestern Medical Center, Dallas, Texas, USA
    Curr Eye Res 33:405-20. 2008
    ..This review is intended to bring to the informed reader the current state of knowledge about meibomian lipids and the art for analyzing them...
  10. ncbi On the lipid composition of human meibum and tears: comparative analysis of nonpolar lipids
    Igor A Butovich
    Department of Ophthalmology and Graduate School of Biomedical Sciences, University of Texas Southwestern Medical Center, Dallas, Texas, USA
    Invest Ophthalmol Vis Sci 49:3779-89. 2008
    ....
  11. ncbi Lipids of human meibum: mass-spectrometric analysis and structural elucidation
    Igor A Butovich
    Department of Ophthalmology, University of Texas Southwestern Medical Center at Dallas, Dallas, TX 75390 9057, USA
    J Lipid Res 48:2220-35. 2007
    ..These observations suggest that MGS are a major source of nonpolar lipids of the WE and Chl-E families for the tear film lipid layer, but not of its previously reported (phospho)lipid, Cer, and fatty acid amide components...
  12. ncbi Meibomian lipid films and the impact of temperature
    Igor A Butovich
    Department of Ophthalmology, Graduate School of Biomedical Sciences, University of Texas Southwestern Medical Center, Dallas, Texas 75390 9057, USA
    Invest Ophthalmol Vis Sci 51:5508-18. 2010
    ..This may have a detrimental impact on the stability and functionality of the human tear film and the tear film lipid layer. The goal of this project was to quantitatively examine the possible impact of temperature on the latter...
  13. ncbi Liquid chromatography-mass spectrometric analysis of lipids present in human meibomian gland secretions
    Igor A Butovich
    Department of Ophthalmology, University of Texas Southwestern Medical Center at Dallas, 5323 Harry Hines Boulevard, Dallas, TX 75390 9057, USA
    Lipids 42:765-76. 2007
    ..These observations suggest that MGS are a major source of the nonpolar lipids of the WE and Chl-E families for the tear film lipid layer (TFLL), but not of the previously reported phospholipid components of the TFLL...
  14. ncbi Fatty acid composition of cholesteryl esters of human meibomian gland secretions
    Igor A Butovich
    Department of Ophthalmology and the Graduate School of Biomedical Sciences, University of Texas Southwestern Medical Center, Dallas, TX, USA
    Steroids 75:726-33. 2010
    ..We conclude that the FA composition of CE can be successfully established in LC-MS experiments conducted in NIM. Meibomian CE have a large presence of both saturated and unsaturated FA with an average molar ratio of 4 to 1, respectively...
  15. ncbi Cholesteryl esters as a depot for very long chain fatty acids in human meibum
    Igor A Butovich
    Department of Ophthalmology and Graduate School of Biomedical Sciences, University of Texas Southwestern Medical Center, Dallas, TX 75390, USA
    J Lipid Res 50:501-13. 2009
    ..Other Chl-containing compounds were detected but not identified at the time. Therefore, Chl-E are a depot for very long chain saturated and monounsaturated fatty acids in human meibum...
  16. ncbi Disruption and destabilization of meibomian lipid films caused by increasing amounts of ceramides and cholesterol
    Juan C Arciniega
    Department of Ophthalmology, University of Texas Southwestern Medical Center, 5323 Harry Hines Boulevard, Dallas, TX 75390 9057, USA
    Invest Ophthalmol Vis Sci 54:1352-60. 2013
    ..We evaluated quantitatively direct effects of ceramide (Cer) and free cholesterol (FC) on meibomian lipid films (MLF) using a Langmuir trough (LT) and a Brewster angle microscope (BAM)...
  17. ncbi Lipidomic analysis of human meibum using HPLC-MSn
    Igor A Butovich
    Department of Ophthalmology, University of Texas, Southwestern Medical Center, Dallas, TX, USA
    Methods Mol Biol 579:221-46. 2009
    ....
  18. ncbi Comparative HPLC-MS analysis of canine and human meibomian lipidomes: many similarities, a few differences
    Igor A Butovich
    University of Texas Southwestern Medical Center, Department of Ophthalmology and the Graduate School of Biomedical Sciences, Dallas, TX, USA
    Sci Rep 1:24. 2011
    ..The lipidomes of cMGS and hMGS were found to be qualitatively similar, which implies similar biosynthetic and biodegradation pathways in canines and humans. However, some quantitative differences between the two were observed...
  19. ncbi Epidermal expression of an Elovl4 transgene rescues neonatal lethality of homozygous Stargardt disease-3 mice
    Anne McMahon
    Department of Ophthalmology, University of Texas Southwestern Medical Center, Dallas, TX 75390, USA
    J Lipid Res 52:1128-38. 2011
    ..In addition to the skin, Elovl4 is also expressed in other tissues, including the retina, brain, and testes. Thus, these mice will facilitate future studies to define the roles of C28-C36 fatty acids in the Elovl4-expressing tissues...
  20. ncbi Inhibition of lipoxygenases and cyclooxygenases by linoleyl hydroxamic acid: comparative in vitro studies
    Igor A Butovich
    Department of Ophthalmology and Graduate School of Biomedical Sciences, University of Texas Southwestern Medical Center, Dallas, TX, USA
    J Lipid Res 49:1284-94. 2008
    ..g., inflammation, cardiovascular disorders, cancer, asthma, allergies, psoriasis, and stroke...
  21. ncbi Impact of evaporation on aqueous tear loss
    James P McCulley
    Department of Ophthalmology, University of Texas Southwestern Medical Center at Dallas, Dallas, Texas, USA
    Trans Am Ophthalmol Soc 104:121-8. 2006
    ..The percent contribution is dependent on environmental conditions such as RH. There was a trend toward increased contribution to AT loss in dry eye patients vs controls, but statistical significance was not reached...
  22. ncbi Correlations in a change in aqueous tear evaporation with a change in relative humidity and the impact
    James P McCulley
    Department of Ophthalmology, The University of Texas Southwestern Medical Center, Dallas, Texas 75390 9057, USA
    Am J Ophthalmol 141:758-60. 2006
    ..To establish scientific relationship between relative humidity (RH) and aqueous tear evaporation to elucidate possible significance of this relationship in normals and aqueous tear deficiency patients...